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Spatiotemporal Expression of tmie in the Inner Ear of Rats during Postnatal Development.
Shin, Mi Jung,Lee, Jeong-Han,Yu, Dong Hoon,Kim, Hye Jung,Bae, Ki Beom,Yuh, Hyung Soo,Kim, Myoung Ok,Hyun, Byung-Hwa,Lee, Sanggyu,Park, Raekil,Ryoo, Zae Young American Association for Laboratory Animal Science 2010 Comparative medicine Vol.60 No.4
<P>The circling (cir/cir) mouse is a murine model for human nonsyndromic deafness DFNB6. Transmembrane inner ear (tmie) is the causative gene and its mutation through deletion of a 40-kilobase genomic region including tmie leads to deafness. The function of Tmie is unknown. To better understand the function of Tmie, we focused on the spatiotemporal expression of tmie in the rat cochlea by using a Tmie-specific antibody. Results showed that tmie expression was prominent in early postnatal rat cochleas in the stereocilia bundles of hair cells. The Tmie signal spread from the stereocilia to the hair cell body region and on to organ of Corti cells. No Tmie signal was observed in cell nuclei; Tmie was localized to the cytoplasm. Because Tmie is predicted to have 1 or 2 transmembrane domains, we postulate that it is localized to membrane-based organelles or the plasma membrane. Our results imply that Tmie exists in the cytoplasm and may have a key role in the maturation and structure of stereocilia bundles in developing hair cells. After hair cell maturation, Tmie is thought to be involved in the maintenance of organ of Corti cells.</P>
Kang, Byeong-Teck,Jang, Dong-Pyo,Gu, Su-Hyun,Kim, Young-Bo,Lim, Chae-Young,Lee, Jong-Hwan,Woo, Eung-Je,Cho, Zang-Hee,Park, Hee-Myung American Association for Laboratory Animal Science 2009 Comparative medicine Vol.59 No.1
<P>The purpose of this study was to evaluate the potential efficacy of 3-dimensional time-of-flight magnetic resonance angiography (TOF-MRA) to validate a canine ischemic stroke model. Ischemic stroke was induced through permanent middle cerebral artery occlusion (MCAO) in 5 healthy Beagle dogs. T2-turbo spin echo images and TOF-MRA were obtained with a 1.5-T magnetic resonance system before and 3 and 10 d after MCAO. In 3 dogs, angiograms of the brain obtained at 3 d after MCAO showed complete occlusion of the MCA; in addition, T2 hyperintensities were present unilaterally in the striatocapsular and cerebral cortex lesions. Partial occlusion of the proximal part of the MCA was identified in the 2 remaining dogs, with T2 hyperintensities present only in the striatocapsular lesions. The occluded sites were confirmed at necropsy. The results of this study demonstrate the potential of TOF-MRA to provide a detailed description of intracranial arteries and aid in the evaluation of flow impairment in a canine MCAO model.</P>
Kang, Byeong-Teck,Jang, Dong-Pyo,Gu, Su-Hyun,Lee, Jong-Hwan,Jung, Dong-In,Lim, Chae-Young,Kim, Ha-Jung,Kim, Young-Bo,Kim, Hyung-Joong,Woo, Eung-Je,Cho, Zang-Hee,Park, Hee-Myung American Association for Laboratory Animal Science 2009 Comparative medicine Vol.59 No.5
<P>The purpose of this study was to evaluate the diagnostic value of magnetic resonance imaging (MRI) and assess the correlation between the volume of the ischemic lesion and neurobehavioral status during the subacute stage of ischemic stroke. Ischemic stroke was induced in 6 healthy laboratory beagles through permanent occlusion of the middle cerebral artery (MCAO). T2-weighted and fluid-attenuated inversion recovery (FLAIR) imaging, diffusion-weighted imaging (DWI), measurement of the apparent diffusion coefficient (ADC) ratio, and neurobehavioral evaluation were performed 3 times serially by using a 1.5-T MR system: before and 3 and 10 d after MCAO. Ischemic lesions demonstrated T2 hyperintensity, FLAIR hyperintensity, and DWI hyperintensity. The ADC ratio was decreased initially but then was increased at 10 d after MCAO. Ischemic lesion volumes on T2-weighted and FLAIR imaging were not significantly different from those on DWI. The lesion volume and neurobehavioral score showed strong correlation. Our results suggest that conventional MRI may be a reliable diagnostic tool during the subacute stage of canine ischemic stroke.</P>
Cho, Yu Ji,Han, Jae Yoon,Lee, Sang Gab,Jeon, Byeong Tak,Choi, Wan Sung,Hwang, Young Sil,Roh, Gu Seob,Lee, Jong Deog American Association for Laboratory Animal Science 2009 Comparative medicine Vol.59 No.4
<P>Angiogenic factors such as vascular endothelial growth factor (VEGF) are implicated in pulmonary hypertension (PH). However, the pathway of angiogenic factor-mediated pathologic angiogenesis in PH remains unclear. In this study, we evaluated the temporal expression of angiopoietin (Ang) 1, Ang2, and their receptor (Tie2) as well as VEGF, endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), and heme oxygenase 1 (HO1) in the monocrotaline-induced PH model. Histologic evaluation showed pathologic vascular remodeling in the arteries of lung sections 1 wk after monocrotaline treatment. Protein levels of Ang1, Ang2, eNOS, iNOS, HO1, and VEGF were increased 1 wk after monocrotaline treatment but Tie2 protein levels were decreased 2 wk afterward. These results suggest that Ang2 mediates vascular remodeling in PH by decreasing Tie2 expression. Therefore, the Ang-Tie2 system may play a role in the pathophysiology of PH.</P>
Comparison of Methods for Determining ABO Blood Type in Cynomolgus Macaques (Macaca fascicularis)
Kim, Tae M.,Park, Hyojun,Cho, Kahee,Kim, Jong S.,Park, Mi K.,Choi, Ju Y.,Park, Jae B.,Park, Wan J.,Kim, Sung J. AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE 2015 Journal of the American Association for Laboratory Vol.54 No.3