Was the Korean alphabet a sole invention of King Sejong?

( Yeon¸ Jae-hoon ) 한국어문학국제학술포럼 2010 Journal of Korean Culture Vol.14 No.-

이 논문에서 우리는 훈민정음의 ‘세종 친제설’을 다시 한번 주장한다. 세종이 집현전 학자들과 협력하거나(협동 가설), 집현전 학자들에게 명령하여(명령 가설) 훈민정음을 창제하였다는 가설을 반박하고, 훈민정음은 세종 단독의 작품이라는 것(친제가설)을 주장하는 것이다. 창제 과정에서 그 당시 세자의 협력이 있었을 가능성은 열어 두었다. 우리의 주장은 언어학 외적인 증거와 언어학 내적인 증거에 토대를 두고 있다. 언어학 외적인 증거는 다양한 역사적 문헌들에 근거를 두고 있다. 언어학 내적인 근거는 용비어천가와 월인천강지곡에 사용된 표기법이 세종의 독특한 음운학적 지식을 반영하고 있다는 데서 출발한다. 이 외에도 훈민정음 서문의 한글 번역문이 108개의 음절로 이루어져 있는 사실이나, 훈민정음의 첫 글자인‘ㄱ’의 발음을 설명하는 글자로서 하필이면 임금 군(君)’자가 선택된 배경에는 뭔가 숨겨진 이유가 있다고 보았다. 또 훈민정음 문자들을 표시하는 한자들을 순서대로 열거하면 ‘군규쾌업’이 되는데, 이것은 ‘임금과 왕자가 즐겁게 일(훈민정음 창제)을 이루었다’는 뜻이 된다. 이 논문에서는 또한 19세기부터 20세기 초까지 서양학자들이나 선교사들이 한글의 기원이나 훈민정음 창제 배경에 대해서 발표한 논문들도 살펴보았다. 우리는 이러한 연구들의 문제점을 지적하였고, 한글 창제에 대한 여러 가지 가설들의 문제점은 1940년 <훈민정음> 원본이 발견되면서 한층 더 분명해진 것으로 보았다. This paper tries to argue that the Korean alphabet is a sole invention of King Sejong on the contrary to the prevalent view that the King either ordered a group of scholars to invent the script (command hypothesis) or worked alongside a team of scholars (cooperation hypothesis). This paper also reviews various observations and theories proposed by western scholars in 19^th and early 20^th century. There is absolutely no evidence or record from the period that shows that anyone else helped Sejong or worked on his orders. No member of the Chipyonjon was involved before 1443, when they compiled "Explanations and Examples of the Correct Sounds for the Instruction of the People" on the back of the invention Sejong had already completed. The conclusion is that King Sejong invented Hangul himself in isolation, perhaps only consulting the crown prince and his other sons. Many attempts have also been made to reduce the origin of the Korean alphabet to other systems of writing, such as Chinese seal characters, Sanskrit, Tibetan, Uighur-Mongol and Phags-pa. All these comparisons, however, are restricted to incidental resemblances of a few letters and are far from convincing. The mystery of the origin of the Korean alphabet was finally solved in July 1940, when the original text of the Hunmin chŏngŭm was found in Andong.

사철나무 알칼로이드, Euojaponine의 NMR스펙트럼의 분석

柳載夏,李沼映,李叔淵,韓秉勳 숙명여자대학교 약학연구소 1994 약학논문집-숙명여자대학교 Vol.10 No.-

The strutures of euojaponines, alkaloidal components from Euonymus japonica are composed of β-agarofuran type sesquiterpene and pyridic dibasic acid, and they are linked via cyclodiester bonds. The structures of these compounds were elucidated by the application of various two dimensional NMR methods. From the results of complete interpretation of NMR spectra, several correlating aspects between structure and spectral pattern of sesquiterpene moiety were found, which can be utilized for the structural determination of the same family compounds.

전자서명을 통한 인증기술과 공개키 기반구조에 대한 고찰

황재훈,박춘석,정연식,송홍엽 연세대학교 산업기술연구소 2000 논문집 Vol.32 No.2

전자서명과 인증의 정의 및 필요성과 개략적인 기술적 요소 등을 정리하고, 정보보호시스템의 보안에 대한 신뢰도를 향상시킬 수 있는 방향을 제안한다. 공개키의 인증문제를 해결하기 위해 발전된 공개키 기반구조, 즉 PKI에 대해서 살펴봄으로써 인증에 대한 심층적 고찰을 수행한다.

