호르몬 불응성 전립선암 환자에서 mitoxantrone과 prednisone의 병합화학요법 후 통증완화 및 삶의 질 측정

이홍우,이지열,김세웅,이충범,강성학,조용현,황태곤,박용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

목적 : 호르몬 불응성 전립선암 환자의 생명을 연장시키는 치료법은 현재로는 없으며, 현 시점에서의 치료목표는 증상의 경감 및 소실에 따른 삶의 질 향상에 두고 있다. 호르몬 불응성 전립선암의 고식적인 치료에 일차적인 치료법으로 간주되는 mitoxantrone과 prednisone의 화학요법이 호르몬 불응성 전립선암 환자의 통증완화 및 삶의 질에 어떠한 영향을 미치는지 알아보았다. 방법 : 1998년 7월부터 1999년 12월까지 증상이 있는 18명의 호르몬 불응성 전립선암 환자를 대상으로 하였으며, 일차적인 치료의 목표는 환자 본인이 기록하는 McGill-Melzack 6단계 통증척도에서 진통제의 증량 없이 2점이 감소(또는 첫 점수가 1점일 경우 통증의 완전소실)하는 것으로 하였다. 이러한 기준은 최소 3주 간격으로 시행한 자가 기록조사에서 연속적으로 2번 이상 유지될 때 유효한 것으로 간주하였다. 건강과 관련된 삶의 질 측정은 전신적 치료의 임상적 응용을 위한 실제적인 측정방법으로 개발되어 환자가 직접 작성하는 전립선암 특이성 삶의 질 측정기구(Prostate Cancer-Specific Quality-of-Life Instrument : PROSQOLI)의 비례연속형의 자가측정 척도(linear analogue self-assessment scale : LASA)를 이용하였으며, ECOG performance status를 사용하여 전신상태의 변화도 측정하였다. 결과 : 통증의 경감으로 나타나는 고식적인 치료의 반응은 66.7%(12/18)에서 나타났으며, 반응의 지속기간은 2개월에서 10개월까지로 평균 4.2±3.6개월이었다. PROSQOLI로 측정한 삶의 질은 통증에 대한 고식적인 치료반응을 보인 12명(66.7%) 모두가 삶의 질이 개선되었으며 특히 통증, 변비, 소변보기, 전반적인 복지상태에서의 유의한(p<0.05) 증가를 보였다. 치료 후 혈장 PSA 수치는 고식적인 반응의 유무에 관계없이 별 다른 변화를 보이지 않았으며, 골주사 또는 전산화 단층촬영으로 측정한 방사선학적 병변은 고식적인 반응을 보인 2명을 제외하고 치료 전과 비교하여 차이를 보이지 않았다. 병합 화학요법과 관련된 특별한 부작용은 관찰되지 않았다. 결론 : 통증을 동반한 호르몬 불응성 전립선암에서 mitoxantrone과 prednisone의 병합화학요법은 66.7%의 환자에서 통증의 감소 및 삶의 질이 향상되었다. 현재는 혈장 PSA 수치, 병소의 크기나 개수등이 치료의 지침이나 치료결과의 판정을 위한 객관적인 기준으로 사용되는 경향이 있지만, 앞으로는 환자를 중심으로 통증을 포함한 삶의 질 측정이 고식적 치료 후 치료결과 판정에 있어 객관적이고 적절한 방법이 될 것이다. Background : There is no evidence that therapeutic modalities prolong the survival of patients with hormone-refractory prostate cancer nowadays. The main goal of treatment is therefore improvement in quality-of-life including palliation of symptoms. We performed this study to investigate the benefit of mitoxantrone and prednisone chemotherapy in patients with symptomatic hormone-refractory prostate cancer using relevant end points of palliation regarding to pain and quality-of-life. Methods : From July 1998 to December 1999, we assessed the 18 patients with symptomatic hormone-refractory prostate cancer receiving mitoxantrone and low dose prednisone. The treatment end point was a palliative response defined as a 2-point decrease in pain assessed by a 6-point pain scale complemented by patients (or complete loss of pain if initially 1+) without an increase in analgesic medication and maintained for two consecutive evaluations at least 3 weeks apart. Health-related quality-of-life was evaluated with a series of linear analogue self-assessment(LASA) scale of the Prostate Cancer-Specific Quality-of-Life Instrument (PROSQOLI) and performance status was also measured. Results : Palliative responses were observed in 12(66.7%) of 18 patients. The duration of palliative responses were 4.2±3.6 months(range: 2 to 10 months). Treatment was well tolerated without specific side effects. There were no differences in prostate-specific antigen (PSA) level following treatment and no significant changes of radiologic findings evaluated by bone scan and/or CT were noted except 2 cases after chemotherapy. All the responding patients had an improvement in quality-of-life scales and performance status, however serum PSA levels were not changed. Conclusions : Chemotherapy with mitoxantrone and prednisone provides palliation and an improvement in quality-of-life for more than half (66.7%) of the patients with symptomatic hormone-refractory prostate cancer.

