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최윤성 ( Yun Sung Choi ),김대현 ( Dae Hyun Kim ),오재헌 ( Jae Heun Oh1 ) 한국임학회 2014 산림과학 공동학술대회 논문집 Vol.2014 No.-
본 연구에서는, 단벌기 바이오매스 생산림(Short rotation forest, SRF)에 식재되어 있는 속성수인 이태리포플러( Populus euramericana)을 이용하여 수확 시 소요되는 동력을 측정하여 수확기계동력원을 선정하기 위한 기초자료를 제공하기 위하여 수행되었다. 실험 수준은 밀기속도(0.41, 1.25,2.5 m/s) 3수준, 절단속도(800, 1,000, 1,200 rpm) 3수준, 직경(50, 70, 90, 110, 130 ㎜) 5수준으로 선정하였다. 실험결과, 밀기속도에 따른 최대토크는 0.41 m/s 일 때 30.4 N-m, 최소동력은 191.37 W로나타났다. 밀기속도 1.25 m/s 일 때 최대토크와 최소동력은 각각 30.1 N-m, 194.88 W, 2.5 m/s 일때 최대토크와 최소동력은 각각 31.9 N-m, 204.10 W로 나타났다. 또한 밀기속도 0.41 m/s 보다 2.5m/s 일 때 최대토크는 각각 4.8, 10, 7.2%, 최소동력은 6.8, 10, 11.8%가 증가하였으며, 밀기속도 0.41m/s 인 경우보다 6.8% 많은 동력을 필요로 하는 것으로 나타났다. 따라서, 실험결과를 바탕으로 측정된 소요 동력 기준으로 수확기계의 동력원을 선정할 수 있을 것으로 판단된다. In this study, Italy poplar( Populus euramericana) was selected for test specimen to measure cutting power when it harvested. Three levels of feed rate (0.41, 1.25, 2.5 m/s), three levels of sawing speed (800, 1,000, 1,200 rpm), and five levels of stem diameter (50, 70, 90, 110, 130 ㎜) were used as test variables. As results, the maximum torque, 30.4 N-m for feed rate 0.41 m/s, the minimum power, 191.37 W. The maximum torque and power, such as 30.1 N-m, 191.37 W for feed rate 1.25 m/s. The maximum torque and power, such as 31.9 N-m, 204.10 W for feed rate 2.5 m/s. Also, feed rate 0.41 m/s than feed rate 1.25 m/s, the maximum torque such as 4.8, 10, 7.2%, minimum power 6.8, 10, 11.8% increased. The feed rate 0.41 m/s than 6.7% many power to required. Using the results of this experiment as the base, The measured power source of the power requirements by the harvesting machine is determined to be able to select.
Clinical and Pathologic Features of Elderly Gastric Cancer
( Joo Hyun Lim ),( Dong Ho Lee ),( Cheol Min Shin ),( Na Yung Kim ),( Young Soo Park ),( Hyun Chae Jung ),( 1in Sung Song ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Background: Gastric cancer is one of the most common cancers in Korea and the incidence of which is great in elderly patients. However, not much is known about elderly gastric cancer. The aim of this study was to evaluate the specific features of gastric cancer in elderly patients. Methods: We reviewed medical records of 1107 patients who had undergone radical gastrectomy for gastric cancers between June 2005 and December 2009. All the patients were divided into two groups: Non-elderly group aged under 65 (n=676) and elderly group aged 65 and above (n=431). Results: There were more symptomatic patients among elderly group compared with non-elderly group (54.2% vs. 62.1%; p=0.009). Comorbidity was more prevalent in the elderly group (29.6% vs. 61.9%; p<0.001). The elderly group showed higher frequency of elevated tumor markers (CEA: 4.9% vs. 8.7%; p=0.041), CA19-9: 6.1% vs. 13.2%; p=0.001) and advanced diseases (42.5% vs. 49.4%, p=0.023).There were no significant differences in N stage (62.4% vs. 58.2%; p=0.164) or H. pylori status (63.6% vs. 57.5%; p=0.153) between the two groups. More cancers were located in lower third among the elderly group (45.1% vs 51.3%; p=0.045). The elderly group had more patients with Lauren intestinal type (40.7% vs. 58.2%; p<0.001) and well (8.0% vs. 13.7%; p=0.002) or moderately differentiated adenocarcinoma (29.6% vs. 44.1%; p<0.001). Rate of complication did not differ between the two groups (6.1% vs. 8.1%; p=0.187). Microsatellite instability (p<0.001) and p53 overexpression (p<0.001) were more frequent in the elderly group. Conclusion: Elderly gastric cancer showed a tendency of being diagnosed at more advanced stage with symptoms. However, it was related to pathologic features known for favorable prognosis except for p53 overexpression. Also surgery in elderly was as tolerable as in young patients. Thus we recommend to consider surgery more frequently for elderly patients with operable gastric cancers.