조직학적 진단된 chronic necrotizing pulmonary aspergillosis 2예

김연숙,정숙인,기현균,김춘관,김신우,한정호,김성민,백경란,송재훈 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

CNPA는 기존의 폐질환 및 폐절제술로 인해 국소방어기전에 저하가 있거나 비특이적 전신면역상태저하를 갖고 있는 환자들에게서 주로 발생하는 만성적인 공동성 폐질환이다. 현재까지 우리나라에서는 CNPA의 보고가 없는 상태이고, 저자들은 최근 조직학적으로 진단된 CNPA 2예를 경험하였기에 보고하는 바이다. 저자들이 경험한 CNPA 환자들은 만성알코올 중독 및 기관지확장증과 같은 기저질환과 폐절제술을 받은 병력이 있었다. Aspergillus가 폐실질을 침윤하고 있는 조직소견과 조직배양에서 Aspergillus가 검출되어 조직학적 진단이 가능하였고, amphotericin B의 정주요법 및 경구 itraconazole 투여와 폐절제술 등으로 성공적으로 치료되었다. 아직 많은 임상의들에게는 낯선 질환인 CNPA의 치료성적은 환자의 동반질환 및 CNPA 자체의 중증도, 진단과 치료 시작의 지연 등에 의해 크게 좌우되므로 만성적으로 진행하는 공동성 폐병변을 갖고 있는 환자에게서 CNPA를 감별하는 것이 중요하다. Chronic necrotizing pulmonary aspergillosis (CNPA) is a chronic cavitary form of pulmonary aspergillosis. Dozens of CNPA cases have been reported in patients with systemic immunologic dysfunction or altered local defense mechanism from preexisting pulmonary disease. Review of literatures revealed that no CNPA cases have been reported in Korea yet. We experienced two cases of CNPA proven by lung biopsy. A 53-year-old alcoholic male in poor nutritional state was admitted with generalized weakness and weight loss. Chest CT revealed a cavitary nodule surrounded with ground-glass attenuation. CT-guided fine needle aspiration and biopsy was done. The biopsy specimen demonstrated dichotomously branching septated hyphae consistent with those of Aspergillus sp. Another case was a 39-year-old man with bronchiectasis who was admitted with persistent hemoptysis. He had a past history of pulmonary tuberculosis. A parahilar lesion with intracavitary soft tissue mass was incidentally detected in high-resolution GT. Left lingular segmentectomy was done due to uncontrolled hemoptysis and CNPA was histologically diagnosed. Both patients were successfully treated with intravenous amphotericin B followed by oral itraconazole. Even though CNPA is unfamiliar to most clinicians, it should be included in differential diagnoses of chronic progressive cavitary pulmonary lesion, especially in patients with immunologic dysfunction.

벤지딘계 염료제조 사업장 근로자의 벤지딘 폭로

노재훈,안연순,김규상,김치년,김현수 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2

To evaluate the differences of benzidine exposure patterns of the workers in two benzidine-based dye manufacturing factories, the concentration of benzidine in air, blood and urine were measured. The air levels of benzidine dihydrochloride and benzidine-based dye were measured by high performance liquid chromatography with ultraviolet detector. Blood samples were collected at 3 hours after exposure and urine samples were collected at the end of shift. Blood and urine samples were analyzed by high performance liquid chromatography with electrochemical detector. The level of benzidine in reaction process (input, diazotization, and coupling) was 0.381±7950g/㎥. The blood benzidine was deteced in 25 workers among 38 in reaction process and their mean levels were 0.0153±.0376 ng/mg Hb. The urinary benzidine was detected for 11 workers among 38 workers in the reaction process. The level of benzidine-based dye in drying and packing process was 52.1748±14.4111g/㎥. The blood benzidine was deteced in 6 workers among 38 in drying and packing process and their mean levels was 0.0062±.0274 ng/mg Hb. The urinary benzidine was detected for 1 worker among 38 workers exposed to benzidine-based dye. The blood and urinary benzidine were detected in workers exposed to benzidine-based dye. Such results suggested that some part of benzidine-based dye was metaboized to benzidine. Therefore, some regulations for manufacturing and use of the benzidine-based dye are needed to prevent its hazards in industries.

