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Kim, Sang Woo,Choi, Jung-Won,Lee, Chang Youn,Lee, Jiyun,Shin, Sunhye,Lim, Soyeon,Lee, Seahyoung,Kim, Il-Kwon,Lee, Hoon-Bum,Hwang, Ki-Chul Cambridge Medical Publications Ltd 2018 The Journal of international medical research Vol.46 No.3
<P><B>Objective</B></P><P>Adipose-derived stromal vascular fractions (SVFs) are heterogeneous complex populations of cells with therapeutic efficacy for tissue generation and vascular stabilization. SVFs have cardiomyogenic potential, and many researchers have examined the possibility of SVF transplantation for heart disease. In cell-based therapies, donor age affects the regenerative capability, cell yield, and differentiation potential of adult tissues; however, opposing or controversial results have been found in humans. We examined whether SVF transplantation into impaired heart tissue shows differential effects according to donor age.</P><P><B>Methods</B></P><P>We investigated differences in protein expression in human umbilical vein endothelial cells (HUVECs) co-cultured with adipose-derived adherent stromal cells (ADASs) from donors of different ages [>40-year-olds (40s group) and >60-year-olds (60s group)] under oxidative stress conditions.</P><P><B>Results</B></P><P>Although co-culturing HUVECs with ADASs ameliorated inflammation due to increased oxidative stress conditions, few differences were observed between the ADASs from the 40s and 60s groups. Moreover, the Database for Annotation, Visualization, and Integrated Discovery classification tool revealed differentially expressed genes in the Kyoto Encyclopedia of Genes and Genomes pathway associated with cytokine–cytokine receptor interaction in response to ADASs.</P><P><B>Conclusion</B></P><P>Protein expression profiles were unchanged in HUVECs induced by isolated ADASs from donors of different ages under oxidative stress conditions.</P>
Changes in brain activation during sedation induced by dexmedetomidine
Kim, Won-Ho,Cho, Dongrae,Lee, Boreom,Song, Jae-Jin,Shin, Teo Jeon Cambridge Medical Publications Ltd 2017 The Journal of international medical research Vol.45 No.3
<P><B>Objective</B></P><P>Dexmedetomidine (DEX) has been widely used as a sedative, acting as an α2-adrenergic agonist on autoreceptors, presynaptic receptors and postsynaptic receptors without risk of respiratory depression. Although consciousness impairment is closely related to disturbances of brain function in different frequency bands, the time-varying DEX effects on cortical activity in specific frequency bands has not yet been studied.</P><P><B>Methods</B></P><P>We used electroencephalography (EEG) to analyse differences in cerebral cortex activity between the awake and sedated states, using electromagnetic tomography (standardized low resolution electromagnetic tomography (sLORETA)) to localize multiple channel scalp recordings of cerebral electric activity to specific brain regions.</P><P><B>Results</B></P><P>The results revealed increased activity in the cuneus at delta-band frequencies, and in the posterior cingulate cortex at theta frequencies, during awake and sedated states induced by DEX at specific frequency bands. Differences in standardized low resolution cingulate gyrus were found in beta1 frequencies (13–18 Hz), and in the cuneus at gamma frequencies.</P><P><B>Conclusion</B></P><P>Cerebral cortical activity was significantly altered in various brain areas during DEX sedation, including parts of the default mode network and common midline core in different frequency ranges. These alterations may elucidate the mechanisms underlying DEX sedation.</P>
BCL6 gene mutations in transitional cell carcinomas.
Cho, H Y,Park, H S,Lin, Z,Kim, I,Joo, K J,Cheon, J Cambridge Medical Publications Ltd 2007 The Journal of international medical research Vol.35 No.2
<P>The B-cell lymphoma-6 (BCL6) gene was initially identified at a translocation site observed frequently in diffuse large B-cell lymphomas. In the present study, BCL6 mutations at the 5' non-coding region in 47 cases of transitional call carcinoma (TCC) were analysed using polymerase chain reaction-single-strand conformation polymorphism. The results were compared with data obtained previously by immunohistochemical staining for the BCL6 protein. Overall, BCL6 mutations were observed in 44.7% of cases. Mutation of the 5' non-coding region was not correlated with histological grade of the tumour; however, the better the histological grade, the greater the mutation rate of the E1.12 fragment. The BCL6 mutation occurred independently of over-expression of the protein. The BCL6 gene mutation and the protein expression were detectable in a large proportion of TCCs. BCL6 protein over-expression as well as BCL6 gene mutation of the E1.12 fragment may play an important role in the morphological differentiation of TCC.</P>
Hwang, S-H,Oh, H-B,Choi, S-E,Hong, S P,Yoo, W Cambridge Medical Publications Ltd 2007 The Journal of international medical research Vol.35 No.6
<P>Restriction fragment mass polymorphism (RFMP) was applied to pooled DNA for selecting informative single nucleotide polymorphisms (SNPs). A total of 225 coding non-synonymous SNPs (cnSNPs) from immunomodulating genes known to be involved in the pathogenesis of asthma were selected from the National Center for Biotechnology Information's (NCBI) SNP database (dbSNP). DNA samples from 200 healthy Koreans were pooled, amplified by polymerase chain reaction, digested with restriction enzymes and the fragments analysed by mass spectrometry. Only 30 of the 225 cnSNPs (13.3%) were informative, i.e.had a minor allele frequency>10%. The percentage of informative cnSNPs varied according to the validation status of the dbSNP, being 42.3% (22/52) when validated by multiple submissions and frequency data, 8.7% (2/23) when validated by multiple submissions alone and 9.1% (3/33) when validated by frequency data alone. Most of the 112 unvalidated cnSNPs were not informative. In conclusion, the RFMP method using pooled DNA is useful in selecting informative SNPs, as also is validation status in the dbSNP.</P>
Decreased expression of annexin A1 during the progression of cervical neoplasia.