Progastrin-releasing peptide as a diagnostic and therapeutic biomarker of small cell lung cancer
오형주,( Ha Young Park ),( Tae Ok Kim1 ),( Chul Kyu Park ),( Hong Jun Shin ),( Hee Jung Ban ),( In Jae Oh ),( Yong Soo Kwon ),( Yu Il Kim ),( Sung Chul Lim ),( Young Chul Kim ),( Soo Hyun Kim ),( Myung G 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: Progastrin-releasing peptide (proGRP) is a recently identified biomarker of small cell lung cancer (SCLC). We aimed this study for evaluating the usefulness of automated proGRP measurement for diagnosis and treatment monitoring in patients with SCLC. Methods: From January 2011 to December 2013, plasma samples were prospectively collected from 452 [213 non-small cell lung cancer (NSCLC), 104 SCLC, 135 other diseases] patients visited for tissue diagnosis and tested by two-step automated immunoassay using the ARCHITECT proGRP assay kit (Abbott Diagnostics, USA). The cutoff level of proGRP was set at 63 pg/mL. Results: The mean proGRP was higher in SCLC (1823.0 ± 2684.0 pg/mL) than in NSCLC (61.0 ± 341.7 pg/mL) and other diseases (51.5 ± 222.6 pg/mL, p<0.001). The sensitivity of proGRP was 85.7% (90/105) in SCLC and 11.8% (25/212) in NSCLC. The specificity was 90.2%, positive predictive value was 72.5%, and negative predictive value was 95.4% in SCLC. The mean proGRP was higher in extensive disease (2158.1 ± 2980.6 pg/mL) than in limited disease (901.4 ± 1216.0 pg/mL, p=0.033). Among the 39 patients with SCLC could be followed, the mean proGRP levels of 23 responders were significantly decreased after chemotherapy (from 1651.5 ± 1386.4 pg/mL to 290.0 ± 524.8 pg/mL, p<0.001), whereas those of the 16 non-responders were not. (from 572.5 ± 790.3 pg/mL to 494.4 ± 610.9 pg/mL, p=0.583). Conclusion: Plasma proGRP could be a useful biomarker of SCLC for diagnosis and treatment monitoring. And the initial level may represent the tumor extent of SCLC.
김창승(Chang Seung Kim),김도익(Do Ik kim),국용인(Yong In Kuk),현규환(Kyu Hwan Hyun),김상수(Sang Soo Kim1) 한국차학회 2016 한국차학회지 Vol.22 No.1
The acaricidal activity of the mixed plant extracts of Gleditsia japonica var. koraien, Camellia sinensis, Cinnamomum cassia, and Lantana camara, toward the tea red spider mite, Tetranychus kanzawai Kishida was evaluated in laboratory bioassays. Treatments with mixtures 1 and 3 were effective against the adult females of T. kanzawai and yielded 87.0 and 85.6% adulticidal activity at 7 days after treatment, respectively. Mixture 3 revealed 78.7% adulticidal activity. However, mixtures 4 and 5 had lower adulticidal activity than the other treatments. The adult females of T. kanzawai treated with mixtures 1 and 3 produced only 22.5-22.8% as many eggs as did the control females. The residue of the plant extracts tested had low adulticidal activity (16.3-27.2%). All of the plant extracts tested were ineffective against the eggs of T. kanzawai. Treatments with mixtures 1 and 3 were effective against the nymphs of T. kanzawai and led to emergence rates of 20.7 and 25.3%, respectively. These results suggest that mixtures 1 and 3 might be used for the control of T. kanzawai.
