Effects of Si on the Microstructure and Work Hardening Behavior of Fe‒17Mn‒1.1C‒xSi High Manganese Steels

Renlong Xiong,Yi Liu,Haitao Si,Huabei Peng,Shanling Wang,Binhan Sun,Hanxin Chen,Hyoung Seop Kim,Yuhua Wen 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.10

In order to improve the work hardening capacity under low stresses and the yield strength of conventional Hadfield steels, theeffects of Si on the microstructure and work hardening behavior of the Fe‒17Mn‒1.1C‒xSi steels under both quasi-statictensile and low load impact are investigated. It is shown that the increase of the Si contents remarkably improves the yieldstrength by 36 MPa per 1 wt% Si in the investigated steel system without significant sacrifice of ductility. The decreasingeffect of Si on the stacking fault energy is strongly affected by carbon, although the variation of carbon content was small. This led to the unexpected similar stacking fault energy between 1Si and 2Si steel. With the increase of the Si contents forthe steels, the critical strain for the onset of mechanical twinning was lowered, which was controlled by the cooperationbetween the stacking fault energy and solid solution strengthening of Si. This resulted in the earlier initiation of mechanicaltwins and an increase in the twin volume fraction. Therefore, the work hardening capacities under both quasi-static tensileand low load impact tests were enhanced. It was also found that the impact deformation decreased as more mechanical twinsabsorbed the impact energy.

De novo assembled transcriptome of horned gall aphid, Schlechtendalia chinensis Bell, suggest changes in functional gene expression during host alternation

Si‐Liang Wang,Zi-Xiang YANG,Pu YANG,Chuan Xi Zhang 한국곤충학회 2016 Entomological Research Vol.46 No.5

The horned gall aphid, Schlechtendalia chinensis Bell, is the most economically valuable galling aphid. It accounts for approximately 75% of Chinese gallnut production, which is important for medical and chemical purposes. The horned gall aphid feeds on the Chinese sumac tree, Rhus chinensis, during the summer, induces galls, and overwinters on the moss Plagiomnium spp. However, the sequence information of S. chinensis is limited, and the functional gene expression changes during host alternation remain obscure. In this study, the transcriptome of the horned gall aphid was sequenced using high‐throughput sequencing technology. Approximately 49 million reads were obtained and were assembled into 99 366 transcripts and 47 400 unigenes. Annotation was performed using a BLAST search against primary databases such as NCBI nr and Swiss‐Prot, as well as enrichment analysis by GO, KOG and KEGG. Differentially expressed genes between spring and autumn migrant aphids were compared, and the expression levels of many genes related to detoxification, digestion and other functional genes were found to have changed, reflecting the adaptation ability of horned gall aphids in different seasons and hosts. Functional genes in wax biosynthesis were upregulated in spring migrant aphids. This study analyzed the expression profile difference between spring and autumn migrant aphids to approach the real functional genes change during host alternation. The transcriptome provides a basis to understanding the functional genes during gall aphid host alternation and the related physiological and molecular characteristics.

VRSA에 대한 항생물질을 생산하는 방선균의 분리

이지연,양시용,고은지,이승구,김시관,조왕식,송민동 建國大學校 自然科學硏究所 2002 建國自然科學硏究誌 Vol.13 No.2

본 연구가 VRSA에 대한 신규 항생물질 생산 균주를 얻기 위하여 실시하였다. 국내외에 채취한 토양시료에서 분리한 방선균 중, 임상분리 VRSA와 돌연변이 유발 VRSA에 대해 항균성을 나타내는 JY-24를 선별하였다. 선발 균주는 원통형의 포자 모양을 갖고 있으며, Bennett's 배지에 배양시 aerial mycelium color는 흰색을 나타냈으며, reverse side color는 대체로 노란색을 나타내었다. 항균물질 생산을 위한 탄소원으로는 fructose, mannose, 질소원으로는 yeast extract가 가장 우수하였으며 glucose의 첨가로 항균 물질 생산성이 증가하는 것으로 나타났다. 최적 초기 pH는 pH 7로 나타났으며, 28 ℃, 37℃, 45 ℃의 온도에서 균이 성장하는 것으로 나타났다. 또한 배양기간에 따라 항균물질 생산성을 조사한 결과, 임상분리 균주에 대해 5일 배양 시 가장 높았으나, 3일 배양과 7일 배양 시 동일한 생산성을 나타내 생산속도가 빠르며, 안정한 물질인 것이 파악되었다. 향후 균주동정 및 항균물질 정제에 관한 연구를 수행하고자 한다. An antibiotic substance producing strain JY-24, effective to the VRSA (Vancomycin-resistant Staphylococcus aureus), was isolated from soil. The spore chain of JY-24 was cylindrical, and its sulface was smooth. The aerial mass color of the strain was white, and its reverse side color was yellow. The strain did not produce soluble pigment. For the production antibiotics, fructose, mannose and yeast extract were favorable as carbon and nitrogen sources. Optimal initial pH for the production of the antibiotic was pH 7. Accumulation of the antibiotic in the culture broth reached at maximal level after 5 days cultivation in Bennett's medium.

