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Minyi Qi,Guiying Li,Nana Yu,Yanfeng Meng,Xunyong Liu 한국고분자학회 2014 Macromolecular Research Vol.22 No.9
In this paper, thermo-sensitive polyelectrolyte complex nanoparticles assembled from chitosan-graftpoly(N-isopropylacrylamide) (CS-g-PNIPAM) and sodium alginate-graft-poly(N-isopropylacrylamide) (SA-g-PNIPAM)were prepared for entrapment and release of 5-fluorouracil (5-FU). The morphology and size of the nanoparticles wereobserved by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The polyelectrolyte complexnanoparticles showed a narrow size distribution. The hydrogen bonding interactions between nanoparticles and5-FU, which was determined by fourier-transformed infrared spectroscopy (FTIR), increased drug loading. Glutaraldehyde,as a cross-linking agent, reinforced the nanoparticle structure and decreased the burst drug release. Whenchanging temperature, pH, or ionic strength, a sustained and controlled drug release was observed. The novel complexnanoparticles with environmentally sensitive properties are expected to be useful in the field of intelligent drugdelivery system.