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Progastrin-releasing peptide as a diagnostic and therapeutic biomarker of small cell lung cancer
오형주,( Ha Young Park ),( Tae Ok Kim1 ),( Chul Kyu Park ),( Hong Jun Shin ),( Hee Jung Ban ),( In Jae Oh ),( Yong Soo Kwon ),( Yu Il Kim ),( Sung Chul Lim ),( Young Chul Kim ),( Soo Hyun Kim ),( Myung G 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: Progastrin-releasing peptide (proGRP) is a recently identified biomarker of small cell lung cancer (SCLC). We aimed this study for evaluating the usefulness of automated proGRP measurement for diagnosis and treatment monitoring in patients with SCLC. Methods: From January 2011 to December 2013, plasma samples were prospectively collected from 452 [213 non-small cell lung cancer (NSCLC), 104 SCLC, 135 other diseases] patients visited for tissue diagnosis and tested by two-step automated immunoassay using the ARCHITECT proGRP assay kit (Abbott Diagnostics, USA). The cutoff level of proGRP was set at 63 pg/mL. Results: The mean proGRP was higher in SCLC (1823.0 ± 2684.0 pg/mL) than in NSCLC (61.0 ± 341.7 pg/mL) and other diseases (51.5 ± 222.6 pg/mL, p<0.001). The sensitivity of proGRP was 85.7% (90/105) in SCLC and 11.8% (25/212) in NSCLC. The specificity was 90.2%, positive predictive value was 72.5%, and negative predictive value was 95.4% in SCLC. The mean proGRP was higher in extensive disease (2158.1 ± 2980.6 pg/mL) than in limited disease (901.4 ± 1216.0 pg/mL, p=0.033). Among the 39 patients with SCLC could be followed, the mean proGRP levels of 23 responders were significantly decreased after chemotherapy (from 1651.5 ± 1386.4 pg/mL to 290.0 ± 524.8 pg/mL, p<0.001), whereas those of the 16 non-responders were not. (from 572.5 ± 790.3 pg/mL to 494.4 ± 610.9 pg/mL, p=0.583). Conclusion: Plasma proGRP could be a useful biomarker of SCLC for diagnosis and treatment monitoring. And the initial level may represent the tumor extent of SCLC.
Proportion And Characteristics Of Transient Nodules In A Retrospective Analysis Of Pulmonary Nodules
( Jin Yeong Yu ),( Su Young Chi ),( Hee Jung Ban ),( Yong Soo Kwon ),( In Jae Oh ),( Kyu Sik Kim ),( Yu Il Kim1 ),( Sung Chul Lim ),( Song Choi ),( Yun Hyeon Kim ),( Young Chul Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.-
이온선택(選擇) 전극법(電極法)과 염광광도법(炎光光度法)에서의 혈청내(血淸內) Na+K+ 농도(濃度)에 대(對)한 정상참고치설정(正常參考値設定)을 위(爲)한 시도(試圖)
정혜인 ( Hae In Jeong ),성일영 ( Il Young Sung ),이현숙 ( Hean Suk Lee ),김영희 ( Young Hee Kim ),유순임 ( Soon 1m Yu ),정악승 ( Nak Seung Chung ) 대한임상검사과학회 1984 대한임상검사과학회지(KJCLS) Vol.16 No.1
Using Corning 405 flame photometer and Corning 902 Na/K analyzer, we have studied on the normal range of Na+ and K+ level in serum by flame photometry and ion selective electrode analyzing method (1) Among the 265 healthy male and female employees, we measured mean, S.D. and obtained recalculated results with excluding those outside::t 3 S.D. The results are as follows; Na+(mEq/L), 405-Flame. 902-I.S.E. Normal range. (X±2 S.D.) 140.66+7.02 142.13+8.02 *N.R. : Normal Range. K+ (mEq/L), 405-Flame. 902-I.S.E. 4.06±0.74 4.12±0.80 Borderline (N.R.*~3 S.D.) N.R.~ ±10.53 N.R.~±12.03 N.R.~±1.11 N.R.~±12.03 (2) Also we tried to calculate the normal range applying Hoffmann`` s method based on the laboratory records of Seoul Paik Hospital during the period of Jan. 1982-Dec. 1982 by flame photometer and Jan. 1983-Dec. 1983 by ion selective electrode analyzer. It was 1, 970 cases (M: F=1. 25 : 1) for flame photometry and 2, 919 cases (M: F=1. 27 : 1) for ion selective electrode analyzing method. The range of 95% on the probability paper are as follows; Na+(mEq/L), 405-Flame. 902-I.S.E. 140.3±7.2 141.2±8.8 K+(mEq/L), 405-Flame, 902-I.S.E. 4.0+0.77 4.1+0.85 (3) After grouping of sex and age on the laboratory records, we measured mean, S.D. with exception of the groups that showed severely irregular pattern and recalculated same above (1) Na (mEq/L) (X±t2 S.D.) 405-Flame, 130.5-148.0 902-I.S.E 127.4-153.3 K (mEq/L) 405-Flame 3.5-5.5 902-I.S.E 2.6-5.4 These ranges are scattered broadly in comparison with above the results of (1), (2). Even though out-ranged groups were excluded from the statistical analysis, it is not suggested as proper method to calculate the mean value under applicated by normal distribution. The result, however, appeared significant for reference value for normal range in or out.patients.
곽승준(Seung Jun Kwack),김순선(Soon Sun Kim),최요우(Yo Woo Choi),이규식(Gyu Seek Rhee),손경희(Kyung Hee Sohn),이이다(Rhee Da Lee),채수영(Soo Young Chae),정용현(Yong-Hyun Chung1),유일재(Il Je Yu1),박귀례(Kui Lea Park) 한국독성학회 2004 Toxicological Research Vol.20 No.2
3-Monochloro-1,2-propanediol(3-MCPD) is a toxic compound, often present in different foods containing acid hydrolyzed(AH) protein, like seasonings and savory food products. The purpose of the present study was to investigate the effects of 3-MCPD on male fertility, sperm and testosterone secretion. In vivo male fertility test was performed for observing the adverse effects of 3-MCPD on the function of male reproductive system and pregnancy outcome. 0.01, 0.05, 0.25, 1 and 5 mg/kg b.w. of 3-MCPD was given daily by gavage to groups of 15 adult male SD rats for 4 weeks. At the end of pre-treatment period, males were mated overnight with normal females. Following morning, males demonstrating successful induction of pregnancy were sacrificed on that day to assess sperm parameters and histopathology of reproductive organs. The resulting pregnant females were sacrificed on day 20 of gestation to evaluate pregnancy outcome. As a result, four-week paternal administration with 3-MCPD resulted in adverse effects on male fertility and pregnancy outcome without remarkable histopathological changes in testes and epididymides; sperm motility, copulation index and fertility index were markedly decreased in the treated group and numbers of live fetuses showed steep dose-response curves. Also, spermatogenesis was investigated in this experiment. However, no<br/> effect was observed on production of sperm in testes treated with 3-MCPD for 4 weeks. Hormone assay was performed for observing the effects of 3-MCPD on testosterone and luteinizing hormone (LH) in blood and testes of male SD rats and cultured primary Leydig cell. In result, significant changes of related hormones did not observed by treatment of 3-MCPD. These results indicated that paternal treatment with 3-MCPD induced spermatotoxic effect, which caused an antifertility on male.