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Zhian Jin,Pujie Wang,Jie Chen,Li He,Lijia Xiao,Kaisen Yong,Shenglin Deng,Lin Zhou 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.5
Purpose: C-end rule (CendR) peptides are found to enhance the penetration of chemotherapeutic agents into tumor cells, whileGX1 is a peptide that homes to gastric cancer (GC) vasculature. This study aimed to synthesize a novel peptide GX1-RPAKPAR(GXC) and to explore the effect of GXC on sensitizing GC cells to chemotherapeutic agents. Materials and Methods: Intracellular Adriamycin concentration analysis was applied to conform whether GXC peptide increasesthe penetration of chemotherapeutic agents into GC cells in vitro. The effect of GXC peptide on sensitizing GC cells to chemotherapeuticswas validated by apoptosis assay and in vitro/vivo drug sensitivity assay. The specificity of GXC to GC tissue was validatedby ex vivo fluorescence imaging. Results: In vitro, administration of GXC significantly increased Adriamycin concentrations inside SGC-7901 cells, and enhancedthe efficacy of chemotherapeutic agents by decreasing the IC50 value. In vivo, FITC-GXC specifically accumulated in GC tissue. Moreover, systemic co-injection with GXC peptide and Adriamycin statistically improved the therapeutic efficacy in SGC-7901xenograft models, surprisingly, without obviously increasing side effects. Conclusion: These results demonstrated that co-administration of the novel peptide GXC with chemotherapeutic agents may bea potential way to enhance the efficacy of anticancer drugs in GC treatment.
Xuancheng Jin,Zhen Cheng,Zhian Ye,Weihua Gong 한국인터넷정보학회 2024 KSII Transactions on Internet and Information Syst Vol.18 No.4
In this paper, the optimizations of multi-hop cooperative molecular communication (CMC) system in cylindrical anomalous-diffusive channel in three-dimensional enviroment are investigated. First, we derive the performance of bit error probability (BEP) of CMC system under decode-and-forward relay strategy. Then for achieving minimum average BEP, the optimization variables are detection thresholds at cooperative nodes and destination node, and the corresponding optimization problem is formulated. Furthermore, we use conjugate gradient (CG) algorithm to solve this optimization problem to search optimal detection thresholds. The numerical results show the optimal detection thresholds can be obtained by CG algorithm, which has good convergence behaviors with fewer iterations to achieve minimized average BEP compared with gradient decent algorithm and Bisection method which are used in molecular communication.