Dehydrocoupling of Bis(1-sila-3-butyl)benzene and 2-Phenyl-1,3-disilapropane to Polymers Using Zirconocene Combination Catalysts

Jun Lee, Jong-Hyun Kim, Soo-Yong Mo, Hee-Gweon Woo1, Do-Heyoung Kim, Jin Jun 조선대학교 기초과학연구원 2011 조선자연과학논문집 Vol.4 No.3

The catalytic dehydrocoupling of bis(1-sila-3-butyl)benzene 1 and 2-phenyl-1,3-disilapropane 2 by Cp2ZrCl2/Red-Al and Cp2ZrCl2/n-BuLi was reported to compare their catalytic efficiency. The dehydrocoupling of monomeric silanes 1 with the Cp2ZrC12/Red-Al and Cp2ZrCl2/n-BuLi combination catalysts produced two phases of polymers: one is a highly crosslinked insoluble solid, and the other is noncross-linked or slightly cross-linked soluble oil and could be a precursor for the solid polymer. The dehydrocoupling of 2 with the Cp2ZrCl2/n-BuLi combination catalyst similarly produced two phases of polymers. By contrast, the catalytic reaction of 2 with the Cp2ZrCl2/Red-Al combination catalyst produced a soluble polymer via redistribution/dehydrocoupling process.

기저질환이 없는 사람에서 발생한 Campylobacter fetus에 의한 재발성 심내막염 1예

전재범,정진원,김성혜,송문희,오형철,안성기,최상호,김남중,김양수,우준희,류지소 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

C. fetus 심내막염은 드물게 발생하는 질환으로 주로 면역능이 저하된 환자에서 발병하고 대동맥판을 침범하는 경우가 많으며 적절한 치료가 되지 않을 경우 치사율이 높다. 저자들은 기저질환이 없던 69세 남자에서 C. fetus 심내막염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 발열로 내원하여 시행한 혈액배양 검사상 C. fetus가 동정되었고 경식도 초음파 검사상 삼첨판에 증식증이 발견되어 심내막염 진단하에 ceftriaxone에 이어 meropenem으로 총 4주간 항생제를 투여받고 호전되었다가 한달 후 다시 재발하였고 판막부전 소견 진행하여 삼첨판 치환술을 시행받고 전신상태 호전되어 퇴원하였다. Campylobacter fetus is a rare cause of endocarditis. To date, only about 30 cases of C. fetus endocarditis have been reported mainly in the elderly with chronic underlying illnesses. Most cases showed tendency to involve aortic valve. This report describes a case of native tricuspid valve infective endocarditis in a 69-year-old man without any underlying disease. Despite adequate antibiotic therapy for 4-weeks, endocarditis recurred and leading to surgical valve replacement.

Thiamphenicol(Urfamycin^(�) 療法의 臨床的 觀察

禹竣熙,沈永秀 대한화학요법학회 1983 대한화학요법학회지 Vol.1 No.1

A clinical trial for therapeutic effect of thiamphenicol was made of 41 cases of medical Eatients which consist of typhoid fever, shigellosis and acute respiratory infection. The results were e d a a t e d by the improvement of clinical symptoms and eradication of causative organism. The result was good in 37 cases (90%). In typhoid fever group, the result was good in 27 cases among 30 cases (90%) wirith mean defeverscence days of 5.27, which was better than other antibiotics, Observed side effect was 1 reversible leukocytopenia. It was tfie conclusion of this observation that the drug is effective in control of acute gastrointestinal infection. and respiratory infection.

Dehydrocoupling of Bis(1-sila-3-butyl)benzene and 2-Phenyl-1,3-disilapropane to Polymers Using Zirconocene Combination Catalysts

Jun Lee,Jong-Hyun Kim,Soo-Yong Mo,Hee-Gweon Woo1,Do-Heyoung Kim,Jin Jun 조선대학교 기초과학연구원 2011 조선자연과학논문집 Vol.4 No.3

