http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Jae Won Soh ) (검색결과 90 건)
- 무료
- 기관 내 무료
- 유료
-
백서와 기니픽의 대뇌피질에서 Opioid Kappa 수용체의 특성에 관한 연구
김기원(Kee-Won Kim),노혜원(Hye-Won Rho),김형일(Hyoung-Il Kim),은재순(Jae-Soon Eun),소수미(Soo-Mi Soh),조규박(Kyu-Park Cho) 대한약리학회 1994 대한약리학잡지 Vol.30 No.2
In this study, we tested the influences of several κ opioid ligands on the [<sup>3</sup>H]diprenorphine binding in rat and guinea pig cortex membrane preparations. Using paradigm to block μ and δ opioid receptors with DAMGO(1μM) and DPDPE(1μM), [<sup>3</sup>H]diprenorphine labeled κ sites. Competition analysis in both rat and guinea pig cortex has shown a single population of [<sup>3</sup>H]diprenorphine binding site with different Kd values, respectively. There is a significant difference in Ki values of (-) WIN44441 and (+)WIN44441 in both rat and guinea pig cortex. Bremazocine, (-)ethylketocyclazocine, (-)cyclazocine, nor-binaltorphimine effectively inhibited the [<sup>3</sup>H]diprenorphine binding with different Ki values in rat and guinea pig cortex. U-69,593, U-50,488H and dynorphine-A (1-8) did not inhibit the [<sup>3</sup>H]diprenorphine binding in rat but in guinea pig cortex. Nor-binaltorphimine was a ligand discriminate the κ<sub>1</sub>, and κ<sub>2</sub> receptor most effectively. We, also, examined the influence of Na ion and GTPγS, a nonhydrolyzable guanine nucleotide analog, on the inhibition of [<sup>3</sup>H]diprenorphine binding by diprenorphine, (-)ethyl-ketocyclazocine, U-69,593 and bremazocine. By the replacement of NaCl with N-methy-D-glucamine or addition of GTPγS, Ki values of diprenorpnine were not changed and that of ethylketocyclazocine were changed significantly in both rat and guinea pig cortex. The Ki value of bremazocine was decreased by removal of Na ion, and increased by GTPγS, however, was not changed by any one of either. These results suggest that there are 2 kinds of subtypes of κ opioid receptor, κ<sub>1</sub>, and κ<sub>2</sub>, showing different Ki values for various κ opioid ligands, also, bremazocine possess the antagonistic property at κ<sub>2</sub> site which is dominant subtype of K receptor in rat cortex.
-
金尙國,姜東洹,張周鎬,金昇一,徐再均,金耕知,孫斗玉,鮮于攝,崔榮烈,尹宇相,金亨燉,方永鎭,朴英震,柳在忠 慶熙大學校 體育科學大學 1989 體育科學論叢 Vol.- No.2
The purpose of this study was to compare the characteristics, change in physique and physical function of college students majoring physical education and Taekwondo (454 males and 64 females of age groups ranging from 18 to 26). The results are as following: 1. The male group of 23yrs old in physical education showed highest values in 7 items(Weight, Chest Girth, Fore Arm Girth, Thigh Girth, Calf Girth, Scapular Skinfold Thickness and Suprailiac Skinfold Thickness). 2. In the Physical function, the male group of 18yrs old showed highest values in Power, Flexibility, and then 21yrs old at Back Strength, Vital Capacity, and 23yrs old at Grip Strength, and 25yrs old at Blood Pressure, respectively. 3. In the physique, the male group of 22yrs old showed highest values in Weight, Chest Girth, Thigh Girth, Calf Girth, and then 24yrs old Upper Arm Girth, Fore Arm Girth, and 19yrs old at Height, Upper Limb Length, respectively. 4. In Physical Function, the 22yrs old showed highest values in Back Strength, Vital Capacity, and then 23yrs old at Side Step, Trunk Extension, but 18yrs old showed lower Values in Grip Strength, Side Step, Vital Capacity and Blood Pressure. 5. The female group of 22yrs old showed highest values in 8 items(Height, Sitting Height, Waist Girth, Upper Limb Length, Lower Limb Length, Skinfold Thickness), and then 18yrs old at 5 items (Weight, Upper Arm Girth, Fore Arm Girth, Thigh Girth, Calf Girth), respectively. 6. In the physical function, the 22yrs old showed highest Values in Grip strength, Back Strength, Power, 5 Minute Run, and 18yrs old at flexibility, Harvard Step Test, respectively. 7. In the change of the physique for two years(1988-1989) in the male group, majoring Physical education the 22yrs old showed increase in 4 items, and the 20yrs old in 3 items, but 18yrs old showed decrease in 3 items. 