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Stilbenes and Oligostilbenes from Leaf and Stem of Vitis amurensis and Their Cytotoxic Activity
Do Thi Ha,Quan Cheng Chen,Tran Manh Hung,Tran Minh Ngoc,Phuong Thien Thuong,김홍진,성연희,민병선,배기환,윤의중 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
Chromatographic separation of the EtOAc fraction from the leaf and stem of Vitis amurensis led to the isolation of six oligostilbenoids (i.e., r-2-viniferin (1), trans-amurensin B (2), trans-ε -viniferin (3), gnetinH (4), amurensin G (5), (+)-ampelopsin A (8)) and four stilbenoids (i.e., trans-resveratrol (6), (+)- ampelopsin F (7), piceatannol (9), and trans-piceid (10)). The structures have been identified on the basis of spectroscopic evidence and physicochemical properties. The isolates were investigated for cytotoxic activity against three cancer cell lines in vitro using the MTT assay method. Amurensin G (5) and trans-resveratrol (6) showed significant cytotoxic activity against L1210, K562 and HTC116 cancer cell lines with IC50 values ranging from 15.7 ± 2.1 to 30.9 ± 1.8 μM. (+)-Ampelopsin A (8) and trans-piceid (10) exhibited considerable cytotoxic activity against L1210 (IC50 values of 30.6 ± 4.1 and 28.7 ± 2.81μM, respectively) and K562 (IC50 values of 38.6 ± 0.82 and 24.6 ± 0.76 μM, respectively). Gnetin H (4)showed only weak cytotoxic activity against L1210 with an IC50 value of 40.1 ± 4.23 μM. On the other hand, r-2-viniverin (1), trans-amurensin B (2), trans-ε -viniferin (3), (+)-ampelopsin F (7), and piceatannol(9) exhibited no activity on three cancer cell lines.
To Dao Cuong,Hoang Thi Ngoc Anh,Tran Thu Huong,Pham Ngoc Khanh,Vu Thi Ha,Tran Manh Hung,김영호,Nguyen Manh Cuong 한국생약학회 2019 Natural Product Sciences Vol.25 No.4
Soluble epoxide hydrolases (sEH) are enzymes present in all living organisms, metabolize epoxy fatty acids to 1,2-diols. sEH in the metabolism of polyunsaturated fatty acids plays a key role in inflammation. In addition, the endogenous lipid mediators in cardiovascular disease are also broken down to diols by the action of sEH that enhanced cardiovascular protection. In this study, sEH inhibitory guided fractionation led to the isolation of five phenolic compounds trans-resveratrol (1), trans-piceatannol (2), sulfuretin (3), (+)-balanophonin (4), and cassigarol E (5) from the ethanol extract of the seeds of Passiflora edulis Sims cultivated in Vietnam. The chemical structures of isolated compounds were determined by the interpretation of NMR spectral data, mass spectra, and comparison with data from the literature. The soluble epoxide hydrolase (sEH) inhibitory activity of isolated compounds was evaluated. Among them, trans-piceatannol (2) showed the most potent inhibitory activity on sEH with an IC50 value of 3.4 mM. This study marks the first time that sulfuretin (3) was isolated from Passiflora edulis as well as (+)-balanophonin (4), and cassigarol E (5) were isolated from Passiflora genus.
Antioxidant Effect of Flavonoids Isolated from the Root of Clematis trichotoma Nakai
Hung, Tran Manh,Thuong, Phuong Thien,Bae, Ki-Hwan The Korean Society of Medicinal Crop Science 2005 한국약용작물학회지 Vol.13 No.5
The antioxidant effect of methanol extract (ME) and water extract (WE) from Clematis trichotoma was evaluated as primary study to scavenge stable 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), inhibited iron-induce lipid peroxidation in linoleic acid emulsion, peroxidation of liposome induced by $Fe^{3+}/H_2O_2/ascorbie$ acid, and on $Fe^{2+}/H_2O_2$ induced the mitochondrial lipid peroxidation. In secondary study, five flavonoids as luteolin (1), quercetin (2), apigenin (3), hirsutrin (4), kaempferol-3-O-glucoside were isolated (5). Among them, compounds 1 and 2 showed good activities in all the model systems. Compound 3 exhibited moderate antioxidant activities in both radical scavenging and these lipid peroxidation systems tested. Compound 4 showed significant inhibitions in liposome peroxidation and compound 5 displayed weak inhibition in all four tested systems. All the results presented herein indicate that products of C. trichotoma maybe useful in inhibiting membrane lipid peroxidation and preventing free radical-linked diseases.
