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( Jin Sub Lee ),( Kyou Chae Lee ),( Sang Lim Kim ),( Weon Ju Lee ),( Seok Jong Lee ),( Shin Woo Kim ),( Ki Bum Park ),( Won Kee Lee ),( Young Hoon Jeon ),( Do Won Kim ),( Yong Hyun Jang ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Although several interventional procedures (IPs) such as epidural sympathetic block and neuromodulation for reducing the acute pain of herpes zoster (HZ) have been indicated to have some level of effectiveness in the prevention of postherpetic neuralgia (PHN), no conclusive evidence is present for this issue. Objectives: To examine the efficacy of interventional pain management during the acute phase of HZ (within 14 days after onset of the rash) in preventing PHN Methods: Databases we used included PubMed, SCOPUS and references of retrieved articles from inception to August 2013, with no limits on the study date or language. A total of 1960 literatures were reviewed. Included studies were randomized controlled and cohort trials that compared IPs, which were combined with standard antiviral therapy aiming at preventing PHN, with antiviral therapy only. Studies must have included VAS for pain assessment. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using Comprehensive Meta Analysis Version 2.0. Results: Five studies of a total of 1413 patients were ultimately included. The results showed IPs combined with antiviral therapy during acute HZ had a preventive effect on the development of PHN over antiviral therapy only at 3 months (ORs 3.28, 95% CIs 1.20 to 8.96; p=0.02) and 6 months (ORs 3.86, 95% CIs 1.25 to 11.89; p=0.02). Conclusion: Current evidence shows that in preventing PHN, interventional pain management can be effective during acute HZ.
김규섭 ( Kyou Sub Kim ),이창훈 ( Chang Hun Lee ),김세호 ( Se Ho Kim ) 한국전통조경학회 2015 한국전통조경학회지 Vol.33 No.2
This study is to review the historical documents about Cinnamomum camphora SIEB. in Goryeo and Joseon Dynasty. First of all, we defined it`s feature and used case by the most appropriate word ``Jang(樟)`` meaning Cinnamomum camphora SIEB. We also discovered some illusions and should suggest a new possibility. First, we analyzed the definition and examples of Cinnamomum camphora SIEB. and come to the conclusion that ``Jang(樟)`` seems to be the most appropriate word. Second, we confirmed that Cinnamomum camphora SIEB. grew in extralimital area. It is believed that it`s because of making a mistake. Third, we confirmed that it is confused Cinnamomum camphora SIEB. with Koelreuteria paniculata in Yi, Gyu-Gyeong`s records. However, it`s required to verify the other cases of the Cinnamomum camphora SIEB.``s records. We expect a follow-up study about it by classifying modern feature and comparing literature matching.
Effect of escitalopram on erythematotelangiectatic rosacea
( Kyou Chae Lee ),( Sang Lim Kim ),( Jin Sub Lee ),( Yoon Hyuk Choi ),( Hyun Ho Son ),( Hong Dae Jung ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: There is no satisfactory treatment for erythematotelangiectatic rosacea. Objectives: To investigate the effect of escitalopram for the treatment of erythematotelangiectatic rosacea Methods: Twenty four subjects (male to female: 3:20, mean age: 44.4 years) were enrolled. Exacerbating factors were analyzed with questionnaire. Escitalopram was given at a dose of 5 mg/day for 8 weeks. Evaluation was performed at baseline and at week 8 and 24. Efficacy was evaluated through severity, investigator`s global assessment (IGA), subjective satisfaction score (SSS), chromameter and skin function test. Safety was monitored through adverse effects. Results: Exacerbating factors were sunlight, stress and hot bathing. At week 8, subjects achieved a significant decrease from 44 to 30 in severity (p<0.05). Out of 23 subjects, 5 were ranked fair, 12 good and 6 excellent in IGA. In addition, 4 were ranked fair, 12 good and 7 excellent in SSS. Chromameter showed statistically significant improvement after treatment with escitalopram, from 19.26 to 17.43 (P<0.05). Skin hydration by corneometer showed a statistically significant increase from 64.91 to 73.62 (p<0.05). Mild adverse effects, such as insomnia, facial swelling and drowsiness, were reported. At week 24, subjects achieved much more improvement in severity, IGA, SSS and chromameter. Conclusion: Escitalopram may be a useful and safe treatment option for the management of erythematotelagiectatic rosacea.
