서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

정상면역을 가진 성인에서 발생한 식도 방선균증

김현수 ( Hyun Soo Kim ),천종운 ( Jong Woon Cheon ),김민수 ( Min Su Kim ),정창길 ( Chang Kil Jung ),김경록 ( Kyung Rok Kim ),최재원 ( Jae Won Choi ),강동우 ( Dong Woo Kang ),김선영 ( Sun Young Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Hyun Soo Kim, Jong Woon Cheon, Min Su Kim, Chang Kil Jung, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang and Sun Young Kim1 Departments of Internal Medicine and Pathology1, DongKang Medical Center, Ulsan, Korea Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

시상하부-뇌하수체 질환에서 종합적 뇌하수체전엽 기능검사의 진단적 의의

김수동,김신우,김정국,하승우,김보완 慶北大學校 醫科大學 1993 慶北醫大誌 Vol.34 No.4

시상하부-뇌하수체질환의 기저질환에 따른 종합적 뇌하수체전엽 자극검사의 진단적 가치를 알아보고자 81례의 뇌하수체 기능부전증환자를 대상으로 시상하부질환군과 Sheehan증후군, 말단비대증과 프로랙틴종, 그리고 뇌하수체선종에서 시야장애가 동반된 군과 장애가 없는 군으로 나누고 기능검사의 결과를 비교하였다. 1. Sheehan증후군 15례 가운데 GH 및 cortisol결핍이 전례(각각 100%)에서 FSH, LH 및 TSH결핍이 11∼12례(73∼80%)에서 관찰되었고 13례(86%)에서는 TRH에 대한 PRL분비증가가 저하 또는 소실되었다. 두개인두종 10례를 포함한 시상하부질환 14례 가운데 12례(86%)는 PRL의 기저지가 비정상직으로 증가되어 있었으며 TRH자극에 대해 PRL분비 증가가 11례(79%)에서 둔화되어 있었다. GH분비능도 11례(79%)에서 저하되었으며 그 밖의 cortisol, LH, TSH, FSH의 순으로 분비능이 저하되어 있었으나 그 빈도는 Sheehan증후군에 비해 전반적으로 낮았다. 2. 말단비대증 18례 가운데 14례(78%)에서 GH기저치가 비정상적으로 증가되어 있었고 13례(72%)는 저혈당자극에 대해 정상적인 GH의 증가를 보였으며 8례(44%)에서 고프로랙틴 혈증이 동반되었다. 프로랙틴종 18례 가운데 전례(100%)에서 PRL기저치가 증가되었고 13례(72%)에서 TRH에 대한 PRL의 증가반응이 둔화되었다. LH, FSH, cortisol 및 TSH분비능의 장애는 말단비대증군에서 프로랙틴종에 비해 다소 높은 빈도를 보이는 경향이었다. 3. 뇌하수체선종 가운데 시야장애가 동반된 21례에서 시야장애가 없는 23례에 비해 GH, cortisol및 LH의 분비반응이 저하된 빈도가 다소 높은 경향이었다. 이상의 결과로 보아 종합적 뇌하수체전엽 기능검사는 시상하부-뇌하수체질환의 기저질환을 진단하는데 중요한 정보를 제공할 수 있다고 생각한다. The combined stimulation test using TRH, LHRH and insulin has allowed investigation of the reserve of all pituitary tropic hormones under physiological and pathological conditions. To evaluate the diagnostic efficacy of this test for differentiating the underlying causes of hypopituitarism, we analyzed retrospectively the results of these tests done in 81 patients with proven hypothalamo-pituitary disorders. 1. In 15 patients with Sheehan's syndrome as a typical type of primary hypopituitarism, responses of both GH and cortisol to insulin-induced hypoglycemia were decreased in 15 cases all (100% in both) and of FSH, LH and TSH in 11 to 12 cases(73-80%). Incremental response of prolactin(PRL) to TRH was diminished or absent in 13 cases(86%). In 14 patients with hypothalamic diseases, including 10 cases of craniopharyn-gioma, as a representative secondary hypopituitarism, the basal PRL levels were abnormally elevated in 12 cases (86%) and both responses of PRL to TRH and of GH to hypoglycemia were blunted in 11 cases (79% in both). The frequency of impaired cortisol secretion was 50%, followed by LH, TSH and FSH secretion : overall frequency much lower than in Sheehan's syndrome. 2. In 18 acromegalics with pituitary adenoma, basal GH levels were abnormally elevated in 14 cases(78%) and incremental responses of GH to hypoglycemia were found in 13(72%). Hyperprolactinemia was accompanied in 8 (44%). In 18 patients with prolactinoma, basal PRL levels were moderately to markedly elevated in all of them(100%) and responses of PRL to TRH were blunted in 13(72%). The frequency of impaired secretion of LH, FSH, cortisol and TSH was slightly higher in acromegalics than in patients with prolactinoma. 3. The frequency of impaired secretion of GH, cortisol and LH tended to be slightly higher in patients with pituitary adenoma associated with visual field defect than those without visual field defect. These results suggest that the combined pituitary stimulation test will give us some of reliable information for evaluating the underlying causes of hypopituitarism.

