알코올에 의해 유발된 진정 및 수행 장애에 대한 카페인의 반전 효과

유남재,김정란,조정혜,왕성근 대한생물치료정신의학회 2004 생물치료정신의학 Vol.10 No.1

연구목적 : 저자들은 알코올의 진정 작용과 수행 붕괴 효과에 대한 카페인의 영향을 확인하기 위해 이 연구를 시행하였다. 방 법 : 건강한 19세에서 25세 사이의 대학생 지원자 14명을 대상으로 Epsworth Slippiness Scale(ESS), Stand-ford Sleepiness Scale(SSS), Visual Analogue Sclae(VAS), Vienna test, Multiple Sleep Latency Test(MSLT) and Breath Ethanol Concentration(BrEC)을 측정하였다. 결 과 : 알코올(1.0g/㎏)은 투여 후 5시간까지 입면잠복기를 단축시키며, 카페인(300mg)은 이러한 단축을 현저히 개선시키는 반전 효과가 있었다. 알코올(1.0g/㎏)은 투여 후 3~5시간 동안 주간 졸음과 피로감을 유발하며, 카페인(150~300mg)은 졸음과 피로감을 개선시키는 효과가 있었다. 경계력은 알코올(0.5~1.0g/㎏) 투여 1시간 후 유의하게 저하되었고 카페인(150~300mg) 투여 3시간 후부터 개선되었으며, 집중력은 알코올(1.0g/㎏) 투여 후 변화가 없었으나 카페인 투여 3시간 후부터 유의하게 향상되었고, 단기 기억은 알코올과 카페인 투여에 유의한 변화가 나타나지 않았다. 기준일, 알코올 투여일, 알코올 및 카페인 투여일에서 각 변량(SSS, MSLT, 졸음, 피로감, 기분, 집중력, 경계력, 단기 기억력)간에는 일관성 있는 유의한 관계가 나타나지 않았다. 정상인에서 알코올은 입면잠복기를 단축시키고 주간 졸음과 피로감을 유발하며, 카페인은 알코올에 의해 유발된 입면잠복기의 단축을 연장시키고 주간 졸음과 피로감 및 경계력과 주의 집중력을 개선시키는 효과가 있었다. 결 론 : 카페인은 알코올의 진정 및 수행 붕괴 효과를 반전시키는 효과가 있음을 알 수 있었다. Objectives : The authors performed this study to identify the effects of caffeine on the alcohoi's sedative and performance disruptive effects. Methods : Epsworth Sleeppiness Scale(ESS), Stanford Sleepiness Scale(SSS), Visual Analogue Scale WAS), Vienna test, Multiple Sleep Latency Test(MSLT) and Breath Ethanol Concentration(BrEc) were checked for the 74 young and healthy college student volunteers aging from 19 to 25 years. Results : Alcohol(1.0g/kg) freduced sleep latency until 5 hours after administration and caffeine(300mg) reversed this effect significantly. Alcohol(1.0g/kg) induced daytime sieepiness and fatigue 3-5 hours after administration and caffeine(l50-300mg) improved sleepiness and fatigue. Vigilance was decreased significantly 1 hour after alcohol administration(0.5-1.0g/kg) and improved 3 hours after caffeine administration(l50-300mg) and attention was not changed after alcohol administration(1.0g/kg) but improved significantly 3 hours after caffeine administration and short-term memory was not changed significantly after alcohol and caffeine administration. On the baseline, the day of alcohol administration only, and alcohol and caffeine administration day, between each vanable(SSS, MSLT, sleepiness, fatigue, mood, vigilance. concentration, and short-term memory) did not show significant consistent correlation. Conclusion : Alcohol decreases sleep latency and induces daytime sleepiness and fatigue, and caffeine prolonges sleep latency and improves daytime sleepiness, fatigue, vigilance and attention in normal subjects. These results showed caffeine reverses alcohol's sedative and performance-disruptive effects.

