수용성 방부처리재의 기상열화 저항성 평가

이명재,이동흡,김규혁 한국목재공학회 2003 목재공학 Vol.31 No.4

수용성 방부처리(AAC, CCA-3, ACQ, CuAz) 소나무 시편의 기상열화에 대한 저항성을 평가하기 위하여 인공촉진열화 방법을 사용하였다. 기상열화에 의한 재색 및 중량변화, 물리적 표면열화, 목재조직의 변화를 종합적으로 고려할 때, AAC 처리시편을 제외한 ACQ, CCA, CuAz 처리시편은 기상열화에 대한 저항성이 있음을 알 수 있었다. 이러한 몇몇 방부처리재가 기상열화에 대하여 저항성을 나타내는 요인탐색을 위해 기상열화 산물을 분석하였는데, 그 결과, ACQ, CCA, CuAz 처리시편에서는 낮은 리그닌 함량이 측정되어 기상열화 저항성을 가지는 처리시편은 리그닌 열화가 적게 일어남을 나타냈다. 이는 방부제 유효성분이 목재 주성분 중 기상열화에 민감한 리그닌 구조에 정착함으로써 리그닌 열화에 대한 저항성이 발현되었기 때문으로 판단된다. This study was carried out to evaluate the weathering durability of waterborne preservative (AAC, ACQ, CCA, CuAz) treated Japanese red pine (Pinus densiflora S. et Z.) sapwood samples by accelerated weathering, and to find out the factor of stability. When considered the color changes, weight losses, surface degradation, and microstructure changes due to weathering, ACQ-, CCA-, and CuAz-treated samples were durable against weathering; the weathering durability of AAC-treated samples was poor and similar to untreated controls. The lignin content in aqueous extracts collected from ACQ-, CCA-, and CuAz-treated samples during weathering was lower than from untreated and AAC-treated ones. From these findings, we might concluded the weathering durability of ACQ-, CCA-, and CuAz-treated samples was enhanced by the fixation of preservative component(s) onto the lignin structure, which is very susceptible to weathering.

기상열화가 방부처리재의 구리성분 용탈에 미치는 영향

이명재,이동흡,김규혁 한국목재공학회 2003 목재공학 Vol.31 No.4

본 연구는 앞서 발표한 「수용성 방부처리재의 촉진 기상열화 저항성 평가」의 부속실험으로서 기상열화가 방부처리재의 유효성분 중 구리의 용탈에 미치는 영향을 평가하기 위하여 수행되었다. ACQ, CCA, CuAz 처리시편을 대상으로 실시한 자외선 조사 유무에 따른 기상열화 조건에서 공통된 유효성분인 구리의 용탈량은 방부제의 종류에 관계없이 인공강우만 실시했을 때보다 자외선 조사를 함께 겸했던 시편에서 높게 나타났다. 방부처리 전후와 방부처리재의 촉진열화 전후의 목재표면을 FTIR을 이용하여 분석하였는데, 그 결과 구리가 정착되는 것으로 판단되는 1731 cm^(-1), 1625 cm^(-1), 1510 cm^(-1)흡수대가 촉진열화에 의해 큰 변화를 나타냈다. 이는 리그닌과 결합되었던 구리가 리그닌의 자외선 열화시 리그닌과 함께 용출 되었음을 시사한다. This is the second in a series of reports on the evaluation of weathering durability of waterborne preservative treated wood by accelcrated weathering. The leaching of copper from AC!-, CCA-, and CuAz-treated samples during weathering was increased by UV irradiation, when compared between full weathering and water-only weathering. The FTIR spectra of the weathered ACQ-, CCA, CuAz-treated samples at 1731㎝^(-1), 1625㎝^(-1), 1510㎝^(-1), which are related to the fixation of copper, were different from those of unweathered controls. This result menas that UV irradiation can weaken the chemical bond between lignin and copper and/or extraction of lignin-copper complex can be occured when lignin erode away by weathering.

다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과

류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-

Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.