Thiazinogeldanamycin, a New Geldanamycin Derivative Produced by Streptomyces hygroscopicus 17997

( Si Yang Ni ),( Lin Zhuan Wu ),( Hong Yuan Wang ),( Mao Luo Gan ),( Yu Cheng Wang ),( Wei Qing He ),( Yi Guang Wang ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.6

A new geldanamycin (GDM) derivative was discovered and isolated from the fermentation broth of Streptomyces hygroscopicus 17997. Its chemical structure was elucidated as thiazinogeldanamycin by LC-MS, sulfur analysis, and NMR. The addition of cysteine to the fermentation medium significantly stimulated the production level of thiazinogeldanamycin, suggesting cysteine as a precursor of thiazinogeldanamycin production. Although showing a decreased cytotoxicity against HepG2 cancer cells, thiazinogeldanamycin exhibited an improved water solubility and photostability. Thiazinogeldanamycin may represent the first natural GDM derivative characterized so far that uses GDM as its precursor. Its appearance also clearly indicates that an appropriate end-point of fermentation is of critical importance for the maximal production of GDM by Streptomyces hygroscopicus 17997.

AN EXPLORATORY APPROACH ON PUBLIC E-PROCUREMENT SYSTEM IN CHINA BASED ON KOREAN SUCCESSFUL IMPLEMENTATION

Wang Si,Andrey Kim,Hoe-Kyun Shin 한국로고스경영학회 2007 한국로고스경영학회 학술발표대회논문집 Vol.2007 No.7월

During the last few years, China has developed governmental procurement, and now it starts to pay attention to public e-procurement. Because Korea has developed governmental procurement for nearly 60 years and deployed the public e-procurement for 10 years, so it has accumulated comprehensive experience. China can learn from Korean successful implementation to solve its some critical problems. Based on analysis of Korean public e-procurement, we construct public e-procurement model for the development of Chinese e-procurement. We define the objects of public e-procurement as direction indicator of its development. And based on operation system of Korean e-procurement, we design an applicable system for China. Finally, we also propose that China should establish its electronic procurement in macroeconomic and microeconomic environment.

Efficacy and Safety of Sorafenib for Advanced Non-Small Cell Lung Cancer: a Meta-analysis of Randomized Controlled Trials

Wang, Wei-Lan,Tang, Zhi-Hui,Xie, Ting-Ting,Xiao, Bing-Kun,Zhang, Xin-Yu,Guo, Dai-Hong,Wang, Dong-Xiao,Pei, Fei,Si, Hai-Yan,Zhu, Man Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Background: Many clinical trials have been conducted to evaluate sorafenib for the treatment of advanced NSCLC, but the results for efficacy have been inconsistent. The aim of this study was to evaluate the efficacy and safety of sorafenib in patients with advanced NSCLC in more detail by meta-analysis. Methods: This meta-analysis of randomized controlled trials (RCTs) was performed after searching PubMed, EMBASE, ASCO Abstracts, ESMO Abstracts, and the proceedings of major conferences for relevant clinical trials. Two reviewers independently assessed the quality of the trials. Outcomes analysis were disease control rate (DCR), progression- free survival (PFS), overall survival (OS) with 95% confidence intervals (CI) and major toxicity. Subgroup analysis was conducted according to sorafenib monotherapy, in combination with chemotherapy or EGFR-TKI to investigate the preferred therapy strategy. Results: Results reported from 6 RCTs involving 2, 748 patients were included in the analysis. Compared to sorafenib-free group, SBT was not associated with higher DCR (RR 1.31 (0.96- 1.79), p=0.09), PFS (HR 0.82 (0.66-1.02), p=0.07) and OS (HR 1.01 (0.92-1.12), p=0.77). In terms of subgroup results, sorafenib monotherapy was associated with significant superior DCR and longer PFS, but failed to show advantage with regard to OS. Grade 3 or greater sorafenib-related adverse events included fatigue, hypertension, diarrhea, oral mucositis, rash and HFSR. Conclusions: SBT was revealed to yield no improvement in DCR, PFS and OS. However, sorafenib as monotherapy showed some activity in NSCLC. Further evaluation may be considered in subsets of patients who may benefit from this treatment. Sorafenib combined inhibition therapy should be limited unless the choice of platinum-doublet regimen, administration sequence or identification of predictive biomarkers are considered to receive better anti-tumor activity and prevention of resistance mechanisms.

