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In this study, we examined a case where lung cancer metastasized to the vulvar area. A 79-year-old woman that was a heavy smoker was referred to our department with a short (two-week) history of dyspnea, and with a painful nodule on her right labium majora, which she had noticed almost three years earlier. Histopathologically, the specimen appeared as a poorly differentiated squamous cell carcinoma. The chest X-ray, chest computerized tomography scan, and percutaneous transthoracic needle biopsy via bronchoscopy revealed squamous cell carcinoma in the right upper lobe of the lung. Based on these clinical and histopathological findings, we concluded that her condition was skin metastasis at the right labium majora from the lung cancer, which occurs very rarely. (Ann Dermatol 23(S2) S179~S181, 2011)
In this study, we examined a case where lung cancer metastasized to the vulvar area. A 79-year-old woman that was a heavy smoker was referred to our department with a short (two-week) history of dyspnea, and with a painful nodule on her right labium majora, which she had noticed almost three years earlier. Histopathologically, the specimen appeared as a poorly differentiated squamous cell carcinoma. The chest X-ray, chest computerized tomography scan, and percutaneous transthoracic needle biopsy via bronchoscopy revealed squamous cell carcinoma in the right upper lobe of the lung. Based on these clinical and histopathological findings, we concluded that her condition was skin metastasis at the right labium majora from the lung cancer, which occurs very rarely. (Ann Dermatol 23(S2)S179∼S181, 2011)
Carcinoid tumors are derived from enterochromaffin cells that are capable of producing a wide range of neuroendocrine mediators including serotonin or 5-hydroxytryptamine. Carcinoid syndrome occurs when mediators produced by the tumor and normally metabolized by the liver escape into the systemic circulation. The syndrome classically involves the gastrointestinal tract, respiratory system, cardiovascular system and the skin. Flushing is almost universal in the syndrome. A 23-year-old woman came to our hospital presenting with flushing on face and trunk. The patient had experienced flushing for 2 years and it was aggravated by emotional change, stress, exercise, and eating spicy food. The patient also had abdominal pain, diarrhea, weight loss and hepatomegaly. Urinary 5-hydroxyindoleacetic acid was elevated (81.5 mg/day). Abdominal computed tomography scans showed multiple hepatic masses diagnosed as a carcinoid tumor by computed tomography-guided needle biopsy. Physicians should consider carcinoid syndrome when patients present with flushing and systemic symptoms. (Korean J Dermatol 2011;49(11):1006∼1009)
Angiosarcoma is a rare malignant tumor of an endothelial cell derivation and it accounts for less than 2% of all sarcomas. It is a highly aggressive neoplasm with a poor prognosis and most patients die within a short period after presentation. Although angiosarcoma may occur in any location on the body, it rarely arises from major vessels, but has a decided predilection for the skin and superficial soft tissue. A 39-year-old man was referred to our department with an asymptomatic, firm, ulcerative nodule on his scalp that was noticed almost 2 months previously. He had been diagnosed with lung angiosarcoma 9 month earlier. Histopathologically, the skin specimen showed angiosarcoma. The histological findings of the metastatic skin cancer are usually the same as that of the primary cancer. Metastatic cutaneous angiosarcoma is uncommon. Based on these clinical and histopathological findings, our case seems to be skin metastasis at the scalp from the lung angiosarcoma. (Korean J Dermatol 2011;49(6):520∼523)
Pachyonychia congenita (PC) is characterized by hypertrophic nail dystrophy, focal palmoplantar keratoderma and blistering, oral leukokeratosis, cyst formation, palmoplantar hyperhydrosis, and follicular keratoses on the trunk and extremities. PC is diagnosed by clinical findings and molecular genetic studies. A 26-year-old man presented with hypertrophic nail dystrophy and subungual debris of all 20 nails, hyperkeratotic plaques on the heels of both soles, and oral leukokeratosis. He had no family history of similar clinical findings. The patient`s clinical presentation and history were consistent with PC. Herein we report on a rare case of pachyonychia congenita with a review of literature. (Korean J Dermatol 2011;49(3):265∼268)
Background: Advances in medicine and improved overall standard of living have brought people`s attention to living a long healthy life. As a consequence, geriatric medicine is now gaining more and more attention in the field of medicine and dermatology is no exception. Objective: The aim of this study was to examine features of the elderly in terms of the prevalence of dermatosis and general and medical skin care patterns. Methods: A detailed survey and complete physical examination were performed on 525 patients aged over 65, who were treated at the endocrinology center at our hospital, from January to December 2011. Results: The elderly gained most information on dermatologic diseases from their families and neighbors. The most common dermatologic disorder was senile lentigo (85.5%), followed by seborrheic keratosis (69.0%), xerosis cutis (63.0%), generalized pruritus (42.3%), onychomycosis (30.3%), and cherry angioma (26.9%). Furthermore, xerosis cutis was more often found in older patient groups among the elderly. When it comes to general skin care, one third of the elderly used moisturizers and 10.7% used sunscreens. Only 1.3% of the elderly received medical skin care. Conclusion: This study can be used as useful baseline data not only for the government to formulate a national health care plan but for each medical center to understand dermatologic disorders of the elderly and educate its staff members on the management of dermatologic problems of the elderly. (Korean J Dermatol 2013;51(1):1∼7)
In this study, comparison of theoretical solutions with experimental results is examined through fracture conditions for the case of float glasses subjected static loading. The range of fracture generation limits and critical penetration energies are solved according to the impactor mass under the high velocity, and analytical method of fracture strength and penetration strength are presented. Also, fracture patterns are investigated according to impact velocities. The results obtained from this study are as follows; 1) Radial cracks are generated from the loading point regardless of plate thickness in the case of the plate subjected to the static loading. In the case of high-speed impact, dimensions of ring cracks become to smaller and length of radial cracks becomes shorter with the rapidity of impact velocity. 2) Kinetic change volume of collision after/before is constant regardless of velocities over the range of critical penetration velocity. 3) Although the same impact energy is working, the critical penetration energy is increased with the shorter of impactor mass. 4) Although the same impact energy is working, the penetration fracture of lighter impactor mass is generated more than that of heavier impactor mass, and the impulse of lighter impacter mass appear more than that of heavier impactor mass. Therefore, the penetration fracture in the case of greater impulse is generated earlier regardless of the of the dimensions of impact loading.