임상 가검물에서 분리된 균(대장균과 황색 포도균)의 약제 내성

김중명,김재식,김경선,김재룡,전동석,최성만,서상철,김인자,김재숭,이건일,김경숙 慶北大學校 醫科大學 1982 慶北醫大誌 Vol.23 No.2

1981년 1월에서 12월말까지 임상 제료에서 분리한 Escherichia coli (E. coli)와 Staphylococcus aureus (S. aureus) 중에서 무작위로 각 50주 씩 선택하여 원판 확산법과 평판 희섭법으로 그 내성주를 조사하여 다음과 같은 성적을 얻었다. 전체적으로 볼 때에 Teteracyclin (TET), Chloramphenicol (CM) 및 Ampicillin (AMP)에 대한 내성주가 가장 많았고, Amikacin (AMK)에 대한 내성주는 가장 적어다. 이것을 균종별로 보면 E. coli에 있어서는 TET, AMP 및 CM는 원판 확산법으로서 74∼76%, 평판 희석법으로서는 78∼94%가 내성주임을 나타내었고, 또 Cephalothin(CEP)은 원판 확산법에서는 8%가 내성주로 나타났으나, 평판 의석법에서는 52%가 내성주로 나타났다. S. aureus에 있어서는 TET는 원판 확산법으로 82%, 평판 희석법으로서는 78%가 내성주로 나왔고 Penicillin (P)은 원판 확산법에서는 56% 평판 희석법으로는 22%의 내성주가 나왔으며, GM과 CM은 원판확산법에서는 18∼44%, 평판 희석법에서는 56∼58%가 내성주로 나왔다. Each 50 strains of Escherichia coli and Staphylococcus aureus were selected at random out of the stock cultures which were isolated from the clinical materials in the bacteriological laboratory of the department of clinical pathology. Kyungpook National University Hospital from the first of January to the end of December in 1982, and their resistance against eight antibiotics were as follows; Escherichia coli and Staphylococcus aureus had the most resistant pattern against tetracyclin, chloramphenicol, and ampicillin, while they had the most sensitive pattern against amikacin in general. Escherichia coli revealed resistant pattern to tetracyclin, ampicillin, and chloramphenicol 74-76% by the disk diffusion method and 78-94% by the plate dilution method, and revealed resistant pattern to cephalothin 8% by the disk diffusion and 52% by the plate dilution. Staphylococcs aureus disclosed resistant pattern to tetracyclin 82% by the disk diffusion and 78% by the plate dilution, and disclosed resistant pattern to penicillin 56% by the disk diffusion and 22% by the plate dilution, and to gentamicin and-chloramphenicol 18-44% by the disk diffusion and 56-58% by the plate dilution.

Two New Records of Sepia (Doratosepion) kobiensis Holye, 1885 and S. tokioensis Ortmann, 1888

Kim, Yeong-Hye,Lee, Dong-Woo,Choi, Kwang-Ho,Yeon, In-Ja,Kim, Young-Seop The Malacological Society of Korea 2004 The Korean Journal of Malacology Vol.20 No.2

The true cuttlefishes genus Sepia (Doratosepion) Linne, 1758, characterized by shell thick, entirely calcareous, shell almost as long as mantle, was collected from the coastal of Dong-Am, Busan, Korea in April, 2004. The specimen agreed closely with description of Sepia (Doratosepion) kobiensis Hoyle, 1885 and S. tokioensis Ortmann, 1888. We herein described the species, being as the first record of S. kobiensis and tokioensis from the region. New Korean names are also provided.

전침 자극에 의한 오디 괄약근 운동성 변화에 관한 연구

이성구,김명완,김홍자,서동환,이상수,김동일,유교상,주연호,민병일,김지훈 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Background/Aims: This study was designed to evaluated the effects of electroacupuncture on the sphincter of Oddi (SO) motility in humans and to correlate the manometric findings with plasma cholecystokinin (CCK) levels. Methods: Eleven patients (M: F= 5: 6) who had various kinds of biliary disorders were enrolled. SO motility was monitored with a conventional low-compliant continuously perfused technique using ERCP (n=9) or percutaneous transhepatic cholangioscope (n=2). After baseline monitoring for phasic wave contractions of SO, electroacupuncture was applied at a specific acupoint, GB 34, in these 11 patients. A nonspecific acupoint 5 cm away from GB 34 was selected as a control. Manometric parameters of SO were also checked in 6 subjects during stimulation of the control acupoint. CCK plasma levels were measured during the time course of electroacupuncture stimulation. Result: All the manometric parameters including the basal pressure of SO, amplitude, frequency and duration of phasic wave contraction of SO were significantly decreased (p< 0.05) during electroacupuncture stimulation. The inhibition of SO contractility was accompanied by increased CCK plasma levels. After removal of electroacupuncture stimulation, restoration of amplitude and duration to basal condition were noted. A tendency towards the return of SO contractility was also observed in basal pressure and frequency. Stimulation of the control acupoint, however, did not affect the SO contractility and plasma CCK levels. Conclusions: Electroacupuncture stimulation of acupoint GB 34 showed reversible inhibition of SO contraction in humans. We speculate that the response of SO to electroacupuncture stimulation may be mediated by some neurohormonal mechanisms including CCK release. (Korean Journal of Gastrointestinal Motility 2000;6:44-41)

