A 12-MHz CW RFQ for the AEBL Project

D. L. Schrage,P. N. Ostroumov,A. Barcikowski,D. Fallin,A. A. Kolomiets 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.3

The Advanced Exotic Beam Laboratory (AEBL) at the Argonne National Laboratory (ANL) will provide a research facility for studies of nuclear phenomena by using beams of short-lived isotopes for research on the nature of nucleonic matter and the origin of the elements, for tests of the Standard Model, for applications in medicine and industry, and for other applied physics research. The proposed design of the AEBL driver linac evolved from the Rare Isotope Accelerator (RIA) project. The AEBL will be a CW linac capable of accelerating uranium ions up to 200 MeV/u and protons to 580 MeV with 400 kW beam power. The AEBL facility also includes a post-accelerator which is designed for acceleration of radioactive ions with charge-to-mass ratios in the range from 1/238 to 1/6. Very low charge-state ions can be most eciently bunched and accelerated by using normally-conducting radio-frequency quadrupole (RFQ) for the rst few MV of the post accelerator. A two-meter long, 12-MHz CW RFQ was designed, built, and tested in the late 1990s as the rst section of a three-section RFQ [18]. This RFQ achieved inter-electrode voltages of 110 kV CW (the peak surface eld was 15 MV/m) and accelerated beams with A/q as large as 132 (132Xe). The AEBL requires a similar RFQ for the post-acceleration of singly-charged unstable nuclides. Our plan is to replace the vanes of this RFQ with a design that incorporates a stronger focusing and that will achieve a higher peak surface eld (16 MV/m) at 82.2-kV inter-vane voltage. The objectives of this project are 1. to conrm the possibility of a low injection energy of 0.4 keV/u which signicantly reduces the voltage required for a high-voltage deck; 2. to test the highest possible peak surface eld on the RFQ electrodes designed for the lowest frequency of 12 MHz compared to existing RFQs worldwide; 3. to provide a technical base for the design of a post-accelerator for the future Advanced Exotic Beam Facility. At the present time, the design is complete, and the fabrication of the 12 MHz RFQ is scheduled to commence in October 2007 with testing planned in 2008. The physics and engineering design of the RFQ is discussed. The Advanced Exotic Beam Laboratory (AEBL) at the Argonne National Laboratory (ANL) will provide a research facility for studies of nuclear phenomena by using beams of short-lived isotopes for research on the nature of nucleonic matter and the origin of the elements, for tests of the Standard Model, for applications in medicine and industry, and for other applied physics research. The proposed design of the AEBL driver linac evolved from the Rare Isotope Accelerator (RIA) project. The AEBL will be a CW linac capable of accelerating uranium ions up to 200 MeV/u and protons to 580 MeV with 400 kW beam power. The AEBL facility also includes a post-accelerator which is designed for acceleration of radioactive ions with charge-to-mass ratios in the range from 1/238 to 1/6. Very low charge-state ions can be most eciently bunched and accelerated by using normally-conducting radio-frequency quadrupole (RFQ) for the rst few MV of the post accelerator. A two-meter long, 12-MHz CW RFQ was designed, built, and tested in the late 1990s as the rst section of a three-section RFQ [18]. This RFQ achieved inter-electrode voltages of 110 kV CW (the peak surface eld was 15 MV/m) and accelerated beams with A/q as large as 132 (132Xe). The AEBL requires a similar RFQ for the post-acceleration of singly-charged unstable nuclides. Our plan is to replace the vanes of this RFQ with a design that incorporates a stronger focusing and that will achieve a higher peak surface eld (16 MV/m) at 82.2-kV inter-vane voltage. The objectives of this project are 1. to conrm the possibility of a low injection energy of 0.4 keV/u which signicantly reduces the voltage required for a high-voltage deck; 2. to test the highest possible peak surface eld on the RFQ electrodes designed for the lowest frequency of 12 MHz compared to existing RFQs worldwide; 3. to provide a technical base for the design of a post-accelerator for the future Advanced Exotic Beam Facility. At the present time, the design is complete, and the fabrication of the 12 MHz RFQ is scheduled to commence in October 2007 with testing planned in 2008. The physics and engineering design of the RFQ is discussed.

