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        • Potential Therapeutic Targets for the Primary Gallbladder Carcinoma: Estrogen Receptors

          Zhang,,Ling-Qiang,Zhang,,Xiu-De,Xu,,Jia,Wan,,Yong,Qu,,Kai,Zhang,,Jing-Yao,Wang,,Zhi-Xin,Wei,,Ji-Chao,Meng,,Fan-Di,Tai,,Ming-Hui,Zhou,,Lei,Liu,,Chang Asian Pacific Organization for Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

          Gallbladder carcinoma, the most frequent malignant neoplasm of the biliary tract system, has always been considered to feature late clinical presentation and diagnosis, limited treatment options and an extremely poor prognosis. In recent years, while the incidence of gallbladder cancer has appeared to be on the increase, the available treatment methods have not greatly improved survival of the affected patients. Thus, exploring new therapeutic targets for this devastating disease is an urgent matter at present. Epidemical studies have demonstrated that the incidence of gallbladder carcinoma exhibits a distinct gender bias, affecting females two to three times more than males, pointing to crucial roles of estrogen. It is well known that estrogen acts on target tissues by binding to estrogen receptors (ERs), which are mainly divided into three subtypes, $ER{\alpha}$, $ER{\beta}$ and $ER{\gamma}$. $ER{\alpha}$ and $ER{\beta}$ appear to have overlapping but also unique even opposite biological effects. As important pathogenic mediators, ERs have been considered to relate to several kinds of tumors. In gallbladder carcinoma tissue, ERs have been shown to be positively expressed, and ERs expression levels are associated with differentiation and prognosis of this cancer. Nevertheless, the exact mechanisms of estrogen inducing growth of gallbladder carcinoma remain poorly understood. On the base of the current investigations, we deduce that estrogen participates in promotion of gallbladder carcinoma by influencing the formation of gallstones, stimulating angiogenesis, and promoting abnormal proliferation. Since ERs mediate the carcinogenic actions of estrogen in gallbladder, and therapy targeting ERs may provide new directions for gallbladder carcinoma. Therefore, it should be stressed that ERs are potential therapeutic targets for gallbladder carcinoma.

        • KCI등재후보

          FEW WALLED CARBON NANOTUBE PRODUCTION IN LARGE-SCALE BY NANO-AGGLOMERATE FLUIDIZED-BED PROCESS

          QIANG,ZHANG,HAO,YU,YI,LIU,WEIZHONG,QIAN,YAO,WANG,GUOHUA,LUO,FEI,WEI 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2008 NANO Vol.3 No.1

          Few walled carbon nanotubes (FWCNTs) have been successfully synthesized using a nano-agglomerate fluidized-bed process. FWCNTs can be obtained by fluidization of Fe(Co/Ni)/Mo/MgO catalysts at a high temperature with methane cracking in a nano-agglomerate fluidized-bed reactor. The products were mainly 2 to 5 walled CNTs with an outer diameter of 1–7 nm in high purity, as revealed by Raman spectrometry, SEM, and HRTEM analysis. Two keys were crucial for this process. The first key was to get the small size of activity catalyst particles which was realized by Mo addition in catalyst. The graphitization of FWCNTs strongly depended on the composition of catalyst. Fe/Mo/MgO catalyst showed the highest activity and the FWCNT product with the best graphitization. Another key for this process was that the particles must be kept in fluidized state during FWCNT formation. Detailed process information was reported in this article, which showed a potential way for the large scale production of FWCNTs, thereby the urgent need for FWCNTs in high performance will be overcome.

        • KCI등재SCOPUS

          Facile Preparation of Mechanical Reinforced and Biocompatible Silk Gels

          Qiang,Zhang,Guocong,Han,Chen,Lu,Qiusheng,Wang,Xiufang,Li,Zuwei,Luo,Renchuan,You,Shuqin,Yan 한국섬유공학회 2019 Fibers and polymers Vol.20 No.4

          Nontoxic and controllable way to fabricate silk fibroin (SF) gel with high mechanical properties is of critical important to biomaterial in tissue engineering. Electrochemically triggered electrophoretic migration and electric charge of the silk molecules both contributed to SF microspheres and electronic gel (e-gel) formation by sol-gel transition. In this study, a novel silk pH e-gel with higher mechanical property was prepared by combining low-voltage electric fields with isoelectric point (pI) adjustment. This green process was mild and friendly without chemical crosslinker. Compressive modulus of the silk pH e-gel was up to 70 MPa that was significantly higher than that of SF gelation spontaneously. Furthermore, analysis of molecule conformation of the silk pH-e-gel demonstrated that most of random coil structures transformed into α-helix and a little β-sheet structures during this process. The silk pH e-gel was loaded with rhodamine B and showed an obvious sustainable release profile. Accumulation releasing amounts was approximately 60 % at day 9. Cytocompatibility of the silk pH-e-gel was evaluated by epithelial cell. The results showed that the gels could support the cell growth and proliferation in vitro. Finally, gel biodegradation was assessed by protease XIV. After biodegradation for 28 days, remaining weight of the gel was about 20.23±2.59 wt%, indicating its good biodegradability. This novel process was established successfully by combining low voltage field with pH-control, which provided an alternative material for regenerative medicine.