Clinical outcomes of stereotactic body radiotherapy for spinal metastases from hepatocellular carcinoma

Lee, Eonju,Kim, Tae Gyu,Park, Hee Chul,Yu, Jeong Il,Lim, Do Hoon,Nam, Heerim,Lee, Hyebin,Lee, Joon Hyeok The Korean Society for Radiation Oncology 2015 Radiation Oncology Journal Vol.33 No.3

Purpose: To investigate the outcomes of patients with spinal metastases from hepatocellular carcinoma (HCC), who were treated by stereotactic body radiotherapy (SBRT). Materials and Methods: This retrospective study evaluated 23 patients who underwent SBRT from October 2008 to August 2012 for 36 spinal metastases from HCC. SBRT consisted of approximately 2 fractionation schedules, which were 18 to 40 Gy in 1 to 4 fractions for group A lesions (n = 15) and 50 Gy in 10 fractions for group B lesions (n = 21). Results: The median follow-up period was 7 months (range, 2 to 16 months). Seven patients developed grade 1 or 2 gastrointestinal toxicity, and one developed grade 2 leucopenia. Compression fractures occurred in association with 25% of the lesions, with a median time to fracture of 2 months. Pain relief occurred in 92.3% and 68.4% of group A and B lesions, respectively. Radiologic response (complete and partial response) occurred in 80.0% and 61.9% of group A and B lesions, respectively. The estimated 1-year spinal-tumor progression-free survival rate was 78.5%. The median overall survival period and 1-year overall survival rate were 9 months (range, 2 to 16 months) and 25.7%, respectively. Conclusion: SBRT for spinal metastases from HCC is well tolerated and effective at providing pain relief and radiologic response. Because compression fractures develop at a high rate following SBRT for spinal metastases from primary HCC, careful follow up of the patient is required.

Protection of Streptozotocin Induced Pancreatic β-cells Dameged by Codium fragile ethanol extract

Gyu-Hyeok Lee,Dae-Hee Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Diabetes mellitus was divided type 2 diabetes mellitus(T2DM), type 1 diabetes mellitus(T1DM). Espacially T2DM has the highest incidence Furthermore, treatment is most insulin administration, blood glucose-lowering drug. There is necessary to develop a treatment for diabetes mellitus through damaged cells protection and without side effect. T2DM generated oxidative stress in pancreatic β-cells due to hyperglycemia, which is a relation to β-cells mass decrease. Consequently, in this study used antioxidants known Codium fragile ethanol extract(CFE). CFE was studied antioxidants and anti-inflammatory however that was unknown anti-diabetic effect. CFE protected from cell death by streptozotocin. Furthermore, CFE meaningfully inhibited apoptosis ratio by streptozotocin, decreased cleaved caspase 3, and cleaved PARP expression level. More importantly, that has appeared intracellular ROS scavenging and activation superoxide 2, catalase expression level with inhibition apoptosis. In case of animal testing, diabetes induced to streptozotocin. And there performed oral administration of CFE. as the results CFE 50mg/kg treated rats was decreased the blood glucose level from 3 weeks.

Isolation and Analysis of the Enzymatic Properties of Thermophilic Fungi from Compost

Lee, Hanbyul,Lee, Young Min,Jang, Yeongseon,Lee, Sangjoon,Lee, Hwanhwi,Ahn, Byoung Jun,Kim, Gyu-Hyeok,Kim, Jae-Jin The Korean Society of Mycology 2014 Mycobiology Vol.42 No.2

To the best of our knowledge, this is the first report on thermophilic fungi isolated in Korea. Three species of thermophiles were isolated from compost and were identified as Myriococcum thermophilum, Thermoascus aurantiacus, and Thermomyces lanuginosus. They can grow at temperatures above $50^{\circ}C$ and produce high levels of cellulolytic and xylanolytic enzymes at high temperatures. Notably, the considerable thermostability of the endo-glucanase produced by T. aurantiacus has made the fungus an attractive source of industrial enzymes.

