Characterization of the effect of He⁺ irradiation on nanoporous-isotropic graphite for molten salt reactors

Zhang, Heyao,He, Zhao,Song, Jinliang,Liu, Zhanjun,Tang, Zhongfeng,Liu, Min,Wang, Yong,Liu, Xiangdong Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.6

Irradiation-induced damage of binderless nanoporous-isotropic graphite (NPIG) prepared by isostatic pressing of mesophase carbon microspheres for molten salt reactor was investigated by 3.0 MeV He⁺ irradiation at room temperature and high temperature of 600 ℃, and IG-110 was used as the comparation. SEM, TEM, X-ray diffraction and Raman spectrum are used to characterize the irradiation effect and the influence of temperature on graphite radiation damage. After irradiation at room temperature, the surface morphology is rougher, the increase of defect clusters makes atom flour bend, the layer spacing increases, and the catalytic graphitization phenomenon of NPIG is observed. However, the density of defects in high temperature environment decreases and other changes are not obvious. Mechanical properties also change due to changes in defects. In addition, SEM and Raman spectra of the cross section show that cracks appear in the depth range of the maximum irradiation dose, and the defect density increases with the increase of irradiation dose.

The Media Literacy of Residents in Southwestern China During the COVID-19 Epidemic

Shan He(Shan He),Lili Yao(Lili Yao),Xingyu Zhao(Xingyu Zhao),Weiwei Liu(Weiwei Liu) 아시아사회과학학회 2023 International Science Research Vol.3 No.2

Objective To measure residents’ abilities to acquire, analyze and evaluate information on media in southwestern China and to explore its predictive factors. Methods The convenience sampling method was used. A web-based questionnaire survey was conducted among 774 residents during the Spring Festival in 2020. Results Young, highly educated, unmarried, high-income, and urban residents preferred to seek and acquire information about COVID-19 epidemic through new media channels. Elderly residents tended to obtain information through television. Residents with low educational background and rural residents were more dependent on community information media. To analyze residents’ abilities in the judgement of 15 statements about COVID-19, residents with a master’s degree or above (OR = 2.755, [95% CI 1.160-6.542]) had better media literacy in identifying false health information released on social networking. Rural residents (OR = 0.609, [95% CI 0.433-0.855]) had lower media literacy. The total score decreased by 2.6% for every one-year increase of age. Conclusion Residents’ abilities to acquire, analyze and evaluate information were affected by their demographic characteristics in southwestern China. The authorities and local communities should develop different approaches of information dissemination, with the help of traditional and new media. It is important to improve the level of residents' media literacy, in order to achieve better effect in information dissemination and reception.

Densifi cation of matrix graphite for spherical fuel elements used in molten salt reactor via addition of green pitch coke

Zhao He,Hongchao Zhao,Jinliang Song,Xiaohui Guo,Zhanjun Liu,Yajuan Zhong,T. James Marrow 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.4

Green pitch coke with an average particle size of 2 mm was adopted as densifier and added to the rawmaterials of conventional A3-3 matrix graphite (MG) to prepare modified A3-3 matrix graphite (MMG)by the quasi-isostatic molding method. The structure, mechanical and thermal properties were assessed. Compared with MG, MMG had a more compact structure, and exhibited improved properties of highermechanical strength, higher thermal conductivity and better molten salt barrier performance. Notably,under the same infiltration pressure of 5 atm, the fluoride salt occupation of MMG was only 0.26 wt%,whereas it was 15.82 wt% for MG. The densification effect of green pitch coke endowed MMG withimproved properties for potential use in the spherical fuel elements of molten salt reactor.

Performance of the R-way Colposcopic Evaluation System in Cervical Cancer Screening

Zhao, Jian,Zhang, Xi,Chen, Rui,Zhao, Yu-Qian,Wang, Ting-Ting,He, Shan,Qiao, You-Lin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10