분편 인플루엔자백신(split influenza vaccine)의 임상효과 및 면역원성에 관한 연구

우흥정,김동림,정희진,천병철,이주연,안정배,김지희,박찬,신영규,김우주,김민자,박승철 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.1

목적 : 아단위 인플루엔자 백신 접종 후 백신의 인플루엔자 예방효과, 인플루엔자 방어 항체형성, 인플루엔자 백신의 안전성을 조사하고자 하였다. 방법 : 총 571명을 대상으로 인플루엔자 백신 접종을 하였고, 이들 접종자에서 인플루엔자 양질환의 이환을 조사하여 인플루엔자 백신의 인플루엔자예방효과를 알아보았고, 백신의 접종 전 및 접종 4주 후 혈청에서 혈구응집억제물(Hemagglutination Inhibition : HAI) 항체 검사를 실시하여 백신의 방어항체생성을 조사하였고, 백신의 안전성을 알아보기 위해 백신접종 후 1주일 이내의 부작용을 조사하였다. 결과 :백신 접종군과 백신 비접종군에서 인플루엔자 양 질환의 이환을 조사한 결과 접종군 28.35%, 비접종군 35.88%으로 나왔으며, p 값이 0.001로 통계적으로 접종군에서 유의하게 낮았고, 인플루엔자 양 질환의 예방 효과는 20.97%를 보였다. 백신의 방어항체 형성의 평가를 위해 유럽의 인플루엔자 백신 허가 기준을 조사하였는데 B/Guangdong/5/94균주의 백신접종 후 항체가 40이상의 비율을 제외한 다른 기준은 모두 만족 시켰다. 부작용은 전체 조사자 521명중 149명(29%)으로 주로 접종 부위의 국소 부작용을 호소했고, 전신 부작용은 2% 내외였으며 특별히 심각한 부작용은 발견되지 않았다. 결론 : 분편 인플루엔자 백신은 인플루엔자양질환의 예방과 방어항체생성에 효과 있으며 안전한 것으로 사료된다. Background : The safety and effectiveness of influenza vaccine are well known in developed country. The influenza vaccination has been recommended as one of the tentative immunization schedule for indicated persons since 1997 in Korea. But there are still no available data about them, even though nearly 5 million doses of influenza vaccine were used in 1997-1998 season. So it is immediately needed to investigate the safety. efficacy and immunogenicity of influenza vaccine among Korean. Methods : We studied the clinical efficacy of influenza vaccine by monitoring Occurrence of influenza-like illness in influenza risk group(vaccination ; 300, non-vaccination; 215) from December in 1997 to March in 1998. We used the split quadrivalent influenza vaccine containing 15 microgram of hemagglutinin of A/Beijing/262/95(HlNl), A/Wuhan/359/95(H3N2), B/Mie/1/93 and B/Guangdong/5/94. Hemagglutination inhibition(HA1) antibody titers were determined before immunization and 1 months after vaccination And we evaluated adverse effect of influenza vaccination at 7 days after vaccination. Results : Influenza vaccination was associated with si@icant reductions in influenza-like spptoms(vaccination group; 28.35%, non-vaccination group, 35.88%, p=0.001). The preventive effect of influenza-like i3lne.s among influenza risk goup was 20.97%. And immunogenicity of influenza A and B exceeded all of the European licensure criteria for immunogenicity except postvaccination proportion of titers 240 of B/Guangdong/5/94 strain. And the adverse effects were mainly local injection site problem and no serious adverse effect was noted. Conclusion : Split influenza vaccine is safe, inmunogenic and eff'tive in influenza risk group in Korea.

비지의 영양학적 품질특성

김군자,류호경,이영근,김동섭 밀양대학교 농업기술개발연구소 2000 農業技術開發硏究所報 Vol.4 No.1

This study was carried out to examine the qualities of soybean curd residue for utilizing as foodstuff. The content of moisture, crude protein, crude fat and ash were 80.98, 3.32, 0.94 and 0.82%, respectively. The major fatty acids were linoleic acid, oleic acid, linolenic acid and stearic acid. The hydrolysate of protein of sobean curd residue was composed chiefly of aspartic acid, glutamic acid, glycine, alanine, arginine and threonine, but the major free amino acids of soybean curd residue were arginine(234.1), ethanolamine (91.6), γ -amino-n-butyric acid(60.2), glutamic acid(55.8), valine(49.8), asparagine(47.3) and Iycine(48.3μ mol/100g). Key words : Soybean curd residue, Fatty acid, Amino acid

