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Gold nanoparticle-mediated photothermal therapy: current status and future perspective.
Hwang, Sekyu,Nam, Jutaek,Jung, Sungwook,Song, Jaejung,Doh, Hyunmi,Kim, Sungjee Future Medicine Ltd. 2014 Nanomedicine Vol. No.
<P>Gold nanoparticles (AuNPs) are attractive photothermal agents for cancer therapy because they show efficient local heating upon excitation of surface plasmon oscillations. The strong absorption, efficient heat conversion, high photostability, inherent low toxicity and well-defined surface chemistry of AuNPs contribute to the growing interest in their photothermal therapy (PTT) applications. The facile tunability of gold nanostructures enables engineering of AuNPs for superior near-infrared photothermal efficacy and target selectivity, which guarantee efficient and deep tissue-penetrating PTT with mitigated concerns regarding side effects by nonspecific distributions. This article discusses the current research findings with representative near-infrared-active AuNPs, which include nanoshell, nanorod, nanocage, nanostar, nanopopcorn and nanoparticle assembly systems. AuNPs successfully demonstrate potential for use in PTT, but several hurdles to clinical applications remain, including long-term toxicity and a need for sophisticated control over biodistribution and clearance. Future research directions are discussed, especially regarding the clinical translation of AuNP photosensitizers.</P>
Mehtala, Jonathan G,Torregrosa-Allen, Sandra,Elzey, Bennett D,Jeon, Mansik,Kim, Chulhong,Wei, Alexander Future Medicine Ltd 2014 Nanomedicine Vol. No.
<P>The synergistic effects of gold nanorod (GNR)-mediated mild hyperthermia (MHT; 42-43C) and cisplatin (CP) activity was evaluated against chemoresistant SKOV3 cells in vitro and with a tumor xenograft model.</P>
Yang, Bo Yeun,Moon, Sung-Hyun,Seelam, Sudhakara Reddy,Jeon, Min Jeong,Lee, Yun-Sang,Lee, Dong Soo,Chung, June-Key,Kim, Young Il,Jeong, Jae Min Future Medicine Ltd 2015 Nanomedicine Vol.10 No.12
<P>We tried to develop a multimodal iron oxide nanoparticles (IO NP) imaging probe by an encapsulation method using specific amphiphiles for (68)Ga-labeling and lymph node-targeting.</P>
Park, Sung Young,Kang, Byung-Soo,Hong, Seunghun Future Medicine Ltd 2013 Nanomedicine Vol.8 No.5
<P>The authors aimed to investigate the effect of carbon nanotube (CNT)-based extracellular environments on the neural differentiation of human mesenchymal stem cells (hMSCs) when combined with chemical inducers.</P>
Jeon, Mansik,Jenkins, Samir,Oh, Junghwan,Kim, Jeehyun,Peterson, Tara,Chen, Jingyi,Kim, Chulhong Future Medicine Ltd 2014 Nanomedicine Vol.9 No.9
<P>The objectives of this study were to demonstrate nonionizing photoacoustic tomography (PAT) of bladders with near-infrared absorbing gold nanocages (GNCs) as an optical-turbid tracer and to investigate the fate of GNCs after photoacoustic imaging.</P>
He, Bo,Kim, Sung Kyoung,Son, Sang Jun,Lee, Sang Bok Future Medicine Ltd 2010 Nanomedicine Vol.5 No.1
<P>Aims: The recent development of 1D barcode arrays has proved their capabilities to be applicable to highly multiplexed bioassays. This article introduces two magnetic decoding protocols for suspension arrays of shape-coded silica nanotubes to process multiplexed assays rapidly and easily, which will benefit the minimization and automation of the arrays. Methods: In the first protocol, the magnetic nanocrystals are incorporated into the inner voids of barcoded silica nanotubes in order to give the nanotubes magnetic properties. The second protocol is performed by trapping the barcoded silica nanotubes onto streptavidin-modified magnetic beads. Results: The rapid and easy decoding process was demonstrated by applying the above two protocols to multiplexed assays, resulting in high selectivity. Furthermore, the magnetic bead-trapped barcode nanotubes provided a great opportunity to exclude the use of dye molecules in multiplexed assays by using barcode nanotubes as signals. Conclusion: The rapid and easy manipulation of encoded carriers using magnetic properties could be used to develop promising suspension arrays for portable bioassays.</P>
Lee, So Jin,Min, Hyun Su,Ku, Sook Hee,Son, Sohee,Kwon, Ick Chan,Kim, Sun Hwa,Kim, Kwangmeyung Future Medicine Ltd 2014 Nanomedicine Vol.9 No.11
<P>A natural based polymer, chitosan has received widespread attention in drug delivery systems due to its valuable physicochemical and biological characteristics. In particular, hydrophobic moiety-conjugated glycol chitosan can form amphiphilic self-assembled glycol chitosan nanoparticles (GCNPs) and simultaneously encapsulate hydrophobic drug molecules inside their hydrophobic core. This GCNP-based drug delivery systems exhibit excellent tumor-homing efficacy, attributed to the long blood circulation and the enhanced permeability and retention effect; this tumor-targeting drug delivery results in improved therapeutic efficiency. In this review, we describe the requisite properties of GCNPs for cancer therapy as well as imaging for diagnosis, such as their basic characteristics, in vitro delivery efficiency and in vivo tumor-targeting ability.</P>