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한국 폐경 여성에서 호르몬 대체요법시 치료 제제에 따른 유방 치밀도의 변화
이동윤 ( Dong Yun Lee ),김상돈 ( Sang Don Kim ),최영식 ( Young Sik Choi ),지병철 ( Byung Chul Jee ),구승엽 ( Seung Yup Ku ),서창석 ( Chang Suk Suh ),최영민 ( Young Min Choi ),김정구 ( Jung Gu Kim ),문신용 ( Shin Yong Moon ),김석현 대한폐경학회 2003 대한폐경학회지 Vol.9 No.3
목적 : 본 연구는 한국 폐경 여성에서 호르몬 대체요법과 연관된 유방 치밀도의 변화를 평가하기 위하여 시행되었다. 연구 대상 및 방법 : 본 연구에서는 호르몬 대체요법을 시행 받은 폐경 여성 294명을 대상으로 치료 제제에 따라 매일 tibolone 2.5 mg을 투여 받은 군(n=119), conjugated equine estrogen(CEE) 0.625 mg/medroxyprogesterone(MPA) 2.5 mg으로 지속적 병합요법을 시행 받은 군(n=93), CEE 0.625 mg으로 단독요법을 시행 받은 군(n=40) 및 raloxifene 30 mg을 투여 받은 군(n=42)으로 대변하였으며, 호르몬 대체요법을 시행 받지 않은 폐경 여성 36명을 대조군으로 설정하였다. 대상 여성에서 유방촬영술(mammography)을 호르몬 치료 시작 전과 치료 1년 후에 각각 시행한 후 유방 치밀도(breast density)의 변화를 후향적으로 각 군에서 비교 관찰하였다. 결과 : 대상 여성의 연령, 분만력, 폐경 연령, 폐경 후 기간, 체중, 신장 및 체질량지수(BMI)는 각 군간에 통계학적으로 유의한 차이가 없었다. 호르몬 대체요법 1년 후 유방촬영술에서 관찰된 유방 치밀도의 증가는 지속적 병합요법군에서 25.8%(24/93)로서 tibolonerns의 11.8%(14/119), raloxifene군의 2.4%(1/42)에 비하여 각각 유의하게 높았다(p<0.05). 결론 : 본 연구 결과 호르몬 대체요법을 시행 받은 폐경 여성에서 관찰된 유방 치밀도의 변화는 치료 제제에 따라 상이하다는 것을 확인하였으며, 특히 progestogen을 이용한 지속적 병합요법이 유방 치밀도 변화에 중요한 영향을 미치는 것으로 사료된다. Objective : This study was performed to evaluate the mammographic changes in breast density that were associated with hormone replacement therapy(HRT) in Korean postmenopausal women. Materials and Methods : In this retrospective study, 294 postmenopausal women were classified as the four groups according to the regimen of HRT; a daily treatment of tibolone 2.5 mg(n=119), conjugated equine estrogen(CEE) 0.625 mg/medroxyprogeserone(MPA) 2.5 mg(n=93), CEE 0.625 mg only(n=40) or raloxifene 60 mg(n=42), and they were compared with the control group of postmenopausal non-HRT users(n=36). Mammography was performed at baseline and after 1 year of treatment, and the incidence of changes in mammographic density was evaluated and compared among the groups. Results: There were no significant differences in age, parity, age at menopause, years after menopause, weight, height, and body mass index(BMI) among the groups. The risk of an increase in mammographic density after 1 year of treatment was significantly higher in CEE/MPA group(24/93, 25.8%), compared with tibolone(14/119, 11.8%) and raloxifene(1/42, 2.4%) group(p<0.05). Conclusion : This study showed that the changes in mammographic breast density related to postmenopausal HRT were dependent on the regimen of HRT. The continuous administration of progestogen as a component of the combined HRT seems to affect the breast density significantly.
Comparison of the Functional Components in Netted and Cantaloupe Melons
Deen Mohammad Deepo,Yun Jae Ahn,Hyeong Jin Eom,Dong Yup Hahn,Hong Yul Kim,Eung Kyoo Choi,Un Sun Hwang,Ki Byung Lim 경상대학교 농업생명과학연구원 2023 농업생명과학연구 Vol.57 No.3
This study assessed the utility of netted melon ‘Top Earl’s’ and cantaloupe melon ‘Alex’ as functional fruits by analysing their moisture content, vitreous sugar, folic acid, citric acid, and beta-carotene levels. High-performance liquid chromatography (HPLC) was used to analyse the free sugar, folic acid, citric acid, and beta-carotene levels. The moisture content was not significantly different between ‘Top Earl’s’ and ‘Alex.’ The glucose, sucrose, and fructose contents were three, two, and one-and-a-half fold higher in ‘Alex’ than in ‘Top Earl’s.’ Moreover, citric acid was approximately three times higher in ‘Alex’ than that in Top Earl’s.’ However, the folic acid content was higher in ‘Top ‘Earl’s’ than ‘Alex,’ and the amount was 124 μg / 100 g FW and 112 μg / 100 g FW respectively. ‘Beta-carotene was undetectable in ‘Top Earl’s,’ whereas it was 1000 μg / 100 g FW in ‘Alex.’ β-carotene, a substance that is converted in the body into vitamin A and acts as an antioxidant, is an important component in healthy food. These results suggested that the cantaloupe melon ‘Alex’ has a higher free sugar content and functional ingredients, such as antioxidants, including citric acid and beta carotene, than the netted melon ‘Top Earl’s.’