Acetylcholinesterase Inhibitory Effect of Lignans Isolated from Schizandra chinensis
Tran Manh Hung,나민균,민병선,Tran Minh Ngoc,IkSoo Lee,XinFeng Zhang,배기환 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.6
The hexane extract of the fruit of Schizandra chinensis (Schisandraceae) was found to show significant inhibition of the activity of acetylcholinesterase enzyme (AChE). In further studies, fourteen lignans were isolated, and evaluated for their inhibitory effect on AChE. The compounds having both aromatic methylenedioxy and hydroxyl groups on their cyclooctadiene ring, such as gomisin C (6), gomisin G (7), gomisin D (8), schisandrol B (11) and gomisin A (13), entirely inhibited AChE in dose dependent manners, with IC50 values of 6.71 ± 0.53, 6.55 ± 0.31, 7.84 ± 0.62, 12.57 ± 1.07 and 13.28 ± 1.68 µM, respectively. These results indicate that the lignans could potentially be a potent class of AChE inhibitors.
Tran Manh Hung,Hoang Duc Manh,Pham Thi Hong Minh,윤의중,나민균,Won Keun Oh,민병선,배기환 한국생약학회 2007 Natural Product Sciences Vol.13 No.4
this study, the twenty-four ethyl acetate extracts of twenty-two medicinal plants, traditionally usedα-amylase and protein tyrosine phosphatase 1B (PTP1B)enzymes inhibitory activity in vitro. The results indicated that, twelve materials (50.0%) showed moderate tostrong inhibitory activity in α-amylase inhibitory activity with IC50 values ranging from 2.5 to 48.8g/mL;meanwhile, ten extracts (41.6%) could demonstrate PTP1B activity with IC50 values less than 30.5g/mL. Someplants presented interesting activities against both of α-amylase and PTP1B enzymes such as Catharanthusroseus, Carthamus tinctorius, Momordica charantia, Gynostemma pentaphyllum, Glycyrrhiza glabra, Smilaxglabra, Psidium guajava (leave), and Rehmannia glutinosa. The study may provide a proof, at least in a part, forthe ethno-medical use in diabetes disease of these plants. KeywordsVietnamese medicinal plants, diabetes, α-amylase, protein tyrosine phosphatase 1B
iCaMs: 안티 콜 피싱 및 메시지 사기를 위한 지능형 시스템
( Manh-hung Tran ),양희규,( Thien-binh Dang ),추현승 ( Hyun-seung Choo ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.2
The damage from voice phishing reaches one trillion won in the past 5 years following report of Business Korea on August 28, 2018. Voice phishing and mobile phone scams are recognized as a top concern not only in Korea but also in over the world in recent years. In this paper, we propose an efficient system to identify the caller and alert or prevent of dangerous to users. Our system includes a mobile application and web server using client and server architecture. The main purpose of this system is to automatically display the information of unidentified callers when a user receives a call or message. A mobile application installs on a mobile phone to automatically get the caller phone number and send it to the server through web services to verify. The web server applies a machine learning to a global phone book with Blacklist and Whitelist to verify the phone number getting from the mobile application and returns the result.