Wang, L D,Yang, Y H,Liu, Y,Song, H T,Zhang, L Y,Li, P L Cambridge Medical Publications Ltd 2008 The Journal of international medical research Vol.36 No.4
<P>The aim of this study was to evaluate whether the expression of annexin A1 (ANXA1) is associated with the progression of cervical neoplasia. ANXA1 expression was examined by immunohistochemistry in paraffin-embedded cervical tissue samples (n = 234), comprising 52 samples of normal cervical epithelia, 30 of cervical intraepithelial neoplasia (CIN) I, 27 of CIN II, 32 of CIN III, and 93 of invasive squamous cell carcinoma (ISCC). ANXA1 expression was strong in normal cervical squamous epithelium and significantly reduced with increasing progression of cervical neoplasia. Moreover, a close association was observed between ANXA1 expression and tumour cell differentiation in ISCC. These preliminary results indicate that ANXA1 may be an effective candidate for detecting CIN lesions and for evaluating tumour cell differentiation in squamous cell carcinoma of the cervix.</P>
Chiesa, A,Pae, C-U,Porcelli, S,Han, C,Lee, S-J,Patkar, A A,Park, M H,Jun, T-Y,Serretti, A Cambridge Medical Publications Ltd 2012 The Journal of international medical research Vol.40 No.1
<P>This study investigated whether selected D-amino acid oxidase activator (DAOA) gene single nucleotide polymorphisms (SNPs; rs3916966, rs3916967, rs2391191, rs3916968, rs7139958, rs9558571, rs778293) are associated with major depressive disorder (MDD) and bipolar disorder (BD), and whether they can predict clinical outcomes in Korean in-patients treated with antidepressants and mood stabilizers, respectively.</P>
Sung, Tae-Yun,Kim, Min-Su,Cho, Choon-Kyu,Park, Dong-Ho,Kang, Po-Soon,Lee, Sang-Eok,Kwon, Won-Kyoung,Woo, Nam-Sik,Kim, Seong-Hyop Cambridge Medical Publications Ltd 2013 The Journal of international medical research Vol.41 No.4
<P>The study evaluated the clinical intraoperative effects of intrathecal administration of fentanyl on shoulder tip pain in patients undergoing laparoscopic total extraperitoneal inguinal hernia repair (TEP) under spinal anaesthesia.</P>
Park, Soo Young,Baek, Hyun Jae,Park, Kwang Suk,Kim, Yong Chul Cambridge Medical Publications Ltd 2014 The Journal of international medical research Vol.42 No.4
<P>A prospective, observational study to investigate how photoplethysmography (PPG) signals change during lumbar sympathetic blockade (LSB), and whether these changes can predict sympathetically mediated pain (SMP).</P>
Choi, Yoon Ji,Lim, Jae Kwan,Park, Jeong Jun,Huh, Hyub,Kim, Dong-Joo,Gong, Chang-Hoon,Yoon, Seung Zhoo Cambridge Medical Publications Ltd 2017 The Journal of international medical research Vol.45 No.3
<P><B>Objective</B></P><P>The efficacy of chlorhexidine- and silver sulfadiazine-coated central venous catheters (CSS-CVC) against catheter-related infection remains controversial. We hypothesized that the loss of silver nanoparticles may reduce the antibacterial efficacy of CSS-CVCs and that this loss could be due to the frictional force between the surface of the CVC and the bloodstream. The objective of this study was to investigate whether the antimicrobial effect of CSS-CVCs decreases with increasing exposure time in a bloodstream model and quantitatively assay the antimicrobial effect of CSS-CVCs compared with polyurethane and antiseptic-impregnated CVCs.</P><P><B>Methods</B></P><P>Each CVC was subjected to 120 hours of saline flow and analyzed at intervals over 24 hours. The analyses included energy-dispersive X-ray spectroscopy, scanning electron microscopy, and optical density after a <I>Staphylococcus aureus</I> incubation test.</P><P><B>Results</B></P><P>The weight percentage of silver in the CSS-CVCs significantly decreased to 56.18% (44.10% ± 3.32%) with 48-hour catheterization and to 18.88% (14.82% ± 1.33%) with 120-hour catheterization compared with the initial weight percentage (78.50% ± 6.32%). In the <I>S. aureus</I> incubation test, the antibacterial function of CSS-CVCs was lost after 48 hours [3 (N/D) of OD]. Similar results were observed in a pilot clinical study using 18 CSS-CVCs.</P><P><B>Conclusions</B></P><P>We found that the efficacy of CSS-CVCs decreased over time and that the antibacterial function was lost after 48 hours of simulated wear-out. Therefore, antibiotic-impregnated CVCs may be a better option when longer (>48 hours) indwelling is needed.</P>