간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현

김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5

Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.

스포츠에 의한 성장기 요추추체종판 장해 분석

김민섭,이종영,이충영,이승훈,임완기,강은균,이종호 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

Apophyseopathy in human growing-up period is divided in three parts, early stage, advancing stage, and ending stage which are analyzed by X-ray test. The tuber of kantenabtrennung, schmorl and rear oxhorn dissociation are one of the these barrier process. We assume that the fracture of apophysis by overusing is the main cause of these barriers.

건축공사시방서에서의 KS규격의 국제인증방안에 관한 연구

김경식,이재섭,김용수,이규진,조용훈,최완철,전재열,이현수,구재동,이기환 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

The purpose of this research is make out construction specifications for International Construction. Using off-shore products incur cost increase and longer delivery term of construction. and inconvenient on International Construction. Expand the range of additional local products conforming to performance. Life Cycle Cost. maintainability. operability. user's acceptability, etc.. And this study is suggest the standard formats and the techniques for construction specification.

TFSCAN 검색 프로그램 TFSCAN의 개발

이병욱,박기정,김기봉,박완,박용하 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.3

TFD는 기능이 알려진 짧은 DNA sequence(signal)들과 그와 연관된 저널 자료로 구성된 데이타베이스이다. 임의의 DNA에서 이 데이타베이스의 sequence들을 검색하여 signal을 찾는 프로그램으로 Dan S. Prestridge가 개발한 SIGNAL SCAN이라는 프로그램이 사용되고 있는데, 이는 간단한 문자열 비교 알고리즘을 사용한다. 본 연구에서는 계산상 보다 효율적인 검색을 위해서, TFD의 sequence를 검색하기 위한 automata를 구성하는 프로그램과, 이 automata에 따라 signal을 검색하도록 하는 TFSCAN이라는 프로그램을 개발하였다. 검색된 signal에 대한 관련 문헌의 검색에서도 인덱싱 방법을 이용하여 계산 속도를 향상시켰다. 프로그램의 사용을 단순화시켰고, 결과 내용을 signal과 관련된 모든 정보를 일목요연하게 보여줄 수 있도록 구성하였다. 이 프로그램을 Web을 통해서도 사용할 수 있도록, GINet Web 서버에 TFSCAN 입력용 form과 CGI 프로그램을 개발·설치하였다. 본 연구의 특정 Motif 패턴으로 구성된 데이타베이스 검색에서, automata를 응용한 알고리즘을 이용하여 계산상 급격히 향상된 결과를 얻을 수 있음을 알 수 있었는데, 이는 생물학의 여러 패턴 검색에 응용될 수 있을 것이다. 더욱 민감한(sensitive) signal 검색을 위해서, 이와 같이 automata를 활용하고, 이 automata를 최적화하는 알고리즘 연구를 계속하고 있다. TFD is a transcription factor database which consists of short functional DNA sequences called as signals and their references. SIGNAL SCAN, developed by Dan S. Prestridge, is used to determine what signals of TFD may exist in a DNA sequence. This program searches TFD database by using a simple algorithm for character string comparison. We developed TFSCAN that aims at searching for signals in an input DNA sequence more efficently than SIGNAL SCAN. Our algorithms consist of two parts, one constructs an automata by scanning sequences of TFD, the other searches for signals through this automata. Searching for signal-related references is radically improved in time by using an indexing method. Usage of TFSCAN is very simple and its output is obvious. We developed and installed a TFSCAN input form and a CGI program in GINet Web server, to use TFSCAN. The algorithm applying automata showed drastical results in improvement of computing time. This approach may apply to recognizing several biological patterns. We have been developing our algorithm to optimize the automata and to search more sensitively for signals.

Unrecording Marine Algae From Korea. Ⅲ.

이기완 제주대학교 해양연구소 1984 해양자원연구소연구보고 Vol.8 No.-

Thalli creeping on calcareous algae, dark red to bright red, distichously branched with 4 alternate determinate branches, bare nodes; determinate branches ±1.2mm long, acute apics slightly bent to conter,12-13 segments : pericentral cells mostly 9-10; trichoblasts lacking; tetrasporangia tetrahedrally divided, ±60ℳm diam; cystocarps urceolate, slight flared rostrum, ±130ℳm diam.

