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Ryu, Seung Wook,Lyeo, Ho-Ki,Lee, Jong Ho,Ahn, Young Bae,Kim, Gun Hwan,Kim, Choon Hwan,Kim, Soo Gil,Lee, Se-Ho,Kim, Ka Young,Kim, Jong Hyeop,Kim, Won,Hwang, Cheol Seong,Kim, Hyeong Joon IOP Pub 2011 Nanotechnology Vol.22 No.25
<P>This study examined the various physical, structural and electrical properties of SiO<SUB>2</SUB> doped Ge<SUB>2</SUB>Sb<SUB>2</SUB>Te<SUB>5</SUB> (SGST) films for phase change random access memory applications. Interestingly, SGST had a layered structure (LS) resulting from the inhomogeneous distribution of SiO<SUB>2</SUB> after annealing. The physical parameters able to affect the reset current of phase change memory (<I>I</I><SUB>res</SUB>) were predicted from the Joule heating and heat conservation equations. When SiO<SUB>2</SUB> was doped into GST, thermal conductivity largely decreased by ∼ 55%. The influence of SiO<SUB>2</SUB>-doping on <I>I</I><SUB>res</SUB> was examined using the test phase change memory cell. <I>I</I><SUB>res</SUB> was reduced by ∼ 45%. An electro-thermal simulation showed that the reduced thermal conductivity contributes to the improvement of cell efficiency as well as the reduction of <I>I</I><SUB>res</SUB>, while the increased dynamic resistance contributes only to the latter. The formation and presence of the LS thermal conductivity in the set state test cell after repeated switching was confirmed. </P>
얼굴·목 아토피피부염에서의 0.1% Tacrolimus 연고 치료의 다기관 관찰연구
류형호 ( Hyeong Ho Ryu ),박영립 ( Young Lip Park ),김광호 ( Kwang Ho Kim ),이종희 ( Jong Hee Lee ),나정임 ( Jung Im Na ),조소연 ( So Yun Cho ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.11
Background: Atopic dermatitis (AD) is a chronic or chronically relapsing, inflammatory, pruritic skin disease. Because tacrolimus ointment does not induce skin atrophy, it is especially indicated in delicate areas such as the face, intertriginous areas and anogenital region. Objective: With the aim of investigating the differences between the established clinical guidelines and actual treatment response, an open-label, non-comparative, multicenter clinical observational study was undertaken. Methods: One hundred and fifty-three patients with AD in the head and neck area were treated with topical tacrolimus 0.1% twice daily. Clinical evaluations were conducted at baseline, week 4 and week 8. Efficacy was assessed through the investigator`s evaluation of the patients` individual signs (erythema, edema, oozing, excoriation, scaling, lichenification and fissuring) and symptoms (burning, pruritus and telangiectasia) using a 4-point grading system. The physician`s and patient`s global assessments and quality of sleep were also evaluated. Results: Among 153 enrolled patients, 25 (16.3%) were lost to follow-up, and 6 (3.9%) dropped out due to adverse events, leaving 79.7% of the population who completed the trial. Head and neck dermatitis was improved or cleared in 93.6% (week 4) and 94.4% (week 8) by physicians and in 92.1% (week 4) and 90.8% (week 8) by patients. Tacrolimus treatment improved the quality of sleep in head and neck dermatitis patients. Eighty-seven percent of the subjects were compliant, applying it at least 3 days per week. Burning sensation was the most frequently reported adverse event, followed by pruritus and aggravation of the lesion. Conclusion: Tacrolimus ointment 0.1% is a safe and effective treatment option for atopic dermatitis of head and neck including eyelids. (Korean J Dermatol 2013;51(11):851∼857)
Sang Hyeong Ryu,Sang Won Min,Jae Ho Kim,Ho Joong Jeong,Ghi Chan Kim,Dong Kyu Kim,Young-Joo Sim 대한재활의학회 2019 Annals of Rehabilitation Medicine Vol.43 No.1
Objective To find out whether levels of fibrin degradation products (FDP) and D-dimer are increased in breast cancer-related lymphedema (BCRL) as in many vascular diseases. FDP and D-dimer have been used in blood tests to help differentiate deep vein thrombosis in the diagnosis of lymphedema. Levels of FDP and D-dimer are often elevated in patients with BCRL. Methods Patients with BCRL (group I), non-lymphedema after breast cancer treatment (group II), and deep venous thrombosis (group III) from January 2012 to December 2016 were enrolled. Levels of FDP and D-dimer were measured in all groups and compared among groups. Results Mean values of FDP and D-dimer of group I were 5.614±12.387 and 1.179±2.408 μg/μL, respectively. These were significantly higher than their upper normal limits set in our institution. Levels of FDP or D-dimer were not significantly different between group I and group II. However, values of FDP and D-dimer in group III were significantly higher than those in group I. Conclusion Values of FDP and D-dimer were much higher in patients with thrombotic disease than those in patients with lymphedema. Thus, FDP and D-dimer can be used to differentiate between DVT and lymphedema. However, elevated levels of FDP or D-dimer cannot indicate the occurrence of lymphedema.
