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Hong, J. Min,Kim, T.-H.,Chae, S.-C.,Koo, K.-H.,Lee, Y. Jong,Park, E. Kyun,Choi, J.-Y.,Ryoo, H.-M.,Kim, S.-Y. W.B. SAUNDERS COMPANY 2007 OSTEOARTHRITIS AND CARTILAGE Vol.15 No.6
<P><B>Summary</B></P><P><B>Objective</B></P><P>Disruption of the vascular supply to the bone and subsequent hypoxia has been implicated in the pathogenesis of osteonecrosis (ON) of the femoral head (ONFH). To evaluate the genetic effect of <I>HIF1α</I>, a key transcription factor in controlling hypoxia condition, on ONFH, we analyzed <I>HIF1α</I> polymorphism and its genetic association with ONFH.</P><P><B>Methods</B></P><P>We directly sequenced the <I>HIF1α</I> gene in 24 Korean individuals and identified four sequence variants. Four polymorphisms (−2755C>A, +41224T>C, +45319C>T, +51610C>T) were genotyped in ONFH (<I>n</I>=384). ONFH patients were divided into three subgroups based on etiological factors: idiopathic (129 cases), steroid (59 cases) and alcohol (196 cases) ON groups.</P><P><B>Results</B></P><P>We found that the allele frequency of −2755C>A and the genotype frequencies of +41224T>C and +51610C>T were significantly associated with idiopathic ONFH in men (<I>P</I>=0.0409, 0.0113, 0.0269, respectively). In addition, haplotype (CTCC) of <I>HIF1α</I> was also significantly associated with idiopathic ONFH in men (<I>P</I>=0.017).</P><P><B>Conclusions</B></P><P>We found that <I>HIF1α</I> polymorphisms are associated with idiopathic ONFH in men. These results suggest that variations in <I>HIF1α</I> may play an important role in the pathogenesis and risk factor for ONFH.</P>
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Park, Y.B.,Ha, C.W.,Kim, J.A.,Han, W.J.,Rhim, J.H.,Lee, H.J.,Kim, K.J.,Park, Y.G.,Chung, J.Y. W.B. SAUNDERS COMPANY 2017 Osteoarthritis and Cartilage Vol. No.
Objective: Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) have gained popularity as a promising cell source for regenerative medicine, but limited in vivo studies have reported cartilage repair. In addition, the roles of MSCs in cartilage repair are not well-understood. The purpose of this study was to investigate the feasibility of transplanting hUCB-MSCs and hyaluronic acid (HA) hydrogel composite to repair articular cartilage defects in a rabbit model and determine whether the transplanted cells persisted or disappeared from the defect site. Design: Osteochondral defects were created in the trochlear grooves of the knees. The hUCB-MSCs and HA composite was transplanted into the defect of experimental knees. Control knees were transplanted by HA or left untreated. Animals were sacrificed at 8 and 16 weeks post-transplantation and additionally at 2 and 4 weeks to evaluate the fate of transplanted cells. The repair tissues were evaluated by gross, histological and immunohistochemical analysis. Results: Transplanting hUCB-MSCs and HA composite resulted in overall superior cartilage repair tissue with better quality than HA alone or no treatment. Cellular architecture and collagen arrangement at 16 weeks were similar to those of surrounding normal articular cartilage tissue. Histological scores also revealed that cartilage repair in experimental knees was better than that in control knees. Immunohistochemical analysis with anti-human nuclear antibody confirmed that the transplanted MSCs disappeared gradually over time. Conclusion: Transplanting hUCB-MSCs and HA composite promote cartilage repair and interactions between hUCB-MSCs and host cells initiated by paracrine action may play an important role in cartilage repair.
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Fatigue in epilepsy: A systematic review and meta-analysis
Kwon, O.Y.,Ahn, H.S.,Kim, H.J. W. B. SAUNDERS COMPANY 2017 SEIZURE Vol.45 No.-
<P>Conclusions: Fatigue is common in epilepsy patients and is closely correlated with depression. The identification and management of fatigue and its risk factors, especially depression, is mandatory for the management of epilepsy. (C) 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.</P>
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