Investigating additional revenue streams for OTT platforms from user perspective

Si–Huan Wang,Yoonhyuk Jung 한국경영정보학회 2022 한국경영정보학회 학술대회논문집 Vol.2022 No.6

Identification of Biomarkers for Diagnosis of Gastric Cancer by Bioinformatics

Wang, Da-Guang,Chen, Guang,Wen, Xiao-Yu,Wang, Dan,Cheng, Zhi-Hua,Sun, Si-Qiao Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4

Background: We aimed to discover potential gene biomarkers for gastric cancer (GC) diagnosis. Materials and Methods: Genechips of 10 GC tissues and 10 gastric mucosa (GM, para-carcinoma tissue, normal control) tissues were generated using an exon array of Affymetrix containing 30,000 genes. The differentially expressed genes (DEGs) between GC tissues and normal control were identified by the Limma package and analyzed by hierarchical clustering analysis. Gene ontology (GO) and pathway enrichment analyses were performed for investigating the functions of DEGs. Receiver operating characteristics (ROC) analysis was performed to measure the effects of biomarker candidates for diagnosis of GC. Results: Totals of 896 up-regulated and 60 down-regulated DEGs were identified to be differentially expressed between GC samples and normal control. Hierarchical clustering analysis showed that DEGs were highly differentially expressed and most DEGs were up-regulated. The most significantly enriched GO-BP term was revealed to be mitotic cell cycle and the most significantly enriched pathway was cell cycle. The intersection analysis showed that most significant DEGs were cyclin B1 (CCNB1) and cyclin B2 (CCNB2). The sensitivities and specificities of CCNB1 and CCNB2 were both high (p<0.0001). Areas under the ROC curve for CCNB1 and CCNB2 were both greater than 0.9 (p<0.0001). Conclusions: CCNB1 and CCNB2, which were involved in cell cycle, played significant roles in the progression and development of GC and these genes may be potential biomarkers for diagnosis and prognosis of GC.

A Study on the Integrated Development of Modern Stationary Brands

Wang, Shi- Si,Chung, Sung- Whan 한국브랜드디자인학회 2008 브랜드디자인학연구 Vol.6 No.1

중국은 경제가 신속하게 발전하는 대국이다. 근 20년간의 발전으로 중국은 이미 세계 문구용품제조의 중심이 되었으며 문구 생산능력은 세계의 문구 생산능력의 40%를 분담하고 있다. 통계에 의하면 국내엔 이미 6000 가의 문구제조공장이 있으며 매년 1500억 원 이상의 상품을 제조하고 있다 .그러나 중국 문화용품은 대규모의 제조단계에만 머물고 있을 뿐 이름이 알려진 브랜드가 적고 낱개의 문화용품의 이윤이 낮다. 그러므로 문화용품의 전면적인 브랜드 개발 생산은 앞으로의 문화용품의 발전방향이다. 몇 년 사이 한국은 디자인으로 경제가 발전해왔고 디자인으로 충족된 생활환경 속에서 문구용품브랜드 디자인의 정체성 개발도 자연히 기타 발전중국보다 일찍 개발되었다. 때문에 디자이너가 문화용품 브랜드에 대한 정체화 개발의 디자인을 연구. 탐구하며 전체 한국 문화용품시장의 발전모식에 대해 치중하여 관찰하여 중국디자인에도 도입 할 수 있는 특수한 디자인 방법을 발견할 수 있다. 본 연구는 한국 문구용품시장의 배경, 문구용품 브랜드의 정체화 개발에 대한 방법을 실례를 토대로 분석과 탐구를 진행하였다. 중국의 디자인 전공 학생들에게 한국문화용품디자인의 발전추세를 반영하는 것을 목적으로 하며 동시에 중국의 젊은 디자이너들이 생각의 폭을 넓혀 자체 발전계획을 바로 잡아 디자이너 개발건설에 건의하는 역할을 하고자한다. 만약 한국문구용품브랜드 정체화개발의 모식을 중국시장에 도입시킨다면 필연코 중국문화용품상업계와 디자인업계에 대한 발전을 가져다 줄 것임을 예상한다. China is a big country in which the economy is rapidly developing. In the recent twenty years, it has become the center of producing stationery in the world and the production power of it has accounted for 40% of that in the world. It is estimated that there are more than 6000 stationery businesses in China and their yearly production value amounts to 150 billion Renminbi yuan. But the stationery products are usually manufactured a large scale. As a result, very few of the brands are known to people and the profit is low as far as each of the products is concerned. So the only way out for the stationery businesses is to develop famous brands on the whole. In this way, some Korean designers have done very well in developing their brands. The economy of Korea has developed rapidly in recent years owing to the progress of design, so the development of integrated brands of stationery design starts earlier than developing countries in such a nice environment full of design in life. Stationery covers an extensive scope of items such as papers, pens, albums, notebooks and so on, many of which can be the choices for design. On the other hand, each item costs low and can find its way to outlet easily. These good conditions benefit a lot the development of individual designers. But the first problem the individual designers have to face is how to make the design objects uniform and the brand image special. The writer made a market investigation on the Korean stationery only to find how they establish their styles of stationery brand in designing. This paper analyzes the background of Korean stationery market, the methods of the integrated development of stationary brands and the characteristics of the design by giving some examples. It aims at introducing the methods of integrated development of Korean stationery brands to the people who concern to the Chinese stationery market. If the methods of Korean stationery brands design and the promotion models of the design products can be introduced to Chinese market, I believe, a great improvement will be made in both the commercial circle and the design circle of our Chinese stationery.

Controlling the Asset Substitution Problem

Si-Wang Ryu 한국재무학회 1991 財務硏究 Vol.4 No.1