http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
정상인 및 신기능장애환자에서의 Ethambutol 의 약동학
김순배(Soon Bae Kim),김대중(Dae Joong Kim),한진석(Jin Suk Han),김성권(Suhng Gwon Kim),이정상(Jung Sang Lee),박찬웅(Chan Woong Park),한용철(Yong Chol Han),신상구(Sang Koo Shin),이선희(Sun Hee Lee) 대한내과학회 1987 대한내과학회지 Vol.33 No.5
N/A Ethambutol is commonly u in chemotheraphy of tuberculosis but little is known about its pharmacokinetics in patients with impaired renal function and there is much difficulty in its dose adjustment in these patients. Pharmacokinetics of single oral dose (15 ㎎/㎏) of ethambutol was studied in 7 normal subjects and 24 patients with impaired renal function including 7 patients on long-term hemodialysis. The results were as follows; 1) In view of parameters in normal subjects, approximately 74% of ethambutol was cleared by the kidney. 2) In patient with renal insufficiency, half-life of ethambutol was prolonged and renal clearance was reduced without change of volume of distribution and non-renal clearance. With these results, we recommended a method of dose adjustment as follows; Ccr≥75 ml/min - 15㎎/㎏, 50≤Ccr<75 - 13㎎/㎏. 25≤Ccr<50 - 10㎎/㎏, 10≤Ccr<25 - 8㎎/㎏, Ccr<10 - 6㎎/㎏. 3) Hemodialysis cleared 3.3% of ethambutol administrated, so supplementary dose after hemodialysis was unnecessary.
흥미영상 : 신경섬유종증 환자의 F-18 FDG PET/CT에서 육종전환으로 오인된 신경섬유종
박순아 ( Soon Ah Park ),송정훈 ( Jeong Hoon Song ),양충용 ( Chung Yong Yang ),김헌수 ( Hun Soo Kim ),박승철 ( Seung Chol Park ) 대한핵의학회 2009 핵의학 분자영상 Vol.43 No.4
We present a patient with high 18F-fluorodeoxyglucose (FDG) uptake detected in a neurofibroma that was confused with sarcomatous transformation on a positron emission tomography/computed tomography (PET/CT) scan. A 39-year-old male patient with a 20-year history of neurofibromatosis-1 (NF-1) performed FDG PET/CT scan for the evaluation of lesions with sarcomatous transformation. The FDG PET/CT images demonstrated varying degrees of increased FDG uptake in the multiple nodules throughout whole body. The left pelvic mass with the highest FDG uptake had a maximum standardized uptake values (maxSUV) 5.0 and surgical resection was performed. Histological analysis confirmed the presence of a benign neurofibroma infiltrated with inflammatory cells. (Nucl Med Mol Imaging 2009;43(4):361-362)
정희순(Hee Soon Chung),유빈(Bin Yoo),김현태(Hyeon Tae Kim),기만덕(Man Deok Kee),한성구(Sung Koo Han),심영수(Young Soo Shim),김건열(Keun Youl Kim),한용철(Yong Chol Han) 대한내과학회 1987 대한내과학회지 Vol.33 No.1
N/A Lung cancer has become one of the most common cancers in Korea. Once signs, symptoms, or screening studies suggest this disease, it is of paramount importance to establish a tissue diagnosis of malignancy and determine the histologic cell type because of different treatment modality in small cell bronchogenic carcinoma. Currently, cytologic examinations including sputum, bronchial washing and brushing are widely used to diagnose and determine cell type in lung cancers. To evaluate the diagnostic yield and its accuracy of each diagnostic method in lung cancer, we have studied with 281 cases of histologically-proven lung cancer patients. The results are summarized as follows; 1) The diagnostic yields of bronchoscopic biopsy, bronchial washing, bronchial brushing, sputum cytology and PCNA (percutaneous needle aspiration) were 74,8% (86,4% with visible bronchoscopic lesion), 48.4%, 66,7%, 58.8% and 90.7%, respectively. 2) The diagnostic accuracy of each diagnostic method in the order named, was 96,8%, 93.4%, 87.3%, 86.9% and 86,8%. In consideration of mixed forms, this value was 98.1%, 93.4lo 89.2%, 89.7%, and 92.6%, respectively. 3) The cytologic examination of percutaneous needle aspriate of lung was the most useful, single test among the cytologic examinations. 4) It is appropriate in lung cancer to repeat the cytologic studies of sputum up to 5 times.
Kang, Woong Chol,Il Moon, Chan,Lee, Kyounghoon,Han, Seung Hwan,Suh, Soon Yong,Moon, Jeonggeun,Shin, Mi Seung,Ahn, Taehoon,Shin, Eak Kyun Lippincott Williams Wilkins, Inc. 2011 Coronary artery disease Vol.22 No.8
BACKGROUND: We compared the relationship between inflammatory markers and neointimal hyperplasia (NIH) after drug-eluting stent (DES) implantation. METHODS: We implanted a single DES in 42 consecutive patients with stable angina. The plasma high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and matrix metalloproteinase-9 (MMP-9) levels were measured before, and 24 and 72 h after the procedure. Angiography and intravascular ultrasound were performed. RESULTS: No relationship was noted between the baseline hs-CRP level and NIH. A significant positive correlation was noted between NIH and the hs-CRP level obtained at 24 h (r=0.435, P=0.004), and 72 h (r=0.334, P=0.031) after the procedure. Interestingly, there was a positive correlation between the change (&Dgr;) in the hs-CRP level and NIH at 24 h (r=0.414, P=0.006). The fourth quartile of the hs-CRP at 24 h after percutaneous coronary intervention (PCI) had significantly larger volume of NIH than the first quartile (20.1±25.1 vs. 2.7±6.4 mm, P<0.05). Moreover, NIH in the fourth quartile (20.9±26.4 mm) was higher than the first quartile (3.3±8.6 mm) of the &Dgr; hs-CRP level at 24 h (P<0.05) after the procedure. Although the IL-6 level at the baseline and 72 h after the procedure were positively correlated with NIH (r=0.337, P=0.029 and r=0.435, P=0.004, respectively), the &Dgr; IL-6 level at any stage was not correlated with NIH. Neither the MMP-9 level nor the &Dgr; MMP-9 level at any stage was correlated with NIH. CONCLUSION: This prospective intravascular ultrasound study showed the inflammatory response after PCI, as measured by hs-CRP levels, but not the baseline hs-CRP level, predict NIH after DES implantation. Neither a change in the IL-6 nor MMP-9 levels at any stage after PCI reflected NIH.