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Hou Ming-Feng,Ou-Yang Fu,Li Chung-Liang,Chen Fang-Ming,Chuang Chieh-Han,Kan Jung-Yu,Wu Cheng-Che,Shih Shen-Liang,Shiau Jun-Ping,Kao Li-Chun,Kao Chieh-Ni,Lee Yi-Chen,Moi Sin-Hua,Yeh Yao-Tsung,Cheng Chi 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.
Wireless Synchronous Transfer of Power and Reverse Signals
Yang Li,Yumei Li,Shaojie Feng,Qingxin Yang,Weihao Dong,Jingtai Zhao,Ming Xue 전력전자학회 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.3
Wireless power transfer via coupled magnetic resonances has been a hot research topic in recent years. In addition, the number of related devices has also been increasing. However, reverse signals transfer is often required in addition to wireless power transfer. The structure of the circuit for a wireless power transfer system via coupled magnetic resonances is analyzed. The advantages and disadvantages of both parallel compensation and series compensation are listed. Then the compensation characteristics of the inductor, capacitor and resistor were studied and an appropriate compensation method was selected. The reverse signals can be transferred by controlling the compensation of the resistor. In addition, it can be demodulated by extracting the change of the primary current. A 3.3 MHz resonant frequency with a 100 kHz reverse signals transfer system platform was established in the laboratory. Experimental results demonstrate that wireless power and reverse signals can be transferred synchronously.
Ming Yang,Wei-feng SHI 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.11
In view of fault diagnosis of the ship generator , the paper proposes improved fault diagnosis method of ship generator ,which is Optimized Neural Network based on Multi-population Chaos Genetic Algorithm. The results prove that the method effectively solves low precision,slow constringency and local minimum of neural network and improves global search ability, optimizes the rate and precision of fault diagnosis. The method has a certain application prospect for the ship power system generator fault diagnosis.
Yang Gao,Ming-Guang Feng,Sheng-Hua Ying 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.1
Oxalic acid is used as a functional molecule by most filamentous fungi, and produced via cytoplasmic pathwayand mitochondrial pathway. The cytoplasmic pathway of oxalate production from oxaloacetate is a one-stepreaction catalyzed by oxaloacetate hydrolase. The entomopathogenic fungus Beauveria bassiana contains a uniqueoxaloacetate hydrolase gene (BbOAH). The role of cytoplasmic pathway of oxalate production in B. bassianadevelopment and virulence was studied via construction of a targeted gene disruption mutant of BbOAH. Disruption of BbOAH resulted in a slight decrease (~30%) in oxalate production, but has no significant influenceon fungal growth. The mutant strain displayed a significant delay at early stage of conidial development, and asignificant defect in dimorphic transition. Additionally, bioassay using the greater waxmoth as host indicated aslight (~20%) decrease in mortality caused by the gene disruption strain. The phenotypic defects of the ΔBbOAHstrain could be restored by ectopic integration of BbOAH. Our findings indicate that BbOAH gene connects thecytoplasmic route of oxalate production to fungal development and virulence, although the cytoplasmic route isnot indispensable for oxalate production in B. bassiana.
Ming Xie,Jin-Long Liang,Han-Dong Huang,Mai-Jian Wang,Tao Zhang,Xue-Feng Yang 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4
Purpose Nonylphenol (NP) is an endocrine disruptor found in products such as cleaners, plastics, and detergents. It exerts actions similar to endogenous 17-estradiol (E2) and is reported to influence various cancers. However, its role in colon cancer remains elusive. Materials and Methods Colon cancer cell lines COLO 205 and SW480 were employed in our study. The cells were treated with NP or E2 followed by measurement of apoptosis and proliferation using flow cytometry and MTT assays, respectively. G protein–coupled estrogen receptor 30 (GPR30) expression was visualized using immunofluorescence and Western blot. To investigate the underlying mechanism, the expression levels of GPR30, p-protein kinase A (PKA), c-myc, cyclin D1, and ERK1/2 were analyzed using Western blot. Meanwhile, the GPR30 antagonist G15 was utilized to validate the role of GPR30 in colon cancer progression. Finally, the effect of a GPR30 inhibitor on tumor growth was determined in vivo using tumor xenograft mouse models. Results NP facilitated the proliferation of colon cancer cells and induced apoptosis failure in vitro. Western blot revealed increased GPR30 expression levels in response to NP treatment. Cyclin D1, p-PKA, c-myc, and proliferating cell nuclear antigen, proteins that regulate the cell cycle, were all upregulated by NP, and NP-mediated ERK1/2 activation and subsequent cell proliferation were abrogated by the GPR30 inhibitor G15. Moreover, colon cancer mice that received G15 administration demonstrated impaired tumor growth in vivo. Conclusion Low dose NP promotes the growth of colon tumors through GPR30-mediated activation of ERK1/2 signaling.
Study on the Lethal Reason of Overwintering Weedy Rice Seed in Cold Rice Production Area in China
Ming-gen Wu,Jie Yang,De-liang Yang,Feng Xu,Min-jie Fu 한국잡초학회 2011 한국잡초학회 별책(학술대회 초록집) Vol.31 No.2
The outdoor trails were carried out to investigate overwintering survival rate of different weedy rice seeds in two latitude areas including Longjing city located in Jilin province and Donggang city located in Liaoning province in China, respectively. The survival rates of all weedy rice seeds which were frozen under the condition of saturated soil for 3 months are about 0%. The germination rates of weedy rice seeds overwintering in air-dried soil are more than 50%. The death of overwintering weedy rice seed in the two production areas was positively related to its dormancy characteristic, seed water content and temperature during seed frozen period.
Feng-Ta Chang,Ming-Yang Cheng 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.10
Industrial applications such as pick-and-place tasks and CNC machining often involve repetitive motions that may contain periodic disturbances. Due to the periodic nature of these applications, the idea of iterative learning control can be exploited to cope with external periodic disturbances so as to improve system performance. In addition, in order to ensure satisfactory motion accuracy for operation scenarios that may encounter significant disturbance, (e.g., machining and polishing), a robust controller is essential. In particular, iterative learning sliding mode control (ILSMC) is shown to be suitable for control applications that encounter periodic disturbances. However, when the disturbance contains high frequency components, ILSMC may become less effective in compensating for external disturbances if its velocity estimation is not accurate enough. In order to cope with the aforementioned problem, this paper develops a gradient-descent-based velocity observer with a residual displacement compensation term to provide accurate velocity feedback to be used in ILSMC. Both theoretical analysis and experimental results are provided to verify the effectiveness of the proposed approach.