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RISS 인기검색어
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- 저자 : Yarong Li (검색결과 5 건)
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Yarong Li,Yaqian Zhou,Huanjin Liu,Chenxu Wei,Shuli Chen,Zhengying Hua,Yan Xu,Yu Wu,Weidong Li 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.10
We investigated the changes in the main active ingredients and pharmacodynamic differences in the therapeutic effect of garlic before and after steaming and the correlation between them. The main active ingredients in raw garlic products (RGPs) and steamed garlic products (SGPs) were determined by high-pressure liquid chromatography and ultraviolet spectroscopy. Acute rapid diarrhea (AD) and antibiotic-induced diarrhea (DD) models were established in rats, and each group was treated with RGP and SGP, respectively. The main chemical components of garlic changed before and after steaming. Garlicin and alliinase were only found in RGP, whereas only alliin was found in SGP. Both RGP and SGP contained garlic polysaccharides. For in vivo experiments on AD, the average rate of loose stools was 100.00 ± 0.00, 31.55 ± 11.76, and 19.14 ± 6.62 in the RGP high-dose and SGP high-dose treatment groups, respectively; in DD, the rates were 91.11 ± 14.40, 19.33 ± 3.63, and 30.56 ± 4.30, respectively (P < .01, treatment vs. model groups). In AD, the average grade of loose stools was 2.33 ± 0.52 and 1.83 ± 0.75 in the model and RGP high-dose treatment groups, respectively (P < .05); in DD, the values were 2.17 ± 0.41 in the model group and 1.67 ± 0.52 in the SGP high-dose treatment group (P < .05). RGP had a better therapeutic effect on AD, mainly related to the antibacterial effect of garlicin in RGP. SGP had a better therapeutic effect on DD, mainly related to the alliin and garlic polysaccharide in SGP. This study could provide evidence to support the clinical use of garlic.
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Jifeng Sun,Yarong Wang,Jie Yang,Dewei Du,Zhanting Li,Junxia Wei,Angang Yang 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.11
Relative deficiency in production of glycoprotein hormone erythropoietin (Epo) is a major cause of renal anemia. This study planned to investigate whether the hypoxia-regulated system of Epo expression, constructed by fusing Epo gene to the chimeric phosphoglycerate kinase (PGK) hypoxia response elements (HRE) in combination with cytomegalovirus immediate-early (CMV IE) basal gene promoter and delivered by plasmid intramuscular injection, might provide a long-term physiologically regulated Epo secretion expression to correct the anemia in adenine-induced uremic rats. Plasmid vectors (pHRE-Epo) were synthesized by fusing human Epo cDNA to the HRE/CMV promoter. Hypoxia-inducible activity of this promoter was evaluated first in vitro and then in vivo in healthy and uremic rats (n = 30 per group). The vectors (pCMV-Epo) in which Epo expression was directed by a constitutive CMV gene promoter served as control. ANOVA and Student’s t-test were used to analyze between-group differences. A high-level expression of Epo was induced by hypoxia in vitro and in vivo. Though both pHRE-Epo and pCMV-Epo corrected anemia,the hematocrit of the pCMV-Epo-treated rats exceeded the normal (P < 0.05), but that of the pHRE-Epo-treated rats didn’t. Hypoxia-regulated system of Epo gene expression constructed by fusing Epo to the HRE/CMV promoter and delivered by plasmid intramuscular injection may provide a long-term and stable Epo expression and secretion in vivo to correct the anemia in adenine-induced uremic rats.
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Huan Liu,Jie Bai,Chunping Li,Shan Wang,Yarong Huang,QI WANG,WEIYAN SUN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.3
Ag nanoparticles (Ag NPs) embedded carbon nano¯bers (CNFs) were prepared by a new routewhich included chemical reaction process, electrospinning and calcination technique. The mor-phology and structure of the composite nano¯bers were investigated by scanning electron mi-croscopy, energy dispersive X-ray spectroscopy, transmission electron microscopy and X-raydi®raction. It indicated that Ag NPs were uniformly distributed in the CNFs. This e®ectivesynthesis method can be used to prepare other composite nano¯bers with functionality. The AgNPs/CNFs that served as supported catalysts were used in the styrene epoxidation by TBHP. The Ag NPs/CNFs catalyst showed its highly catalytic activity for the epoxidation of styrene(conversion: 40.6%, SO selectivity: 35.9%). This kind of composite nano¯ber membrane wasproved e®ectively catalytic activity and recycled easily in the styrene epoxidation.
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Shumin Wang,Mei Ping,Bin Song,Yarong Guo,Yuanfei Li,Junmei Jia 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.9
Purpose: Gastric cancer (GC) is a malignant tumor with a high mortality rate. Drug resistance is a major obstacle to GC therapy. This study aimed to investigate the role and mechanism of exosomal circPRRX1 in doxorubicin resistance in GC. Materials and Methods: HGC-27 and AGS cells were exposed to different doses of doxorubicin to construct doxorubicin-resistantcell lines. Levels of circPRRX1, miR-3064-5p, and nonreceptor tyrosine phosphatase 14 (PTPN14) were detected by quantitativereal-time PCR or Western blot assay. Then, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide, transwell,and Western blot assays were used to explore the function of circPRRX1 in GC cells. Interactions among circPRRX1, miR-3064-5p,and PTPN14 were confirmed by dual-luciferase reporter assay. The in vivo function of circPRRX1 was analyzed in a xenograft tumormodel. Results: CircPRRX1 was highly expressed in doxorubicin-resistant GC cell lines. Knockdown of circPRRX1 reversed doxorubicinresistance in doxorubicin-resistant GC cells. Additionally, extracellular circPRRX1 was carried by exosomes to spread doxorubicinresistance. CircPRRX1 silencing reduced doxorubicin resistance by targeting miR-3064-5p or regulating PTPN14. In GC patients,high levels of circPRRX1 in serum exosomes were associated with poor responses to doxorubicin treatment. Moreover, depletionof circPRRX1 reduced doxorubicin resistance in vivo. Conclusion: CircPRRX1 strengthened doxorubicin resistance by modulating miR-3064-5p/PTPN14 signaling and might be atherapeutic target for GC patients.
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Jie Bai,Liping Guo,Haiou Liang,Tong Xu,Chunping Li,Qingrun Meng,Huan Liu,Yarong Huang 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.12
Well-dispersed palladium nanoparticles (Pd NPs) were prepared under the condition that trisodium citrate was the reduction agent and polyvinylpyrrolidone (PVP) was the stabilizing agent via sol-gel process. By making good use of the advanced electrospinning technology we obtained Pd NPs/PVP composite nanofibers films. Optical properties were examined by UV-visible absorbance spectra (UV-vis) and Fourier transform infrared spectroscopy (FTIR). The morphology and distribution of Pd NPs in/on PVP matrix were characterized by scanning electron microscope (SEM)and transmission electron microscope (TEM). The results showed that Pd NPs presented as spherical spots and distributed in/on PVP nanofibers uniformly; their diameter was 4-10 nm and decreased with the increase of PVP. The as-prepared Pd NPs/PVP hybrid mats possess catalytic activity, stability and reusability, as verified by performance in Heck reaction.
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