        • KCI등재SCOPUS

          Effects of Copper Oxide and Carbon Nanotubes on Thermal Stability of Silicone Rubber Nanocomposites

          Qiang,Zhang,Lu,Bai,Junping,Zheng 한국고분자학회 2016 폴리머 Vol.40 No.2

          Silicone rubber (SR) filled with carbon nanotubes (CNTs), copper oxide (CuO) and CuO modified CNTs (CuO-CNTs) were prepared to detect the effects of these additives on thermal stability of SR by thermogravimetric analysis and tensile testing before and after aging. Flynn-Wall-Ozawa method was also employed to analyze the thermal degradation kinetics. The results indicated that all the additives could increase the initial thermal degradation temperature and thermal oxidative aging properties of SR and a synergistic effect was found in CuO-CNTs/SR. Meanwhile, activation energies of SR filled with additives increased significantly relative to neat SR and found to be optimal for CuO-CNTs/SR with activation energy increasing to 231.29, 121.68 kJ·mol-1 larger than that of blank sample. It is because that CNTs and CuO could promote each other to capture the free radicals generated by thermal oxidative reaction of the methyl side groups and thereby terminate the process.

        • KCI등재후보

          SYNTHESIS OF SINGLE-WALLED CARBON NANOTUBES FROM LIQUEFIED PETROLEUM GAS

          QIANG,ZHANG,YI,LIU,JIAQI,HUANG,WEIZHONG,QIAN,YAO,WANG,FEI,WEI 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2008 NANO Vol.3 No.2

          Hydrocarbons such as methane, ethylene, and CO with high purity (> 99.9%) have been widely used to synthesize single-walled carbon nanotubes (SWCNTs). Here, liquefied petroleum gas (LPG) was used to synthesize SWCNTs by catalytic chemical vapor deposition. The LPG converted into CNTs and other stable hydrocarbons. The BET specific surface area of SWCNT was about 583 m2/g. The as-grown SWCNT showed good graphitization. The graphitization can be further modulated by the growth temperature. Certain amount of sulfur in LPG was a promoter for SWCNT growth. Compared SWCNTs obtained from methane, more semiconductive SWCNTs were synthesized from LPG as carbon source. The LPG is in low price, thus, a methodology to lower the production cost of SWCNTs with hydrocarbon mixtures is realized.

        • SCIESCOPUSKCI등재

          CORROSION BEHAVIOR OF NI-BASE ALLOYS IN SUPERCRITICAL WATER

          Zhang,,Qiang,Tang,,Rui,Li,,Cong,Luo,,Xin,Long,,Chongsheng,Yin,,Kaiju Korean Nuclear Society 2009 Nuclear Engineering and Technology Vol.41 No.2

          Corrosion of nickel-base alloys (Hastelloy C-276, Inconel 625, and Inconel X-750) in $500^{\circ}C$, 25 MPa supercritical water (with 10 wppb oxygen) was investigated to evaluate the suitability of these alloys for use in supercritical water reactors. Oxide scales formed on the samples were characterized by gravimetry, scanning electron microscopy/energy dispersive spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The results indicate that, during the 1000 h exposure, a dense spinel oxide layer, mainly consisting of a fine Cr-rich inner layer ($NiCr_2O_4$) underneath a coarse Fe-rich outer layer ($NiFe_2O_4$), developed on each alloy. Besides general corrosion, nodular corrosion occurred on alloy 625 possibly resulting from local attack of ${\gamma}"$ clusters in the matrix. The mass gains for all alloys were small, while alloy X-750 exhibited the highest oxidation rate, probably due to the absence of Mo.

