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Yoon, Chang-Yun,Park, Jung Tak,Jhee, Jong Hyun,Noh, Juhwan,Kee, Youn Kyung,Seo, Changhwan,Lee, Misol,Cha, Min-Uk,Kim, Hyoungnae,Park, Seohyun,Yun, Hae-Ryong,Jung, Su-Young,Han, Seung Hyeok,Yoo, Tae-Hy American Society for Clinical Nutrition 2017 The American journal of clinical nutrition Vol.106 No.1
<P>Conclusions: High dietary phosphorus density is associated with an increased risk of CKD development in DM patients with normal renal function. The causality in this association needs to be tested in a randomized controlled trial.</P>
Kim, Ji Yeon,Kwon, Oran American Society for Clinical Nutrition 2009 The American journal of clinical nutrition Vol.89 No.1
<P>BACKGROUND: Numerous animal and in vitro studies provided evidence for a relation between garlic intake and cancer risk reduction. Several studies also reported an inverse association in humans. However, no claims have been made about garlic intake and cancer risk reduction with respect to food labeling. OBJECTIVE: The objective of this study was to evaluate the scientific evidence for garlic intake with respect to the risk of different types of cancer using the US Food and Drug Administration's evidence-based review system for the scientific evaluation of health claims. DESIGN: Literature searches were conducted by using the Medline and EMBASE databases for the period 1955-2007 with search terms Allium sativum, vegetables, diet, and nutrition in combination with cancer, neoplasm, and individual cancers. The search was limited to human studies published in English and Korean. RESULTS: With the use of the US Food and Drug Administration's evidence-based review system for the scientific evaluation of health claims, 19 human studies were identified and reviewed to evaluate the strength of the evidence that supports a relation between garlic intake and reduced risk of different cancers with respect to food labeling. CONCLUSIONS: There was no credible evidence to support a relation between garlic intake and a reduced risk of gastric, breast, lung, or endometrial cancer. Very limited evidence supported a relation between garlic consumption and reduced risk of colon, prostate, esophageal, larynx, oral, ovary, or renal cell cancers.</P>
Kang, Ju Wan,Choi, Hyun Seung,Kim, Kyubo,Choi, Jae Young American Society for Clinical Nutrition 2014 The American journal of clinical nutrition Vol.99 No.6
<P><B>Background:</B> Previous animal studies have shown that vitamins may prevent age-related hearing loss. However, no concrete conclusions have been reached about the association between vitamin intake and presbycusis in humans.</P><P><B>Objective:</B> We investigated the association between dietary vitamin intake and hearing thresholds in adults between 50 and 80 y of age by using data from a large population-based survey.</P><P><B>Design:</B> We used data from the 2011 Korea National Health and Nutrition Examination Survey. A pure-tone audiogram and physical examination of the ear were performed, and vitamin intake was calculated by using the 24-h recall method. Data from 1910 participants were analyzed through univariate and multivariate linear regression analyses.</P><P><B>Results:</B> After adjustment for age, sex, smoking, and exposure to occupational and explosive noise, intake of vitamin C correlated with better hearing at midfrequency (2000 and 3000 Hz) (coefficient: −0.012; 95% CI: −0.022, −0.002). Dietary supplement use was positively associated with better hearing at all frequencies. The univariate analysis indicated that dietary intakes of retinol, riboflavin, niacin, and vitamin C were positively correlated with better hearing at most frequencies. In contrast, serum concentrations of vitamin D were associated with worse hearing at mid and high (4000 and 6000 Hz) frequencies.</P><P><B>Conclusions:</B> Dietary intake of vitamin C was associated with better hearing in the older population. Because less than one-half of elderly participants in this study consumed a sufficient amount of vitamins, and vitamin intake decreased with age, we should consider proper diet counseling to prevent hearing decline.</P>