항암화학요법 중 호중구감소증이 발생한 저위험군 발열 환자들을 대상으로 한 경구 항균제 요법의 임상적 유용성 및 안정성에 대한 연구

김연숙,이혁,기현균,김춘관,김신우,김성민,백경란,김원석,윤성수,이홍기,강원기,박찬형,박근칠,송재훈 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 항암화학요법 중 호중구감소증을 동반한 발열이 발생하는 암환자들을 치료하기 위한 다양한 항균제와 여러 가지 방법들이 시도되고 있는 가운데, 합병증과 사망률의 발생가능성이 적은 저위험군 환자들을 대상으로 초기 72시간동안 정주 항균제를 투여한 이후 경구 항균제로 전환하는 요법의 유용성과 안정성을 평가해보고자 본 연구를 시행하였다. 방법 : 1998년 2월부터 1999년 9월까지 본원에서 항암화학요법 중 호중구감소증과 발열이 발생한 환자들 가운데 기저 암질환이 고형암이거나 림프종이고, 입원당시 패혈증의 증후가 없으며 입원 72시간이내에 해열되고 백혈구수치가 증가 추세인 환자들을 대상으로 하여 72시간 동안 정주 항균제를 투여한 이후 경우 ciprofloxacin 750㎎을 하루 2회씩 투여하여 총 4일간 투여하였다. 모든 환자들은 열이 떨어지고 호중구감소증이 회복될 때까지 입원하도록 하였다. 결과 : 총 38명 환자의 40예가 등록이 되었고, 환자들의 기저암 질환은 고형함이 72.5%, 림프종이 27.5%였다. 입원당시 평균 호중구치수는 156/㎕였고, 호중구수치가 100/㎕미만인 경우는 65%였으며, 호중구감소증이 지속된 기간의 평균은 2.4일이었다. 40예 중 39예가 항균제의 변형이나 추가 없이 호중구감소증과 발열로부터 회복이 되어 97.5%의 성공율(95% 신뢰구간: 86.8-99.9%)을 보였다. 부작용으로 피부발진이 있었던 경우가 한 예 있었는데, 증상이 경하여 경구 항균제를 지속할 수 있었다. 심와부의 동통으로 복용을 지속할 수 없어서 대상에서 제외된 예가 또 한 예 있었다. 결론 : 항암요법 중 호중구감소증과 발열을 동반한 환자들 가운데 저위험군 환자들에서 항균제 72시간정주 이후 경구 항균제로의 전환요법은 효과적이고도 안전한 치료방법이라고 할 수 있다. Background : Oral antibiotic therapy following empirical intravenous antibiotics may be effective and safe for febrile neutropenic patients with lowrisk for complications. Methods : We conducted a prospective clinical trial of oral antibiotic therapy in the patients with neutropenia and fever during chemotherapy for cancer. Underlying malignancies were solid tumor or lymphoma with short duration of neurtropenia and the patients had no evidence of clinically or microbiologically documented infections. Oral ciprofloxacin was given to the patients who lacked signs of sepsis on admission, had a rising tendency of neutrophil count (ANC >100 /㎕ ) at 72 hours, and were afebrile at 72 hours. All patients were hospitalized until neutropenia and fever resolved. Results : A total of 40 episodes of 38 patients were enrolled from February 1998 to September 1999. The mean neutrophil counts on admission were 156/㎕ and the mean duration of neutropenia was 2.4 days. The episodes which had neutrophil count below 100 /㎕ were 26 (65%). Treatment was successful in 39 of 40 episodes (97.5% : 95 % confidence interval, 86.8% to 99.9%). Adverse reactions of oral ciprofloxacin were skin rash and epigastric soreness in two cases, respectively. There were no deaths during the study. Conclusions : For low-risk febrile patients with neutropenia during cancer chemotherapy, switch therapy to oral ciprofloxacin at 72 hours following intravenous broad-spectrum antibiotics is effective and safe,