퍼지 PID제어기를 이용한 직류 전동기의 속도제어에 관한 연구

김동희,박순규,김자룡 진주여자전문대학 1994 論文集 Vol.17 No.-

본 논문은 직류서보 전동기 시스템의 퍼지논리를 이용한 PID제어의 한 기법이다. 이러한 제어기법은 재래식 조정기법(ITAE table)을 이용하여 정상적인 제어기의 변수를 조정한 다음 퍼지제어 행렬을 사용하여 시스템이 동작하는 동안 작은 이득값의 변화를 결정함으로서 전동기의 속도제어 시스템의 정상상태오차와 과도응답의 성능을 향상시킬 수 있으리라 기대된다. 이러한 시스템은 마이크로프로세서를 이용함으로서 쉽게 실현할 수 있다. This paper present an approach to use fuzzy logic PID control of DC servo control system. This approach assumes that available nominal controller parameter settings through some classical tuning technique (ITAE table). By using an appropriate fuzzy matrix(which is 3- separate Look-up Table), we determine small changes on these gain values during the system operation, and these lead to improved performance of the transient and steady behavior of the motor speed control system, this achieved at the expense of some small extra computational effort, which can be very easily undertaken by a microprocessor.

반복작업에 의해 발생한 척골관 증후군 1례

김정원,박인선,이영준,김유창,김필자,강동묵,이채언 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : To report cubital tunnel syndrome due to repetitive motions. Methods : A worker complaining muscle weakness and atrophy of the right hand intrinsic muscles admitted to a hospital. We evaluated him with blood tests, neurophysio-logic studies (NCV & EMG), plain X-ray and US at the both elbows. We investigated his occupational history, and videotaped his work motions based on the work cycle at his previous work site. Finally, an ergonomics expert analyzed the motions using rapid upper limb assessment (RULA). Results : NCV & EMG studies reveals slow conduction velocity on both ulnar nerve across the elbow, more severely in the right side. US shows us compatible finding with diffuse neuritis of both ulnar nerves at both elbows. RULA score is 7. Conclusion : We confirmed that the worker's symptoms were related to his previous jobs demanding repetitive motions using the elbow joints. It is necessary that we should prepare appropriate measures to evaluate, prevent, rehabilitate, and help injured workers to return to work.

Risperidone으로 유발된 심실조기수축 1례

김자윤,안동현 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.2

리스페리돈은 새로운 비전형 항정신병약제의 하나이며, 정신분열병의 치료제로서 빠른 속도로 그 사용이 일반화되어가고 있다. 저자들은 53세의 정 신분열병 여자환자에서 risperidone투여 중에 발생한 심실조기수축의 1례를 경험했다. 이 환자에서 발생한 심실조기수축증이 반드시 risperidone의 투여에 의한 것이라고 단정지어 말할 수는 없을 것이다. 하지만 risperidone의 투여초기인 점과 급작스러운 부정맥의 증상악화 등은 이 약물과 심장독성과의 연관 가능성을 생각해 보게 한다 Risperidone is a potent antipsychotic agent, used in the management of the manifestations of schizophrenia. And it has recently become one of the most popular antipsychotics. We experienced one case of ventricular premature complexes that occurred during the risperidone treatment in a 53-year-old female patient with schizophrenia. Abrupt aggravation of the cardiac arrhythmia and the associated symptoms suggest the possibility that the use of risperidone might have tarred them. Although other possibilities exist, risperidone cannot be ruled out as the cause of the patient's cardiac adverse effect.