Cholinesterase Inhibitory Activities of Alkaloids from Corydalis Tuber
Tran Manh Hung,Phuong Thien Thuong,Nguyen Trung Nhan,Nguyen Thi Thanh Mai,Tran Le Quan,최재수,우미희,민병선,배기환 한국생약학회 2011 Natural Product Sciences Vol.17 No.2
Several isoquinoline alkaloids (1 - 18), which have basic chemical structures as protoberberine and aporphine skeletones, were evaluated for their inhibitory activities on AChE and BuChE. Among them, compounds 3, 4, 6, 8 and 12 showed the potent AchE activity with the IC50 values ranging from 10.2 ? 0.5 mM to 24.5 ? 1.6 mM, meanwhile, compound 14 - 17 exhibited strong inhibitory activity with IC50 values from 2.1 ? 0.2 to 5.5 ? 0.3 mM. Compounds 14 - 17 exhibited selective inhibition for AChE compared with BuChE. The isoquinoline alkaloid possesses aromatic methylenedioxy groups and quaternary nitrogen atoms are crucial for the anti-cholinesterase inhibitory activity.
Tran, Phi-Long,Kim, Okwha,Tran, Huynh Nguyen Khanh,Tran, Manh Hung,Min, Byung-Sun,Hwangbo, Cheol,Lee, Jeong-Hyung Elsevier 2019 Food and chemical toxicology Vol.129 No.-
<P><B>Abstract</B></P> <P>The flower buds of <I>Cleistocalyx operculatus</I> are used as an important ingredient in herbal tea and herbal products in several tropical countries. However, their protective effects and underlying mechanisms on lipopolysaccharide (LPS)-induced endotoxic shock remain unclear. The aim of this study was to investigate the anti-inflammatory effects of ethanol extract of <I>C. operculatus</I> flower buds (ECO) and its major constituent 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC) in macrophages and in an experimental LPS-induced sepsis mouse model. ECO inhibited the LPS-induced production and expression of pro-inflammatory mediators in macrophages. In an endotoxic shock mouse model, the oral administration of ECO rescued LPS-induced mortality, and attenuated LPS-induced increases in the serum levels of pro-inflammatory mediators, and damage of the lung and liver tissues. ECO increased the nuclear translocation of the nuclear factor erythroid 2-related factor 2 (Nrf2), as well as the expression of Nrf2 target genes, including heme oxygenase-1 (HO-1), in macrophages. Similar to the effects of ECO, DMC also inhibited the LPS-induced inflammatory response in macrophages and endotoxic shock in mice, and activated the Nrf2/HO-1 pathway. In conclusion, our findings suggested that ECO and its major constituent, DMC, attenuated LPS-induced endotoxic shock by activating the Nrf2/HO-1 pathway.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The flower buds of Cleistocalyx operculatus are used as an ingredient in herbal products in several tropical countries. </LI> <LI> The anti-inflammatory effects of C. operculatus flower buds (ECO) and its major constituent DMC are demonstrated. </LI> <LI> ECO and DMC attenuates lipopolysaccharide-induced inflammatory response in macrophages and endotoxic shock in mice. </LI> <LI> The Nrf2/HO-1 pathway is attributable to the anti-inflammatory properties of ECO and DMC in macrophages. </LI> <LI> The mechanism explains the anti-inflammatory effects of ECO and DMC. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Cytotoxic Saponins from the Root of Dipsacus asper Wall
Tran Manh Hung,WenYi Jin,Phuong Thien Thuong,송경식,성연희,배기환 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.9
Cytotoxic activitiy of seven hederagenin saponins isolated from the root of Dipsacus asper were investigated in vitro against L1210, HL-60 and SK-OV-3 tumor cell lines by the MTT method. 3-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin (2), 3-O-β-Dxylopyranosyl-( 1→3)-α-L-Rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin (6) and 3-O-β-D-glucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin (7) exhibited the potent cytotoxicity against the three tumor cell lines with IC50 values ranging from 4.7 to 8.7 µg/mL, with the exception of compound 7, which exhibited weak cytotoxic activity against SK-OV-3 (IC50 22.5 µg/mL). Other compounds did not exhibit any cytotoxic activity (IC50 > 30 µg/mL).