동-텅스텐과 동의 마찰용접시 중심부 가공에 따른 특성에 관한 연구

이준형,성기완,민택기 충남대학교 산업기술연구소 2001 산업기술연구논문집 Vol.16 No.1

The study deals with the strength of weld zone, the properties of fracture surface and the microstructure of weld zone which are obtained from the variation of diameter and upset pressure in the friction welding Cu-W and Cu with the diameters of drilling hole 2mm, 4mm, 6mm, 8mm and drilling depth 8mm. The welding conditions was fixed welding conditions of rotation speed 2000rpm, friction pressure 45MPa, upset time 5.0sec and pressure time 0.6sec. The upset pressure was variationed 100MPa and 150 MPa. The result are summarized as follows ; 1.As the result of tensile test, the maximum tensile strength was obtained 314MPa when the upset pressure is 150MPa and also the hole diameter 2mm. It exceeds 310MPa in base metal(Cu) tensile strength. 2.As the result of shear test, when the upset pressure is 150MPa and the hole diameter 2mm, the maximum tensil strength was obtained 314MPa and it corresponds to about 95% of base metal(Cu) shear strength (196MPa). 3.According to the SEM analysis of weld zone, the minute tungsten(W) grains are mixed mechanically in the inside of weld interface Cu. Especially, when the diameter of hole with the maximum tensile strength is 2mm. The tungsten(W) grains are found to be mixed irregularly.

급성심근경색증을 가진 한국인에 있어 Chlamydia Pneumoniae 감염의 영향에 대한 연구

이은미,오동주,황교승,안정천,송우혁,임도선,박창규,김영훈,서홍석,심완주,노영무,정희진,김우주,김종헌,송기준 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

취업 및 국가기술자격 취득 증진 방안 연구

이완영,백기영,김영환,장세봉 永同大學校 1997 硏究論叢 Vol.3 No.1

본 연구는 도시공학 전공 학생의 국가기술자격 취득 및 취업, 진학 등에 필수적으로 요구되는 도시공학 관련 기초지식을 연마하고 전공지식을 심화 교육함으로서 산·학·연 연계체계에 기초하여 도시공학 전공 학생의 취업증진을 도모하기 위한 종합적이고 구체적인 방안을 모색하고자 하는 것이다. 이를 위하여 본 연구에서는 사회수요에 부응하기 위한 기술교육의 강화, 국가기술자격 취득 제고, 현장실습제도 등 3가지 측면에서 취업증진을 위한 추진실적 및 문제점을 점검하고 이에 대한 향후 개선방안을 모색하고자 하였다. The purpose of this study is to search for the comprehensive and concrete methods of increasing the graduates' employment based on both fundamental and advanced knowledge concerned urban engineering major. For this , existing condition, problems and improvement of students employment are searched in 3 view points such as strengthening of technical education to follow the social demands, enhancement of acquisition of the national qualifying examination and making the best of the field training system.

분리막 시스템을 이용한 정수공정의 연구

이기완,고태석 동신대학교 환경연구소 1998 환경연구 Vol.3 No.1

황룡강을 수원으로 하는 상수원수와 침전상징수의 정수를 위하여 MF(정밀여과)공정을 적용하였다. 현장에서의 실험결과는 낮은 운전압력일수록 높은 탁도 제거율을 보였으며, 상징수의 탁도는 2~4 NTU로서 MF처리시 1kg/㎠에서는 0.3~0.4 NTU로 2kg/㎠에서는 0.4~0.5 NTU로 감소되었다. 이들 유출탁도는 음용수 기준인 1.1 NTU를 민족 할 정도이었다. 원수는 15~20 NTU의 높은 탁도로서 원수를 직접 MF처리할 경우, 유출수는 1kg/㎠에서 1.9~4.8 NTU로 2kg/㎠ 에서 2.1~4.9 NTU로 나타났다. 이들 탁도는 처리수 기준을 초과하였으므로, 기준을 만족하기 위해서는 다단계의 MF 처리가 권장된다. 막 의 역세척 소요시간은 약 6분이 적합하였다. MF처리공정은 재래식 모래여과기와 비교할 때 작은 소요부지 면적, 막의 내구성과 수명, 약품비등에서 수처리에 효과적임을 보여주었다. MF(Micro Filtration) process was applied to the treatment of raw water and clarified water in water treatment plant sourced from the Hwangryong river. As results of experiments and field study the lower the operating pressure, the higher the turbidity removed. Turbidity of clarified water were reduced from 2~4 to 0.3~0.4 NTU at 1kg/㎠ and 0.4~0.5 NTU at 2kg/㎠ by MF process. These effluent turbidities were acceptable to the drinking water standard of 1.1 NTU. For the raw water of high turbidity with 15~20 NTU the effluents were 1.9~4.8 NTU at 1kg/㎠ and 2.1~4.9 NTU at 2kg/㎠. These turbidities exceeded the standard value of treated water. To meet the standard, multistage operations were executed with the raw water and its turbidity decreased to 0.1 NTU. The proper time for backwashing of the unit was about 6 minutes. Compared with a traditional sand filter, MF process showed the effectiveness of Water treatment due to small area, long life spans and less chericals required.

표준치료에도 불구하고 3차례나 반복해서 발생한 삼일열 말라리아

이해영,한주용,이기덕,박완범,김성한,강철인,문정주,오명돈,최강원 대한감염학회 2002 감염 Vol.34 No.6