        • KCI등재SCOPUS

          CORROSION BEHAVIOR OF NI-BASE ALLOYS IN SUPERCRITICAL WATER

          QIANG,ZHANG,RUI,TANG,CONG,LI,XIN,LUO,CHONGSHENG,LONG,KAIJU,YIN 한국원자력학회 2009 Nuclear Engineering and Technology Vol.41 No.1

          Corrosion of nickel-base alloys (Hastelloy C-276, Inconel 625, and Inconel X-750) in 500 °C, 25 MPa supercritical water (with 10 wppb oxygen) was investigated to evaluate the suitability of these alloys for use in supercritical water reactors. Oxide scales formed on the samples were characterized by gravimetry, scanning electron microscopy/energy dispersive spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The results indicate that, during the 1000 h exposure, a dense spinel oxide layer, mainly consisting of a fine Cr-rich inner layer (NiCr2O4) underneath a coarse Fe-rich outer layer (NiFe2O4), developed on each alloy. Besides general corrosion, nodular corrosion occurred on alloy 625 possibly resulting from local attack of ” clusters in the matrix. The mass gains for all alloys were small, while alloy X-750 exhibited the highest oxidation rate, probably due to the absence of Mo.

        • Design of Course-Keeping Controller for a Ship Based on Backstepping and Neural Networks

          Qiang,ZHANG,Na,JIANG,Yancai,HU,Dewei,PAN 국제이네비해양경제학회 2017 International Journal of e-Navigation and Maritime Vol.7 No.1

          Due to the existence of uncertainties and the unknown time variant environmental disturbances for ship course nonlinear control system, the ship course adaptive neural network robust course-keeping controller is designed by combining the backstepping technique. The neural networks (NNs) are employed for the compensating of the nonlinear term of the nonlinear ship course-keeping control system. The designed adaptive laws are designed to estimate the weights of NNs and the bounds of unknown environmental disturbances. The first order commander are introduced to solve the problem of repeating differential operations in the traditional backstepping design method, which let the designed controller easier to implement in navigation practice and structure simplicity. Theoretically, it indicates that the proposed controller can track the setting course in arbitrary expected accuracy, while keeping all control signals in the ship course control closed-loop system are uniformly ultimately bounded. Finally, the training ship of Dalian Maritime University is taken for example; simulation results illustrated the effectiveness and the robustness of the proposed controller.

        • Clinical Significance of SH2B1 Adaptor Protein Expression in Non-small Cell Lung Cancer

          Zhang,,Hang,Duan,,Chao-Jun,Chen,,Wei,Wang,,Shao-Qiang,Zhang,,Sheng-Kang,Dong,,Shuo,Cheng,,Yuan-Da,Zhang,,Chun-Fang Asian Pacific Organization for Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

          The SH2B1 adaptor protein is recruited to multiple ligand-activated receptor tyrosine kinases that play important role in the physiologic and pathologic features of many cancers. The purpose of this study was to assess SH2B1 expression and to explore its contribution to the non-small cell lung cancer (NSCLC). Methods: SH2B1 expression in 114 primary NSCLC tissue specimens was analyzed by immunohistochemistry and correlated with clinicopathological parameters and patients' outcome. Additionally, 15 paired NSCLC background tissues, 5 NSCLC cell lines and a normal HBE cell line were evaluated for SH2B1 expression by RT-PCR and immunoblotting, immunofluorescence being applied for the cell lines. Results: SH2B1 was found to be overexpressed in NSCLC tissues and NSCLC cell lines. More importantly, high SH2B1 expression was significantly associated with tumor grade, tumor size, clinical stage, lymph node metastasis, and recurrence respectively. Survival analysis demonstrated that patients with high SH2B1 expression had both poorer disease-free survival and overall survival than other patients. Multivariate Cox regression analysis revealed that SH2B1 overexpression was an independent prognostic factor for patients with NSCLC. Conclusions: Our findings suggest that the SH2B1 protein may contribute to the malignant progression of NSCLC and could offer a novel prognostic indicator for patients with NSCLC.

        • Design of LPG Remote Cargo Operation Simulator with Automatic Bargaining Function

          Zhang,Qiang,Zhou,Xinwei 국제이네비해양경제학회 2019 International Journal of e-Navigation and Maritime Vol.13 No.1

          Liquefied gas carrier cargo handling operations are critical to ship safety. In order to improve the quality and efficiency of cargo handling of liquefied gas carriers, the loading and unloading operation of the liquefied gas carrier was studied and a set of LPG remote cargo operation simulator with automatic bargaining function was designed. Introducing the components of the simulator: the console unit and the simulated cargo tank unit in brief, the design ideas and specific functions of the automatic barge and remote control of the core part of the system are introduced in detail. The simulator feasibility verification is carried out by comparing the error between the actual loading and unloading operation with the system simulation loading and unloading operation. The simulation training functions verification is carried out by testing people who use the simulator for training. The final results show that the error is within the acceptable range, and people who use the simulator for training can pass an authoritative comprehensive exam. It is shown that that the system can simulate the important operations in the cargo handling process and has an excellent training effect.

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