Development of Sensitive Analytical Method of Rhodanthpyrone A by a LC-MS/MS and its Application to Bioavailability Study in Rats

Kang, Bitna,Yoon, Jeong A,Song, Im-Sook,Han, Young Taek,Choi, Min-Koo Korean Society for Mass Spectrometry 2019 Mass spectrometry letters Vol.10 No.3

A sensitive analytical method of rhodanthpyrone A in rat plasma was developed using a liquid chromatography-tandem mass spectrometry (LC-MS/MS). Rhodanthpyrone A and rhodanthpyrone B (internal standard) in rat plasma were extracted by a liquid-liquid extraction method with ethyl acetate. This extraction method gave results in high and reproducible extraction recovery in the range of 73.75-79.90% with no interfering peaks around the peak elution time of rhodanthpyrone A and B. The standard calibration curves for rhodanthpyrone A ranged from 0.5 to 2000 ng/mL were linear with $r^2$ > 0.994 and the inter- and intra-day accuracy and precision and the stability were within acceptance criteria. Using this validated analytical method, pharmacokinetics of rhodanthpyrone A following intravenous and oral administration of rhodanthpyrone A at doses of 2 mg/kg and 30 mg/kg, respectively, were investigated. Rhodanthpyrone A in rat plasma showed multi-exponential elimination pattern with high clearance and volume of distribution values. The absolute oral bioavailability of this compound was calculated as 3.7%. Collectively, the newly developed sensitive LC-MS/MS analytical method of rhodanthpyrone A could be successfully applied to investigate the pharmacokinetic properties of this compound and would be useful for the further studies on the efficacy, toxicity, and biopharmaceutics of rhodanthpyrone A.

Lebesgue’s criterion for the Riemann integration with respect to a state on a separable unital C*- algebra

A. I. Shtern 장전수학회 2016 Advanced Studies in Contemporary Mathematics Vol.26 No.2

In the paper “Semicontinuous envelopes, Riemann integral, and uniform distribution in C*-algebras” (Funct. Anal. Appl. 29 (4), 268– 275 (1995)(1996)), the author had constructed the Riemann integral with respect to a state on a separable unital C*-algebra A. In particular, the semicontinuous hulls of elements of the enveloping von Neumann algebra A of A were introduced and studied and, for a given state ! on A, a class of selfadjoint elements of the algebra A that are Riemann integrable with respect to the state ω were introduced. It was also proved that this class is the self-adjoint part of a C*-algebra, and relations to the uniform distribution of states of the C*-algebra A with respect to the state ω were indicated. In the present note, we supplement these results by a version of Lebesgue’s criterion for the Riemann integrability of self-adjoint elements of A.

A spick-and-span approach to the immobilization of horseradish peroxidase on Au nanospheres incorporated with a methionine/graphene biomatrix for the determination of endocrine disruptor bisphenol A

Vilian, A.T. Ezhil,Giribabu, Krishnan,Choe, Sang Rak,Muruganantham, Rethinasabapathy,Lee, Hoomin,Roh, Changhyun,Huh, Yun Suk,Han, Young-Kyu Elsevier Sequoia 2017 Sensors and actuators. B Chemical Vol.251 No.-

<P><B>Abstract</B></P> <P>In the present study, we employ a straightforward, benign strategy to prepare thiol-functionalized reduced graphene oxide (S-RGO) using methionine as the sulphur source and reducing agent. The immobilization of horseradish peroxidase (HRP) over the AuNPs/S-RGO was developed by incorporating AuNPs on the S-RGO surface. The fabricated HRP/AuNPs/S-RGO electrode exhibits a remarkable decrease in the overpotential and a significantly increased oxidation peak current of bisphenol A (BPA) compared with the bare glassy carbon electrode (GCE) and AuNPs/S-RGO electrode. The biosensor shows an excellent amperometric analytical performance with a low detection limit of 2.6×10<SUP>−12</SUP> M and a linear range from 2.0×10<SUP>−11</SUP> to 1.18×10<SUP>−9</SUP> M, with the response time <2s for BPA. From the results, the apparent Michaelis-Menten constant was calculated as 8.14nM. The HRP/AuNPs/S-RGO biosensor exhibited faster response, adequate storage stability, inexpensive, simple fabrication with disposability, satisfactory reproducibility and repeatability, and outstanding selectivity. Finally, the constructed biosensor was utilized successfully for detecting BPA in tomato juice and milk samples with acceptable results.</P> <P><B>Highlights</B></P> <P> <UL> <LI> HRP/AuNPs/S-RGO biocomposite has been prepared to determine bisphenol A. </LI> <LI> The AuNPs/S-RGO is a promising platform for HRP immobilization. </LI> <LI> The biosensor exhibits excellent stability, reproducibility and high selectivity. </LI> <LI> It exhibits LOD of 2.6×10<SUP>−12</SUP> in a wide linear range from 2.0×10<SUP>−11</SUP> to 1.18×10<SUP>−9</SUP> M. </LI> <LI> It detects bisphenol A in real samples such as tomato juice and milk. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

