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Park, Sook A,Park, Il-Ho,Cho, Jung-Sun,Moon, You-Mi,Lee, Seung Hoon,Kim, Tae Hoon,Lee, Sang Hag,Lee, Heung-Man OceanSide Publications 2012 American journal of rhinology & allergy Vol.26 No.2
<P>[6]-Gingerol is one of the major pungent principles of ginger and has diverse effects, including anti-inflammatory, and antioxidative effects. Reactive oxygen species (ROS) are released during the phenotypic transformation of fibroblasts to myofibroblasts, a process that is involved in the growth of nasal polyps by inducing extracellular matrix (ECM) accumulation. The purpose of this study was to determine the effect of [6]-gingerol on myofibroblast differentiation and collagen production of nasal polyp-derived fibroblasts (NPDFs) and to determine if the effect of [6]-gingerol is linked to an antioxidant effect.</P>
Inhibitory effect of prostaglandin E(2) on the migration of nasal fibroblasts.
Shin, Jae-Min,Park, Il-Ho,Moon, You-Mi,Hong, Sung-Moon,Cho, Jung-Sun,Um, Ji-Young,Lee, Heung-Man OceanSide Publications 2014 American journal of rhinology & allergy Vol.28 No.3
<P>Fibroblast migration is crucial for normal wound repair after sinonasal surgery. Prostaglandin E2 (PGE2) is a potent inhibitor of fibroblast functions including chemotaxis, proliferation, and matrix production. The purpose of this study was to determine whether PGE2 affects the migration of nasal fibroblasts and to investigate the mechanism of action of PGE2 on nasal fibroblasts.</P>
Cho, Soo-Na,Song, Chang-Hwa,Jin, Jun,Kim, Sung Ha,Rha, Ki-Sang,Kim, Yong Min OceanSide Publications 2014 American journal of rhinology & allergy Vol.28 No.1
<P>The pathogenesis of nasal polyposis has not been fully understood. Recent studies indicate that there is a subset of CD4(+)CD25(high)FoxP3(+)T cells (regulatory T cells [Tregs]) that express retinoic acid receptor related orphan receptor C (RORC) or IL-17, and these cells might be new proinflammatory cells because of the expression of IL-17 with loss of their suppressive function. The goals of this study were to localize Th17-like Tregs (Th17-like Tregs or RORC(+)Tregs) in nasal polyps and to investigate the role of staphylococcal enterotoxin B (SEB) on the differentiation of Tregs to RORC(+)Tregs in vitro.</P>
Advantages of glove finger-coated polyvinyl acetate pack in endoscopic sinus surgery.
Kim, Dae Woo,Lee, Eun-Jae,Kim, Sang-Wook,Jeon, Sea-Yuong OceanSide Publications 2012 American journal of rhinology & allergy Vol.26 No.5
<P>This study investigated the efficacy of glove finger-coated polyvinyl acetate (PA) pack on hemostasis, pain levels, and wound healing after endoscopic sinus surgery (ESS).</P>
Serum clusterin level in children with atopic dermatitis
Sol, In Suk,Kim, Yoon Hee,Lee, Kyung Eun,Hong, Jung Yeon,Kim, Mi Na,Kim, Yun Seon,Oh, Mi Seon,Kim, Min Jung,Yoon, Seo Hee,Park, Young A.,Kim, Kyung Won,Sohn, Myung Hyun,Kim, Kyu-Earn Oceanside Publications 2016 Allergy and asthma proceedings Vol.37 No.4
Frontal sinus inverted papilloma: surgical strategy based on the site of attachment.
Yoon, Bit-Na,Batra, Pete S,Citardi, Martin J,Roh, Hwan-Jung OceanSide Publications 2009 American journal of rhinology & allergy Vol.23 No.3
<P>BACKGROUND: The surgical management of inverted papilloma (IP) involving the frontal sinus (FS) remains a challenge given the narrow confines of the frontal recess and the close proximity to critical structures. The objective of this study was to elucidate a surgical strategy for management of frontal sinus IP based on the site of attachment. METHODS: A retrospective chart review was performed on 18 patients with FS IP treated at the Pusan National University Hospital and the Cleveland Clinic Foundation between 1998 and 2008. RESULTS: The mean age was 53.8 years with a male/female ratio of 13:5. The sites of tumor attachment included the medial wall (MW; six cases), posterior wall (PW; five cases), diffuse (all walls involved; five cases), intersinus septal cell (three cases), lateral wall (two cases), and anterior wall (two cases). IP involvement was unifocal in 10 cases and multifocal in 8 cases. Unifocal IP attached to the MW or PW was managed strictly by endoscopic frontal sinusotomy (EFS) in five of six cases (83%). Multifocal IP required endoscopic modified Lothrop (EML) and/or open approaches (endoscopic frontal trephination [EFT], four, osteoplastic flap [OPF], one) in seven of eight cases (88%). One additional patient with bilateral anterior table involvement required OPF. Four (22%) patients developed recurrences. Two were managed by EML, one was managed by EFS, and one was managed by EFT and EFS. Two patients developed cerebrospinal fluid leaks that were managed endoscopically without untoward effects. All patients were free of disease at the time of last evaluation with a mean follow-up of 36.6 months. CONCLUSION: Frontal sinus IP with MW or PW involvement can generally be managed by standard EFS. Tumors with multifocal involvement often require EML, along with adjunct EFT in selected cases. OPF can be avoided as the primary surgical approach in most patients with sinonasal papilloma of FS.</P>