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Atefeh Seyyedan,Farhana Yahya,Mohammad Fauzi Fahmi Kamarolzaman,Zarizal Suhaili,Mohd Nasir Mohd Desa,Hussain Mohd Khairi,Muhammad Nazrul Somchit,Corazon Abdullah Fatimah,Lay Kek Teh,Mohd Zaki Salleh,Z 셀메드 세포교정의약학회 2013 TANG Vol.3 No.3
Piper sarmentosum is a creeping herb belongs to the family of Piperaceae. It is locally known to the Malays as ‘Pokok kadok’ and can be found in different regions of South-East Asia including Malaysia. Ethnopharmacologically, various parts of the plant (e.g. leave, fruit and root) are widely used in Asian countries for centuries to treat different types of diseases and ailments such as hypertension, diabetes, joint aches, muscle pain, coughs, influenza, toothaches and rheumatism. Scientific findings also demonstrated different pharmacological actions of various parts of P. sarmentosum such as adulticidal, antitermite, antioxidant, antifungal, antituberclosis, antiplasmoid, antimalarial, hypoglycemia, antiinflammatory, antinoceptive, antipyretic, antibacterial, anticancer, antituberculosis, antiangiogenesis, antimicrobial, antifeedant and cytotoxic activities. Different types of phytochemical constituents have been successfully identified and isolated from various parts of P. sarmentosum. Therefore, the information related to the botany, ethnomedicinal uses, phytochemical constituents and pharmacological activities of P. sarmentosum were reviewed here.
Syafawati Shamsahal Din,Siti Syariah Mamat,Noor Aisyah Ismail,Wan Noraziemah Wan Zainulddin,Zalina Zabidi,Farhana Yahya,Farah Hidayah Kamisan,Norhafizah Mohtarrudin,Fezah Othman,Zarizal Suhaili,Zainul 셀메드 세포교정의약학회 2012 TANG Vol.2 No.4
The present study aimed to determine the hepatoprotective activity of the chloroform extract of D. linearis leaves (CEDL) using the paracetamol (PCM)- and carbon tetrachloride (CCl4)-induced liver injury models in rats. The rats received dH2O (negative control), 200 mg/kg of silymarin (positive control) or CEDL (50, 250 and 500 mg/kg) orally once daily for 7 days and then were subjected to the hepatotoxic induction on the 7th day. The samples (i.e. blood and liver) were collected and underwent biochemical and microscopical analysis, respectively. From the data obtained, both inducers caused significant (p < 0.05) increase in the levels of AST and ALT when compared to the control group, which were significantly (p < 0.05) reduced by CEDL in a generally dose-dependent manner. These biochemical findings were supported by the histopathological analysis and histological scoring. In conclusion, CEDL possesses potential hepatoprotective activity, which could be associated with its flavonoid and tannin contents with the mechanisms of hepatoprotection linked to either its antioxidant or anti-inflammtory /immunomodulating activities. Further in-depth studies are required to identify the responsible bioactive compound.