8. In the change of the physical function for two years in the male group, the 20yrs old showed increase in 4 items, and the 21, 25, 26yrs old in 3 items, but the 19yrs old showed decrease in 6 items, and 18, 22 yrs old in 5 items, respectively. 9. The change of the physique for two years in all female group, of 18, 19, 20, 21yrs old showed increase in 11 items except Skinfold Thickness. 10. In the change of physical function for two years in female group, the 18yrs old showed increase in 3 items, and then 20yrs old in 5 items, but 19, 22yrs old decreased 12 items, respectively. 11. The highest significant difference in physique between male and female was found in weight(mean Value 17.5%), and the lowest difference was found Thigh Girth, Calf Girth(1,3%), Upper Limb Length, Lower Limb Length(2.5%). 12. The Highest difference in physical function was Strength (mean Value 40%), Vital Capacity (33%), Power(22%), but Lower Trunk Flexion, Foot Balance(3.4%). 13. In the difference of Physique and physical function between physical education major and taekwondo major, the physical education showed higher values in skinfold Thickines (mean Value 16.5%), Weight, Waist Girth(4.7%) and Strength(33%), Endurance(5.6%), but subjects majoring Taekwondo showed higher values in Flexibility and Foot Balance. 14. In all male groups, Waist Girth, Scapular Skinfold Thickness, Back Strength, Sargent Jump, Trunk Extension and Diastolic Blood Pressure were showed a significantly related at 0.001 level.
-
金尙國,姜東洹,金昇一,徐再均,金耕知,孫斗玉,鮮于攝,崔榮烈,尹宇相,金亨燉,方永鎭,李錫元 慶熙大學校 體育科學大學 1988 體育科學論叢 Vol.- No.1
The purpose of this study was to compare the characterists and change in physique and physical function by college student of physical education major(287males and 40 females of age groups ranging from 18 to 26). The results were as following; 1) The characteristics of physique and physical function by sex and age. ① The male group of 18yrs old showed higher values in Height, Weight, Upper Limb Length, Strength, Flexibility, and Vital Capacity than any other groups, but female group showed lower values in Height, Weight, Chest Girth, Lower Limb Length, Thigh, Girth, Calf Girth and all of the Physical function. ② The male group of 19yrs old showed high values in power and Agility, then female group showed in Strength and Flexibility. ③ The male group of 20yrs old showed the lower values in Weight, Waist Girth, Upper Limb Length, Fore Arm Girth, Thigh Girh.Calf Girth, Vital Capacity, and female group are very lowed in Upper Arm Lenght, Fore Arm Length, Skin Fold Thickness and 5 minute Run. ④ The male group of 23yrs old showed the high values in Upper Arm Girth, Fore Arm Girth and Balance, and then female group higher in Weight, Chest Girth, Waist Girth, Upper Arm Girth, Fore Arm Girth, Thigh Girth, Power, Shuttle Run, Balance and vital capacity than any other age Groups. ⑤ In male group, Chest Girth, and Blood Pressure were significantly related, and Side Step and Trunk Extension were nagatively related to the age at 0.1% level, and then in female group, Sargent Jump, Standing Long Jump and Vital Capacity were showed a significantly related at 0.5% level. 2) The difference of physique and physical function between male and female by age. ① Everage difference in whole physique items except skinfold thickness was 9.8%, and that 21.1% in all of physical function except Trunk Flextion between male and female group subjects. ② About the ages, the 18yrs old male group showed the 22.8% higher values of 26 items, but 22yrs old male group were about 12.2% in 23 items, thus it is very lower than any other groups. 3) The difference of physique and physical function between General group and physical education group in age-matched. ① In the physique male physical education groups showed about 7% higher in Weight, Chest Girth, Upper Limb Length, Upper Arm Girth, Thigh Girth, and female group showed about 7% higher in Weight and Upper Limb Length. ② In the physical function, Trunk Flextion, 5 minute Run, and Blood Pressure(Diastolic) were about 8% high values in whole group, and female group showed about 8% higher in Standing Long Jump, Shuttle Run, and Trunk Extension. ③ In 22yrs old male and female physical education group were very dominated in physique and physical function than the other age group against the general group.