신체형 환자의 애착 특성

김용희,송지영,반건호,김종우,신용선 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The purpose of this study was to evaluate the relationship betseen attachment style and somatization in patients with somatoform disorder. Methods : Data was collected by self-report questionnaires. 134 normal subjects and 30 patients with somatoform disorder were enrolled in this study. All subjects completed a psychometric assessment that consisted the Revised Adults Attachment Scale(RAAS), Inventory of Parent and Peer Attachment (IPPA), Sungshin Self-concept Inventory (SSCI), and SCL-90-R. Results : 1) Somatoform patients showed more anxious attachment style than normal control. 2) Anxious attachments were combined with mistrust of their parents, emotional instability, and interpersonal mistrust which may play a significant portion of variance in somatization. Conclusion : We found that patients with somatoform disorder had more anxious attachment style than normal subjects. Insecure attachment patterns may significantly explain the phenomenon of somatization.

인쇄회로기판 제조 공정에 대한 냉각판 구조의 영향

이지수,김지민,박주용,이성우,심재우 한국공업화학회 2004 응용화학 Vol.8 No.1

Because of strong demand of compacted consumer electronics and rapid improvements in the miniaturization of electronic devices, compact or high density multi-layered PCBs (Printed Circuit Board) production facility with high productivity is being actively sought out. In the cooling process of lamination, it is very important to diminish the temperature deviation within the epoxy resin with respect to the position of press. In this study, we measured the temperature distribution of cooling process for CCL (Copper Clad Laminate) manufacturing. As the result, temperature change in the first plate was bigger than the one in the sixth plate. Much higher efficiency of cooling was observed when copper separator was used compared to the cooling at the natural convection state. In addition, when cooled by the copper plate, the temperature deviation between plates in CCL went up to maximum of 9 degrees.

Effect of Chlorella Diet Supplementation on Blood and Urine Cadmium Levels in Cadmium Poisoned Rats

김용호,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2003 Journal of biomedical laboratory sciences Vol.9 No.3

This study was conducted to investigate the influence of chlorella diet supplementation. Blood accumulation and urine excretion levels were measured after the Sprague-Dawley (SD) rats were fed on a chlorella diet supplementation mixed with 40 ppm of CdCl₂. Four groups tested for blood accumulation and urine excretion levels. All four groups fed on a basic diet with a cadmium mixture. The diet for the first group contained only basic diet and the cadmium added to the drinking water. The diet for the three other groups contained cadmium to the drinking water, and 1%, 5% and 10% of chlorella added to the basic diet. A concentration of cadmium for the first group showed a 3.2±0.4 ㎍/l blood accumulatior. level and 41.5±32.9 ㎍/l urinary excretion level, and the second group, which was fed on the basic diet with 1% of chlorella added and cadmium to the drinking water showed a 1.5±0.6 ㎍/l blood level and only 14.1±1.6 ㎍/l urinary excretion level. The other two groups, which were fed on 5% and 10% of chlorella concentration and cadmium to the drinking water did not exhibit any notable effects greater than the group fed on 1% concentration of chlorella. The results suggest that the blood accumulation and urinary excretion of Cadmium are influenced by the chlorella diet supplementation from the concentration of 1% of the basic diet.

