Erratum to Tanshinone IIA Protects Endothelial Cells from H₂O₂-Induced Injuries via PXR Activation [Biomol Ther 25(6), 599-608 (2017)]

( Haiyan Zhu ),( Zhiwu Chen ),( Zengchun Ma ),( Hongling Tan ),( Chengrong Xiao ),( Xianglin Tang ),( Boli Zhang ),( Yuguang Wang ),( Yue Gao ) 한국응용약물학회 2024 Biomolecules & Therapeutics(구 응용약물학회지) Vol.32 No.2

Tanshinone IIA Protects Endothelial Cells from H₂O₂-Induced Injuries via PXR Activation

Zhu, Haiyan,Chen, Zhiwu,Ma, Zengchun,Tan, Hongling,Xiao, Chengrong,Tang, Xianglin,Zhang, Boli,Wang, Yuguang,Gao, Yue The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.6

Tanshinone IIA (Tan IIA) is a pharmacologically active substance extracted from the rhizome of Salvia miltiorrhiza Bunge (also known as the Chinese herb Danshen), and is widely used to treat atherosclerosis. The pregnane X receptor (PXR) is a nuclear receptor that is a key regulator of xenobiotic and endobiotic detoxification. Tan IIA is an efficacious PXR agonist that has a potential protective effect on endothelial injuries induced by xenobiotics and endobiotics via PXR activation. Previously numerous studies have demonstrated the possible effects of Tan IIA on human umbilical vein endothelial cells, but the further mechanism for its exerts the protective effect is not well established. To study the protective effects of Tan IIA against hydrogen peroxide ($H_2O_2$) in human umbilical vein endothelial cells (HUVECs), we pretreated cells with or without different concentrations of Tan IIA for 24 h, then exposed the cells to $400{\mu}M$ $H_2O_2$ for another 3 h. Therefore, our data strongly suggests that Tan IIA may lead to increased regeneration of glutathione (GSH) from the glutathione disulfide (GSSG) produced during the GSH peroxidase-catalyzed decomposition of $H_2O_2$ in HUVECs, and the PXR plays a significant role in this process. Tan IIA may also exert protective effects against $H_2O_2$-induced apoptosis through the mitochondrial apoptosis pathway associated with the participation of PXR. Tan IIA protected HUVECs from inflammatory mediators triggered by $H_2O_2$ via PXR activation. In conclusion, Tan IIA protected HUVECs against $H_2O_2$-induced cell injury through PXR-dependent mechanisms.

Tanshinone IIA Protects Endothelial Cells from H2O2-Induced Injuries via PXR Activation

Haiyan Zhu,Zhiwu Chen,Zengchun Ma,Hongling Tan,Chengrong Xiao,Xianglin Tang,Boli Zhang,Yuguang Wang,Yue Gao 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.6

Tanshinone IIA (Tan IIA) is a pharmacologically active substance extracted from the rhizome of Salvia miltiorrhiza Bunge (also known as the Chinese herb Danshen), and is widely used to treat atherosclerosis. The pregnane X receptor (PXR) is a nuclear receptor that is a key regulator of xenobiotic and endobiotic detoxification. Tan IIA is an efficacious PXR agonist that has a potential protective effect on endothelial injuries induced by xenobiotics and endobiotics via PXR activation. Previously numerous studies have demonstrated the possible effects of Tan IIA on human umbilical vein endothelial cells, but the further mechanism for its exerts the protective effect is not well established. To study the protective effects of Tan IIA against hydrogen peroxide (H2O2) in human umbilical vein endothelial cells (HUVECs), we pretreated cells with or without different concentrations of Tan IIA for 24 h, then exposed the cells to 400 μM H2O2 for another 3 h. Therefore, our data strongly suggests that Tan IIA may lead to increased regeneration of glutathione (GSH) from the glutathione disulfide (GSSG) produced during the GSH peroxidase-catalyzed decomposition of H2O2 in HUVECs, and the PXR plays a significant role in this process. Tan IIA may also exert protective effects against H2O2-induced apoptosis through the mitochondrial apoptosis pathway associated with the participation of PXR. Tan IIA protected HUVECs from inflammatory mediators triggered by H2O2 via PXR activation. In conclusion, Tan IIA protected HUVECs against H2O2-induced cell injury through PXR-dependent mechanisms.

