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정신분열병 환자에서 정신병적 증상과 위스콘신카드 분류검사와의 관계
엄양기,김철권,조진석,변원탄 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.5
The purpose of this study was to investigate 1) the difference of performance on the Wisconsin Card Sorting Test(WCST) between schizophrenecs and normal controls, 2) and the change of performance while clinically improved. WCSTs were administered in 28 schizophrenics and 32 normal controls. The results were as follows. 1) Schizophrenic patients performed poorly on the WCST compared to normal controls. 2) There was no significant change of performance in WCST as clinical symptoms improved 3) There was no significant correlation between the performance of the Wisconsin Card Sorting Test and age, sex, education level and volcabulary test in both groups. These findings suggest that the WCST mat be an indicator of vulnerability to schizophrenia.
( Seok-jin Eom ),( Jae-young Choi ) 서울대학교 행정대학원 2017 Journal of Policy Studies Vol.32 No.3
This research examines a way the Korean developmental state achieved a synergy between state and society for industrial development: business associations. In the machinery industry, a business association was involved in formulating industrial policy for promoting the machinery industry and in implementing policy programs such as the prohibition of the import of machinery made in foreign countries. The association also functioned as a channel through which information relevant to the industry was provided to government. The association had a professional staff and an internal governance structure that helped prevented rent seeking and encouraged synergy between public and private sector.
Eom, Seok Hyun,Jin, So-Jung,Jeong, Hee-Yeong,Song, Youngju,Lim, You Jin,Kim, Jong-In,Lee, Youn-Hyung,Kang, Hee MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.5
<P>Kudzu (<I>Pueraria montana</I> var. <I>lobata</I> (Willd.) Sanjappa & Pradeep) is a perennial leguminous vine, and its root and flower have been used for herbal medicine in Asia for a long time. Most dietary flavonoids are reported to be concentrated in its root, not in its aerial parts including leaves. In this study, we investigated whether kudzu leaf and its major constituent, robinin (kaempferol-3-<I>O</I>-robinoside-7-<I>O</I>-rhanmoside) possessed anti-inflammatory activity. To test this hypothesis, we used peritoneal macrophages isolated from BALB/c mice and stimulated the cells with lipopolysaccharide (LPS) or LPS plus interferon (IFN)-γ. Compared with kudzu root extract, its leaf extract was more potent in inhibiting the production of inducible nitric oxide synthase (iNOS), cyclooxygenase-2, tumor necrosis factor-α, and interleukin-6. Kudzu leaf extract decreased LPS-induced activation of c-Jun N-terminal kinase (JNK) and TANK-binding kinase 1(TBK1) with no effects on nuclear factor-κB and activator protein 1 transcriptional activity. Also, kudzu leaf extract inhibited LPS/IFN-γ-induced signal transducer and activator of transcription 1 (STAT1) activation partly via an altered level of STAT1 expression. Robinin, being present in 0.46% of dry weight of leaf extract, but almost undetected in the root, decreased iNOS protein involving modulation of JNK and STAT1 activation. However, robinin showed no impact on other inflammatory markers. Our data provide evidence that kudzu leaf is an excellent food source of as yet unknown anti-inflammatory constituents.</P>
Eom, Dae-Seok,Choi, Won-Seok,Ji, Suena,Cho, Jin W.,Oh, Young J. Lippincott Williams Wilkins, Inc. 2005 NEUROREPORT - Vol.16 No.8
Recent studies indicate that activation of stress-activated protein kinases may be implicated in a broad range of biological activities including differentiation. To directly examine whether stress-activated protein kinases are involved in neuronal differentiation, we utilized retinoic acid-induced and spontaneous models of neurite outgrowth in dopaminergic neurons. Here, we show that retinoic acid-induced neurite outgrowth in MN9D dopaminergic neuronal cells was accompanied by activation of c-Jun N-terminal kinase but not p38. Consequently, cotreatment with a specific inhibitor of c-Jun N-terminal kinase or overexpression of c-Jun N-terminal kinase-binding domain of c-Jun N-terminal kinase-interacting protein-1 blocked retinoic acid-induced neurite outgrowth. In primary cultures of dopaminergic neurons, the extent of neurite outgrowth increased spontaneously in a time-dependent manner. When these cultures were treated with a specific inhibitor of c-Jun N-terminal kinase, the total extent of neurites, the primary neurite length and the number of neurites per cell were suppressed significantly. Thus, our data indicate that the c-Jun N-terminal kinase signal seems to play an important role during morphological differentiation in cultured dopaminergic neurons.
