A Rapid Convergent Max-SINR Algorithm for Interference Alignment Based on Principle Direction Search

( Zhilu Wu ),( Lihui Jiang ),( Guanghui Ren ),( Gangyi Wang ),( Nan Zhao ),( Yaqin Zhao ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.5

The maximal signal-to-interference-plus-noise ratio (Max-SINR) algorithm for interference alignment (IA) has received considerable attention for its high sum rate achievement in the multiple-input multiple-output (MIMO) interference channel. However, its complexity may increase dramatically when the number of users approaches the IA feasibility bound, and the number of iterations and computational time may become unacceptable. In this paper, we study the properties of the Max-SINR algorithm thoroughly by presenting theoretical insight into the algorithm and by providing the potential of reducing the overall computational cost. Furthermore, a novel IA algorithm based on the principle direction search is proposed, which can converge more rapidly than the conventional Max-SINR method. In the proposed algorithm, it searches along the principle direction, which is found to approximately point to the convergence values, and can approach the convergence solutions rapidly. In addition, the closed-form solution of the optimal step size can be formulated in the sense of minimal interference leakage. Simulation results demonstrate that the proposed algorithm outperforms the conventional minimal interference leakage and Max-SINR algorithms in terms of the convergence rate while guaranteeing the high throughput of IA networks.

NEDD8-activating enzyme inhibitor, MLN4924 (Pevonedistat) induces NOXA-dependent apoptosis through up-regulation of ATF-4

Liu, Xiaojun,Jiang, Yanan,Wu, Jianfu,Zhang, Wenjuan,Liang, Yupei,Jia, Lijun,Yu, Jinha,Jeong, L.S.,Li, Lihui Elsevier 2017 Biochemical and biophysical research communication Vol. No.

<P><B>Abstract</B></P> <P>It has been reported that MLN4924 can inhibit cell growth and metastasis in various kinds of cancer. We have reported that MLN4924 is able to inhibit angiogenesis through the induction of cell apoptosis both in vitro and in vivo models. Moreover, Neddylation inhibition using MLN4924 triggered the accumulation of pro-apoptotic protein NOXA in Human umbilical vein endothelial cells (HUVECs). However, the mechanism of MLN4924-induced NOXA up-regulation has not been addressed in HUVECs yet. In this study, we investigated how MLN4924 induced NOXA expression and cellular apoptosis in HUVECs treated with MLN4924 at indicated concentrations. MLN4924-induced apoptosis was evaluated by Annexin V-FITC/PI analysis and expression of genes associated with apoptosis was assessed by Quantitative RT-PCR and western blotting. As a result, MLN4924 triggered NOXA-dependent apoptosis in a dose-dependent manner in HUVECs. Mechanistically, inactivation of Neddylation pathway caused up-regulation of activating transcription factor 4 (ATF-4), a substrate of Cullin-Ring E3 ubiquitin ligases (CRL). NOXA was subsequently transactivated by ATF-4 and further induced apoptosis. More importantly, knockdown of ATF-4 by siRNA significantly decreased NOXA expression and apoptotic induction in HUVECs. In summary, our study reveals a new mechanism underlying MLN4924-induced NOXA accumulation in HUVECs, which may help extend further study of MLN4924 for angiogenesis inhibition treatment.</P> <P><B>Highlights</B></P> <P> <UL> <LI> MLN4924 triggered NOXA-dependent apoptosis in a dose-dependent manner in HUVECs. </LI> <LI> Inactivation of neddylation caused up-regulation of ATF4, a substrate of CRL. </LI> <LI> NOXA was transactivated by ATF4 and further induced apoptosis. </LI> <LI> Knockdown of ATF-4 significantly decreased NOXA expression and apoptotic induction. </LI> <LI> We revealed a new mechanism underlying MLN4924-induced NOXA accumulation in HUVECs. </LI> </UL> </P>

Visibility Measurement in an Atmospheric Environment Simulation Chamber

Hongda Ta,Zibo Zhuang,Lihui Jiang,Dongsong Sun 한국광학회 2017 Current Optics and Photonics Vol.1 No.3

