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Ex Vivo T Cell Cytokine Expression Predicts Survival in Patients with Severe Alcoholic Hepatitis
( Ashwin D. Dhanda ),( Euan Yates ),( Lauren P. Schewitz-bowers ),( Philippa J. Lait ),( Richard W. J. Lee ),( Matthew E. Cramp ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2020 Gut and Liver Vol.14 No.2
Alcoholic hepatitis (AH) is an acute inflammatory liver condition with high early mortality rate. Steroids improve short-term survival but nonresponders have the worst outcomes. There is a clinical need to identify these high-risk individuals at the time of presentation. T cells are implicated in AH and steroid responsiveness. We measured ex vivo T cell cytokine expression as a candidate biomarker of outcomes in patients with AH. Consecutive patients (bilirubin >80 μmol/L and ratio of aspartate aminotransferase to alanine aminotransferase >1.5 who were heavy alcohol consumers with discriminant function [DF] ≥32), were recruited from University Hospitals Plymouth NHS Trust. T cells were obtained and stimulated ex vivo. Cytokine expression levels were determined by flow cytometry and protein multiplex analysis. Twenty-three patients were recruited (10 male; median age 51 years; baseline DF 67; 30% 90-day mortality). Compared to T cells from nonsurvivors at day 90, T cells from survivors had higher baseline baseline intracellular interleukin (IL)-10:IL-17A ratio (0.43 vs 1.20, p=0.02). Multiplex protein analysis identified interferon γ (IFNγ) and tumor necrosis factor-α (TNF-α) as independent predictors of 90-day mortality (p=0.04, p=0.01, respectively). The ratio of IFNγ to TNF-α was predictive of 90-day mortality (1.4 vs 0.2, p=0.03). These data demonstrate the potential utility of T cell cytokine release assays performed on pretreatment blood samples as biomarkers of survival in patients with severe AH. Our key findings were that intracellular IL-10:IL-17A and IFNγ:TNF-α in culture supernatants were predictors of 90-day mortality. This offers the promise of developing T cell-based diagnostic tools for risk stratification. (Gut Liver 2020;14:265-268)
Tunneling decay of self-gravitating vortices
Dupuis, É,ric,Gobeil, Yan,Lee, Bum-Hoon,Lee, Wonwoo,MacKenzie, Richard,Paranjape, Manu B.,Yajnik, Urjit A.,Yeom, Dong-han,Gwak, B.,Kang, G.,Kim, C.,Kim, H.-C.,Lee, C.-H.,Lee, J.,Lee, S.,Lee, W. EDP Sciences 2018 The European Physical Journal Conferences Vol.168 No.-
<P>We investigate tunneling decay of false vortices in the presence of gravity, in which vortices are trapped in the false vacuum of a theory of scalar electrodynamics in three dimensions. The core of the vortex contains magnetic flux in the true vacuum, while outside the vortex is the appropriate topologically nontrivial false vacuum. We numerically obtain vortex solutions which are classically stable; however, they could decay via tunneling. To show this phenomenon, we construct the proper junction conditions in curved spacetime. We find that the tunneling exponent for the vortices is half that for Coleman-de Luccia bubbles and discuss possible future applications.</P>
Woo, C.G.,Seo, S.,Kim, S.W.,Jang, S.J.,Park, K.S.,Song, J.Y.,Lee, B.,Richards, M.W.,Bayliss, R.,Lee, D.H.,Choi, J. Elsevier 2017 Annals of Oncology Vol.28 No.4
<P>Conclusion: Our findings show that group EML4-ALK variants 3a/b may be a major source of ALK inhibitor resistance in the clinic. The variant-specific genotype of the EML4-ALK fusion allows for more precise stratification of patients with advanced NSCLC.</P>
A MACHINE-LEARNING METHOD TO INFER FUNDAMENTAL STELLAR PARAMETERS FROM PHOTOMETRIC LIGHT CURVES
Miller, A. A.,Bloom, J. S.,Richards, J. W.,Lee, Y. S.,Starr, D. L.,Butler, N. R.,Tokarz, S.,Smith, N.,Eisner, J. A. IOP Publishing 2015 The Astrophysical journal Vol.798 No.2
