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          • The Ca <sub>V</sub> 3.2 T-Type Ca <sup>2+</sup> Channel Is Required for Pressure Overload-Induced Cardiac Hypertrophy in Mice

            Chiang, Chien-Sung,Huang, Ching-Hui,Chieng, Hockling,Chang, Ya-Ting,Chang, Dory,Chen, Ji-Jr,Chen, Yong-Cyuan,Chen, Yen-Hui,Shin, Hee-Sup,Campbell, Kevin P.,Chen, Chien-Chang Ovid Technologies Wolters Kluwer -American Heart A 2009 Circulation research Vol.104 No.4

            <P>Voltage-gated T-type Ca(2+) channels (T-channels) are normally expressed during embryonic development in ventricular myocytes but are undetectable in adult ventricular myocytes. Interestingly, T-channels are reexpressed in hypertrophied or failing hearts. It is unclear whether T-channels play a role in the pathogenesis of cardiomyopathy and what the mechanism might be. Here we show that the alpha(1H) voltage-gated T-type Ca(2+) channel (Ca(v)3.2) is involved in the pathogenesis of cardiac hypertrophy via the activation of calcineurin/nuclear factor of activated T cells (NFAT) pathway. Specifically, pressure overload-induced hypertrophy was severely suppressed in mice deficient for Ca(v)3.2 (Ca(v)3.2(-/-)) but not in mice deficient for Ca(v)3.1 (Ca(v)3.1(-/-)). Angiotensin II-induced cardiac hypertrophy was also suppressed in Ca(v)3.2(-/-) mice. Consistent with these findings, cultured neonatal myocytes isolated from Ca(v)3.2(-/-) mice fail to respond hypertrophic stimulation by treatment with angiotensin II. Together, these results demonstrate the importance of Ca(v)3.2 in the development of cardiac hypertrophy both in vitro and in vivo. To test whether Ca(v)3.2 mediates the hypertrophic response through the calcineurin/NFAT pathway, we generated Ca(v)3.2(-/-), NFAT-luciferase reporter mice and showed that NFAT-luciferase reporter activity failed to increase after pressure overload in the Ca(v)3.2(-/-)/NFAT-Luc mice. Our results provide strong genetic evidence that Ca(v)3.2 indeed plays a pivotal role in the induction of calcineurin/NFAT hypertrophic signaling and is crucial for the activation of pathological cardiac hypertrophy.</P>

          • Sustainable Development Strategy for CasinoIndustIy of Hualien Area

            ( Shiunn-der Kuo ),( Ching-sung Chiang ),( Chia-yon Chen ) 세계문화관광학회 2008 International Journal of Culture and tourism Resea Vol.1 No.1

            In the past years, liberalizing casino operation inTaiwan has been long a controversial issue. They questioned why Hualien shouldn``t follow the path to success in Las Vegas to resolve povelty and economical depression commonly occun``ed in Hualien area. Due to tourism downtum in recent years, as a result aggravating the budget deficit of local government, casino establishment is urgently considered as a way to prosper local economic activities. Casinos will be legally established at the time of ripeness in the near future. Based on this assumption, this study summarizes preliminarily a number issues potentially present on the development of gaming business at Hualien with respect to infi-asnucture and tourism development at Hualien according to the analyses of reviewing the literature on the definition and categories of casino, influence of gaming indusny in all aspects, and cun``Cntsituation and perspective of tourism development at Hualien. This study firstly employed Participatory Local Appraisal to form a consensus from local resident for sustainable development of Hualien area. Then, SWOT matrix analysis, expert judged Fuzzy Delphi method to determine the most valuable issues on the development of casino industly at Hualien in both respects.

          • Sustainable Development Strategy for CasinoIndustry of Hualien Area

            Shiunn-Der Kuo,Ching-Sung Chiang,Chia-Yon Chen 세계문화관광학회 2008 International Journal of Culture and tourism Resea Vol.1 No.1

            '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

            In the past years, liberalizing casino operation in Taiwan has been long a controversial issue. They questioned why Hualien shouldn't follow the path to success in Las Vegas to resolve poverty and economical depression commonly occurred in Hualien area. Due to tourism downturn in recent years, as a result aggravating the budget deficit of local government, casino establishment is urgently considered as a way to prosper local economic activities. Casinos will be legally established at the time of ripeness in the near future. Based on this assumption, this study summarizes preliminarily a number issues potentially present on the development of gaming business at Hualien with respect to infrastructure and tourism development at Hualien according to the analyses of reviewing the literature on the definition and categories of casino, influence of gaming industry in all aspects, and current situation and perspective of tourism development at Hualien. This study firstly employed Participatory Local Appraisal to form a consensus from local resident for sustainable development of Hualien area. Then, SWOT matrix analysis, expert judged Fuzzy Delphi method to determine the most valuable issues on the development of casino industry at Hualien in both respects.

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