농촌지역의 주의력결핍-과잉행동장애와 학습장애의 역학적 연구

김자윤,안동현,신영전 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 농촌지역 초등학생의 주의력결핍-과잉행동장애와 학습장애, 정신지체의 유병률을 조사하고, 보다 효과적인 장애아동 발견방법을 구하기 위해 연구를 계획하였다. 방 법 : 경기도 일개 군내 5개 면의 6개 초등학교, 1,256명에서 전체 학생을 대상으로 교사가 설문지를 작성한후 이를 통해 1차 선별하는 전수(total population) 조사방법과 교사가 직접 1차 선별하는 핵심요원(Key informant) 조사방법을 이용해 문제아동을 선별하였고, 대상아동은 현장을 방문해 정신과적 면담이나 지능검사를 통해 확진하였다. 결 과 : 1) 유별률은 주의력결핍-과잉행동장애가 1.99%, 학습장애가 0.40%, 경도이상의 정신지체가 2.23%이었다. 2) 전수 조사와 핵심요원 조사를 비교하면, 전수 조사의 경우 경도 이상의 정신지체의 유병률이 유의하게 높은 것(전수 조사 3.29%, 핵심요원 조사 1.23%) 외에 핵심요원 조사와 유별률에서 유의한 차이는 없었다. 핵심요원 조사는 주의력결핍-과잉행동장애와 정신지체 등에 의한 학습부진의 양성 예측도가 전수 조사에서 사용된 파탄적 행동장애 평정 척도(Disruptive Behavior Disorders Rating Scale, DBDRS)나 학업 수행 평정 척도(Academic Performance Rating Scale, APRS)보다 높았다(DBDRS : 전수 조사 17.33%, 핵심요원 조사 41.67% ; APRS : 전수 조사 39.22%, 핵심요원 조사 44.44%). 진단 받은 아동만을 비교할 때 두 집단의 질병분포에서 유의한 차이는 없었다. 3) 부모와 교사가 다같이 아동의 문제를 인식하고 있을 때 실제 장애의 가능성이 높았다. 결 론 : 조사된 시점유병률은 주의력결핍-과잉행동장애가 1.99%, 학습장애, 정신지체가 각각 0.40%와 2.23%였다. 양성예측도와 진단별 일치도로 비교할 때 핵심요원을 이용한 조사가 장애아동 발견에 보다 효율적이었다. 장애아동 발견에 있어 교사 혹은 부모의 단일 경로의 정보는 신뢰도가 상대적으로 낮았고 두 경로를 합쳤을 때 신뢰도가 더욱 높아짐을 볼 수 있었다. 이 연구의 결과는 우리 나라 초등학생에서 주의력결핍-과잉행동장애와 정신지체의 유병률을 조사했다는 의의와 함께, 향후 학교 대상의 역할조사에서 핵심요원 조사방법의 유효성을 증명하는 것이다. Objectives : We atlempted to determine the prevalence rate of attention deficit-hyperactivity disorder, learning disorder, and mental retardation of elementary school children in a rural area, and to evaluate a cost, and time-efficient method for identifying of children with such disabilities. Methods : We studied 1,256 children from 6 elementary schools in a rural aiea using used two-stage design. At the first step, we used the key informant and the total population survey methods for identifying children with disability. Teacher checklists were used as screening instru-ments in total population survey. And at the second step, child interview and KEDI-WISC were employed to make diagnoses. Results : 1) The prevalence rate of attention-deficit/hyperactivity disorder(ADHD) was 1.99%. The prevalence rates of learning disorder(LD) and mental retardation(MR) were 0.40% and 2.23%, respectively. 2) The prevalence rate of MR was significantly higher in total population method compared with key informant method(3.29% vs. 1.23%). Other comparison of prevalence rates in two methods was not significantly different. Positive predictabilities of ADHD and learning disabilities by key informants were higher than by DBDRS and APRS, the checklists used in total population methods. 3) The probability of illness was much higher when the teacher and parents reported the problems of child concurrently. Conclusions : The prevalence rate of ADHD in elementary school children in the rural area was 1.99%. And the prevalence rates of LD and MR were 0.40% and 2.23%, respectively. Key informant method was more effective compared with total population survey in positive predictability and diagnostic concordance, In identifying children with disabilities, the combined data from teacher and a parent was most reliable.

정지형 자전거 운동 훈련이 건강한 여성의 체구성,심폐기능 및 유연성에 미치는 효과

김동옥,최정숙,안혜영,민혜숙,이경숙,박연환,송미령,최명애,최정안,김매자 서울대학교 간호대학 간호과학연구소 1999 간호학 논문집 Vol.13 No.1

The purpose of this study was to determine the changes in body composition, cardiopulmonary function, and flexibility following 8 weeks' bicycle ergometer exercise training. The subjects of this research consisted of healthy adult women between 30 and 40 years of age. Initial intensity of bicycle ergometer exercise was based on the target heart rate equivalent to 55% of maximal oxygen uptake, and intensity of the exercise increased by 5% every 2 weeks. Body composition, cardiopulmonary function at rest and during maximal exercise, as well as flexibility were determined before and after 8 weeks of bicycle ergometer exercise training. Masimal exercise was performed on the treadmill according to Bruce Protocol. The results obtained were as follows; 1. There were o changes in body weight, percent body fat, fat body weight, and lean body weight as well. The ventilation volume for 1 minute, respiratory quotient and expired CO₂ volume have not changed significantly after the training, either. 2. As a result of training, resting systolic and diastolic blood pressure decreased significantly(p<.05) 3. Maximal heart rate, maximal oxygen consumption and maximal running time increased significantly after the training(p<.05) 4. Pelvic flexibility increased slightly after the training, however, it did not reach the statistical significance. Trunk flexion forward increased significantly after the training(p<.05). From these results, it may be concluded that 8 weeks bicycle ergometr training improve the cardiopulmonary function and flexibility in healthy adult women between 30-40 years of age.