-
( Ho Su Lee ),( Hye Won Hye Won ),( Jong Soo Lee ),( Jong Cheol Kim ),( Jae Won Choe ),( Jae Seung Soh ),( Seo Hyun Lee ),( Jung Ho Bae ),( Dong Hoon Yang ),( Seung Jae Myung ),( Suk Kyun Yang ),( Jin 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The recurrence rate after cold forceps polypectomy (CFP) of diminutive polyps = 5 mm in size has not been fully determined. The aim of this study was to analyze the long-term follow-up results and recurrence rate after CFP of diminutive polyps. Methods: We retrospectively reviewed the medical records of 884 (738 men; median age, 53 years) asymptomatic subjects who underwent surveillance colonoscopies after CFP of 1-2 diminutive adenomatous polyps at the screening colonoscopy. Cumulative recurrence at the CFP site was analyzed. Risk factors for recurrence were investigated. Results: Overall recurrence rate during a period of 59.7 months was 17% after CFP of 1,111 diminutive polyps. Definite recurrence was 4% and 13% was probable recurrence. Recurrence as advanced adenoma was 0.5% (5/1,111). The cumulative probabilities of recurrence at 3, 5, and 7 years after CFP were 10.0%, 16.0%, and 21.1%, respectively. Multivariate analysis revealed that polyps of 4-5 mm and right colonic polyps were risk factors for recurrence (hazard ratio [HR] 1.37; 95% confidence interval [CI] 1.01- 1.86 and HR 1.49; 95% CI 1.08-2.04, respectively). The recurrence rate of 10 endoscopists who performed at least 50 CFPs ranged from 11.0% to 25.2%; the probability of recurrence in those with the top half recurrence rate was 1.6-fold higher than that of the other half (95% CI 1.17-2.19). Conclusions: Although overall recurrence was frequent after CFP of diminutive polyps, recurrence as advanced adenoma was rare. Large polyp size, right colon polyp, and endoscopists were risk factors for recurrence after CFP.
-
-
-
사람 대뇌피질에서 Kappa Opioid 수용체의 이질성
소수미,한낙천,장전,은재순,김기원 의과학연구소 1996 全北醫大論文集 Vol.20 No.1
Experimental data have shown that there are considerable species differences in the distribution of opioid receptor types in mammalian brain. We have evaluated the properties of non-μ non-δ binding of [^3H]-diprenorphine([^3H]DIP), a nonselective opioid antagonist, in human cortex membranes. Bindings to μ and δ site were inhibited by the use of an excess of competing selective agonists, DAMGO(1μM) and DPDPE(1 μM), for these sites. Dynorphine-A(1-13), U-69, 593 and U-50, 488H, selective k_1 agonists, (-)ethyketocyclazocine and nor-binaltorphimine, k_1 and k_2 opioid ligands, inhibited the [^3H] DIP binding to human cortex membranes with high affinities. In the presence of cold ligands, I μM each of DAMGO, DPDPE and U-69, 593, that block μ-, δ-, and k_1 sites, poioid binding still remained. Specific binding of[^3H]DIP to this stie was not influenced by U-50, 488H or β-endorphin even in micromolar dose range, but inhibited y DIP, bremazocine, (-)eyhylketocylazocine and nor-binaltorphimine. The concentration-inhibition curves of these ligands in the presence of DAMGO and DPDPE were displaced further to right by the addition of U-69, 593. These data suggest that there are at least 2 kinds of k-opioid binding sites(k_1 and k_2) in human cortex.
-
Parameter Study of Boiling Model for CFD Simulation of Multiphase-Thermal Flow in a Pipe
Soh-Myung Chung,Yong-Seok Seo,Gyu-Mok Jeon,Jae-Won Kim,Jong-Chun Park 한국해양공학회 2021 韓國海洋工學會誌 Vol.35 No.1
The demand for eco-friendly energy is expected to increase due to the recently strengthened environmental regulations. In particular, the flow inside the pipe used in a cargo handling system (CHS) or fuel gas supply system (FGSS) of hydrogen transport ships and hydrogen-powered ships exhibits a very complex pattern of multiphase-thermal flow, including the boiling phenomenon and high accuracy analysis is required concerning safety. In this study, a feasibility study applying the boiling model was conducted to analyze the multiphase-thermal flow in the pipe considering the phase change. Two types of boiling models were employed and compared to implement the subcooled boiling phenomenon in nucleate boiling numerically. One was the "Rohsenow boiling model", which is the most commonly used one among the VOF (Volume-of-Fluid) boiling models under the Eulerian-Eulerian framework. The other was the "wall boiling model", which is suitable for nucleate boiling among the Eulerian multiphase models. Moreover, a comparative study was conducted by combining the nucleate site density and bubble departure diameter model that could influence the accuracy of the wall boiling model. A comparison of the Rohsenow boiling and the wall boiling models showed that the wall boiling model relatively well represented the process of bubble formation and development, even though more computation time was consumed. Among the combination of models used in the wall boiling model, the simulation results were affected significantly by the bubble departure diameter model, which had a very close relationship with the grid size. The present results are expected to provide useful information for identifying the characteristics of various parameters of the boiling model used in CFD simulations of multiphase-thermalflow, including phase change and selecting the appropriate parameters.
-
-
ScienceON
스콜라연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
