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- 발행기관 : Sociedade Brasileira de Genética (검색결과 4 건)
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Kim, Min Jee,Jeong, Jun Seong,Kim, Jong Seok,Jeong, Su Yeon,Kim, Iksoo Sociedade Brasileira de Genética 2017 Genetics and molecular biology Vol.40 No.3
<P><B>Abstract</B></P><P>The mitochondrial genome (mitogenome) characteristics of the monotypic Lasiocampoidea are largely unknown, because only limited number of mitogenomes is available from this superfamily. In this study, we sequenced the complete mitogenome of the lappet moth, <I>Kunugia undans</I> (Lepidoptera: Lasiocampidae) and compared it to those of Lasiocampoidea and macroheteroceran superfamilies (59 species in six superfamilies). The 15,570-bp <I>K. undans</I> genome had one additional <I>trnR</I> that was located between <I>trnA</I> and <I>trnN</I> loci and this feature was unique in Macroheterocera, including Lasiocampoidea. Considering that the two <I>trnR</I> copies are located in tandem with proper secondary structures and identical anticodons, a gene duplication event might be responsible for the presence of the two tRNAs. Nearly all macroheteroceran species, excluding Lasiocampoidea, have a spacer sequence (1–34 bp) at the <I>trnS</I><SUB><I>2</I></SUB> and <I>ND1</I> junction, but most lasiocampid species, including <I>K. undans,</I> have an overlap at the <I>trnS</I><SUB><I>2</I></SUB> and <I>ND1</I> junction, which represents a different genomic feature in Lasiocampoidea. Nevertheless, a TTAGTAT motif, which is typically detected in Macroheterocera at the <I>trnS</I><SUB><I>2</I></SUB> and <I>ND1</I> junction, was also detected in all Lasiocampoidea. In summary, the general mitogenome characteristics of Lasiocampoidea did not differ greatly from the remaining macroheteroceran superfamilies, but it did exhibit some unique features.</P>
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Yang, Seung Hak,Lim, Joung Soo,Khan, Modabber Ahmed,Kim, Bong Soo,Choi, Dong Yoon,Lee, Eun Young,Ahn, Hee Kwon Sociedade Brasileira de Genética 2015 Genetics and molecular biology Vol.38 No.3
<P>The leachate generated by the decomposition of animal carcass has been implicated as an environmental contaminant surrounding the burial site. High-throughput nucleotide sequencing was conducted to investigate the bacterial communities in leachates from the decomposition of pig carcasses. We acquired 51,230 reads from six different samples (1, 2, 3, 4, 6 and 14 week-old carcasses) and found that sequences representing the phylum Firmicutes predominated. The diversity of bacterial 16S rRNA gene sequences in the leachate was the highest at 6 weeks, in contrast to those at 2 and 14 weeks. The relative abundance of Firmicutes was reduced, while the proportion of Bacteroidetes and Proteobacteria increased from 3–6 weeks. The representation of phyla was restored after 14 weeks. However, the community structures between the samples taken at 1–2 and 14 weeks differed at the bacterial classification level. The trend in pH was similar to the changes seen in bacterial communities, indicating that the pH of the leachate could be related to the shift in the microbial community. The results indicate that the composition of bacterial communities in leachates of decomposing pig carcasses shifted continuously during the study period and might be influenced by the burial site.</P>
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Lee, Jae Eun,Kim, Jung Hwa Sociedade Brasileira de Genética 2015 Genetics and molecular biology Vol.38 No.4
<P><B>Abstract</B></P><P>Valproic acid (VPA) is a clinically available histone deacetylase inhibitor with promising anticancer attributes. Recent studies have demonstrated the anticancer effects of VPA on prostate cancer cells. However, little is known about the differential effects of VPA between metastatic and non-metastatic prostate cancer cells and the relationship between the expression of metastasis suppressor proteins and VPA. In the present study, we demonstrate that inhibition of cell viability and invasion by VPA was more effective in the metastatic prostate cancer cell line PC3 than in the tumorigenic but non-metastatic prostate cell line, RWPE2. Further, we identified that the metastasis suppressor NDRG1 is upregulated in PC3 by VPA treatment. In contrast, NDRG1 was not increased in RWPE2 cells. Also, the suppressed invasion of PC3 cells by VPA treatment was relieved by NDRG1 knockdown. Taken together, we suggest that the anticancer effect of VPA on prostate cancer cells is, in part, mediated through upregulation of NDRG1. We also conclude that VPA has differential effects on the metastasis suppressor gene and invasion ability between non-metastatic and metastatic prostate cancer cells.</P>
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Yeo, Sujung,An, Keon Sang,Hong, Yeon-Mi,Choi, Yeong-Gon,Rosen, Bruce,Kim, Sung-Hoon,Lim, Sabina Sociedade Brasileira de Genética 2015 Genetics and molecular biology Vol.38 No.1
<P>Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transcript array in the SN region related to the inhibitory effects of acupuncture in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonism model. In this model, acupuncture stimulation at GB34 and LR3 attenuated the decrease in tyrosine hydroxylase in the SN region; stimulation at non-acupoints did not suppress this decrease. Gene array analysis revealed that 22 (10 annotated genes: <I>Cdh1</I>, <I>Itih2</I>, <I>Mpzl2</I>, <I>Rdh9</I>, <I>Serping1</I>, <I>Slc6a13</I>, <I>Slc6a20a</I>, <I>Slc6a4</I>, <I>Tph2</I>, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation. In addition, 17 (two annotated genes: <I>4921530L21Rik</I> and <I>Gm13931</I>) probes that were down-regulated in MPTP animals compared to controls were exclusively up-regulated by acupuncture stimulation. These findings indicate that the 39 probes (12 annotated genes) affected by MPTP and acupuncture may be responsible for the inhibitory effects of acupuncture on degeneration-related gene expression in the SN following damage induced by MPTP intoxication.</P>
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