보일러내의 Nox 저감 3차원 수치모델

전영남,송형운,김정열,유경석 조선대학교 환경공해연구소 2004 環境公害硏究 Vol.18 No.-

This paper presents numerical simulation of the flow and combustion process in a pulverized coal fired utility boiler of 350MWe with 24 swirl burners installed at the boiler front wall. The numerical model is applied to an Eulerian-Eulerian model of coal combusiton and NOx formation, It uses Eulerian, time averaged, conservation equations for all the dependent variables. Especial attention is paid to the accuracy of the representation of the several physical submodels of the coal particle, such as particle drying, volatilization or heterogenous combustion. In this systematic investigation, burning characteristics of pulverized coal were calcuated temperature, NOx, unburned carbon content of char and exhaust gas composition in utility boiler. Parametric screening studies have been achieved for the suggestion of improvement operating conditions for reducing NOx and unburned carbon content.

비정형 자료의 정량화를 위한 정보계측 기법의 개발

정남수,이정재,김한중,허유만 한국농업정보과학회 2003 농업정보과학 Vol.4 No.1

Statistical total information was suggested by modifying Gell-Mann's total information in the process of dividing by bit number of composing elements. Results of application satisfied set condition of information suggested by Gell-Mann, converged in the case that all elements are known, and expressed the differences with deterministic information. To find the relation with real value, total information gathered in Encyclopedia regressed with land value and showed significant relation. Further research on automatic gathering information in more stable IGUS like internet would benefit assessing ambiguous value like environment and human feeling.

랫드에서 법제유황과 비법제유황의 독성비교

김근수, 정유리, 이남진, 홍성희, 유종훈, 정재황, 강종구 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.2

본문참고

정상인에서 부분적 수면박탈이 수면구조에 미치는 영향

왕성근,이정규,이충숙,최하석,유남재,정인형,이선우 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

To identify the effects of partial sleep deprivation on the sleep structure, the authors performed polysomnographic study for 9 healthy young adults. The subjects were college students, ranging in age from 20 to 25 years, without personal past or present histories of medical, neurological, or psychiatric illness and suffering from current sleep disturbance or parasomomnias. Sleep records were analyzed according to the criteria of Rechtschaffen and Kales' manual and tried paired t-test. The results were summarized as follows. 1. As for sleep parameters, total sleep time(TST), REM latency and REM duration were not changed significantly during deprivation period and recovery period compared with baseline. Sleep efficiency increased significantly during deprivation period and recovery period compaired with baseline, and sleep latency and WASO were shortened significantly during deprivation period and recovery period compared with baseline. 2. As for sleep structure, 1) The absolute value(minutes) of stage 1 decreased significantly during deprivation period and first recovery night compared with baseline, and the relative value(percentage) of stage 1 decreased significantly during deprivation period and recovery period compared with baseline. 2) The absolute value(minutes) of stage 2 decreased significantly during deprivation period compared with baseline, and the relative value(percentage) of stage 2 decreased significantly during deprivation period and first recovery night compared with baseline. 3) The absolute value(minutes) of slow wave sleep were not changed significantly during deprivation period and recovery period compared with baseline, and the relative value(percentage) of slow wave sleep increased significantly during recovery period compared with baseline. 4) The absolute value(minutes) of REM sleep decreased significantly during deprivation period compared with baseline, and the relative value(percentage) of REM sleep decreased significantly in the first deprivation night but, were not changed significantly during recovery period compared with baseline.

쌍태아에서 제 1태아의 분만 후 제 2태아의 지연분만 : 중례보고

김주환,서민정,유희정,노권일,조대현,박정규,이정헌,조성남,손영수 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

With the widespread use of fertility medications and techniques of in vitro fertilization, multiple gestation has become epidemic in modern obstetric practice. Delivery of the initial fetus in a multiple gestation usually is followed by delivery of the subsequent fetus or fetuses shortly thereafter. However in rare circumstances, the delivery is delayed for days due to disappearance of uterine contraction after delivery of the first fetus. When uterine activity ceases after the delivery of the first neonate, a policy of nonintervention may be considered in case of an immature or very premature delivery, in order to achieve a gestational age for the remaining fetus(es) more compatible with neonatal survival. We report a case of twin gestation with prolongation of the delivery interval between the twins for 46 days.

