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Park, J. M.,Choi, M.-G.,Kim, S. W.,Chung, I.-S.,Yang, C. W.,Kim, Y. S.,Jung, C. K.,Lee, K. Y.,Kang, J.-H. Wiley (Blackwell Publishing) 2010 American journal of transplantation Vol.10 No.9
<P>This study was to evaluate the frequency of colorectal neoplasia in renal transplant recipients and to investigate the association with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection. We compared the frequency of colorectal neoplasia among renal transplant recipients with that of the healthy subjects. Specimens of colorectal neoplasia were examined for EBV and CMV using in situ hybridization and immunohistochemistry, respectively. Of 796 renal transplantation cohorts, 315 were enrolled. The frequency of colorectal neoplasia among the patients was 22.9%. Compared with the healthy subjects, the odds ratio (OR) for advanced adenoma was 3.32 (95% CI, 1.81-6.10). The frequency of cancer among the patients was 1.9% (OR, 12.0; 95% CI, 1.45-99.7). A long interval between transplantation and colonoscopy was a significant factor in the development of advanced colorectal neoplasia. EBV positivity was detected in 30.6% of colorectal neoplasia specimens from renal transplant recipients, which was higher than that for the controls (p = 0.002). CMV was not detected in any lesions of patients or controls. In conclusion, renal transplant recipients have a significantly increased risk of advanced colorectal neoplasia. EBV was more frequently found in specimens of advanced colorectal neoplasm obtained from the renal transplant recipients.</P>
Kim, Seo Young,Kim, Jong-Eun,Lee, Ki Won,Lee, Hyong Joo Wiley (Blackwell Publishing) 2009 Annals of the New York Academy of Sciences Vol.1171 No.1
<P>We investigated the antiproliferative effects of the cytoplasmic fraction of Lactococcus lactis ssp. lactis (L.lac CF) on the SNU-1 human stomach cancer cell line. The proliferation of SNU-1 cells was inhibited by treatment with L.lac CF in a time- and dose-dependent manner. L.lac CF caused G0/G1 cell cycle arrest, which was associated with an increase in p53 and p21 expression, the reduction of cyclin D1 expression, and retinoblastoma protein phosphorylation. L.lac CF induced apoptosis in SNU-1 cells, as demonstrated by increased nucleus condensation and a sub-G1 peak. Caspase-3 activation, the induction of p53, and the downregulation of Bcl-2 were also observed in L.lac CF-treated cells. Thus, the inhibitory effect of L.lac CF on SNU-1 cell growth is mainly attributable to the induction of G0/G1 cell cycle arrest and apoptosis.</P>
Jang, Young Jin,Kim, Jong-Eun,Kang, Nam Joo,Lee, Ki Won,Lee, Hyong Joo Wiley (Blackwell Publishing) 2009 Annals of the New York Academy of Sciences Vol.1171 No.1
<P>Alzheimer's disease (AD) is an age-related neurodegenerative disorder in which apoptosis plays a potentially important role. 4-Hydroxynonenal (HNE) is a major lipid peroxidation product produced by oxidative stress, and its level is elevated in the AD brain. In the present study, piceatannol (but not resveratrol) at the concentration of 20 micromol/L inhibited HNE-induced PC12 cell death. Treatment with HNE induced nuclear condensation in PC12 cells, and this was attenuated by piceatannol treatment. HNE induced poly(ADP-ribose) polymerase cleavage and decreased Bcl-2 expression, with both of these effects being attenuated by piceatannol. Piceatannol also inhibited the phosphorylation of c-Jun N-terminal kinase, which is a key regulator of HNE-induced PC12 cell death. These results indicate that piceatannol has therapeutic potential in the prevention of AD.</P>
Steroid Biosynthesis within the Frog Brain : A Model of Neuroendocrine Regulation
Rego, Jean-Luc Do,Seong, Jae Young,Burel, Delphine,Luu-The, Van,Larhammar, Dan,Tsutsui, Kazuyoshi,Pelletier, Georges,Tonon, Marie-Christine,Vaudry, Hubert Wiley (Blackwell Publishing) 2009 Annals of the New York Academy of Sciences Vol.1163 No.1
<P>There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes are biologically active, as shown by the ability of brain tissue explants to convert [(3)H]pregnenolone into various radiolabeled steroids. The frog brain has also been extensively used as a model to study the mechanism of regulation of neurosteroidogenesis by neurotransmitters and neuropeptides. It has been demonstrated that the biosynthesis of neurosteroids is inhibited by gamma-aminobutyric acid (GABA), acting through GABA(A) receptors, and neuropeptide Y, acting through Y1 receptors, and is stimulated by the octadecaneuropeptide (ODN), acting through central-type benzodiazepine receptors, triakontatetraneuropeptide (TTN), acting through peripheral-type benzodiazepine receptors, and vasotocin, acting through V1a-like receptors. These data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis.</P>
