http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Bo- Gun Kho ) (검색결과 30 건)
- 무료
- 기관 내 무료
- 유료
-
-
Development of machine learning-based early warning system
( Bo-gun Kho ),( In-jae Oh ),( Min-seok Kim ),( Tae-ok Kim ),( Cheol-kyu Park ),( Young-chul Kim ),( Soon Whan Kang ),( Jae Hoon Jung ),( Sung Hoon Baek ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
A rapid response system is a patient safety system that prevents unexpected mortality by providing immediate interventions. But there are also difficulties in costs and human resources for implementation. Machine learning is an application of artificial intelligence that provides systems the ability to automatically learn and improve from experience without being explicitly programmed. We try to develop an early warning system to predict intubation and cardiopulmonary resuscitation using machine learning. The training set was composed of all patients admitted to Chonnam National University Hwasun Hospital for two years (event group 277 vs. non-event group 3576 cases), and the test set was made from all patients admitted to Chonnam National University Hospital for four months (event group 61 vs. non-event group 2334 cases). The algorithm is developed using blood pressure, heart rate, body temperature, respiratory rate, and oxygen saturation. We compared the ensemble model with recurrent neural network (RNN), random forest, logistic regression, and modified early warning score (MEWS) using receiver operating characteristic area under curve (ROC AUC) and precision recall AUC (PR AUC) analyses. The ROC AUC value of the ensemble model was 0.9219 and the PR AUC was 0.0732. This values showed higher tendency than those of other models (RNN: 0.8806 and 0.0732, random forest: 0.9125 and 0.0566, logistic regression: 0.8734 and 0.0513, MEWS: 0.7253 and 0.0468). And the score of the event group rose above the threshold 36 hours before events in the ensemble model. Development of machine learning-based early warning system is feasible because the ensemble model showed high ROC AUC value than traditional models. However, the low PR AUC value suggests that more efforts are needed to use in practice.
-
고보건 ( Bo Gun Kho ),고명주 ( Myoung Ju Koh ),김우정 ( Woo Jeung Kim ),김희욱 ( Hee Wook Kim ),허철웅 ( Cheal Wung Huh ),정혜문 ( Hye Moon Chung ),김형중 ( Hyung Jung Kim ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.2
Pulmonary sequestration is a rare congenital anomaly of the lung in which it is separately supplied from the aorta or one of its branches. Bilateral pulmonary sequestration is very rare, particularly in adults. In bilateral pulmonary sequestration, resection of both sides is usually recommended if both sides are infected and symptomatic. We report the case of a 37-year-old female patient with bilateral intralobar pulmonary sequestration treated by staged bilateral lower lobectomy.
-
Concordance with artificial intelligence and multidisciplinary tumor board for lung cancer
( Min-Seok Kim ),( Bo-Gun Kho ),( Chul-Kyu Park ),( In-Jae Oh ),( Young-Chul Kim ),( Seok Kim ),( Ju-Sik Yun ),( Sang-Yun Song ),( Kook-Joo Na ),( Jae-Uk Jeong ),( Mee Sun Yoon ),( Sung-Ja Ahn ),( Sae 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0
Background: IBM Watson for Oncology (WFO) is a cognitive computing system which helps physicians quickly identify key information from extensive medical records and explore best treatment option. We evaluated the level of agreement between WFO and multidisciplinary team (MDT) for lung cancer. Methods: From January to December 2018, newly diagnosed lung cancer cases in Chonnam National University Hwasun Hospital were retrospectively examined using WFO version 18.4 according to four treatment categories; surgery, radiotherapy, chemoradiotherapy, and palliative care - including chemotherapy, targeted therapy, immunotherapy. Treatment recommendations were considered concordant if the MDT recommendations were designated ‘recommended’ by WFO. The concordance between MDT and WFO was assessed by Cohen’s kappa value. Results: Total 405 (male 340, female 65) cases with different histology (adenocarcinoma 157, squamous cell carcinoma 132, small cell carcinoma 94, the others 22 cases) were enrolled in this study. The overall concordance rate between MDT and WFO was 92.4% (k=0.881, p<0.001). The strength of agreement was very good in stage 4 NS CLC (100%, k=1.000) and extensive disease SCLC (100%, k=1.000). The concordance was good in stage 1 NSCLC (92.4%, k=0.855) and moderate in stage 3 NSCLC (80.8%, k=0.622). But that was relatively low in stage 2 NSCLC (83.3%, k=0.556) and limited disease SCLC (84.6%, k=0.435). The discordant cases occurred in surgery (7/57, 12.3%), radiotherapy (2/12, 16.7%), and chemoradiotherapy (15/129, 11.6%). There was no discordance case in metastatic disease. Conclusion: Treatment recommendations made by WFO and MDT were different according to tumor stage, and WFO could be clinically useful in metastatic stage lung cancer. However patient-doctor relationship and shared decision making might be more important than artificial intelligence in non-metastatic stage.
