http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Zhang Wentao,Zheng Zongtai,Wang Keyi,Mao Weipu,Li Xue,Wang Guangchun,Zhang Yuanyuan,Huang Jianhua,Zhang Ning,Wu Pengfei,Liu Ji,Zhang Haimin,Che Jianping,Peng Bo,Zheng Junhua,Li Wei,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.
Wentao Hu,Xiehuai Luo,Zheng Yan 한국고분자학회 2017 폴리머 Vol.41 No.6
The effects of epoxy composites (EP) filled with tetrapod-like zinc oxide whiskers (T-ZnOw) were investigated in this study. The composites were blended by a self-regulation powerful shear mixer at different mixing clearances. The microstructure, curing behavior, mechanical performance, thermal and electrical properties were examined. The results showed that the particles of T-ZnOw are dispersed more uniformly in the epoxy matrix mixed by the powerful shear mixer compared with those mixed by the traditional mixing method. Both the initial reaction of extrapolation temperature (T0) and the peak temperature (Tp) enlarge with the augment of the clearance (δ). The range of curing temperature narrows down. ΔH, tensile and impact strength of composites decreases with the increasing of δ.
Research on Routing Protocols and Simulation Analysis for Opportunistic Networks
Wentao Wang,Feng Guo,Fang Zheng,Wan Tang,Jiangqing Wang 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.3
Opportunistic networks are a kind of Ad Hoc networks that make use of meeting opportunities from mobile nodes to realize the network communication which doesn't need a full path between the source nodes and destination nodes. It’s tolerant in latency and network division. It’s a great challenge to design routing protocols in opportunistic networks in that the movements of nodes are uncertain leading to intermittent connection which make it hard to transmit message to its destination. However, the problems have also attracted more and more attention from researchers. Firstly, in this paper, we introduced the basic concept of opportunistic networks. Secondly we classified and interpreted routing protocols according to the infrastructure, scenario, forwarding mechanism etc. Thirdly, we carried out the computer simulation and analysis for opportunistic network routing protocols in aspect of message delivery ratio, network latency, routing overhead and the number of lost packets. Then we summarized the advantages and disadvantages of routing protocol and discussed its applicability. Finally we looked ahead the hotspot of recent routing protocols under opportunistic networks.
Zibin Zheng,Wentao Lyu,Qihua Hong,Hua Yang,Ying Li,Shengjun Zhao,Ying Ren,Yingping Xiao Asian Australasian Association of Animal Productio 2023 Animal Bioscience Vol.36 No.10
Objective: The objective of this study was to investigate the phylogenetic and expression analysis of the angiopoietin-like (ANGPTL) gene family and their role in lipid metabolism in pigs. Methods: In this study, the amino acid sequence analysis, phylogenetic analysis, and chromosome adjacent gene analysis were performed to identify the ANGPTL gene family in pigs. According to the body weight data from 60 Jinhua pigs, different tissues of 6 pigs with average body weight were used to determine the expression profile of ANGPTL1-8. The ileum, subcutaneous fat, and liver of 8 pigs with distinct fatness were selected to analyze the gene expression of ANGPTL3, ANGPTL4, and ANGPTL8. Results: The sequence length of ANGPTLs in pigs was between 1,186 and 1,991 bp, and the pig ANGPTL family members shared common features with human homologous genes, including the high similarity of the amino acid sequence and chromosome flanking genes. Amino acid sequence analysis showed that ANGPTL1-7 had a highly conserved domain except for ANGPTL8. Phylogenetic analysis showed that each ANGPTL homologous gene shared a common origin. Quantitative reverse-transcription polymerase chain reaction analysis showed that ANGPTL family members had different expression patterns in different tissues. ANGPTL3 and ANGPTL8 were mainly expressed in the liver, while ANGPTL4 was expressed in many other tissues, such as the intestine and subcutaneous fat. The expression levels of ANGPTL3 in the liver and ANGPTL4 in the liver, intestine and subcutaneous fat of Jinhua pigs with low propensity for adipogenesis were significantly higher than those of high propensity for adipogenesis. Conclusion: These results increase our knowledge about the biological role of the ANGPTL family in this important economic species, it will also help to better understand the role of ANGPTL3, ANGPTL4, and ANGPTL8 in lipid metabolism of pigs, and provide innovative ideas for developing strategies to improve meat quality of pigs.
Jeon, Mansik,Song, Wentao,Huynh, Elizabeth,Kim, Jungho,Kim, Jeesu,Helfield, Brandon L.,Leung, Ben Y. C.,Goertz, David E.,Zheng, Gang,Oh, Jungtaek,Lovell, Jonathan F.,Kim, Chulhong SPIE--the International Society for Optical Engine 2014 Journal of biomedical optics Vol.19 No.1
Ultrasound and photoacoustic imaging are highly complementary modalities since both use ultrasonic detection for operation. Increasingly, photoacoustic and ultrasound have been integrated in terms of hardware instrumentation. To generate a broadly accessible dual-modality contrast agent, we generated microbubbles (a standard ultrasound contrast agent) in a solution of methylene blue (a standard photoacoustic dye). This MB2 solution was formed effectively and was optimized as a dual-modality contrast solution. As microbubble concentration increased (with methylene blue concentration constant), photoacoustic signal was attenuated in the MB2 solution. When methylene blue concentration increased (with microbubble concentration held constant), no ultrasonic interference was observed. Using an MB2 solution that strongly attenuated all photoacoustic signal, high powered ultrasound could be used to burst the microbubbles and dramatically enhance photoacoustic contrast (>800-fold increase), providing a new method for spatiotemporal control of photoacoustic signal generation. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Yu Zhenjun,Li Yuhan,Shao Shuai,Guo Beichen,Zhang Mengxia,Zheng Lina,Zhang Kun,Zhou Feng,Zhang Li,Chen Chiyi,Jiang Wentao,Hong Wei,Han Tao 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Some long noncoding RNAs (lncRNAs), which harbor microRNAs in their gene sequence and are also known as microRNA host gene derived lncRNAs (lnc-MIRHGs), play a dominant role alongside miRNAs, or both perform biological functions synergistically or independently. However, only a small number of lnc-MIRHGs have been identified. Here, multiple liver injury datasets were analyzed to screen and identify the target lncRNA Mir122hg. Mir122hg was mainly enriched in liver tissues with human-mouse homology. In both CCl4-induced acute liver injury and Dgal/LPS-induced fulminant liver failure in mice, Mir122hg was sharply downregulated at the early stage, while a subsequent significant increase was only found in the CCl4 group with liver recovery. Overexpression and silencing assays confirmed that Mir122hg played a protective role in acute injury by promoting hepatocyte proliferation in vivo and in vitro. Consistent with the results of gene enrichment analysis, Mir122hg binding to C/EBPα affected its transcriptional repression, promoted gene transcription of downstream chemokines, Cxcl2, Cxcl3, and Cxcl5, and exerted pro-proliferative effects on hepatocytes through activation of the AKT/GSK-3β/p27 signaling pathway by CXC/CXCR2 complexes. This study identifies a novel lncRNA with protective effects in acute liver injury and demonstrates that the binding of Mir122hg-C/EBPα promotes hepatocyte proliferation via upregulation of CXC chemokine and activation of AKT signaling.