Baik, Inkyung,Lee, SeungKu,Kim, Seong Hwan,Shin, Chol American Society for Nutrition 2013 The Journal of nutrition Vol.143 No.10
<P>There are limited data from prospective studies regarding interactions between lipoprotein lipase gene (<I>LPL</I>) and lifestyle factors in association with HDL-cholesterol (HDL-C) concentrations, a biomarker of coronary heart disease risk. Our prospective cohort study investigated the interactive effects of a common <I>LPL</I> polymorphism and lifestyle factors, including obesity, smoking, alcohol consumption, physical activity, and dietary intake, on follow-up measurements of HDL-C and triglyceride (TG) concentrations. A total of 5314 Korean men and women aged 40–69 y participated in the study. Serum HDL-C and TG concentrations were measured in all participants at baseline and 6-y follow-up examinations. On the basis of genome-wide association data for HDL-C and TG concentrations, we selected the most significant polymorphism (rs10503669), which was in high linkage disequilibrium with the serine 447 stop (<I>S447×</I>) mutation (D′ = 0.99) of <I>LPL</I>. We found that carrying the T allele reflecting the <I>LPL ×447</I> allele was positively associated with follow-up measurement of HDL-C concentrations (<I>P</I> < 0.001). In the linear regression model adjusted for baseline HDL-C concentration and potential risk factors, we observed interactive effects of the polymorphism and consumption of alcohol (<I>P</I>-interaction < 0.01) and unsaturated fat (<I>P</I>-interaction < 0.05) on follow-up measurement of HDL-C concentrations. We also observed interactive effects of the polymorphism and body mass index (<I>P</I>-interaction < 0.01) on follow-up measurement of TG concentrations after adjusting for the baseline level and potential risk factors. Our findings suggest that carriers of the <I>LPL ×447</I> allele benefit from moderate alcohol consumption and a diet high in unsaturated fat to minimize reduction of blood HDL-C concentrations and that obese persons who do not carry the <I>LPL ×447</I> allele need to control body weight to prevent hypertriglyceridemia.</P>
Activation of Caspase-8 Contributes to 3,3′-Diindolylmethane-Induced Apoptosis in Colon Cancer Cells
Kim, Eun Ji,Park, So Young,Shin, Hyun-Kyung,Kwon, Dae Young,Surh, Young-Joon,Park, Jung Han Yoon American Society for Nutrition 2007 The Journal of nutrition Vol.137 No.1
<P>3,3'-Diindolylmethane (DIM) is the major in vivo product of acid-catalyzed oligomerization of indole-3-carbinol, which is a promising anticancer agent present in cruciferous vegetables and has itself been reported to have anticarcinogenic properties. This study examined DIM-mediated regulation of apoptosis in the HCT116 (wild-type p53) and HT-29 (mutant p53) human colon cancer cell lines. DIM (0-30 micromol/L) substantially decreased the number of viable cells and induced apoptosis of HCT116 and HT-29 cells in a concentration-dependent manner. Western-blot analyses of total cell lysates revealed that DIM increased the activation of caspase-3, -7, -8, and -9 and enhanced poly(ADP-ribose) polymerase cleavage in both HCT116 and HT-29 cells. In addition, DIM increased the translocation of cytochrome c and Smac/Diablo from the mitochondria to the cytoplasm. In concert with the caspase-8 activation by DIM, increased levels of Fas and truncated Bid were observed. DIM did not affect the protein levels of p53, Bcl-2, Bax, or Fas ligand (FasL) in HCT116 cells. In HT-29 cells, however, DIM decreased Bcl-2 levels, although the protein levels of Bax or FasL were not affected. The caspase-8 inhibitor Z-IETD-FMK attenuated the DIM-induced apoptosis, indicating that increased activation of this enzyme contributed to the increase in p53-independent apoptosis that was observed in colon cancer cells. We have demonstrated that DIM induces apoptosis in colon cancer cells, providing insights into the mechanisms underlying its antitumorigenic activities.</P>