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      • KCI등재후보
      • SCOPUSKCI등재

        C -11 및 F - 18 표지 콜린의 합성과 체내동태에 관한 연구

        전권수,유국현,김상욱,임상무,홍성운,서용섭,양승대,안순혁,허민구 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.3

        Objectives: Recently, [methyl-(11)^C]-(β-Hydroxyethyl)trimethylammonium ([(11)^C]choline) has been discovered to be a very effective tracer in imaging various human tumors using positron emission tomography. Because of the short half-life of C-11, it is very difficult to use in a routine imaging procedure and needs a frequent synthesis of [(11)^]choline. This can be supplemented by the substitution of [(11)^Ccholine with [methyS-18]fluorocholine. Here, we would like to report cell uptake and biodistribution of [(11)^Ccholine and [(18)^F]fluorocholine as a basic study. Methods [(11)^C]Choline was prepared by the treatment of [(11)^C]CHzI with N,N-dimethylaminoethanol and [18F]fluorocholine was synthesized from reaction of CHzBr[18F]F with N,N-dimethylaminoethanol. The radiochemical purity was checked by high performance liquid chromatography (HPLC). The biodistribution of [(11)^C]choline and [(18)^F]fluorocholine was determined in balb/c mouse at 5 min, 20 min, 40 min and 80 min. The cell uptake wa measured using glioma (9L) and colon adeocarcinoma (SW620). Results: The radiochemical purity was more than 98% after purification. In the liver, uptake did not change over time the uptake was 20/ID/g for [C]choline and 13%ID/g for [(18)^F]fluorocholine. In the kidney, radioactivity decreased over tirne the uptake was 15%1D/g for [(11)^Ccholine and 20%ID/g for [(18)^F]fluorocholine, 80 min post-injection. The cell uptake of [(11)^Ccholine was 4.93% for glioma (9L) and 18.69F for colon adenocarcinoma (SW620). For [(18)^F]fluorocholine, 1.77% for glioma (9L) and 2.77% for colon adenocarcinoma (SW620). Conclusion: [(11)^CCholine and [(18)^F]fluorocholine showed a different cell uptake tendency, depending on cancer cell line. (Korean J Nucl Med 200135:185-191)

      • SCOPUSKCI등재

        SUPEROXIDE DISMUTASE 가 허혈 손상된 백서 근육 조직에 미치는 영향

        민대홍,김승홍,백무현,김승한 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.4

        Superoxide radicals have been shown to play an important role in the cellular injury of reperfused ischemic tissue. We examined the protective effect of superoxide dismutase(SOD), one of the derivatives of superoxide rradical scavengers, on the reperfusion injury of replanted rat limb with 6 - hour is - chemic period. Biochemically, the amounts of superoxide radicals in ischemic hindlimbs treated with SOD have decreased significantly compared to those of control group.(p<0.01) Histologically, SOD treated extremities demonstrated less inflammatory reaction and degenerative change than control group. Our results indicate that the administration of SOD to a amputation part by means of intraarterial perfusion after prolonged period of warm ischemia significantly decreases the tissue damage.

      • SCOPUSKCI등재

        연골이식을 이용한 와우형 이개 기형의 교정

        민대홍,김영수,백무현,김승홍 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.1

        Among the congenital ear deformity, the snail shell(escargot) ear is a combined form of the lop and satyr ear, and corresponds to Tanzer's "constricted ear, group Ⅲ" and correspond to the "severe cupped" ear of Fukuda, and has been called "cucurucho"(ice-cream cone) by Malbec. Embryologically, hillocks three and four and the intervening cleft are affected, and there is severe underdevelopment of the upper ear, including the intervening anterior and superior helix, the upper scapha and scaphal fossa, superior crus and triangular fossa. The upper ear is rolled forward and downward, deviating the longitudinal axis. Correction methods of the snail shell ear were various from the Kislov method to the rib cartilage graft for radical treatment of full-blown microtia. We recently the case of a 26 years old woman who presented the lidding of the upper one third helix and corrected this deformity with the contralateral conchal cartilage graft. Thus we got the good result.

      • SCOPUSKCI등재

        부분층 피부결손에 DuoDERME를 이용한 폐쇄성 드레싱의 효과

        민대홍,김영수,백무현,김승홍 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.1

        The purpose of study is to evaluate the effects of occlusive wet dressing by using the synthetic skin substitute, DuoDERM E, in the management of 2nd degree burn wounds and donor sites of split thickness skin graft. The outer layer of DuoFERM E is made of a polyurethane foam, which is impermeable to oxygen, water and microorganisms. Therefore, moisture from the gel cannot evaporate through the dressing. This property, in combination with the adherence to the healthy skin, provides a moist wound environment and a very effective proper bacterial barrier. Forty seven patients (22 patients with 2nd degree burn and 25 patients with skin graft donor sites) were divided into two groups. The DuoDERM E dressed group consisted of 12 patients with the the 2nd degree burn and 10 patients with skin graft donor sites, and conventionally petrolatum treated control group consited of 10 paitents with 2nd degree burn and 10 patients with skin graft donor sites respectively. We investigated pain, comfort, limitation of activity, number if dressing changes and time for complete healing. The DuoDERM E dressed group had less pain, more comfort, less limitation of activity, less frequent dressing changes, more rapid wound healing than control group. From these results, with concluded that the occlusive dressing with DuoDERM E was an effective alternative to the conventional gauze dressing in partial thickness skin defects.