흡연에 의한 급성 호산구성 폐렴 2예

박종빈,김학렬,주현준,유태양,신성남,신정현,송정섭,황기은,김소영,양세훈,정은택 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

최근 흡연을 시작한 젊은 성언에서 급성 호산구성 폐렴의 발생에 대한 증례가 보고되고 있다. 급성 호산구성 폐렴은 대개 발열을 동반하기 때문에 초기에는 감염성 폐렴으로 잘못 진단, 치료되는 경우가 많다. 아직 정확한 병태 생리 및 조직학적 소견은 밝혀져 있지 않지만 병력 청취 및 임상 양상, 방사선 소견의 관찰을 통해 급성 호산구성 폐렴을 의심하고, 진단을 위해 기관지 폐포 세척액 검사를 시행한다면 좀 더 쉽게 진단 내릴 수 있을 것이다. 본 저자들은 최근 처음 시작한 흡연에 의해 발생한 급성 호산구성 폐렴을 진단하고, 스테로이드를 투여하여 성공적으로 치료한 환자 2예를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Acute eosinophilic pneumonia(AEP) is characterized by acute febrile respiratory illness associated with diffuse pulmonary infiltration and pulmonary eosinophilia. The specific etiology for acute eosinophilic pneumonia is elusive. By some investigators, cigarette smoking is suggested as a causative substance which can cause AEP. In recent, the authors experienced two cases of AEP following cigarette smoking. Both cases had characteristic features including age around 20 years, new onset smoking before occurance of AEP, diffuse infiltration on chest radiography, pulmonary eosinophilia based on bronchoalveolar lavage and acute improvement after steroid therapy. These clinical features are resemble with previous smoking induced AEP case reports. Base on these clinical features, cigarette smoking associated AEP could be diagnosed more easily.

First Report of Peanut stunt virus on Glycine max in Korea

Nam, Moon,Park, Seok-Jin,Kim, Yu-Jeong,Kim, Jeong-Seon,Park, Chung-Youl,Lee, Jun-Seong,Choi, Hong-Soo,Kim, Jeong-Soo,Kim, Hong-Gi,Lee, Su-Heon The Korean Society of Plant Pathology 2012 Plant Pathology Journal Vol.28 No.3

High Throughput Sequencing Enables Discovery of Microsatellite Markers for the Assessment of Genetic Diversity in Masu Salmon (Oncorhynchus masou)

Jeong-Nam Yu,Seung-Ho Choi,Seon-Man Kweon,Sang Ki Kim,Deuk-Hee Jin,Gill-Seon Kim,Soonok Kim 한국수산과학회 양식분과 2014 한국수산과학회 양식분과 학술대회 Vol.2014 No.10

Haploidy influences Bak and Bcl-xL mRNA expression and increases incidence of apoptosis in porcine embryos

Jeong, Yu-Jeong,Cui, Xiang-Shun,Kim, Bong-Ki,Kim, Il Hwa,Kim, Teoan,Chung, Yon-Bok,Kim, Nam-Hyung Cambridge University Press 2005 Zygote Vol.13 No.1

<P>The objective of this study was to determine developmental pattern, total cell number, apoptosis and apoptosis-related gene expression in haploid and diploid embryos following parthenogenetic activation. <I>In vitro</I>-matured porcine oocytes were activated by electrical pulses and cultured in the absence or presence of cytochalasin B for 3 h. Zygotes with two polar bodies (haploid) and one polar body (diploid) were carefully selected and were further cultured in NCSU 23 medium containing 0.4% bovine serum albumin (BSA) for 7 days. The percentage of development to blastocyst stage was higher (<I>p</I><0.01) in the diploid than in the haploid parthenotes. In haploid blastocysts, average total cell number was significantly reduced (<I>p</I><0.05) and apoptosis was increased at day 7. The relative abundance of Bcl-xL and Bak mRNA in the diploid blastocysts was similar to that of <I>in vivo</I>-fertilized embryos. However, Bcl-xL was significantly decreased, and Bak mRNA was significantly increased (<I>p</I><0.05) in haploid parthenotes compared with the diploid parthenotes. These results suggest that the haploid state affects apoptosis-related gene expression which results in increased apoptosis and decreased developmental competence of haploid parthenotes.</P>