부하순환 하에서 제V급 복합레진 수복물의 미세변연누출에 대한 재접착제의 효과에 관한 연구

윤연희,김영재,김정욱,장기택,이상훈,김종철,한세현 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.3

저점도의 레진을 복합레진 수복물 위에 도포하는 것은 미세누출방지와 변연 완전성(integrity) 유지를 위한 한 방법이다. 하지만 장기간 관찰하면, 수복물은 저작압에 의한 영향을 받게 되는데, 저점도의 레진으로 수복물 변연부를 재접착(rebonding)하였을 때 저작압에 의한 응력에 견디면서 계속하여 수복물에 긍정적인 영향을 주는지에 대한 연구는 미흡한 실정이다. 본 연구는 부하순환(load cycling) 하에서 제Ⅴ급 수복물의 미세변연누출에 대한 재접착제 (rebonding agent)의 효과를 알아보고자 하였다. 40개의 건전한 소구치의 협면에 제Ⅴ급 와동을 형성하고 제조사의 지시대로 광중합복합레진으로 수복하였다. 20개씩 무작위로 나누어 표면전색을 하지 않는 Ⅰ군과 표면을 산부식 후 재접착한 Ⅱ군으로 설정하였다. 열순환 후 각 군에서 10개씩의 하위군 (A군=No load cycling군, B군=Load cycling군)으로 나누어 이중 B군의 시편에 1 Hz의 속도로 수직력이 4-100까지 100,000회의 부하순환을 가하였다. methylene blue용액에 침윤시켜 변연의 미세누출릉도를 평가하여 다음과 같은 결과를 얻었다. 1. 교합변연에서는 재접착과 무관하게 유의한 차이가 없었다(ⅠA-ⅡA군, ⅠB-ⅡB군) (p>0.05). 2. 치은변연의 경우는 부하순환을 하지 않은 군의 경우 재접착을 한 군(ⅡA군)이 재접착을 하지 않은 군 (ⅠA군)에 비해 더 적은 미세누출결과를 보였다(p<0.05). 3. 치은 변연에서 부하순환을 시행한 군의 경우에는 재접착을 한 군(ⅡB군)과 재접착을 하지 않은 군 (ⅠB군)과 유의차가 없는 비슷한 미세누출의 결과를 보였다(p>0.05). One clinical technique recommended f3r improving marginal integrity is "rebonding" or application of unfilled resins to the surface of composite restoration. But continuously the restorations are affected with occlusal load. There is room for doubt that the rebonding agent has the positive effect on microleakage in spite of the stress generated by the occlusal load. This study determined the effect of rebonding on microleakage of Class Ⅴ resin composite restorations under load cycling. Class Ⅴ cavities were prepared on the buccal surface of 40 sound extracted premolars and restored with a hybrid light-cured resin composite according to manufacturers' directions. They wert randomly divided into two groups consisting of 20 samples a control(group Ⅰ), without surface sealing, and the other group (group Ⅱ) in which margins were etched and rebonded. After thermocycling, each of groups was divided into subgroups (group A, B), and load cycling(total 100,000 cycles with 4-100N load at a rate of 1 Hz) were applied on the group B. Assessment of microleakage utilized methylene blue dye penetration. The following results were obtained : 1. In the occlusal region, no significant difference was noted in the scores regardless of whether or not the rebonding agent was used (group ⅠA-ⅡA, ⅠB-ⅡB) (p>0.05). 2. In the cervical region, the control group with rebonding (group ⅡA) showed the better result than the group without rebonding (group ⅠA) (p<0.05). 3. In the cervical region, the rebonded group with load cycling(group ⅡB) showed similar results to the groupf·ithout rebonding(group ⅠB) and no significant difference was noted(p>0.05).