Photoreflectance 및 Photocurrent 측정에 의한 반절연성 GaAs의 광학적 특성

김기홍,김동렬,배인호,김대년,김인수 嶺南大學校 基礎科學 硏究所 1998 基礎科學硏究 Vol.18 No.-

We report on the room temperature optical characterization of semi-insulating GaAs. The energy gap of semi-insulating GaAs was determined to be 1.41eV by photoreflectance(PR)and possible orgin of the photoreflectance signal is discussed. From photoreflectance(PC)measurement, the peak of PC is observed at 1.40 eV, corresponding to GaAs band to band transition. The influence of temperature and dependent upon the chopper frequency on the PC of semi-insulating GaAs is studied.

Group Size And Measure Of Group-Level Properties

Kim,Kyoung-Su,Kim In-Sook,Jun,Gyung-Ju,Yang,Dong-Min 한국인적자원관리학회 2009 인적자원관리연구 Vol.16 No.4

Bliese와 Halverson(1998)은 집단수준의 효과를 분석하는데 있어서 기존에 사용되어 온 eta-squared 보다는 eta-squared 값이 사용되어야만 한다는 것을 주장하였다 그러나 이들이 제시한 수정된 eta-squared 접근은 다음과 같은 한계점을 가지게 되는 바 첫째, 이 접근법은 개인수준의 데이터를 집단 수준의 데이터로 만드는데 있어서의 정당성을 제공하는 기준을 구체적으로 제시하고 있지 못하다는 것을 들 수 있고, 둘째, 이 접근법은 또한 집단 내 효과를 용인하고 분석하는 기준을 제공하고 있지 못하다는 점을 들 수 있다 본 논문에서는 이러한 한계점을 극복할 수 있는 몇 가지의 대안을 제시하고 있으며, 이와 더불어 개인수준의 데이터를 집단 수준으로 만드는 것에 대한 정당성을 위한 또 하나의 추가적인 절차를 제시하였다 Bliese and Halverson(1998) argue that corrected eta-squared, rather than eta-squared, should be used for analyzing group-level effects However, their proposed corrected eta-squared approach has the following limitations (1) it fails to specify a criterion for justifying the aggregation of individual-level data to the group level and (2) it fails to specify a criterion for analyzing and allowing for within-group effects In this paper, we suggest several alternatives that overcome these limitations We suggest an additional procedure for justifying the aggregation of individual-level data to the group level

영원일대(동강)의 수자원 조사

한진수 ( Jin Su Han ),김동석 ( Dong Seog Kim ) 대구가톨릭대학교 자연과학연구소 2003 자연과학연구논문집 Vol.1 No.2

빌라조경 설계사례에 관한 연구 : Case Study of Jang-chung Dong Villa

김동찬,이윤수,유재설,박익수,임동민,임상재 경희대학교 부설 디자인연구원 1998 예술· 디자인학연구 Vol.1 No.1

The goal of this study is to propose a plan for the Jang-Chung Dong Villa. This Villa is located on Jang-Chung Dong Jung-Gu, Seoul. And, this place is where high-class residential area. This Site area covers about 1925.6m². This base idea of this plan is to provide a community of dwelling houses with identity and amenity in outdoor spaces in order to create the high-class environment of outdoor spaces. Design principles are established as follow; to make spaces for flexibility in the garden related activities, to provide many chances to contact with nature, and to feel pride in the villa life.

혈관질환 정보관리 시스템

김동익,김덕경,허세호,이병붕,김용신,김은숙,문지영,도영수,신성욱,김동수,김만태,진재욱,김용신 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1

As medical technology progresses rapidly, there is a rise in the average age along with the Korean dietary lifestyle becoming more westernized, which leads to an increase in the number of vascular disease patients in Korea. Thus, we need to manage the medical information of a disease systematically in order to diagnose and treat constructively. However, since there has been no standardized method of man agement to date, a great deal of information could not be properly utilized nor studied. Therefore, the departments of Cardiology, Radiology and Neurology of Samsung Seoul Hospital recently got together to develop an information management system called the Vascular Data System. This program was developed to be run on win98 O/S, upper Pentium Ⅲ, and upper 128 MB Memory, and its source code is Dephi 4.0. It was configured for the user to set the configurations as well as do a variety of search and analysis. If this program were to be updated continuously, it may be used extensively as well as in various parts of clinical research activities.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.