$n$-weak amenability and strong double limit property

A.R. Medghalchi,T. Yazdanpanah 대한수학회 2005 대한수학회보 Vol.42 No.2

Let {mathcal A} be a Banach algebra, we say that {mathcalA}has the strongly double limit property (SDLP) if for each boundednet (a_{alpha}) in {mathcal A} and each bounded net(a^*_{beta}) in {mathcal A}^*, lim_{alpha}lim_{beta}leftlangle a_{alpha} , a^*_{beta}rightrangle = lim_{beta} lim_{alpha} leftlangle a_{alpha}, a^*_{beta} rightrangle whenever both iterated limits exist. In this paperamong other results we show that if {mathcal A} has the SDLP and{mathcal A}^{**} is (n-2)-weakly amenable, then {mathcal A} isn-weakly amenable. In particular, it is shown that if {mathcalA}^{**} is weakly amenable and {mathcal A} has the SDLP, then ${\mathcal A}$ is weakly amenable

Solvothermal synthesis of high-performance Ni-Co layered double hydroxide nanofoam electrode for electrochemical energy storage

Patel, R.,Inamdar, A.I.,Hou, B.,Cha, S.,Ansari, A.T.,Gunjakar, J.L.,Im, H.,Kim, H. ELSEVIER 2017 Current Applied Physics Vol.17 No.4

<P>A nanofoam nickel cobalt layered double hydroxide (NiCo(OH)(2)) electrode film is fabricated on a stainless-steel substrate with the use of a simple one-step solvothermal process. The nanofoam NiCo(OH)(2) electrode exhibits a high specific capacitance of 2710.2 Fig at a current density.of 9.1 A/g, and a good capacity retention of similar to 70% after 2000 charge-discharge cycles at a high current density of 31.8 A/g. An energy density of 60.23 Wh/kg is obtained at a power density of 1.8 kW/kg. The excellent electrochemical energy storage performance of the NiCo(OH)(2) electrode is due to the synergetic effect of a significantly improved ionic diffusion and an effective charge transfer, which is linked to a well-dispersed interconnected nanofoam morphology and binder-free direct contact with the current collector. (C) 2017 Elsevier B.V. All rights reserved.</P>

Upper edge-to-vertex detour monophonic number of a graph

A. P. Santhakumaran,P. Titus,K. Ganesamoorthy 장전수학회 2016 Advanced Studies in Contemporary Mathematics Vol.26 No.2

For a connected graph G = (V,E) of order at least three, the monophonic distance dm(u, v) is the length of a longest u−v monophonic path in G. A u − v path of length dm(u, v) is called a u − v detour monophonic. For subsets A and B of V , the monophonic distance dm(A,B) is defined as dm(A,B) = min{dm(x, y) : x ∈ A, y ∈ B}. A u−v path of length dm(A, B) is called an A−B detour monophonic path joining the sets A,B ⊆ V, where u ∈ A and v ∈ B. A set S ⊆ E is called an edge-to-vertex detour monophonic set of G if every vertex of G is incident with an edge of S or lies on a detour monophonic path joining a pair of edges of S. The edge-to-vertex detour monophonic number dmev(G) of G is the minimum cardinality of its edge-to-vertex detour monophonic sets and any edge-to-vertex detour monophonic set of car- dinality dmev(G) is an edge-to-vertex detour monophonic basis of G. An edge-to-vertex detour monophonic set S in a connected graph G is called a minimal edge-to-vertex detour monophonic set of G if no proper subset of S is an edge-to-vertex detour monophonic set of G. The upper edge-to-vertex detour monophonic number dm+ ev(G) of G is the maxi- mum cardinality of a minimal edge-to-vertex detour monophonic set of G. We determine bounds for it and certain general properties of these concepts are studied. It is shown that for every pair a, b of integers with 2 ≤ a ≤ b, there exists a connected graph G with dmev(G) = a and dm+ ev(G) = b.

A microfluidic electrochemical aptasensor for enrichment and detection of bisphenol A.

Kashefi-Kheyrabadi, Leila,Kim, Junmoo,Gwak, Hogyeong,Hyun, Kyung-A.,Bae, Nam Ho,Lee, Seok Jae,Jung, Hyo-Il Elsevier 2018 Biosensors & bioelectronics Vol.117 No.-

