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        Biosorption of Zn2+ and Pb2+ from aqueous solutions using native and microwave treated Flammulina velutipes stipe

        Yun Wu,Zhongze Zhou,Ruiwen Yan,Jun Zheng 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.8

        Native stipe (NS) and microwave treated stipe (MTS) of Flammulina velutipes were utilized for the biosorptionof Zn2+ and Pb2+ ions from aqueous solution. The effects of pH, contact time, and initial concentration on thebiosorption were studied for each metal separately. The desired pH of aqueous solution was found to be 6.0 for theremoval of Zn2+ ions and 5.0 for the removal of Pb2+ ions. The percent removal of both metals was found to increasewith the increase in contact time; biosorption equilibrium was established in about 60min. The maximum biosorptionof Zn2+ and Pb2+ ions from single component systems can be successfully described by Langmuir and Freundlich models;the biosorption kinetics can be accurately described by a second-order kinetic model. The present data from these studiesconfirms that the native and microwave treated forms of Flammulina velutipes stipe have the potential to be used forthe biosorption of Zn2+ and Pb2+ ions from aqueous solution. The metal biosorption capacities of NS for Zn2+ and Pb2+were 58.14 and 151.51 mg g−1, respectively, while the biosorption capacities of MTS for the both metals were 95.24and 172.41 mg g−1, respectively.

      • Norcantharidin Anti-Angiogenesis Activity Possibly through an Endothelial Cell Pathway in Human Colorectal Cancer

        Yu, Tao,Hou, Fenggang,Liu, Manman,Zhou, Lihong,Li, Dan,Liu, Jianrong,Fan, Zhongze,Li, Qi Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

        The present study was based on the unexpected discovery that norcantharidin exerted anti-angiogenesis activity when effects on growth of human colon cancer were studied. The aim was to further verify this finding and explore possible mechanisms using a tumor xenograft model in nude mice. We confirmed that norcantharidin (5 or 15 mg/kg) could inhibit angiogenesis of human colon cancer in vivo. In vitro, crossing river assay, cell adhesion assay and tube formation assay indicated that NCTD could reduce the migration, adhesion and vascular network tube formation ability of HUVECs. At the same time, the expression levels of VEGF and VEGFR-2 proteins which play important roles in angiogenesis were reduced as examined by western blotting analysis. Taken together, the results firstly showed NCTD could inhibit angiogenesis of human colon cancer in vivo, probably associated with effects on migration, adhesion and vascular network tube formation of HUVECs and expression levels of VEGF and VEGFR-2 proteins.

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