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Kwon Eun-Kyung,Kang Tae-Wook,Oh Taeyun,Choo Oak-Sung,예영민,Park Hae-Sim,Ban Ga-Young 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.5
Dysregulation of the arachidonic acid metabolic pathway is the most widely known pathomechanism of aspirin-exacerbated respiratory disease (AERD). This study aimed to perform integrative analysis of transcriptomic and epigenomic profiling with network analysis to determine the novel pathogenic features of AERD. Ten patients with asthma including 5 patients with AERD and another 5 patients with aspirin tolerant asthma (ATA) were enrolled. Nasal scraping was performed and nasal mucosa was used in omics profiling. Peripheral eosinophil counts, sputum eosinophil counts, fractional exhaled nitric oxide levels, and pulmonary function test results were evaluated. Differentially expressed genes (DEGs), differentially methylated probes (DMPs) and differentially correlated genes (DCGs) between patients with AERD and those with ATA were analyzed. Network analysis using ingenuity pathway analysis (IPA) was performed to determine the gene connection network and signaling pathways. In total, 1,736 DEGs, 1,401 DMPs, and 19 pairs for DCGs were identified. Among DCGs, genes related to vesicle transport (e.g., RAB3B and STX2) and sphingolipid dysregulation (e.g., SMPD3) were found to be hypo-methylated and up-regulated in AERD. Using the canonical pathway analysis of IPA with 78 asthma-related DEGs, signaling pathways of T helper cell differentiation/activation and Fcε receptor I were generated. Up-regulation of RORγt and FcER1A were noted in AERD. Gene expression levels of RAB3B, SYNE1, STX2, SMPD3 and RORγt were significantly associated with sputum eosinophil counts. Quantitative real-time polymerase chain reaction was performed and mRNA expression levels of STX2, SMPD3, RORγt, and FcER1A were significantly higher in AERD compared to ATA. Distinct pathogenic features were identified by using integrative multi-omics data analysis in patients with AERD.
Prevalence and Factors of Chronic Kidney Disease
( Seul Hyun Oh ),( Ha Yeon Kim ),( Chan Young Oak ),( Min Jee Kim ),( Chang Seong Kim ),( Joon Seok Choi ),( Hyung Chul Lee ),( Jeong Woo Park ),( Eun Hui Bae ),( Seong Kwon Ma ),( Nam Ho Kim ),( Soo 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.4
Purpose: The prevalence of chronic kidney disease (CKD) is increasing. Accordingly, hospitalization and mortalities associated with CKD also have increased. The present study aimed to determine the prevalence of CKD, and explore the causative risk factors. Methods: One thousand one hundred and forty-seven patients who underwent the mass health screening test at Chonnam National University Hospital between July 2007 and December 2007 were studied. The prevalence of CKD and possible risk factors such as gender, previous history of diabetes mellitus and hypertension, smoker status (current and ex-smoker), BMI, increased LDL cholesterol, triglyceride levels, HDL cholesterol level and anemia were analyzed. Results: There were 631 male and 616 female subjects. Mean age was 48.6 years and mean glomerular filtration rate was 117.2±28.7 ml/min/1.73m(2). The prevalence of CKD was 10.3%, and the prevalence of advanced CKD (CKD stage 3-5) was 0.5%. The prevalence of advanced CKD was higher in subjects with diabetes. The awareness of CKD was very low. Factors independently associated with CKD were sex favoring men (odd ratio [OR], 2.106; 95% CI, 1.436-3.090), smoker (OR, 0.575; 95% CI, 0.382-0.867), DM (OR, 2.395; 95% CI, 1.338-4.286), inadequate blood sugar (OR, 2.536; 95% CI, 1.267-5.077), HDL<40 mg/dL (OR, 0.418; 95% CI, 0.191-0.915) in a univariate analysis. With a multivariate analysis, female gender (OR, 2.123; 95% CI, 1.209-3.730) was the only independent risk factor for CKD. Conclusion: Since the CKD is a public health burden, closer attention is needed to prevent the CKD in the high-risk group.
복통을 호소한 20세 환자에서 발견된 인식되지 못한 질내 이물
오은경 ( Eun Kyeong Oh ),송재연 ( Jae Yeon Song ),조현희 ( Hyun Hee Jo ),권동진 ( Dong Jin Kwon ),임용택 ( Yong Taik Lim ),유영옥 ( Young Oak Lew ),김은중 ( Eun Jung Kim ),김장흡 ( Jang Heup Kim ),김미란 ( Mee Ran Kim ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.8
The foreign bodies in vagina cause intense inflammation. Genital complaints in patients could indicate the presence of a vaginal foreign object. Vaginal bleeding and blood-stained, foul-smelling discharge are considered to be the main clinical manifestations of vaginal foreign bodies, and toilet tissue reported as the most commonly found foreign body. The insertion of foreign bodies into the vagina is not uncommon but presentation as lower abdominal pain in an gynaecological clinic is rare. The causes of insertion are sexual stimulation, sexual abuse, accident of post-surgery and most cases find a solution after vaginal speculum examination. We describe a case of foreign body in the vagina of a patient presenting with chronic lower abdominal pain but undetectable and unrecognized in general examination.
원저 : 폐암 환자에서 촉진되지 않는 경부 림프절에 대한 초음파 유도 하 세침흡인 세포검사의 유용성
김희규 ( Hee Kyoo Kim ),하승인 ( Seung In Ha ),김유리 ( Yu Ri Kim ),박찬복 ( Chan Bog Park ),옥철호 ( Chul Ho Oak ),장태원 ( Tae Won Jang ),정만홍 ( Maan Hong Jung ),오경승 ( Kyung Seung Oh ),천봉권 ( Bong Kwon Chun ),이민기 ( Min 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.56 No.5