Obtaining accurate visibility measurements is a common atmospheric optical problem, and of vitalsignificance to civil aviation. To effectively evaluate and improve the accuracy of visibility measurements,an outdoor atmospheric simulation chamber with dimensions of 1.8×1.6×55.7 m3was constructed. Thesimulation chamber could provide a relatively homogeneous haze environment, in which the visibility variedfrom 10 km to 0.2 km over 5 hours. A baseline-changing visibility measurement system was constructedin the chamber. A mobile platform (receiver) was moved from 5 m to 45 m, stopping every 5 m, tomeasure and record the transmittance. The total least-squares method was used to fit the extinctioncoefficient. During the experiment conducted in the chamber, the unit weight variance was as low as1.33×10-4under high-visibility conditions, and the coefficient of determination (R2) was as high as 0.99under low-visibility conditions, indicating high stability and accuracy of the system used to measure theextinction coefficients and strong consistency between repeated measurements. A Grimm portable aerosolspectrometer (PAS) was used to record the aerosol distribution, and then Mie theory was used to calculatethe extinction coefficients. The theoretical results were found to be consistent with the measurements andexhibited a positive correlation, although they were higher than the measured values.

Transcriptome analysis in different chieh‑qua cultivars provides new insights into drought‑stress response

Min Wang,Xiaoming He,Biao Jiang,Wenrui Liu,Yu’e Lin,Dasen Xie,Zhaojun Liang,Lihui Chen,Qingwu Peng 한국식물생명공학회 2019 Plant biotechnology reports Vol.13 No.6

Drought, one of the crucial environmental constraints, seriously threats the quality and yield in chieh-qua. Therefore, cultivat-ing drought-tolerant variety is greatly necessary for its normal growth under water deficiency. However, at present, molecular knowledge on drought resistance is mostly unclear in chieh-qua. In the study, characteristics of two diverse genetic chieh-qua variety, A39 (drought-resistance) and H5 (drought-sensitivity), were analyzed. Under drought stress, H5 exerted high water loss rate, increased malonaldehyde (MDA) content, and decreased enzyme activity of glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) compared with A39. In addition, based on the transcriptome results, we obtained a total of 1821 (511 up-regulated and 1310 down-regulated) and 2114 (1282 up-regulated and 832 down- regulated) differentially expressed genes (DEGs) in the A39 versus H5 under normal and water-deficiency stress, respectively. Several DEGs involved in the cuticle synthesis (cytochrome P450 genes: CYP94A2, CYP86B1, CYP86A7), carbohydrate metabolism, and plant hormone signal transduction (small auxin-up RNA genes: SAUR32, SAUR72; JA-induced genes: TIFY 10A, TIFY 10C; ABA related genes: PYL2, PYL4) were explored and related to drought resistance. These expression patterns observed in the RNA-seq data were further confirmed with quantitative real-time PCR (qRT-PCR). In all, these results not only provided a new insight into analyzing genes of drought response, but also laid a foundation for isolating crucial genes involved in drought stress in chieh-qua.

Olive Leaf Extract Facilitates Healing of Experimental Cartilaginous Injuries in Rabbits

Dezheng Gong,Chengyan Geng,Liping Jiang,Lihui Wang,Hiroyuki Yoshimuram,Laifu Zhong 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.3

We investigated the restorative effect of orally administered olive leaf extract (OLE) on experimentally produced cartilaginous injuries in rabbits. In total, three holes in the left stifle joint, including one in the medial trochlear ridge and two in the trochlear sulcus (proximal and distal) of articular cartilage, were prepared surgically using a drill. For the control group only tap water alone was administered daily, and for the OLE group a water-based solution of OLE (500 mg/kg/day) was administered daily. The injured areas were observed macroscopically and histologically at 3 weeks after the operation. The results indicate that OLE facilitated healing of the three holes and increased the weight of the biceps femoris muscle. Histological examination revealed that in the OLE group, matured cartilage tissues and connective tissues were mixed with regenerated or maturing cartilage tissues with massive proliferation in the injured parts, around which the proliferation of undifferentiated blast cells and the tissue with cartilage substrates were observed. The histological score of the OLE group was significantly lower than that of the control group. The percentage of proliferating cell nuclear antigen–positive cartilage cells in the OLE group was higher than in the control group. Mean density of the restored area observed with Safranin O staining was higher in the OLE group than in the control group. Therefore, OLE is effective for enhancing the healing of cartilaginous injuries. OLE may also have a beneficial effect of slowing and reducing the pathogenesis of degenerative joint diseases in humans.