한국 비만 여성에서 인터루킨-1 베타 유전자 다형성과 사상체질과의 관련성 연구
이정훈 ( Jung Hun Lee ),서병윤 ( Byung Yun Seo ),한상엽 ( Sang Yup Han ),염승룡 ( Seung Ryong Yeom ),이수경 ( Soo Kyung Lee ),권영달 ( Young Dal Kwon ),송용선 ( Yung Sun Song ) 한방재활의학과학회 2005 한방재활의학과학회지 Vol.15 No.3
목적 : 사이토카인은 지방조직 대사의 중요한 조절인자이며 mRNA 발현 연구에서 지방세포가 IL-1β발현과 밀접한 관련이 있음이 입증되었 다. 본 연구에서는 비만, IL-1β유전자 내 엑손 (exon) 5의 +3953부위 다형성과 사상체질과의 관련성을 조사하였다. 방법 : 본 연구에서는 현저한 체질량지수 (body mass index, BMI) 다양성을 보이는 건강한 여성 181명을 대상으로 BMI와 사상체질에 따라 IL-1β유전자형을 PCR-RFLP를 이용, 분석하고, IL-1βT 대립유전자의 빈도를 측정하여 통계 처리하였다. 결과 : 체질량지수 25미만의 normal&overweight group에 비하여 obeseⅠ group (25≤BMI<30kg/m2)에서 IL-1βT 대립유전자의 빈도가 유의하 게 감소하였으나(OR = 0.296, CI = 0.09-0.99, P = 0.049), obese Ⅱ group에서는 통계적으로 유의성이 없었다. T 대립유전자 이형접 합체나 동형접합체 보유자는 물리적, 임상적인 특성에 있어서 유의한 차이를 보이지는 않았다. 더욱이 태음인에서 IL-1β T 대립유전 자의 빈도가 normal&overweight group에 비하여 obeseⅠ group (25≤BMI<30kg/m2)에서 명확하게 감소하였으나(OR = 0.152, CI = 0.04-0.60, P = 0.007), obese Ⅱ group에서는 통계적으로 유의성이 없었다. 결론 : 본 연구의 결과는 한국여성에서 IL-1β유전자와 BMI가 관련성이 있으며, 사상체질 분류상 특히 태음인과 관련성이 있는 것을 의미 한다.
치주치료를 받은(1981-1995) 환자들의 연령과 치료술식에 대한 조사 연구
이영석,염창엽,김상목,김병옥,한경윤,Lee, Young-Seok,Yun, Chang-Yup,Kim, Sang-Mok,Kim, Byung-Ock,Han, kyung-Yoon 대한치주과학회 2001 Journal of Periodontal & Implant Science Vol.31 No.1
The aim of this study was to recommend the optimal age for prevention of periodontal disease and to investigate the trend of treatment modality according to different period. From the chart recordings of the patients who had been treated periodontally from Jan. 1981 to Dec. 1995 in the dept .of periodontics, Chosun University Dental Hospital, those of the periodontally treated patients on more than 4 sixtants were selected for the present study. The distribution of the patients was counted according to the age group and the gender. And they were divided into 3 groups(group 1: 1987-1958, group 2: 1985-1990, group 3: 1991-1995) by 5 year interval according to the treated year. The periodontal treatment modalities were classified into non-surgical therapy, pocket elimination surgery, regenerative periodontal surgery, mucoginigival surgery, clinical crown lengthening, and others. The results were as follows; 1.In the distribution of the periodontally treated patients according to the age group, 40's age group was the highest, and 30's, 40's, and 50's age groups occupied more than two thirds(73%). 2.The sexual distribution of the periodontally treated patients showed that males(53.4%) were a little more than females(46.6%). Within 20's group female was higher, but within 40's male was higher. 3.Regardless of the age group and the gender, pocket elimination surgery was the most frequent treatment modality. 4.In group 1 and 2(1987-1990) the main treatment modality was pocket elimination surgery and non-surgical therapy, but in group 3(1991-1995) it was regenerative periodontal surgery and pocket elimination surgery. The above results suggest that the prevention of periodontal disease should be initiated from early twenties, and the most frequent treatment modality may be closely related with development of new material and method.
비외과적 치주처치의 선행 유무에 따른 치주 판막술 후 임상적 평가
신호범,염창엽,김상목,김병옥,한경윤,Sinn, Ho-Beom,Yun, Chang-Yup,Kim, Sang-Mok,Kim, Byung-Ock,Han, Kyung-Yoon 대한치주과학회 2001 Journal of Periodontal & Implant Science Vol.31 No.1
In the treatment of chronic adult periodontitis, scaling and root planing have been generally performed prior to periodontal flap surgery. The purpose of this study was to evaluate the clinical significance of nonsurgical periodontal therapy prior to periodontal flap surgery in patients with chronic adult periodontitis. Fifty six molars showing bilateral bony defects and 4-6mm periodontal pocket in twelve patients with chronic adult periodontitis were selected. By randomized split-mouth design, in one side, flap operation was performed 4 weeks after scaling and root planing, in the other group, flap operation was only performed without scaling and root planing. Probing pocket depth, gingival recession, clinical attachment level, gingival index, plaque index, and tooth mobility were measured at baseline, before flap operation and post-operation