-
-
Park, Ha-Young,Oh, In-Jae,Kho, Bo Gun,Kim, Tae-Ok,Shin, Hong-Joon,Park, Cheol Kyu,Kwon, Yong-Soo,Kim, Yu-Il,Lim, Sung-Chul,Kim, Young-Chul,Choi, Yoo-Duk The Korean Academy of Tuberculosis and Respiratory 2019 Tuberculosis and Respiratory Diseases Vol.82 No.3
Background: Programmed death-ligand 1 (PD-L1), a transmembrane protein, binds to the programmed death-1 (PD-1) receptor, and anti-PD-1 therapy enables immune responses against tumors. This study aimed to assess clinical characteristics of PD-L1 expression using immunohistochemistry among Korean patients with lung cancer. Methods: We retrospectively reviewed the data of patients with pathologically proven lung cancer from a single institution. PD-L1 expression determined by Tumor Proportion Score (TPS) was detected using 22C3 pharmDx (Agilent Technologies) and SP263 (Ventana Medical Systems) assays. Results: From July 2016 to July 2017, 267 patients were enrolled. The main histologic type was adenocarcinoma (69.3%). Most participants were smokers (67.4%) and had clinical stage IV disease (60.7%). In total, 116 (42%) and 58 (21%) patients had TPS ${\geq}1%$ and ${\geq}50%$, respectively. The patients were significantly older in TPS ${\geq}1%$ group than in TPS <1% group ($64.83{\pm}9.38years$ vs. $61.73{\pm}10.78years$, p=0.014), not in TPS ${\geq}50%$ cutoff value ($64.69{\pm}9.39$ vs. $62.36{\pm}10.51$, p=0.178). Regarding histologic grade, higher proportions of poorly differentiated tumor were observed in the TPS ${\geq}1%$ (40.8% vs. 25.8%, p=0.020) and TPS ${\geq}50%$ groups (53.2% vs. 27.2%, p=0.004). Among 34 patients examined with 22C3 and SP263 assays, 27 had positive results in both assays, with a cutoff of TPS ${\geq}1%$ (r=0.826; 95% confidence interval, 0.736-0.916). Conclusion: PD-L1 expression, defined as TPS ${\geq}1%$, was related to older age and poorly differentiated histology. There was a similar distribution of PD-L1 expression in both 22C3 and SP263 results.
-
( Ha-young Park ),( In-jae Oh ),( Bo Gun Kho ),( Tae-ok Kim ),( Hong-joon Shin ),( Cheol Kyu Park ),( Yong-soo Kwon ),( Yu-il Kim ),( Sung-chul Lim ),( Young-chul Kim ),( Yoo-duk Choi ) 대한결핵 및 호흡기학회 2019 Tuberculosis and Respiratory Diseases Vol.82 No.3
Background: Programmed death-ligand 1 (PD-L1), a transmembrane protein, binds to the programmed death-1 (PD- 1) receptor, and anti-PD-1 therapy enables immune responses against tumors. This study aimed to assess clinical characteristics of PD-L1 expression using immunohistochemistry among Korean patients with lung cancer. Methods: We retrospectively reviewed the data of patients with pathologically proven lung cancer from a single institution. PD-L1 expression determined by Tumor Proportion Score (TPS) was detected using 22C3 pharmDx (Agilent Technologies) and SP263 (Ventana Medical Systems) assays. Results: From July 2016 to July 2017, 267 patients were enrolled. The main histologic type was adenocarcinoma (69.3%). Most participants were smokers (67.4%) and had clinical stage IV disease (60.7%). In total, 116 (42%) and 58 (21%) patients had TPS ≥1% and ≥50%, respectively. The patients were significantly older in TPS ≥1% group than in TPS <1% group (64.83 ± 9.38 years vs. 61.73 ± 10.78 years, p=0.014), not in TPS ≥50% cutoff value (64.69 ± 9.39 vs. 62.36 ± 10.51, p= 0.178). Regarding histologic grade, higher proportions of poorly differentiated tumor were observed in the TPS ≥1% (40.8% vs. 25.8%, p=0.020) and TPS ≥50% groups (53.2% vs. 27.2%, p=0.004). Among 34 patients examined with 22C3 and SP263 assays, 27 had positive results in both assays, with a cutoff of TPS ≥1% (r=0.826; 95% confidence interval, 0.736-0.916). Conclusion: PD-L1 expression, defined as TPS ≥1%, was related to older age and poorly differentiated histology. There was a similar distribution of PD-L1 expression in both 22C3 and SP263 results.