Size-Tunable, Fast, and Facile Synthesis of Titanium Oxide Nanotube Powders for Dye-Sensitized Solar Cells

Lee, Kun Seok,Kwon, Jeong,Im, Jeong Hyeok,Lee, Chang Ryul,Park, Nam-Gyu,Park, Jong Hyeok American Chemical Society 2012 ACS APPLIED MATERIALS & INTERFACES Vol.4 No.8

<P>Size-tunable titanium oxide (TiO<SUB>2</SUB>) nanotube powders offering both a light-scattering effect and a light-harvesting function were synthesized by a fast and facile anodizing method. When used to prepare the TiO<SUB>2</SUB> layer for a photoanode, their photovoltaic performances were much worse than that of a nanocrystal TiO<SUB>2</SUB> layer. However, when the TiO<SUB>2</SUB> nanotube powders were used as a light-scattering layer on a nanocrystal TiO<SUB>2</SUB> layer, the highest conversion efficiency was obtained because of more noticeable light absorption of the longer wavelength, which was not attainable from a pure nanocrystal TiO<SUB>2</SUB> layer or the combination of nanocrystal TiO<SUB>2</SUB>/commercialized light-scattering particles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2012/aamick.2012.4.issue-8/am300892j/production/images/medium/am-2012-00892j_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am300892j'>ACS Electronic Supporting Info</A></P>

Dye-sensitized solar cells with Pt- and TCO-free counter electrodes

Lee, Kun Seok,Lee, Hang Ken,Wang, Dong Hwan,Park, Nam-Gyu,Lee, Jun Young,Park, O Ok,Park, Jong Hyeok Royal Society of Chemistry 2010 Chemical communications Vol.46 No.25

<P>Here for the first time, we demonstrate novel DSSCs with a Pt- and TCO-free counter electrode, which have a highly conductive polymer exhibiting high catalytic ability and charge transport, and the photovoltaic performance increases as we increase the PEDOT film conductivity.</P> <P>Graphic Abstract</P><P>Here for the first time, we demonstrate novel DSSCs with a Pt- and TCO-free counter electrode, which have a highly conductive polymer exhibiting high catalytic ability and charge transport. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc00432d'> </P>

NMR Study of the pH Effect on the DNA Binding Affinity of Human RPA

Lee, Min-Woo,Choi, Ju-Hyeok,Choi, Jae-Gyu,Lee, Ae-Ree,Lee, Joon-Hwa 한국자기공명학회 2016 Journal of the Korean Magnetic Resonance Society Vol.20 No.3

The replication protein A (RPA) plays a crucial role in DNA replication, recombination, and repair. RPA consists of 70, 32 and 14 kDa subunits and has high single-stranded DNA (ssDNA) binding affinity. The largest subunit, RPA70, mainly contributes to bind to ssDNA as well as interact with many cellular and viral proteins. In this study, we performed nuclear magnetic resonance experiments on the complex of the DNA binding domain A of human RPA70 (RPA70A) with ssDNA, d(CCCCC), at various pH, to understand the effect of pH on the ssDNA binding of RPA70A. The chemical shift perturbations of binding residues were most significant at pH 6.5 and they reduced with pH increment. This study provides valuable insights into the molecular mechanism of the ssDNA binding of human RPA.

증례 : 호흡기 ; 골수형성이상증후군에서 폐 침윤과 흉수를 동반한 스위트 증후군 1예

고규봉 ( Gyu Bong Ko ),이혁규 ( Hyeok Gyu Lee ),이호성 ( Ho Sung Lee ),최재성 ( Jae Sung Choi ),서기현 ( Ki Hyun Seo ),나주옥 ( Ju Ock Na ),김용훈 ( Yong Hoon Kim ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2

저자들은 75세 골수형성이상증후군 환자에서 폐 침윤과 동반된 양측 흉수가 발생한 스위트 증후군 1예를 경험하였기에 이를 보고한다. Sweet`s syndrome is characterized by a constellation of clinical symptoms, physical features, and pathologic findings, which include fever, leukocytosis, tender erythematous skin lesions, and a diffuse infiltrate consisting predominantly of mature neutrophils in the upper dermis. Pulmonary involvement in Sweet`s syndrome is rare. In addition, a pleural effusion has been rarely reported in the pulmonary involvement of Sweet`s syndrome. We report a case of Sweet`s syndrome presenting with pulmonary involvement and a bilateral pleural effusion in a patient with myelodysplastic syndrome. (Korean J Med 2011;80:216-220)