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Parthenolide promotes apoptotic cell death and inhibits the migration and invasion of SW620 cells
Liu, Yu Chuan,Kim, Se Lim,Park, Young Ran,Lee, Soo-Teik,Kim, Sang Wook Korean Association for the Study of Intestinal Dis 2017 Intestinal Research Vol.15 No.2
<P><B>Background/Aims</B></P><P>Parthenolide (PT), a principle component derived from feverfew (<I>Tanacetum parthenium</I>), is a promising anticancer agent and has been shown to promote apoptotic cell death in various cancer cells. In this study, we focused on its functional role in apoptosis, migration, and invasion of human colorectal cancer (CRC) cells.</P><P><B>Methods</B></P><P>SW620 cells were employed as representative human CRC cells. We performed the MTT assay and cell cycle analysis to measure apoptotic cell death. The wound healing, Transwell migration, and Matrigel invasion assays were performed to investigate the effect of PT on cell migration/invasion. Western blotting was used to establish the signaling pathway of apoptosis and cell migration/invasion.</P><P><B>Results</B></P><P>PT exerts antiproliferative effect and induces apoptotic cell death of SW620 cells. In addition, PT prevents cell migration and invasion in a dose-dependent manner. Moreover, PT markedly suppressed migration/invasion-related protein expression, including E-cadherin, β-catenin, vimentin, Snail, cyclooxygenase-2, matrix metalloproteinase-2 (MMP-2), and MMP-9 in SW620 cells. PT also inhibited the expression of antiapoptotic proteins (Bcl-2 and Bcl-xL) and activated apoptosis terminal factor (caspase-3) in a dose-dependent manner.</P><P><B>Conclusions</B></P><P>Our results suggest that PT is a potential novel therapeutic agent for aggressive CRC treatment.</P>
Ham, Hyoju,Lee, Bo-In,Oh, Hyun Jin,Park, Se Hwan,Kim, Jin Su,Park, Jae Myung,Cho, Young Seok,Choi, Myung-Gyu Korean Association for the Study of Intestinal Dis 2017 Intestinal Research Vol.15 No.4
<P>Celiac disease (CD) is an immune-mediated enteropathy and is a rare disease in Asia, including in Korea. However, the ingestion of wheat products, which can act as a precipitating factor of CD, has increased rapidly. CD is a common cause of malabsorption, but many patients can present with various atypical manifestations as first presented symptoms, including anemia, osteopenia, infertility, and neurological symptoms. Thus, making a diagnosis is challenging. We report a case of CD that mimicked amyotrophic lateral sclerosis (ALS). The patient was a sexagenary man with a history of progressive motor weakness for 2 years. He was highly suspected as having ALS. During evaluation of his neurological symptoms, esophagogastroduodenoscopy (EGD) was performed because he had experienced loose stools and weight loss for the previous 7 months. On EGD, the duodenal mucosa appeared smooth. A biopsy revealed severe lymphoplasma cell infiltration with flattened villi. His serum endomysial antibody (immunoglobulin A) titer was 1:160 (reference, <1:40). Finally, he was diagnosed as having CD, and a gluten-free diet was immediately begun. At a 4-month follow-up, his weight and the quality of his stool had improved gradually, and the neurological manifestations had not progressed.</P>