      • SCOPUSKCI등재

        가토에서 음각틀을 이용한 이개 재건의 실험적 연구

        민대홍,김승홍,백무현,김원석 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.4

        The formation or reconstruction of an auricle is one of the most difficult operations in plastic and reconstructive facial surgery. The difficulties of its reconstruction include delicate structures of the ear, extremely thin skin, difficulty in color match, and springing effect of the thin supporting skeleton consists of cartilage with its peculiar recesses and bumps. Even though, several techniques have been using for auricular reconstruction, it would be difficult to obtain an ideal auricle. Furthermore surgeon's talent and sufficient practice might be needed for a satisfactory result. We attempted auricular reconstruction using negative auricular plastic mold in 10 white rabbits in order to pursue a simple and satisfactory method. Diced cartilage chips were filled into a subcutaneous pocket placed in the negative auricular mold. Mild negative pressure was maintained in the space between the cartilage-subcutaneous tissue-skin complex and mold for two months. The results were as follows: 1.An ideal shaped suitable supporting skeleton was newly formed and the fabricated new auricle had a near normal appearance. 2.Under the microscopic examination, the diced cartilage chips have conglomerated together to form a solid skin - connective tissue - cartilage framework and evenmore matured chondrocytes were noted.

      • 中風 動物 모델의 運動機能失調에 對한 硏究

        洪茂昌,申玟圭,禹太律 慶熙大學校韓醫科大學韓醫學硏究所 1999 慶熙韓醫大論文集 Vol.22 No.1

        We induced brain ischemia using middle cerebral artery occlusion(MCAo) and studied the results of walking initiation and circling test, posture reflex test, water bath swimming test to characterize the motor dysfunction and establish the model of stroke by MCAo for oriental medicine. Analysis of total rotation angle during 1 min. swimming showed significant motor dysfunction in occlusion group(3hrs, 6hrs, 9hrs, 24hrs after MCAo). Analysis of rectal rotation number during 1 min. swimming showed significant difference between control group and occlusion group(3hrs, 6hrs, 9hrs, 24hrs after MCAo). Analysis of posture reflex test showed significant difference between control group and occlusion group(3hrs, 6hrs, 9hrs, 24hrs, after MCAo). Significant motor dysfunctions are shown at start time in 24hrs, at inner circle time and outer circle time in 9hrs, 24hrs, at contalaterl or ipsilateral circling number or 180°turn in 3hrs, 6hrs, 9hrs, 24hrs during walking initiation and circling test. Results revealed that brain ischemia by intraluminal method was good at stroke model for oriental medicine which chiefly reveals motor dysfunction by paralysis of one side and behavior index suggested in this article could be used as a useful index for assessment of motor dysfunction.

      • SCOPUSKCI등재

        FIBRIN GLUE가 이식 피부의 접착 및 생착에 미치는 효과

        백무현,홍종현,박언섭,민대홍,김승홍,김미경 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.2

        The ability of a skin graft to adhere initially to a wound a bed is dependent on the formation of a stable fibrin bond the elastin in the graft and the elastin in the bed. the Factors preventiong such adhesion most commonly include bleeding, infection, mechanical disturbances of the adhesive mechanism, i.e., motion. This study was conducted to evaluate the adhesive effect of fibrin glue in the full-thickness skin grafts at 3,5,30,120minute and 8 hours after gluing in mice and the effect of fibrin glue on the skin graft take at the 3,7,15post operative days in rabbits. The result were as follows; (1) Mechanical testing demostrated that the shear adhesive strength of non-fibrin gluing control group was found to be 2.84m²(SD=2.68) after 3minutes of fixation At, 5minutes, the adhesive strength was 9.78gm/㎠(SD=2.68) after 3minutes of fixation. At 5minutes, the adhesive strength was 9.78gm/㎠(SD=5.61);at 30minutes, 30.78gm/㎠(SD=5.42); at 2hours, 53.14gm/㎠(SD=11.50); and at 8 hours, 108.08gm/㎠(SD=15.78) and that the shear adhesive strength of fibrin glue applied group was found to be 17.50gm/㎠(SD=5.79) after 3minutes of of fixation(after gluing). AT 5minutes, the adhesive strength was 24.30gm/㎠(SD=3.57); at 30minutes, 105.48gm/㎠(SD=15.27); at 2hours, 167.54gm/㎠(SD=58.12); and at 8hours, 286.22gm/㎠(SD=28.27). These results in shear adhesive strength were a significantly different between the experimental and the control groups at early skin grafts adherence. (2) The histologic examination did not demonstrate significant difference in healing process when the fibrin glue applied group were compared with the control group. With the above results, fibrin glue improved in early graft adherence without interference of the take of graft.

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