Tanshinone IIA Protects Endothelial Cells from H₂O₂-Induced Injuries via PXR Activation

( Haiyan Zhu ),( Zhiwu Chen ),( Zengchun Ma ),( Hongling Tan ),( Chengrong Xiao ),( Xianglin Tang ),( Boli Zhang ),( Yuguang Wang ),( Yue Gao ) 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.6

Tanshinone IIA (Tan IIA) is a pharmacologically active substance extracted from the rhizome of Salvia miltiorrhiza Bunge (also known as the Chinese herb Danshen), and is widely used to treat atherosclerosis. The pregnane X receptor (PXR) is a nuclear receptor that is a key regulator of xenobiotic and endobiotic detoxification. Tan IIA is an efficacious PXR agonist that has a potential protective effect on endothelial injuries induced by xenobiotics and endobiotics via PXR activation. Previously numerous studies have demonstrated the possible effects of Tan IIA on human umbilical vein endothelial cells, but the further mechanism for its exerts the protective effect is not well established. To study the protective effects of Tan IIA against hydrogen peroxide (H₂O₂) in human umbilical vein endothelial cells (HUVECs), we pretreated cells with or without different concentrations of Tan IIA for 24 h, then exposed the cells to 400 μM H₂O₂ for another 3 h. Therefore, our data strongly suggests that Tan IIA may lead to increased regeneration of glutathione (GSH) from the glutathione disulfide (GSSG) produced during the GSH peroxidase-catalyzed decomposition of H₂O₂ in HUVECs, and the PXR plays a significant role in this process. Tan IIA may also exert protective effects against H₂O₂-induced apoptosis through the mitochondrial apoptosis pathway associated with the participation of PXR. Tan IIA protected HUVECs from inflammatory mediators triggered by H₂O₂ via PXR activation. In conclusion, Tan IIA protected HUVECs against H₂O₂-induced cell injury through PXR-dependent mechanisms.

Genetic individualization of sable (Martes zibellina L. 1758) using microsatellites

Bo Li,DanWu,Yingying Cai,Monakhov Vladimir G,Wei Zhang,Yanchun Xu 한국통합생물학회 2018 Animal cells and systems Vol.22 No.4

Genetic individualization based on non-invasive sampling is crucial for estimating the numbers of individuals in endangered mammalian populations. In sable (Martes zibellina)-poaching cases, identifying the number of animals involved is critical for determining the penalty. In addition, investigating animal numbers for wild sable populations requires genetic individualization when collecting several samples in neighboring regions. Microsatellites have been demonstrated to be reliable markers for individual identification. Thirty-three microsatellite loci derived from Mustelidae were selected to develop a genetic individualization method for sable. Three reference populations containing 54 unrelated sables were used to calculate allele number, allelic frequencies, and the polymorphic information content of each locus. The data were subsequently used to assess the validity of a combination of twelve loci for sable individualization. We defined twelve polymorphic loci that were easy to be amplified and genotyped. Four significant deviations from Hardy-Weinberg equilibrium were observed among the 12 loci in the three populations. The match probability of an individual from the reference populations with a random individual based on the 12 loci was 1.37 × 10−13. Using the combination of the twelve loci provides sufficient power to individualize sables considering the levels of microsatellite polymorphism observed. These loci were successfully applied to a case of sable poaching and provided valid evidence to determine the penalty. The genetic individualization of sable based on these loci might also be useful to investigate the numbers of animals in wild populations.

Containment Control for Directed Networks Multi-agent System with Nonlinear Dynamics and Communication Time-delays

Bo Li,Zengqiang Chen,Chun-yan Zhang,Zhong-Xin Liu,Qing Zhang 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.3

In this paper, containment control problem in directed networks for second-order multi-agent systemswith inherent nonlinear dynamics and time-delays are investigated. A distributed control protocol is proposedfor each follower using the relative states among neighboring agents. Based on Lyapunov-Razumikhin theorem,some sufficient conditions in terms of linear matrix inequalities (LMIs) are derived to ensure that all followersasymptotically converge to the convex hull spanned by the dynamic leaders. Finally, simulation results are presentedto illustrate the effectiveness of the conclusion.