Random Amplified Polymorphic DNA 분석을 통한 Methicillin 내성 황색포도구균의 분자역학적 조사

전희재,김정만,우종수 대한감염학회 2005 감염과 화학요법 Vol.37 No.1

목적 : 본 연구는 중환자실 환자 및 의료종사자에서 검출된 MRSA의 역학조사에 신속하고 간편한 방법인 random amplified polymorphic DNA (RAPD)의 유용성을 평가하고자 하였다. 재료 및 방법 : 1998년 10월부터 12월 및 2001년 5월부터 7월까지 동아대학교병원 중환자실 입원 환자 및 의료종사자의 검체 각각 10, 15예 및 8, 5예를 대상으로 mecA gene의 유무와 항균제 감수성 검사를 실시하고, 3가지 primer를 이용하여 RAPD를 시행하였다. 결과 : 환자에서 분리된 MRSA 25주 중 21주(84%)와 의료진에서 분리된 13주 중 12주(92%)가 mecA 양성이었고, mecA 양성 MRSA를 RAPD로 분석한 결과 모두 18가지 유형으로 분류되었다. 결론 : RAPD 방법을 이용한 유전자 형별 분석은 MRSA의 균주 분별에 유용하며, 또한 중환자실에서 유행 발생한 MRSA의 신속한 역학조사에 유용할 것으로 생각한다. Background : The random amplified polymorphic DNA (RAPD) analysis was investigated to see if this method could be a useful tool for monitoring of epidemic outbreaks of methicillin-resistant Staphylococcus aureus (MRSA) among patients and healthcare workers (HCW) in the intensive care units (ICU). Methods : Thirty-eight MRSA strains were isolated from patients and HCW in Dong-A University Hospital ICU from October, 1998 to December, 1998 (10 patients and 8 HCW) and May, 2001 to July, 2001 (15 patients and 5 HCW). All strains were typed according to antimicrobial susceptibility and RAPD analysis patterns. mecA genes were detected using polymerase chain reaction (PCR). Results : Twenty one of 25 (84%) and 12 of 13 (92%) MRSA, isolated from patients and HCW, respectively, were mecA positive. mecA positive MRSA were classified into 18 different types by RAPD analysis. Conclusion : DNA fingerprinting using RAPD analysis is a simple, effective, and rapid method for discriminating MRSA strains, and may be applicable in detecting outbreaks of S. aureus infections in the ICU.

유입 바베시아증 1예

우준희,조용균,김은옥,채종일,김양수,양성연,유지소,이성순 대한감염학회 1997 감염 Vol.29 No.1

최근 외국으로의 여행이 빈번해지면서 유입 감염되는 경우가 많아지고 있는 추세이며 임상 증세가 말라리아와 유사하여 다소 진단이 어려울 수가 있어 한번쯤 바베시아증을 생각하는 것이 바람직하겠다. 저자들은 아프리카에 다녀온 뒤 나타난 바베시아증을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Babesiosis is a tick-borne, malaria-like illness caused by Babesia species that infect erythrocytes of mammals incidentally. The family Babesiidae is characterized by consisting of nonpigmented intraerythrocytic parasites that reproduce within erythocytes by asynchronous, asexual budding into two or four daughter cells (tetrad). We experienced a case of human babesiosis presenting fever and chills. The patient was a 49-year old man, who had been in Africa (Ethiopia, Uganda). Three weeks before admission intermittent spiking fever had developed, which had been accompanied by severe chills. The peripheral blood smear (Giemsa-stain) revealed characteristic forms of a intracellular quadraple parasite compatible with Babesia. The patient was improved significantly by the treatment with quinine and clindamycin for a week.

전신성 항진균 요법

우준희,정두련,류지소 대한의진균학회 1997 대한의진균학회지 Vol.2 No.2

There is an increasing tendency of systemic fungal infection because of increse in the number of immunocompromised patients such as the patients receiving anticancer chemotherapy or organ transplant. The frequency of systemic fungal infection is problematic, since it is often difficult for clinicians to manage the patients with fungal infection. Amphotericin B was one of the representative antifungal agent for the systemic antifungal infection even though it has many kinds of adverse reactions for instance nephrotoxicity, electrolyte imbalance, etc. Therefore ketoconazole, fluconazole, and itraconazole were developed and prescribed with effect. Because of increase in the number of resistant strains of Candida, Fusrium or Trichosporon nowadays, as for azole antifungal agents there were something to be desired. Other new antifungal agents with fungicidal effect under development include ployoxins, echinocandins and pradimicin.

성인원외폐렴의 원인미생물에대한 전향적 다기관 연구 : 성인원외폐렴의 원인으로 세균의 역할을 중심으로

우준희,강재명,김양수,신완식,류진홍,최정현,김양리,정희진,어수택,박춘식,정문현,정기석,이찬주,류지소 대한감염학회 2001 감염 Vol.33 No.1

Background : Communite-acquired peumonia (CAP) is one of the leading causes of mortality and morbidity. Despite progress in diagnostic techniques and treatments, management of pneumonia remains challenging, because the precise etiology remains uncertain in as many as 49% of cases. The limitaions of identifying etiologic agents make it necessary to use empiric antibiotics in almost all patients, and furthermore emergence of antibiotic-resistant organisms pose difficulties to the selection of an empiric antibiotic regimen. For the optimal choice of empirical antibiotics, we should know the frequency of etiologic agents and antimicrobial resistance rates in the community. Methods : A prospective multicenter study of community-acquired pneumonia in Korea was carried out between May 1997 and April 2000. The microbiologic diagnosis was based on the results of sputum culture, blood culture and pleural culture. Results : Five hundred eighty eight cases of community-acquired peumonia in 562 patients admitted to the hospitals. The mean age was 59.9 with male predominance (58.3%), and 370 (63%) had underlyin gillness. The etiologic agents were identified in 38.3%, and the list of individual agents, in decreasing order, was Streprococcus pneumoniae (21.7%), Klebsiella pneumoniae (14.8%) Pseudomonas aeruginosa (9.8%), Staphylococcus aureus (9.5%), viridans group streptococci (5.7%), Enterobacter cloacae (4.2%), Hemophillus Influenza (3.8%), The rates of admission to the intensive care unit was 10.4%. The motality was 7.1%. Susceptible rates of S. pneumoniae to penicillin was 36.6% and showed multidrug resistant. Forty percents of S. aureus were methicillin-resistant S. aureus. K. penumoniae were susceptible to cephalosporin and quinolone. Conclusion : In Korea, S.pneumoniae is the most important agent causing community-acquired pneumonia. Susceptible rates of S. pneumoniae to penicillin was 36.6% and showed multidrug resistant. Gram negative bacteria such as K. pneumoniae, P. aeruginosa showed high incidence when compared with that of other countries. Most of them had underlying diseases including bronchiectasis and chronic obstructive pulmonary diseases. (Korean J Infect Dis 33:1∼7, 2001)