급성신부전증 이환견에 대한 복막투석 치료 1례

김건우,이병희,김유수,심재현,김지용,이영원,김덕환,송근호 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

A fourteen-month-old intact female Poodle was referred to the Veterinary Teaching Hospital, College of Veterinary Medicine, Chungnam National University. The patient was presented with history of vomiting, inappetence, ataxia, insomnia, tachypnea and convulsion for 5 days. Biochemical examination revealed BUN (254.2 mg/dl), creatinine (9.22 mg/dl) and phosphate (14 mg/dl). Epithelial cells of urinary tract, neutrophils, macrophages, a large number of gram negative and smaller number of gram positive bacteria were presented on urine test. Ultrasonographic findings show hyperechogenic kidney and indistinguishableness of renal cortex and medulla. Based on the results of examination described above, this case was diagnosed as acute renal failure with interstitial nephritis by urinary tract infection (UTI). Treatments with fluids therapy, diuretics, and peritoneal dialysis during hospitalization showed good results with no clinical signs.

대량의 각혈로 사망한 장티푸스 1예

한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.

균일 가열 수직 원형관에서의 일반화된 임계열유속 예측 상관식 개발

이성우,박주용,이지수,심재우 한국공업화학회 2004 응용화학 Vol.8 No.1

A new generalized CHF (Critical Heat Flux) correlation was suggested for water flow in uniformly heated vertical round tubes. The parametric ranges of experimental data were as follows : 0..101≤p (pressure) ≤ 20.679 MPa, 9.92 ≤ G (mass flux) ≤ 18,619.39 lg/㎡s, 0.00102 ≤ D (diameter) ≤ 0.04468 m, 0.03 ≤ L (length) ≤ 4.97 m, -609.33 ≤ Inlet subcooling ≤ 1,655.34 kJ/kg, 0.11 ≤ q_(c) (CHF) ≤ 21.41 MW/㎡, and -0.87 ≤ X_(e) (exit qualities) ≤ 1.58. The new correlation was based on the local condition hypothesis. The new correlation was compared with 4 existing CHF correlation from world literature that claimed to have comparatively good predictions. The results of this study showed that prediction of CHF by the new correlation was in very good agreement with 8,951 experimental CHF data points composed of 12 different sources[1]. The new correlation predicted CHF better than the other ones with average error of -1.34% and root mean square error of 13.44%.

섬유상 활성탄에서 페놀계 유도체의 속도흡착특성

이지수,김지민,박주용,이성우,심재우 한국공업화학회 2004 응용화학 Vol.8 No.1

Adsorption characteristics of phenolic compounds by activated carbon fiber have been investigated. Accurate description of kinetic adsorption that can predict the behavior of adsorption equipment it very important in many industrial areas, particularly in environmental applications. In this study, adsorption behavior of phenolic compounds was predicted by the use of Freundlich and Langmuir isothermal adsorption equation. In addition, a two parameter curve fit was used for the comparison. The equilibrium kinetic constant was predicted by Langmuir equation and maximum amount of adsorption was obtained from each isothermal equation. About 40% of substrates were removed within 5 minutes from the initial state of adsorption.

동박적층판 구조에 대한 냉각효율의 예측

이지수,김지민,박주용,이성우,심재우 한국공업화학회 2004 응용화학 Vol.8 No.1

To produce high quality PCB (Printed Circuit Board). CCL (Copper Clad Laminate) that can result in uniform quality is very important. Research and studying the temperature distribution and stress analysis within CCL may not be sufficient. In this study, the temperature distribution of CCL with a separator construction was measured and it was compared with a simulation result. It was found that the separator thickness influenced temperature distribution within CCl. The application of separator was the most effective means of enhancing cooling performance and laminated in a copper-steel-copper separator was effective in uniform cooling.

회전거울을 이용한 광속도 측정에 대한 연구

柳志旭,洪思容,金英猷,李春雨 公州大學校 基礎科學硏究所 1993 自然科學硏究 Vol.2 No.-

회전거울을 이용한 광속측정법은 거울의 회전에 기인한 광원점의 상 변위를 측정함으로써 단순한 장치로 비교적 정확한 측정값을 기대할 수 있다. 그러나 정밀하고 적절한 기구정렬이 없이는 상을 찾기 어렵다. 이 논문에서는 이와 같은 문제점을 고찰하고 그 해결책을 모색하였다. 정밀한 기구정렬을 거쳐 공기중에서 측정한 광속은 c=2.99±.16×108m/s이었다. An advanced undergrauate laboratory experiment is described which uses a laser, a rotating mirror assembly, a fixed mirror and a measuring microscope to determine the speed of light using time of flight. We investigated the alignment methods to obtain a good image. The measurement value was c=2.99±.16×108m/s in air.