A Method of Network Public Opinion Analysis Based on Quantum Particle Swarm Algorithm Optimization Least Square Vector Machine

Bo Li,BaoXing Bai,Changsheng Zhang,Yixue Jiang 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.8

Prediction of network public opinion is a complicated prediction featuring poor information, small samples and uncertainty. A prediction model of network public opinion based on grey support vector machine (SVM) is specified to increase prediction accuracy. First, network data are preprocessed by text clustering, hotpot extraction and data aggregation. Then a time series model GM(1,1) is established and SVM is used to modify prediction outcomes of GM(1,1). At last, simulation experiment is conducted to test performance of the model. Simulation results indicate that grey SVM improves the prediction accuracy of network public opinion compared with traditional prediction models. The predictions have certain practical values.

Modeling and Multi-objective Optimization Method of Machine Tool Energy Consumption Considering Tool Wear

Bo Li,Xitian Tian,Min Zhang 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.1

The natural energy crisis and the increasingly serious environmental problems have imposed all industries to reduce energy consumption. During milling process, selecting a correct cutting parameters can not only greatly improve production quality and processing efficiency, but also can reduce energy consumption, in addition, tool wear also has a great impact on them. Therefore, a milling power consumption model of CNC machine tools is established based on modern machining theory is established in this article, unlike traditional energy consumption models, our model takes full account of cutting conditions and tool wear. The surface roughness of parts is one of the important indicators to measure the machining quality of machine tools. Therefore, taking milling process as research object, a multi-objective cutting parameters optimization model that takes the machining surface roughness, material removal rate (MRR) and machining energy consumption as the optimization goals was established. Furthermore, an intelligent optimization algorithm was proposed based on improved Teaching–Learning- Based Optimization (TLBO) to solve the model under various limited milling conditions. Finally, comparing experimental results of optimized parameter and empirical parameters, it shows that goals of reducing energy consumption, improving productivity and machining quality can be achieved by optimizing cutting parameters.

Comprehensive analysis of the prognostic value and immune implications of the TTK gene in lung adenocarcinoma: a meta-analysis and bioinformatics analysis

Bo Li,Xiaojuan Gu,Hanbing Zhang,Hao Xiong 한국통합생물학회 2022 Animal cells and systems Vol.26 No.3

Background: High expression levels of the TTK gene are closely related to tumor occurrence and poor prognosis, as confirmed by some studies. Our study explored the prognosis of lung adenocarcinoma (LUAD) patients with different TTK levels and the possible pathological mechanism of TTK in LUAD. Methods: We extensively searched literature databases and high-throughput sequencing databases and included relevant literature or datasets in the meta-analysis according to the inclusion and exclusion criteria. Hazard ratios (HRs) and 95% confidence intervals (CIs) related to TTK expression were calculated, publication bias was assessed, and sensitivity tests were performed. We also compared the relationship between cancer immune infiltrating cells and tumor mutation burden (TMB) in patients with different TTK expression levels via bioinformatics analysis. The half maximal inhibitory concentration (IC50) of some chemotherapeutic and targeted therapy drugs were calculated. The potential biological functions or pathways associated with different TTK expression levels were determined by gene set enrichment analysis (GSEA). Results: The meta-analysis revealed that higher TTK expression level was significantly associated with poor prognosis in LUAD patients, both in overall survival (OS) and progression-free survival (PFS). The expression level of TTK was significantly correlated with presence of some immune cells and TMB. Tumors with higher TTK expression levels were mostly enriched for the cell cycle, DNA replication and homologous recombination pathways. In addition, patients with different TTK expression levels were differently sensitive to some antitumor drugs. Conclusion: TTK may be a promising prognostic biomarker for LUAD and is worthy of further investigation.