Objective: To investigate the diagnostic value of the R-way colposcopic evaluation system (R-way system) in cervical cancer screening. Materials and Methods: Between August 2013 and August 2014, a total of 1,059 cases referred to colposcopy in Peking University First Hospital were studied using both the R-way system and conventional colposcopy. Our study evaluated and compared the diagnostic ability of the two methods in detecting high-grade lesions and cervical cancer (hereinafter called CIN2+). Evaluation indicators including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Youden index and the area under the curve (AUC) of the receiver operating characteristic (ROC) were calculated. Results: The R-way system had a slightly lower specificity (94.5%) than conventional colposcopy (96.0%) for CIN2+ detection (P=0.181). However, the sensitivity (77.8%) was significantly higher than with the conventional colposcopic method (46.6%) (${\chi}^2=64.351$, P<0.001). In addition, the AUC of the ROC for CIN2+ detection using the R-way system (0.839) was larger than that with conventional colposcopy (0.731) (Z=4.348, P<0.001). If preliminary result had been drawn from cervical exfoliated cytology before colposcopy referral, combination of the R-way system with cytology could increase the sensitivity to 93.9% for CIN2+ detection (excluding ASCUS\LSIL), confirmed by multipoint biopsy or ECC. Conclusions: The diagnostic value of the R-way evaluation system is higher than that of conventional colposcopic evaluation in cervical cancer screening. Moreover, taking the ease of use and standardized quality control management into account, the R-way system is highly preferable.

High Expression of Bcl-2 Protein Predicts Favorable Outcome in Non-small Cell Lung Cancer: Evidence from a Systematic Review and Meta-analysis

Zhao, Xian-Da,He, Yu-Yu,Gao, Jun,Zhao, Chen,Zhang, Ling-Lin,Tian, Jing-Yuan,Chen, Hong-Lei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Background: The prognostic value of Bcl-2 protein expression in non-small cell lung cancer (NSCLC) is under debate. We therefore systematically reviewed the evidence for Bcl-2 protein effects on NSCLC survival to elucidate this issue. Materials and Methods: An electronic search in Pubmed and Embase complemented by manual searches in article references were conducted to identify eligible studies to evaluate the association between Bcl-2 protein expression and overall survival (OS) as well as disease free survival (DFS) of NSCLC patients. Combined hazard ratios (HRs) with corresponding 95% confidence intervals (95%CIs) were pooled using the random-effects model. Results: A total of 50 trials (including 52 cohorts) encompassing 7,765 patients were pooled in the meta-analysis regarding Bcl-2 expression and OS of NSCLC patients. High expression of Bcl-2 protein had a favorable impact (HR=0.76, 95%CI=0.67-0.86). In the group of Bcl-2 expression and DFS, 11 studies including 2,634 patients were included. The synthesized result indicated high expression of Bcl-2 protein might predict good DFS (HR=0.85, 95%CI=0.75-0.95). Conclusions: Our present meta-analysis demonstrated favorable prognostic values of Bcl-2 expression in patients with NSCLC. Further prospective trails are welcomed to validate the utility of assessing Bcl-2 in NSCLC patient management.

Effect of Circuit Parameters on Stability of Voltage-fed Buck-Boost Converter in Discontinuous Conduction Mode

Zhao-He Feng,Ren-Xi Gong,Qing-Yu Wang 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.4

The state transition matrix are obtained by solving state equations in terms of Laplace inverse transformation and Cayley-Hamilton theorem, and an establishment of a precise discreteiterative mapping of the voltage-fed buck-boost converter operating in discontinuous conduction mode is made. On the basis of the mapping, the converter bifurcation diagrams and Lyapunov exponent diagrams with the input voltage, the resistance, the inductance and the capacitance as the bifurcation parameters are obtained, and the effect of the parameters on the system stability is deeply studied. The results obtained show that they have a great influence on the stability of the system, and the general trend is that the increase of either the voltage-fed coefficient, input voltage or the load resistance, or the decrease of the filtering inductance, capacitance will make the system stability become poorer, and that all the parameters have a critical value, and when they are greater or less than the values, the system will go through stable 1T orbits, stable 2T orbits, 4T orbits, 8T orbits and eventually approaches chaos.