Kang, Min Kyung,Kang, Nam Joo,Jang, Young Jin,Lee, Ki Won,Lee, Hyong Joo Wiley (Blackwell Publishing) 2009 Annals of the New York Academy of Sciences Vol.1171 No.1
<P>Oxidative stress induced by reactive oxygen species (ROS) is strongly associated with the pathogenesis of various neurodegenerative disorders, including Alzheimer's disease. We investigated the possible combined effects of gallic acid and resveratrol, which are major antioxidants present in fruit, including grapes, on PC12 rat pheochromocytoma (PC12) cell death. Gallic acid did not protect against H(2)O(2)-induced PC12 cell death; it reduced the viability of PC12 cells in a dose-dependent manner. Gallic acid also induced cleavage of poly (ADP-ribose) polymerase, which is strongly related to apoptosis in neurons. Gallic acid induced the phosphorylation of c-Jun N-terminal protein kinase (JNK) and the downregulation of Bcl-2 in PC12 cells. Treatment of PC12 cells with resveratrol increased their viability in a dose-dependent manner by blocking the activation of JNK and the downregulation of Bcl-2. Furthermore, gallic acid led to a progressive reduction in the viability of vector-transfected PC12 cells, which was delayed in PC12 cells that overexpressed Bcl-2. The JNK inhibitor SP600125 protected against gallic acid-induced PC12 cell death. Collectively, these findings suggest that the combined effects of dietary phenolic phytochemicals on oxidative neuronal cell death and antioxidants differ in ROS-mediated neuronal cell death.</P>
Cloning and Expression of Vitellogenin 2 Gene from the Intertidal Copepod Tigriopus japonicus
Hwang, Dae-Sik,Lee, Kyun-Woo,Lee, Jae-Seong Wiley (Blackwell Publishing) 2009 Annals of the New York Academy of Sciences Vol.1163 No.1
<P>Vitellogenin (Vg) is the precursor of the egg yolk protein vitellin. Vg induction has been used as a biomarker of exposure to endocrine disrupting chemicals in fish. However, in copepods limited information on the Vg gene is available only from two species, the salmon louse Lepeophtheirus salmonis and the intertidal copepod Tigriopus japonicus. By differential display of RNA expression between male and female adults, we identified another Vg member, i.e., vitellogenin 2 (Vg2) gene from T. japonicus. The full cDNA sequence was 5629 bp containing 5400 bp of an open reading frame. The expression of Vg transcripts was negligible in all naupliar stages and copepodid stages 1 to 4 but was detectable in female copepods of stage 5 and 6. Female adults expressed over 270 times more Vg transcripts than male adults.</P>
Rituximab-induced vasculitis: A case report and review of the medical published work
KIM, Min Joo,KIM, Hyung Ok,KIM, Ho Yeon,PARK, Young Min Wiley (Blackwell Publishing) 2009 The Journal of Dermatology Vol.36 No.5
<P>Rituximab is an anti-CD20 chimeric murine/human monoclonal antibody mainly used in the treatment of patients with a cutaneous lymphoid malignancy. Among the side-effects associated with rituximab administration, vasculitis has been rarely reported. There are two reported cases in the English language medical published work. We describe a 38-year-old Korean man with cutaneous vasculitis occurring 1 day after rituximab administration.</P>
Kim, Mi-Sung,Kwon, Jung Yeon,Kang, Nam Joo,Lee, Ki Won,Lee, Hyong Joo Wiley (Blackwell Publishing) 2009 Annals of the New York Academy of Sciences Vol.1171 No.1
<P>Mutations in Ras play a critical role in the development of human cancers, including breast cancer. We investigated the possible antiproliferative effects of the naturally occurring dihydrochalcone phloretin [2',4',6'-trihydroxy-3-(4-hydroxyphenyl)-propiophenone] on H-Ras-transformed MCF10A human breast epithelial (H-Ras MCF10A) cells. Phloretin suppressed H-Ras MCF10A cell proliferation in a dose-dependent manner and induced nuclear condensation in the cells, indicating that phloretin-induced cell death occurs mainly via the induction of apoptosis. Prominent upregulation of p53 and Bax and cleavage of poly (ADP)-ribose polymerase were also detected in the phloretin-treated cells. Finally, phloretin markedly increased caspase-3 activity as well as JNK and p38 mitogen-activated protein kinase signaling. Our findings suggest that the phloretin-induced apoptosis of breast tumor cells contributes to the chemopreventive potential of phloretin against breast cancer.</P>