보건관리자의 자격에 따른 사업장 보건관리 업무수행 행태

이재희,노재훈,김규상,안연순 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

This study was conducted to find out the characteristics, type of the duty and job satisfaction of health care managers at the worksite. The subjects of this study were 306 health care managers serving at worksite situated in Kyungin presently in 1994, concerning their job. Major dependent variables were health management, environmental management, and health planning related with health care managers job; these variables were measured by nominal scale consisted of 9 items respectively. The collected data were analysed and some major results are as follows: 1. It appeared that according to the qualification of health care managers, nurses showed high performing rate in duty of health management and health planning, industrial hygienist showed high performing rate relating to working environment managemant, and regarding their holding an additional post, the number of environmental managers held more an additionnal post than other qualified managers, thereby showing significant relatively, and however, no relation with qualification was there in decision-making. 2. The performing rate relating to health management was significantly correlate with female, youth, unmarried, higher education, general affairs in post of duty, general employee in position, only duty of health, low monthly income and nurse. But, the performing rate relating to environmental management was significantly correlate with manufacturing industries, industrial health and safety committee, male, old age, married, long work duration, additional post, high monthly income, and hygienist and environmental managers. The performing rate relating to health and environmental management, but the performing rate relating to health management was not significantly correlate with the performing rate relating to environmental management. 3. In multiple regression analysis, common major determinants of the performing duty relating to health management, environmental management and health planning were industrial health and safety committee, type of industry, education, and qualification of industry's health care managers. Additionally, age was selected as highly correlated with the performing duty relating to environmental management, and work duration and post of duty of health care managers in industry were selected as highly correlated with the performing duty relating to health planning. Based on the results indicated above, it could be understood that characteristics of the worksite - industrial health and safety committee, scale and types of industry, and characteristics of health care managers - age, education, post of duty, work duration and qualification had relations with their type of the duty. Therefore, it is required that the reference to the above-showing results such as guiding for them to precisely grasp their performing duty according to their qualification, heightening their participation in decision-making, extending the industrial health service, etc., operation and management of health care managers at the worksite should be made into being more efficient.

불소방출성 콤포짓트 레진계 수복재의 특성

김상훈,백병주,김재곤,양연미,박정렬 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.3

본 연구에서는 구강 환경과 유사한 조건에서 불소방출성을 보이는 콤포짓트 레진계 수복재의 내구성과 불소방출성을 조사하기 위해 4종의 콤포머와 1종의 불소방출성 콤포짓트 레진을 실험재료로 선택하고 5℃와 55℃ 수중에서의 열순환 처리 후의 인장강도, 열순환 처리 후 칫솔에 대한 작용력 1.5N으로 100,000회 칫솔질을 시행하였을 때의 표면조도 및 불소치약 칫솔질 후 37℃ 수중에서의 불소이온 용출 양상을 조사한 결과 다음과 같은 결론을 얻었다. 1. 인장강도는 TC(Tetric^(ⓡ) Ceram)군에서 32.3 MPa, CF(Compoglass F)군에서 16.8 MPa이고, TC군과 DF(Dyract^(ⓡ) flow)군 및 CF군에서 유의한 차이를 보였다(P<0.05). 2. 칫솔질 마모시험 후의 표면조도 Ra는 TC군에서 0.287, FT(F2000)군에서 1.516이고, FT군과 나머지 시험군 사이에 유의한 차이를 보였다(P<0.05). 3. 칫솔질 마모시험 후의 표면에서는 필러의 돌출과 탈락 양상이 관찰되었다. 4. 불소치약 Perio Alpine Herb로 칫솔질 한 후 콤포머는 초기에 높은 용출을 보인 후 시간이 경과하면서 용출량이 감소하는 양상을 보였지만, 불소방출성 콤포짓트 레진의 TC군에서는 초기단계부터 낮으면서도 지속적인 용출을 보였다. 5. 불소치약 Perio Alpine Herb로 칫솔질 한 후 1시간이 경과하였을 때의 불소이온 용출량은 CF군에서 2.064μg/cm², TC군에서 0.1119μg/cm²이고, CF군의 용출량이 나머지 시험군에 비해 유의하게 높은 값을 보였다(P<0.05). The objectives of this study were to examine the properties of fluoride-releasing resin composite restorative materials. Four commercially available compomer materials (Compoglass F: CF, Dyract^(ⓡ) AP: DA. Dyract^(ⓡ) flow:DF, F2000: FT) and one fluoride-releasing composite resin (Tetric^(ⓡ) Ceram: TC) were selected as experimental materials. Rectangular-shaped tensile test specimens were fabricated in a teflon mold giving 5 mm in gauge length and 2 mm in thickness. Disk-shaped specimens were fabricated in the split teflon mold with diameter of 15mm and thickness of 1 mm. After curing for an hour, specimens were immersed in deionized water at 37℃±1℃ for 30 days. All specimens were thermocycled for 10,000 cycles with 15 seconds of dwelling time in each 5℃ and 55℃ water baths. Toothbrush abrasion test was conducted under a load of 1.5 N and the abraded surfaces were examined with surface roughness tester (SV-3000, Mitutoyo Co, Japan) and SEM (JSM-5800, JEOL, Japan). Fluoride recharging was done by toothbrushing for 3 min. using a fluoride toothpaste (Perio Alpine Herb, LG Household & Health Care, Korea). The results obtained were summarized as follows; 1. The highest tensile strength value of 32.3 MPa was observed in TC group and the lowest value of 16.8 MPa was observed in CF group. The tensile strength of TC group was significantly higher than those of CF and DF groups (P<0.05). 2. The lowest Ra value of 0.287 was observed in TC group and the highest value of 1.516 was observed in FT group. The Ra value of FT group was significantly higher than other groups (P<0.05). 3. The abraded surfaces revealed the increase of surface roughness due to the protrusion and missing of filler particles. 4. The release of fluoride of compomers after tooth brushing by Perio Alpine Herb was initially large and then followed by small and continuously. But it remains small and constant in fluoride-releasing composite resin of TC. 5. The highest value of fluoride release after toothbrushing by Perio Alpine Herb was 2.064 μg/cm² in CF group and the lowest value was 0.119μg/cm² in TC group. The amount of fluoride release of CF group was significantly higher than other groups (P<0.05).