Alumina 첨가에 따르는 Hydroxyapatite의 기계적 성질
이승규,이동윤,이영섭,김창은 연세대학교 산업기술연구소 1990 논문집 Vol.22 No.1
For the purpose of improving mechanical strength of hydroxyaptite, various amount of alumina powder were added to hydroxyaptite which were prepared by precipitation method using Ca(NO₃)₂4H₂O and (NH₄)₂HPO₄under the Ca/P mole ratio 1.67 and pH 11. Hydroxyaptite-alumina powder composite were sintered in H₂O gas atmosphere at 1150-1400℃. Adding alumina, hydroxyaptite was decomposed to β-tricalcium phosphate and co-existed with hydroxyaptite. In case of added alumina, bending strength was higher than that of hydroxyaptite. Maximum bending strength was 161MPa at 1300℃, 5.0wt% alumina. Added alumina restrained grain growth of the hydroxyaptite.
( Sang Lim Kim ),( Kyou Chae Lee ),( Jin Sub Lee ),( Yoon Hyuk Choi ),( Hyun Ho Son ),( Hong Dae Jung ),( Mi Yeung Sohn ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Acne is a inflammatory skin disorders caused by inflammatory biomarkers. Magnesium ascorbyl phosphate (MAP) is a stable precursor of vitamin C. It achieves a constant delivery of vitamin C into the skin and has antioxidative effects. Objectives: To evaluate changes in the expression of inflammatory biomarkers after treatment of cultured sebocytes with MAP Methods: RT-PCR, ELISA and western blotting were performed for inflammatory cytokines, matrix metalloproteinases (MMPs), antimicrobial peptides (AMPs) and keratinocyte differentiation markers before and after treatment of cultured sebocytes with MAP (10-2 mol), lipopolysaccharide (LPS) and a combination of MAP and LPS. RT-PCR and western blotting were also done for Toll-like receptor-4 (TLR-4) and NF-ĸB before and after treatment of cultured sebocytes with MAP, LPS and a combination of MAP and LPS. Results: The expressions of inflammatory cytokines (e.g., IL-1 β and IL-8) and MMPs (e.g., MMP-9) were decreased after treatment with MAP and a combination of MAP and LPS, and increased after treatment with LPS. AMPs (e.g., LL-37) were decreased after treatment with MAP and a combination of MAP and LPS, and increased after treatment with LPS. The expression of TLR-4 and NF-ĸB was decreased after treatment with MAP and a combination of MAP and LPS, and increased after treatment with LPS. Conclusion: MAP, which is a stable precursor of vitamin C, may be a good effective and alternative agent to improve inflammatory reaction in acne.
혈청 Creatine Kinase효소분석 표준화에 관한 연구(6)
이창규 ( Chang Kyou Lee ),이승관 ( Seung Gwan Lee ),조경진 ( Kyung Jin Cho ),정수경 ( Su Kyung Jung ),박종성 ( Jong Sung Park ),박상숙 ( Sang Suk Park ),류정록 ( Jung Rok Ryu ),남현철 ( Huan Chul Nam ),김상섭 ( Sang Sub Kim ),김 대한임상검사과학회 1998 대한임상검사과학회지(KJCLS) Vol.30 No.3
In European countries or Japan they made an attempt for the standardization of assays in AST, AL T, ALP, CK, ill and GGT 10 years ago. For the actualization of the trial, they managed to succeeded in development of certified reference material and enzyme reference material. And they are now forecasting the unification of test results produced differently urder the respective situatons. Then, throogh the highly developed communication system, someone can access any test results whenever or whereever only if they want to. It means that we can expect much greater improvements in medical services through the information exchanges. In this study the authors tried to ascertain the interchangeability comparing the obtained results of the CK tests between two general hospitals. Fortunately, the data got in the internal QC programs came to fall within the normal tolerances. The reference intervals for the CK test were different according to the chosen reagents and the results from the pooled sear were also shown differently each other. However. from the two hospitals. we could get glucose K factors, upon which the measurements were obtained and compared. Using K factors we measured the CKs, then we mulply the CK values by correction coefficients. We could found that the two results were showing good coincidence in the comparison. The main purpose of the standardization of enzyme assays is the creation of a new unified value can be expressed differently otherwise. Using the standardizad values we can exploit the data everywhere, reduce the medical costs from repeated or duplicated tests, save the foreign exchanges preventing the diversification of import connections.