( Hyun Young Woo ),( Jeong Won Jang ),( Sang Gyune Kim ),( Chang Hyeong Lee ),( Tae Yeob Kim ),( Won Young Tak ),( Sung Kyu Choi ),( Mong Cho1 ),( Jong Young Choi ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Cirrhosis-related complications are indications for transplantation. However, the mode of complication has not been evaluated so far. To better address this issue, we investigated the mode of cirrhosis related complication and impact of these complications on survival in prospective, multicenter, inception cohort study of subjects with liver cirrhosis presenting with the first onset of decompensated complication. Methods: In this observational study, 1515 patients with the confirmed onset time of the first decompensated complication were enrolled. The mortality risk of cirrhosis-related complications, including ascites, portal hypertensive gastrointestinal bleeding (PHGB), spontaneous bacterial peritonitis (SBP), hepatic encephalopathy (HE), hepatorenal syndrome (HRS), was analyzed in these cirrhotic patients. Result: As the first complication, ascites was the most frequent (53.8%), followed PHGB (36.2%), HE (7.6%), SBP (1.7%) and HRS (0.7%). During follow-up (mean 32±47 months), 484 (31.9%) experienced subsequent decompensations and the proportion of subsequent complication was consistently changed; the proportion of HE, SBP, HRS increased as time progressed. The interval between subsequent decompensative events was progressively shortened. The mortality rate according to the first complication was as follows; Ascites =PHGB> HE=SBP>HRS. The mortality rate of patients experienceing subsequent complication was significantly higher than those without subsequent complication. According to the kinds of subsequent complication, survival of HE was also higher than HRS but lower than ascites or PHGB and similar to that of SBP and this difference of survival disappeared after repeated complication. Conclusion: The mortality risk correlated with initial complication and the risk increases as the number of complication episodes is repeated. Patient`s mean age was 56±11.50 years and 72.1% was male. The cause of liver cirrhosis is hepatitis B virus (38.6%), alcohol (35.5%) and hepatitis C virus (8.9%).
Assessment of In Vitro Assay System for Thyroid HormoneDisruptors Using Rat Pituitary GH3 Cells
Hee Jin Kim1,Hae Young Park1,Jeonga Kim1,Il Hyun Kang2,Tae Sung Kim2,Soon Young Han2,Tae Seok Kang2,Kui Lea Park2,Hyung Sik Kim1 한국독성학회 2006 Toxicological Research Vol.22 No.4
The development of in vitro assays has been recommended to screening and test-ing the potential endocrine disruptors (EDs). These assay systems focus only on identifying thethe thyroid hormone (TH) disruptors. The aim of this study was to evaluate a test system to detectTH disruptors using rat pituitary tumor GH3 cells. The test system is based on the TH-dependentincrease in growth rate. As expected, L-3,5,3-triiodothyronine (T3) markedly induced a morphologicalchange in GH 3 cells from flattened fibroblastic types to rounded or spindle-shaped types. T3 stimu-lated GH3 cell growth in a dose-dependent manner with the maximum growth-stimulating effect9 M. In addition, T3 increased the release of growth hor-mone and prolactin into the medium of the GH3 cells culture. Using this assay system, the TH-dis-rupting activities of bisphenol A (BPA) and its related compounds were examined. BPA,dimethylbisphenol A (DMBPA), and TCI-EP significantly enhanced the growth of GH3 cells in therange of 1 × 10-5M to 1 × 10-6M concentrations. In conclusion, this in vitro assay system might bestandardization before it can be used as a broad-based screening tool.