Seok Jin Kim,Young Rok Do,Ho-Sup Lee,Won-Sik Lee,Jee Hyun Kong,Jae-Yong Kwak,Hyeon-Seok Eom,Joon Ho Moon,Jun Ho Yi,Jeong-Ok Lee,Jae-Cheol Jo,Deok-Hwan Yang 대한혈액학회 2023 Blood Research Vol.58 No.4
Background Brentuximab vedotin (BV), a potent antibody-drug conjugate, targets the CD30 antigen. In Korea, BV has been approved for the treatment of relapsed or refractory Hodgkin lymphoma (HL), anaplastic large-cell lymphoma (ALCL), and cutaneous T-cell lymphomas, including mycosis fungoides (MF). However, there are limited data reflecting real-world experiences with BV treatment for HL, ALCL, and MF. Methods This was a multicenter, non-interventional registry study of the efficacy and safety of BV in patients with relapsed or refractory CD30-positive lymphoma (CISL1803/BRAVO). Outcomes were determined based on the occurrence of relapse or progression and overall survival after BV treatment. Results A total of 85 patients were enrolled in this study. The median number of BV cycles was 10 (range, 2‒16) in the patients with HL. The objective response rate (ORR) of patients with HL to BV was 85.4% (41/48), comprising 27 complete responses (CRs) and 14 partial responses (PRs). The ORR of ALCL was 88% (22/25), consisting of 17 CRs and five PRs, whereas the ORR of MF was 92% (11/12). At the median follow-up of 44.6 months after BV treatment, the median post-BV progression-free survival of HL, ALCL, and MF patients was 23.6 months, 29.0 months, and 16.7 months, respectively (P =0.641). The most common side effect of BV was peripheral neuropathy; 22 patients (25.9%, 22/85) experienced peripheral neuropathy (all grades). Conclusion The treatment outcomes of patients with relapsed or refractory CD30-positive lymphoma improved with BV treatment, and the safety profile was manageable.
The Rural Saemaul Undong Revisited from the Perspective of Good Governance
( Seok Jin Eom ) 서울대학교 행정대학원 2011 Journal of Policy Studies Vol.26 No.2
This study analyzes the rural Saemaul Undong of the 1970s in the Republic of Korea from the perspective of good governance. Diverse characteristics of good governance appeared in the Saemaul Undong-in particular, spontaneous participation by village people. This participation was not only a primary factor in the achievements of the Saemaul Undong, but also made it consensusoriented, responsive, and transparent in terms of decision-making and project implementation at the village level. Participation in the villages was promoted and supported by government intervention and strategies, which brought not only efficiency, effectiveness, and accountability, but also increased equity and inclusiveness in the Saemaul Undong. The Saemaul Undong embodied a number of characteristics of good governance.
Improving Governmental Transparency in Korea: Toward Institutionalized and ICT-Enabled Transparency
( Seok Jin Eom ) 서울대학교 행정대학원 2014 Journal of Policy Studies Vol.29 No.1
The main purpose of this study is to examine how governmental transparency has improved in Korea. To this end, the author examines the periodic characteristics of governmental transparency while also analyzing the information that each administration in Korea has produced. Also investigated are institutional arrangements for accessing this information and the adoption of ICTs in government. It was not until the democratic transition of 1987 that the transparency of the government began to improve in Korea. The key characteristic of the transparency policy after democratization was the pursuit of the simultaneous progress of institutionalized and ICT-enabled governmental transparency. Citizens` accessibility to and the disclosure of public information were institutionalized. Furthermore, ICTs enable citizens to access such information more efficiently through nonstop operations and one-click services. In the course of establishing the institutions to improve governmental transparency, however, executive dominance and bureaucrats` resistance to governmental transparency were the major challenges.