<P><B>Abstract</B></P> <P>Bisphenol A (BPA) is an organic monomer used to make common consumer goods such as plastic containers, sports equipment, and cosmetics which are heavily produced worldwide. A growing interest has been drawn to general public as BPA is one of the major endocrine disrupting chemicals threating human health. To date, numerous BPA sensors have been attempted to be developed but important challenges still remained such as limited linearity range, easy to use, and long term response time. To address the present issues, a microfluidic channel should be integrated into an electrochemical aptasensor and it is called Geometrically Activated Surface Interaction (GASI) chip. The vigorous generation of the micro-vortex in the GASI fluidic chamber provides the high collision chances between BPA and anti-BPA aptamer (BPAPT) and consequently more BPA molecules can be captured on the aptasensor surface, which finally results in high sensitivity of the aptasensor. To construct the integrated aptasensor, a miniaturized gold electrode is fabricated using shadow mask and e-beam evaporation process. Afterward, BPAPT is immobilized on a nanostructured gold electrode via thiol chemistry, and other terminus of the aptamer is labeled with a ferrocene (Fc) redox probe. Then, the microfluidic channel is mounted over the miniaturized gold electrode to introduce and enrich BPA to the aptasensor. Upon the specific interaction between BPA and its aptamer, configuration of aptamer is changed so that Fc tag approaches to the electrode surface and direct oxidation signal of Fc and BPA are followed as analytical signals. The unique microfluidic integrated electrochemical aptasensor delivers a wide linear dynamic range over 5 × 10<SUP>–12</SUP> to 1 × 10<SUP>−9</SUP> M, with a limit of detection 2 × 10<SUP>–13</SUP> M. This aptasensor provides a precise platform for simple, selective and more importantly rapid detection of BPA. Such kind of sensing platforms can serve as a fertile ground for designing miniaturized portable sensors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> GASI generates micro-vortex resulting in enhanced capture of BPA and subsequently enhanced sensitivity of the aptasensor. </LI> <LI> The aptasensor has low LOD, wide linear dynamic range and good response time compared to conventional aptasensors. </LI> </UL> </P>

A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype

Kim, Hyun Jin,Li, Qin,Tjon-Kon-Sang, Sandra,So, Insuk,Kiselyov, Kirill,Soyombo, Abigail A,Muallem, Shmuel Wiley (John WileySons) 2008 The EMBO journal Vol.27 No.8

<P>TRPML3 belongs to the TRPML subfamily of the transient receptor potential (TRP) channels. The A419P mutation in TRPML3 causes the varitint-waddler phenotype as a result of gain-of-function mutation (GOF). Regulation of the channels and the mechanism by which the A419P mutation leads to GOF are not known. We report here that TRPML3 is a Ca(2+)-permeable channel with a unique form of regulation by extracytosolic (luminal) H(+) (H(+)(e-cyto)). Regulation by H(+)(e-cyto) is mediated by a string of three histidines (H252, H273, H283) in the large extracytosolic loop between transmembrane domains (TMD) 1 and 2. Each of the histidines has a unique role, whereby H252 and H273 retard access of H(+)(e-cyto) to the inhibitory H283. Notably, the H283A mutation has the same phenotype as A419P and locks the channel in an open state, whereas the H283R mutation inactivates the channel. Accordingly, A419P eliminates regulation of TRPML3 by H(+)(e-cyto), and confers full activation to TRPML3(H283R). Activation of TRPML3 and regulation by H(+)(e-cyto) are altered by both the alpha-helix-destabilizing A419G and the alpha-helix-favouring A419M and A419K. These findings suggest that regulation of TRPML3 by H(+)(e-cyto) is due to an effect of the large extracytosolic loop on the orientation of fifth TMD and thus pore opening and show that the GOF of TRPML3(A419P) is due to disruption of this communication.</P>

Edge-to-vertex detour number of a graph

A. P. Santhakumaran,S. Athisayanathan 장전수학회 2011 Advanced Studies in Contemporary Mathematics Vol.21 No.4

For two vertices u and v in a graph G = (V,E), the detour distance D(u, v)is the length of a longest u–v path in G. A u–v path of length D(u, v) is called a u–v detour. For subsets A and B of V , the detour distance D(A,B)is defined as D(A,B) = min{D(x, y) : x ∈ A, y ∈ B}. A u–v path of length D(A,B) is called an A–B detour joining the sets A, B ⊆ V where u ∈ A and v ∈ B. A vertex x is said to lie on an A–B detour if x is a vertex of an A–B detour. A set S ⊆ E is called an edge-to-vertex detour set if every vertex of G is incident with an edge of S or lies on a detour joining a pair of edges of S. The edge-to-vertex detour number dn_2(G) of G is the minimum order of its edge-to-vertex detour sets and any edge-to-vertex detour set of order dn_2(G) is an edge-to-vertex detour basis of G. Certain general properties of these concepts are studied. The edge-to-vertex detour numbers of certain classes of graphs are determined. Its relationship with the detour diameter is discussed and it is proved that for each triple D, k, q of integers with 2 ≤ k ≤ q − D + 2 and D ≥ 4 there is a connected graph G of order p with detour diameter D and dn_2(G) = k. It is also proved that for any three positive integers a, b, k with k ≥ 2 and a < b ≤ 2a, there is a connected graph with detour radius a, detour diameter b and dn_2(G) = k.