주사용 세팔로스포린 항생제 YH-1226의 항균스펙트럼 분석 : YH-1226과 cefpirome, cefmenoxime, ciprofloxacin의 시험관내 항균효과 비교

우준희,김백남,이종욱,류지소 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.1

Background and methods The in vitro activity of YE-1226, a newly developed parentral cephalosporin was compared to those of cefpirome, cefmenoxime, and ciprofloxacin against 223 clinical isolates by measuring minimal inhibitory concentration. Results . YH-1226 and cefpirome were all active against E. coli, K. pneumonzae, and C. fieuizdzz. 81% of were susceptible to cefmenoxime, 75% to ciprofloxacin. For Enterobacter cloacae 95% were susceptible to YH-1226, 83%, 65%, and 85% were susceptible to cefpiiome. cefmenoxime, and ciprofloxacin. For P. aeruginosa, 68%, 58%, 48%, and 65% were susceptible to YH- 1226, cefpirome, cefmenoxime, and ciprofloxacin, respectively. For S. epidennzdzs, 80% were susceptible to YH-1226, 70%, 60%, and 70% were susceptible to cefpirome, cefmenoxime, and ciprofloxacin. With regard to gram-positive strains except S. epidermidis, 69% were susceptible to YH-1226, 57% to cefpirome, 56% to cefmenoxime, and 50% to ciprofloxacin. Conclusion : The broad antimicrobial activity suggests that YH-1226 may be an alternative in the treatment of bacterial infections.

성인 Enterovirus 뇌막염에 대한 치료적 접근과 임상발현

우준희,조용균,김양수 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

목적:성인 장관바이러스 뇌막염의 임상상과 치료방침 등을 분석하기위하여 저자들은 1996년 5월부터 12월까지 서울중앙병원에 입원하였던 무균성뇌막염 환자 28예 가운데 장관바이러스에 의한 뇌막염환자 10례를 대상으로하여 임상연구를 시행하였다. 방법:대상환자의 뇌척수액을 shell vial culture법과 PCR을 이용하여 분리 동정하였으며 임상상과 치료방침은 의무기록을 분석하였다. 결과: 임상증상은 발열 100%, 두통 100%, 전신쇠약 80%, 구토 60%, 설사 20%, 근육통 20%, 식욕부진 10%, 경련 10%로 뇌막염의 특이한 소견은 비교적 드물게 나타났다. 뇌척수액 백혈구수는 평균 318/㎣, 호중구는 평균 24%, 림프구는 편균 62%이었고, 단백은 평균 100㎎/dL로 증가되었는데, ekdd은 평균 64㎎/dL로 정상범위에 속했다. 결론:무균성뇌막염 환자에서 신속한 원인바이러스의 동정은 의료부담을 감축시킬 수 있으며, 성인에서도 무균성뇌막염의 원인으로 장관바이러스는 어린이레서처럼 중요하다. Background : Enterovirus is of the etiologic agents of aseptic meningitis and 85% of pediatric aseptic meningitis was caused by enterovirus. In adults to determine the demographic and clinical characteristics of aseptic meningitis and to evaluate the management tactics, we conducted a comprehensive chart review with virologic studies. Methods : Cerebrospinal fluid from the adult patients with aseptic meningitis was inoculated with precultured fibroblast utilising shell culture. Also simultanenous polymerase chain reaction was performed. Results : Ten adult cases of enterovirus meningitis were identified among twenty-eight cases of aseptic meningitis in which viral isolation was attempted. Analysis of cerebrospinal fluid revealed that an increased total white blood cell count and an increased protein concentration tended to be associated with increasing patient age. Variation in management strategies were noted in the use of computed tomography of the brain, the administration of empirical antimicrobial agents, and duration of hospitalization. Conclusion : Rapid isolation of enterovirus, and a conservative management could have solved the considerable health problem. In adults, Enterovirus is also a main etiologic agent in aseptic meningitis as well as in children.