-
P-49 Major adverse cardiovascular events and hyperuricemia during treatment of tuberculosis
( Hong-joon Shin ),( Ha-young Park ),( Bo-gun Kho ),( Jin-sun Chang ),( Tae-ok Kim ),( Cheol-kyu Park ),( Jung-hwan Lim ),( In-jae Oh ),( Yu-il Kim ),( Sung-chul Lim ),( Young-chul Kim ),( Yong-soo Kw 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Background: Hyperuricemia is common drug effect during treatment of tuberculosis consisting pyrazinamide (PZA). However, it is unclear the relationship between PZA-induced hyperuricemia and major adverse cardiovascular events (MACE). Aim: We evaluated the relationship between MACE and hyperuricemia in patients treated with PZA-based antituberculous drugs. Methods: We retrospectively reviewed the medical charts of patients who treated with tuberculosis at Chonnam National University Hospital between January 2010 and June 2017. Results: Total 1,674 patients were treated with tuberculosis. Among them, 229 patients were excluded due to lack of available serum uric acid levels because of early follow-up loss or local transfer. Mean age was 57.9 and 887 patients (61.4%) were male. Most patients (75.6%) who treated with tuberculosis were diagnosed pulmonary tuberculosis. The initial standard treatment regimens of isoniazid, rifampin, ethambutol, and PZA were introduced to most patients (92.9%). Among them, 61.9% patients at 2 weeks and 59.5% at 2 months form starting treatment had hyperuricemia. MACE were occured only 17 patients (1.2%) during treatment. There was no relationship between hyperuricemia and MACE in the univariate analysis (odds ratio, 0.72; 95% confidence interval, 0.18─2.90; P=0.648). Conclusion: Most patients who received PZA-based antituberculous drugs had hyperuricemia, however, it was not associated with development of MACE.
-
( Hong-joon Shin ),( Min-seok Kim ),( Bo Gun Kho ),( Ha Young Park ),( Tae-ok Kim ),( Cheol-kyu Park ),( Yong-soo Kwon ),( In-jae Oh ),( Yu-il Kim ),( Sung-chul Lim ),( Young- Chul Kim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Pneumocystis jirovecii pneumonia (PCP) is a fatal respiratory infection frequently associated with immunocompromised (IC) conditions. Although PCP has been reported in non-immunocompromised (non-IC) patients, however, few studies have been conducted. This study was aimed to compare the clinical characteristics and prognosis of PCP in IC and non-IC patients. Methods: We retrospectively analyzed patients who were suspected of having PCP with polymerase chain reaction (PCR) test positive for Pneumocystis jirovecii from January 2013 to May 2019. IC group was classified into human immunodeficiency virus (HIV), hematologic, solid organ tumor, rheumatologic and immunosuppressive agent group. Results: A total 192 PCP cases including 176 IC cases and 16 non-IC cases were analyzed. Patients were older in the non-IC group compared with the IC group (72.5 vs. 62.0, P=0.002). Hematologic malignancy was the most common (47.2%), followed by HIV (14.8%) in the IC group. The interval between test for PCP-PCR and PCP treatment was shorter in the IC group compared with non-IC group (0 [0-3] vs. 4.0 [2.2-7.7] days, P=0.001). In-hospital mortality was not significantly different between IC and non-IC groups (43.2% vs. 62.5%, P=0.189). Age (odds ratio [OR] 1.05; 95% confidence interval [CI] 1.02-1.09; P=0.002) and PaO<sub>2</sub>/FiO<sub>2</sub> (OR 0.99; 95% CI 0.98-1.00; P=0.039) were the prognostic factors for in-hospital mortality in the multivariate logistic regression analysis. There was no significant difference between IC and non-IC group in 6-month survival. However, HIV group had better 6-month survival compared with non- IC group in the subgroup analysis (Hazard ratio 0.16; 95% CI 0.05-0.53; P=0.003]. Conclusion: Patients with PCP in non-IC group were older than IC group, and had similar prognosis as other IC group except HIV group.
-
( Hong-joon Shin ),( Jae-kyeong Lee ),( Hyung-joo Oh ),( Min-seok Kim ),( Bo Gun Kho ),( Ha Young Park ),( Tae-ok Kim ),( Cheol-kyu Park ),( Yong-soo Kwon ),( In-jae Oh ),( Yu-il Kim ),( Sung-chul Lim 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background TB transmission in hospital is still concern problem. Airborne isolation can be discontinued in hospitalized patients with suspected active pulmonary TB when three consecutive sputum AFB smears are negative. However, bronchoscopy is performed in patients with difficult sputum exams. This study was investigated usefulness of TB-PCR with bronchial washing to predict discontinuation of airborne isolation in patients with suspected active pulmonary tuberculosis . Methods We retrospectively reviewed hospitalized patients underwent bronchoscopy who were isolated for suspected active pulmonary TB from January 2016 to December 2019. Patients who were positive for sputum TB-PCR were excluded. The criteria for discontinuation of airborne isolation was negative for three consecutive sputum AFB smears. Results Total 170 patients were enrolled. Males were 103 (60.6%) and mean age was 64.5. The Results of sputum AFB smear were negative in 150 patients, positive in 9 patients. Total 139 patients underwent sputum PCR, and the Results were all negative. AFB smears and TB-PCRs for bronchial washing were positive in 12 and 26 patients, respectively. Eleven patients were negative for AFB smear and TB-PCR of bronchial washing, but TB grew in culture. Of these patients, 5 had negative Results for three consecutive sputum AFB smears. But 6 patients tested of sputum AFB smears within 2 times. TB was finally excluded in 133 patients. Predictive value for discontinuation of airborne isolation by TB-PCR of bronchial washing was 95.8%. Conclusion Although the negative Results for bronchial washing cannot exclude pulmonary TB, the Results can predict discontinuation of airborne isolation in patients with suspected active pulmonary TB.
ScienceON연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