톨루엔 디이소시아네이트 폭로 근로자들의 생물학적 모니터링

안연순,노재훈,김치년,박윤정,정상혁 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2

Toluene diisocyanate(TDI) is widely used in the production of flexible polyurethane foams, as well as in the formulation of polyurethane paints and coatings. The commercial material is generally a mixture of 2,4- and 2, 6-TDI, the predominant mix being 80% 2,4 and 20% 2,6-TDI. The 2,4-isomer is considerably more reactive than the 2,6-TDI at ambient temperatures due to steric factors involving the positions of the isocyanate groups relative to the ring methyl group. Because of this difference in the reactivities of the isomers, it seemed probable that there might be an increase in the amount of 2,6-TDI offgased relative to the 2,4-isomer. Therefore a relative enrichment of the 2,6-TDI has been found in industrial atmospheres. Toluene diamines, which are metabolites of TDI, in urine have a linear relation with exposure to TDI, so that urianry TDA could be used as a biological index of the exposure to TDI. This study was conducted to investigate the distribution of TDI isomer in industrial atmospheres and to propose proper biological monitoring methods by identifying the relationships between the environmental TDI exposure and concentration of TDA in urine. Concentrations of 2, 4-TDI and 2, 6-TDI in air were 4.38㎍/㎥ and 25.43㎍/㎥, respectively. The Threshold Limited Value of 40㎍/㎥ was exceeded for the 2, 6-TDI in about 46.8%(22 samples) of the samples, while the 2, 4-TDI was not at all exceeded. The ratio between 2, 4-TDI and 2, 6-TDI varied in air samples in the range of 2.4%:97.6%-51.0%:49.0%. There was an enrichment of 2, 6-TDI in air relative to the 2, 4-TDI. Concentrations of 2, 4-TDA and 2, 6-TDA in urine were 1.31㎍/g creatinine and 4.16㎍/g creatinine, respectively. The ratio between 2, 4-TDA and 2, 6-TDA varied in urine samples in the range of 1.4%:98.6%-99.9%:0.1%. There was an enrichment of 2, 6-TDA in urine relative to the 2, 4-TDA. No relation between the concerations of TDA isomer in urine and concerations of TDI isomer in air was found. Above results of this study, workers were more exposed to the 2, 6-TDI relative to the 2, 4-TDI in industrial atmospheres. Therefore, the establishment of TLV for 2, 6-TDI should be considered. Also, the further studies on biological monitorigs of workers exposed to TDI should be continued.