<P>A fundamental challenge for wide-field imaging surveys is obtaining follow-up spectroscopic observations: there are >10(9) photometrically cataloged sources, yet modern spectroscopic surveys are limited to similar to fewx10(6) targets. As we approach the Large Synoptic Survey Telescope era, new algorithmic solutions are required to cope with the data deluge. Here we report the development of a machine-learning framework capable of inferring fundamental stellar parameters (T-eff, log g, and [Fe/H]) using photometric-brightness variations and color alone. A training set is constructed from a systematic spectroscopic survey of variables with Hectospec/ Multi-Mirror Telescope. In sum, the training set includes similar to 9000 spectra, for which stellar parameters are measured using the SEGUE Stellar Parameters Pipeline (SSPP). We employed the random forest algorithm to perform a non-parametric regression that predicts Teff, log g, and [Fe/H] from photometric time-domain observations. Our final optimized model produces a cross-validated rms error (RMSE) of 165 K, 0.39 dex, and 0.33 dex for T-eff, log g, and [Fe/H], respectively. Examining the subset of sources for which the SSPP measurements are most reliable, the RMSE reduces to 125 K, 0.37 dex, and 0.27 dex, respectively, comparable to what is achievable via low-resolution spectroscopy. For variable stars this represents a approximate to 12%-20% improvement in RMSE relative to models trained with single-epoch photometric colors. As an application of our method, we estimate stellar parameters for similar to 54,000 known variables. We argue that this method may convert photometric time-domain surveys into pseudo-spectrographic engines, enabling the construction of extremely detailed maps of the Milky Way, its structure, and history.</P>
Interferometric constraints on quantum geometrical shear noise correlations
Chou, Aaron,Glass, Henry,Richard Gustafson, H,Hogan, Craig J,Kamai, Brittany L,Kwon, Ohkyung,Lanza, Robert,McCuller, Lee,Meyer, Stephan S,Richardson, Jonathan W,Stoughton, Chris,Tomlin, Ray,Weiss, Rai IOP 2017 Classical and quantum gravity Vol.34 No.16
<P>Final measurements and analysis are reported from the first-generation Holometer, the first instrument capable of measuring correlated variations in space-time position at strain noise power spectral densities smaller than a Planck time. The apparatus consists of two co-located, but independent and isolated, 40 m power-recycled Michelson interferometers, whose outputs are cross-correlated to 25 MHz. The data are sensitive to correlations of differential position across the apparatus over a broad band of frequencies up to and exceeding the inverse light crossing time, 7.6 MHz. By measuring with Planck precision the correlation of position variations at spacelike separations, the Holometer searches for faint, irreducible correlated position noise backgrounds predicted by some models of quantum space-time geometry. The first-generation optical layout is sensitive to quantum geometrical noise correlations with shear symmetry—those that can be interpreted as a fundamental noncommutativity of space-time position in orthogonal directions. General experimental constraints are placed on parameters of a set of models of spatial shear noise correlations, with a sensitivity that exceeds the Planck-scale holographic information bound on position states by a large factor. This result significantly extends the upper limits placed on models of directional noncommutativity by currently operating gravitational wave observatories.</P>
Ramponi, Laura,Yasui, Youichi,Murawski, Christopher D.,Ferkel, Richard D.,DiGiovanni, Christopher W.,Kerkhoffs, Gino M.M.J.,Calder, James D.F.,Takao, Masato,Vannini, Francesca,Choi, Woo Jin,Lee, Jin W SAGE Publications 2017 AMERICAN JOURNAL OF SPORTS MEDICINE - Vol.45 No.7
<P>Conclusion: An assessment of the currently available data does suggest that BMS may best be reserved for OLT sizes less than 107.4 mm(2) in area and/or 10.2 mm in diameter. Future development in legitimate prognostic size guidelines based on high-quality evidence that correlate with outcomes will surely provide patients with the best potential for successful long-term outcomes.</P>