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Effect of surface modification of chitosan microsphere on osteoblast proliferation
( Xumengcan ),김정헌,홍재윤,이우걸 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Chitosan (CHN) is widely used as a biomaterial due to its biocompatibility and biodegradability. CHN molecules are characterized by carrying a high positive charge that is different from most other biomolecules. In this study, we prepared CHN microspheres, thoroughly examined the surface morphology and physicochemical properties of CHN microsphere cap coating by scanning electron microscopy and the surface decomposition of water after coating, and verified the cap coating micro by cell experiments. The number of microspheres and the effect of coating time on the adhesion, proliferation and differentiation of osteoblast cell. <sup>**</sup> This research was supported by the Ministry of Trade, Industry and Energy (MOTIE), KOREA, through the Education Program for Creative and Industrial Convergence. (Grant Number N0000717).
1P-181 A Study on the education of bone regeneration with PCL microsphere as a drug-delivery carrier
( Xumengcan ),이우걸,마진쉬엔,한예지,신동선,심성진,김현기,이병주 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Drugs used for the treatment diseases can cause Micro and submicrosized colloidal spheres have been used as therapeutic purposes for the treatment of various diseases, cancers in particular. In this study, we prepared microspheres using poly(e-caprolactone) for the use of drug delivery. The effects of preparation conditions such as concentration, mixing rate, size, and emulsifier type were analyzed using various methods including scanning electron microscope and the optimal condition was identified. Bisphosphonate was incorporated and examined the drug release pattern. The release efficiency was evaluated in terms of osteoblast proliferation and differentiation.
Release Kinetics of Alendronate from Chitosan Microsphere
( Xumengcan ),마진쉬엔,홍재윤,오지영,이우걸 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Chitosan (CHN) is widely used as biomaterials due to its biocompa-tibility and biodegradability. In particular, CHN molecule carries highly positive charges different from most of other biomolecules. CHN can be used as a drug carrier in drug delivery system. In this study, we pre-pared alendronate-loaded CHN microspheres and evaluated the efficacy of drug loading and release pattern. The physicochemical properties of drug-loaded CHN microspheres including size, surface charge, surface morphology were thoroughly examined using zeta potential, scanning electron microscope. The drug release pattern was evaluated using high performance liquid chromatography. The effects of drug release on the growth and differentiation of osteoblastic cells were characterized via cellular assays.
Study on the Preparation of Chitosan Scaffold Using Biomimetic Method
( Xumengcan ),윤다솜,김나연,박수정,서종휘,이재학,한승우,이우걸 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Chitosan is a naturally-derived polysaccharide composed of D-glucosamine and N-acetyl-D-glucosamine. Chitosan is obtained from chitin shells of shrimp and other crustaceans by treating with an alkaline substance. Chitosan has been widely used as a number of biomedical uses. Chitosan can be used as hemostatic bandage, antibacterial agent, and drug carrier. In this study, we investigated the surface of chitosan scaffold was mineralized under biomimetic environment in order to develop a biocompatible hard tissue substitute. The physical and chemical properties of mineralized chitosan scaffold were examined using various analytical methods. Its biocompatibility was evaluated in terms of viability and differentiation using osteosarcoma MG63 cells. Our results demonstrated that the biomimetically mineralized chitosan scaffold can be potentially used for the preparation of artificial bone substitute.
Effects of Incorporation of Apatitic Ceramic Particles in Chitosan Scaffold
( Xumengcan ),윤다솜,김나연,박수정,서종휘,이재학,한승우,이우걸 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Porous scaffolds are one of essential tools in the field of tissue engi-neering. A number of materials have been utilized in the preparation of 3D scaffolds which can be used to fill the empty space of damaged tissue and buster the rate of tissue regeneration. Bone substitutes need to be strong enough to be used in load bearing applications. On the other hand, polymeric 3D scaffold can promote cellular responses quicker than conventional materials, such as metallic and ceramic materials. Attempts have been devoted to development of scaffolds with improved biofunctionality. In this study, we prepared a chitosan scaffold incorporated with apatitic ceramic particles for the purpose of improving biocompatibility and bone regeneration capability. The structural natures and chemical and physical properties were examined using analytical methods, including SEM, FTIR, and EDS.
Investigation on the Effects of PCL Blending on the Bioactivity of PCL/PLLA Scaffold
마진쉬엔,( Xumengcan ),홍재윤,오지영,이우걸 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Skeletal damages increases in accordance to high elderly population. Tissue engineering can be a good alternative to overcome these problem and attracts great interest in research. Conventional implant materials can be very effective to promote bone regeneration but will be difficult due to immune response and lack of resources. In this study, we prepared 3D polymeric scaffold by blending poly(e-caprolactone) and poly(L-lactic acid) at designated blending ratios. The physicochemical properties of the prepared scaffolds were examined in terms of 3D architecture, water uptake, and chemical states. The blending effects on osteoblast growth and differential patterns were evaluated via cell assays. Our result demonstrates that the our scaffold can be utilized in the preparation of bone substitutes. <sup>**</sup> This research was supported by the Ministry of Trade, Industry and Energy(MOTIE), KOREA, through the Education Program for Creative and Industrial Convergence. (Grant Number N0000717).