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- 발행기관 : Associação Brasileira de Divulga&cce (검색결과 3 건)
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Yousefi, Milad,Yousefi, Moslem,Fogliatto, F.S.,Ferreira, R.P.M.,Kim, J.H. Associação Brasileira de Divulga&cce 2018 Brazilian journal of medical and biological resear Vol.51 No.3
<P>The objective of this study was to develop an agent based modeling (ABM) framework to simulate the behavior of patients who leave a public hospital emergency department (ED) without being seen (LWBS). In doing so, the study complements computer modeling and cellular automata (CA) techniques to simulate the behavior of patients in an ED. After verifying and validating the model by comparing it with data from a real case study, the significance of four preventive policies including increasing number of triage nurses, fast-track treatment, increasing the waiting room capacity and reducing treatment time were investigated by utilizing ordinary least squares regression. After applying the preventing policies in ED, an average of 42.14% reduction in the number of patients who leave without being seen and 6.05% reduction in the average length of stay (LOS) of patients was reported. This study is the first to apply CA in an ED simulation. Comparing the average LOS before and after applying CA with actual times from emergency department information system showed an 11% improvement. The simulation results indicated that the most effective approach to reduce the rate of LWBS is applying fast-track treatment. The ABM approach represents a flexible tool that can be constructed to reflect any given environment. It is also a support system for decision-makers to assess the relative impact of control strategies.</P>
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Macelignan inhibits bee pathogenic fungi <i>Ascophaera apis</i> growth through HOG1 pathway
Shin, Y.K.,Kim, K.Y. Associação Brasileira de Divulga&cce 2016 Brazilian journal of medical and biological resear Vol.49 No.7
<P><I>Ascosphaera apis</I> is a bee pathogen that causes bee larvae infection disease, to which treatment is not yet well investigated. The aim of this study was to investigate antifungal susceptibility <I>in vitro</I> against <I>A. apis</I> and to identify a new antifungal agent for this pathogen through minimal inhibitory concentration (MIC) assay and western blot analysis. Macelignan had 1.56 and 3.125 μg/mL MIC against <I>A. apis</I> after 24 and 48 h, respectively, exhibiting the strongest growth inhibition against <I>A. apis</I> among the tested compounds (corosolic acid, dehydrocostus lactone, loganic acid, tracheloside, fangchinoline and emodin-8-O-β-D-glucopyranoside). Furthermore, macelignan showed a narrow-ranged spectrum against various fungal strains without any mammalian cell cytotoxicity. In spite of miconazole having powerful broad-ranged anti-fungal activity including <I>A. apis</I>, it demonstrated strong cytotoxicity. Therefore, even if macelignan alone was effective as an antifungal agent to treat <I>A. apis</I>, combined treatment with miconazole was more useful to overcome toxicity, drug resistance occurrence and cost effectiveness. Finally, HOG1 was revealed as a target molecule of macelignan in the anti-<I>A. apis</I> activity by inhibiting phosphorylation using <I>S. cerevisiae</I> as a model system. Based on our results, macelignan, a food-grade antimicrobial compound, would be an effective antifungal agent against <I>A. apis</I> infection in bees.</P>
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Chung, H.J.,Hassan, M.M.,Park, J.O.,Kim, H.J.,Hong, S.T. Associação Brasileira de Divulga&cce 2015 Brazilian journal of medical and biological resear Vol.48 No.5
<P>Recent advances have raised hope that transplantation of adherent somatic cells could provide dramatic new therapies for various diseases. However, current methods for transplanting adherent somatic cells are not efficient enough for therapeutic applications. Here, we report the development of a novel method to generate quasi-natural cell blocks for high-efficiency transplantation of adherent somatic cells. The blocks were created by providing a unique environment in which cultured cells generated their own extracellular matrix. Initially, stromal cells isolated from mice were expanded <I>in vitro</I> in liquid cell culture medium followed by transferring the cells into a hydrogel shell. After incubation for 1 day with mechanical agitation, the encapsulated cell mass was perforated with a thin needle and then incubated for an additional 6 days to form a quasi-natural cell block. Allograft transplantation of the cell block into C57BL/6 mice resulted in perfect adaptation of the allograft and complete integration into the tissue of the recipient. This method could be widely applied for repairing damaged cells or tissues, stem cell transplantation, <I>ex vivo</I> gene therapy, or plastic surgery.</P>
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