The physics and chemistry of graphene-on-surfaces

Zhao, G.,Li, X.,Huang, M.,Zhen, Z.,Zhong, Y.,Chen, Q.,Zhao, X.,He, Y.,Hu, R.,Yang, T. Royal Society of Chemistry 2017 Chemical Society reviews Vol.46 No.15

Excluding molten fluoride salt from nuclear graphite by SiC/glassy carbon composite coating

Zhao He,Jinliang Song,Pengfei Lian,Dongqing Zhang,Zhanjun Liu 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.5

SiC coating and SiC/glassy carbon composite coating were prepared on IG-110 nuclear graphite (ToyoTanso Co., Ltd., Japan) to strengthen its inertness to molten fluoride salt used in molten salt reactor(MSR). Two kinds of modified graphite were obtained and correspondingly named as IG-110-1 and IG-110-2, which referred to modified IG-110 with a single SiC coating and a SiC/glassy carbon compositecoating, respectively. Both structure and property of modified graphite were carefully researched andcontrasted with virgin IG-110. Results indicated that modified graphite presented better comprehensiveproperties such as more compact structure and higher resistance to molten salt infiltration. With theprotection of coatings, the infiltration amounts of fluoride salt into modified graphite were much lessthan that into virgin IG-110 at the same circumstance. Especially, the infiltration amount of fluoride saltinto IG-110-2 under 5 atm was merely 0.26 wt%, which was much less than that into virgin IG-110 under1.5 atm (13.5 wt%) and the critical index proposed for nuclear graphite used in MSR (0.5 wt%). The SiC/glassy carbon composite coating gave rise to highest resistance to molten salt infiltration into IG-110-2,and thus demonstrated it could be a promising protective coating for nuclear graphite used in MSR.

Preliminary Report on Breeding of Coarse Size Variety ${CU_1}{\times}{CU_2}$ of Bombyx mori L

Zhao, Yuan,Wu, Yangchun,Qian, Heying,He, Yiyuan,He, Simei Korean Society of Sericultural Science 2004 International Journal of Industrial Entomology Vol.9 No.1

A number of Chinese, Japanese and European silkworm strains with coarse size filament were used for breeding the coarse size variety. Through cross breeding combined with pedigree selection within thirteen generations, a pair of coarse size silkworm variety, named ${CU_1}{\times}{CU_2}$, was obtained after five years. Laboratory trials showed that the filament size of its 4F_1$ hybrid was over 4.3 D, and the other economic characters were also good.

Production of Transgenic Pigs with an Introduced Missense Mutation of the Bone Morphogenetic Protein Receptor Type IB Gene Related to Prolificacy

Zhao, Xueyan,Yang, Qiang,Zhao, Kewei,Jiang, Chao,Ren, Dongren,Xu, Pan,He, Xiaofang,Liao, Rongrong,Jiang, Kai,Ma, Junwu,Xiao, Shijun,Ren, Jun,Xing, Yuyun Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.7

In the last few decades, transgenic animal technology has witnessed an increasingly wide application in animal breeding. Reproductive traits are economically important to the pig industry. It has been shown that the bone morphogenetic protein receptor type IB (BMPR1B) A746G polymorphism is responsible for the fertility in sheep. However, this causal mutation exits exclusively in sheep and goat. In this study, we attempted to create transgenic pigs by introducing this mutation with the aim to improve reproductive traits in pigs. We successfully constructed a vector containing porcine BMPR1B coding sequence (CDS) with the mutant G allele of A746G mutation. In total, we obtained 24 cloned male piglets using handmade cloning (HMC) technique, and 12 individuals survived till maturation. A set of polymerase chain reactions indicated that 11 of 12 matured boars were transgene-positive individuals, and that the transgenic vector was most likely disrupted during cloning. Of 11 positive pigs, one (No. 11) lost a part of the terminator region but had the intact promoter and the CDS regions. cDNA sequencing showed that the introduced allele (746G) was expressed in multiple tissues of transgene-positive offspring of No.11. Western blot analysis revealed that BMPR1B protein expression in multiple tissues of transgene-positive $F_1$ piglets was 0.5 to 2-fold higher than that in the transgene-negative siblings. The No. 11 boar showed normal litter size performance as normal pigs from the same breed. Transgene-positive $F_1$ boars produced by No. 11 had higher semen volume, sperm concentration and total sperm per ejaculate than the negative siblings, although the differences did not reached statistical significance. Transgene-positive $F_1$ sows had similar litter size performance to the negative siblings, and more data are needed to adequately assess the litter size performance. In conclusion, we obtained 24 cloned transgenic pigs with the modified porcine BMPR1B CDS using HMC. cDNA sequencing and western blot indicated that the exogenous BMPR1B CDS was successfully expressed in host pigs. The transgenic pigs showed normal litter size performance. However, no significant differences in litter size were found between transgene-positive and negative sows. Our study provides new insight into producing cloned transgenic livestock related to reproductive traits.