류정호 ( Jeong Ho Ryu ),방형돈 ( Hyeong Don Bang ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.4
Juvenile xanthogranuloma(JXG) is a disorder of histiocytes usually associated with cutaneous lesions. JXG developing in soft tissue is rare and receives little attention. Therefore deeply located JXG may present a diagnostic difficulty in the absence of cutaneous lesions. Clinically, deep JXG seems to occur as solitary lesions on the trunk rather than on the head and neck region and tends to be composed of a monotonous population of histiocytic cells, with rare, if any, foamy macrophages or Touton-type multinucleated giant cells. We report an unusual case of JXG in a 4-month-old male infant who had a deep-seated mass located on the subcutaneous and muscle layer of the left forearm. (Korean J Dermatol 2003;41(4) : 479-483)
A Case of Paraneoplastic Limbic Encephalitis Associated with Small Cell Lung Cancer
Ryu, Ja Young,Lee, Seung Hyeun,Lee, Eun Joo,Min, Kyung Hoon,Hur, Gyu Young,Lee, Sung Yong,Kim, Je Hyeong,Lee, Sang Yeub,Shin, Chol,Shim, Jae Jeong,In, Kwang Ho,Kang, Kyung Ho,Yoo, Se Hwa The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.73 No.5
Paraneoplastic limbic encephalitis (PLE) is a rare syndrome characterized by memory impairment, affective and behavioral disturbances and seizures. Among many different neoplasms known to cause PLE, small cell lung cancer (SCLC) is the most frequently reported. The pathogenesis is not fully understood but is believed to be autoimmune-related. We experienced a patient with typical clinical features of PLE. A 67-year-old man presented with seizure and disorientation. Brain magnetic resonance imaging demonstrated high signal intensity in the bilateral amygdala and hippocampus in flair and T2-weighted images suggestive of limbic encephalitis. Cerebrospinal fluid tapping revealed no evidence of malignant cells or infection. Positron emission tomography/computed tomography showed a lung mass with pleural effusion and a consequent biopsy confirmed the diagnosis of PLE associated with SCLC. The patient was subsequently treated with chemotherapy and neurologic symptoms gradually improved.
류기형,최종호,권범선,박진우,윤태상,김영성 동국대학교 의학연구소 2006 東國醫學 Vol.13 No.2
급성 알콜성 근병증은 알콜 중독자 1%정도에서 발생하는 드문 병으로 종대성 근육통 등의 증상 발현 후 수 일내에 진행하며 횡문근 융해로 인한 치명적인 신 손상을 유발할 수 있어 빠른 진단과 처치를 필요로 한다. 20년간 매일 소주 3병정도를 마셨던 46세 남자 환자가 양측 어깨 및 상지에 심한 근육통을 주소로 내원하였다. 이학적 검사에서 도수근력은 상지 및 하지 모두 good grade이었으나, 근 수축 시 심한 통증을 호소하였으며 통증으로 인해 지구력이 상당히 감소되어 있었다. 양쪽 어깨 및 팔에 종대성 근육통(시각상사척도 8)이 있었으나 관절운동범위는 모두 정상이었다. 혈액 검사 소견에서 혈청 CK 2287 U/L, Myoglobin 437 ng/ml, AST 135 U/L, ALT 31 U/L, BUN 24 mg/dl, creatinine 1.0 mg/dl이었다. 근전도 소견에서는 침 근전도에서 대부분의 근위부 근육에서 비정상 자발전위가 관찰되었고, 작은 진폭의 지속시간이 짧은 다상성 운동 활동 전위가 관찰되었다. 좌측 상완 이두근에서 시행한 근 생검에서 급성 알코올 근병증으로 진단되었다. 내원 1주일 후 종대성 근육통(시각상사척도 8점)이 대퇴부까지 진행되었으며, 침상 안정 및 대증 치료를 시행하였고, 내원 1개월 후 환자는 통증을 호소하지 않았으며, 정상 독립보행 및 독립적으로 일상생활동작을 수행할 수 있는 상태로 퇴원하였다. 저자들은 알콜성 말초 신경병증을 가진 환자에서 발생한 급성 알콜성 근병증 1예를 경험하였기에 보고하는 바이다. Acute alcoholic myopathy progresses in number work after symptoms onset of edematous myalgia and so on for stalk of rare disease that happen in alcoholist 1%. This disease need fast diagnosis and treatment because can cause fetal renal injury by rhadomyolysis. 46-year-old man patient who has drunken soju 3 bottles every day 20 years explained both sides shoulder and upper limbs serious myalgia to address on source coming to help do. Upper limbs and all lower limbs of manual muscle test were Good grade in physical examination, but to core contraction serious pain did complaint and endurance by ache was decreased fairly. There was myalgia (VAS 8) for stalk both shoulder and arm and range of motion of all joint were normal. Serum CK 2287 U/L, myoglobin 437 ng/ml, AST 135 U/L were increased in laboratory finding, but serum phosphate and potassium were within normal limits. Needle electrodiagnostic findings at most proximal muscle of upper extremity in electrodiagnostic study is abnormal spontaneous activity at rest and low amplitude, short duration, low amplitude polyphasic motor unit action potential on minimal volition. The finding of muscle biopsy at left biceps brachialis was revealed alcoholic myopathy. Edematous myalgia (VAS 8) was gone to thigh after 1 week. Enforced bed rest and supportive care, and patient did not complain pain after 1 month, and he discharged in state that can achieve normal gait pattern and independent activities of daily living.