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Go, Y.Y.,Kim, Y.S.,Cheon, S.,Nam, S.,Ku, K.B.,Kim, M.,Cho, N.H.,Park, H.,Alison Lee, P.Y.,Lin, Y.C.,Tsai, Y.L.,Thomas Wang, H.T.,Balasuriya, U.B.R. American Society for Investigative Pathology and t 2017 The Journal of Molecular Diagnostics Vol.19 No.6
<P>Middle East respiratory syndrome (MERS) is an emerging zoonotic viral respiratory disease that was first identified in Saudi Arabia in 2012. In 2015, the largest MERS outbreak outside of the Middle East region occurred in the Republic of Korea. The rapid nosocomial transmission of MERS-coronavirus (MERS-CoV) in Korean health care settings highlighted the importance and urgent need for a rapid and reliable on-site diagnostic assay to implement effective control and preventive measures. Here, the evaluation and validation of two newly developed reverse transcription insulated isothermal PCR (RT-iiPCR) methods targeting the ORF1a and upE genes of MERS-CoV are described. Compared with World Health Organization recommended singleplex real-time quantitative RT-PCR (RT-qPCR) assays, both RT-iiPCR assays had comparable analytical sensitivity for the detection of MERS-CoV RNA in tissue culture fluid and in sputum samples spiked with infectious virus. Furthermore, clinical evaluation was performed with sputum samples collected from subjects with acute and chronic respiratory illnesses, including patients infected with MERS-CoV. The overall agreement values between the two RT-iiPCR assays and the reference RT-qPCR assays were 98.06% (95% CI, 94.43%-100%; K = 0.96) and 99.03% (95% CI, 95.88%-100%; K = 0.99) for ORF1a and upE assays, respectively. The ORF1a and upE MERS-CoV RT-iiPCR assays coupled with a field deployable system provide a platform for a highly sensitive and specific on-site tool for diagnosis of MERS-CoV infections.</P>
Robust, Tunable Biological Oscillations from Interlinked Positive and Negative Feedback Loops
Tsai, T. Y.-C.,Choi, Y. S.,Ma, W.,Pomerening, J. R.,Tang, C.,Ferrell, J. E. American Association for the Advancement of Scienc 2008 Science Vol.321 No.5885
<P>A simple negative feedback loop of interacting genes or proteins has the potential to generate sustained oscillations. However, many biological oscillators also have a positive feedback loop, raising the question of what advantages the extra loop imparts. Through computational studies, we show that it is generally difficult to adjust a negative feedback oscillator's frequency without compromising its amplitude, whereas with positive-plus-negative feedback, one can achieve a widely tunable frequency and near-constant amplitude. This tunability makes the latter design suitable for biological rhythms like heartbeats and cell cycles that need to provide a constant output over a range of frequencies. Positive-plus-negative oscillators also appear to be more robust and easier to evolve, rationalizing why they are found in contexts where an adjustable frequency is unimportant.</P>
Area-preserving scheme for efficiency enhancement in single-pass tapered free electron lasers
Tsai, C.-Y.,Emma, C.,Wu, J.,Yoon, M.,Wang, X.,Yang, C.,Zhou, G. Elsevier 2019 Nuclear Instruments & Methods in Physics Research. Vol.913 No.-
<P><B>Abstract</B></P> <P>Efficiency enhancement of a single-pass short-wavelength high-gain tapered free electron laser (FEL) has recently been intensively studied. The goal is to sustain the growth of radiation power in the post-saturation regime. Among the various schemes, the undulator tapering is considered an effective route to achieve higher power extraction efficiency. The tapering strategy can be of constant or varying resonant phase along the undulator axis. In this paper we propose an efficiency-enhancement scheme based on preservation of the longitudinal phase space area which ensures trapping of resonant particles in the ponderomotive bucket as long as possible along the undulator axis before significant particle depletion occurs. In the meanwhile such a scheme takes advantage of the increase of the radiation field amplitude to precipitate the particle deceleration process at the middle stage of undulator tapering. We analyze such an area-preserving scheme of undulator tapering by formulating the post-saturation FEL interaction in a one-dimensional (1-D) model via introduction of the particle trapping fraction. The output performance is evaluated through numerical iteration and confirmed with 1-D particle tracking simulations. The results show that the optimal power extraction efficiency based on the proposed scheme, together with a prebunched beam, can be greatly improved within relatively short taper length compared with other schemes before radiation diffraction effect becomes significant. Besides, the undesired sideband effects are found to be effectively suppressed. For the proposed area-preserving taper scheme, we also derive an analytical approximate formula for the resonant phase as a function of undulator axis. We expect that the analysis can shed light on the aim to further enhance the power extraction efficiency in single-pass tapered FELs.</P>
A Fe-based Metallic Glass Bilayer Membrane for Biochip Micropump Application
( Y. F. Huang ),( Z. Y. Wang ),( Y. Y. Chen ),( C. C. Liao ),( Y. C. Tsai ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
This paper presents a Fe-based (Fe<sub>76</sub>Si<sub>9</sub>B<sub>10</sub>P<sub>5</sub>) metallic glass (MG) bilayer membrane for bio-chip micropump application. A Fe-based metallic glass integrated with a polydimethylsiloxane (PDMS) diaphragm is proposed and developed for an actuation membrane in this work. An actuation bilayer membrane integrated Fe-based metallic glass and PDMS diaphragm by the standard MEMS fabrication process is proposed and developed in this work. The permanent magnets on two sides are employed for polarizing the Fe-based metallic glass thin film. The magnetic field generated by the coil underneath the actuation membrane is used to attract and repel the actuation bilayer membrane. Different sputtering conditions were carried out for optimizing the Fe-based metallic glass process. The deflection of the fabricated actuation bilayer membrane was measured by laser displacement sensor. As the frequency continuously increases, the magnetic field generated by the coil decreases. The maximum magnetic field is 140 G. When 1 Hz AC 20 voltage was applied to the magnetic coil, the maximum deflection of the actuation bilayer membrane is 5 μm. The characterization experiments reveal that the Fe-based MG actuation membrane can be driven by the external electromagnetic force.
A Hybrid QFD Framework for New Product Development
( Y. C. Tsai ),( K. S. Chin ),( J. B. Yang ) 한국품질경영학회 2002 The Asian Journal on Quality Vol.3 No.2
Nowadays, new product development (NPD) is one of the most crucial factors for business success. The manufacturing firms cannot afford the resources in the long development cycle and the costly redesigns. Good product planning is crucial to ensure the success of NPD, while the Quality Function deployment (QFD) is an effective tool to help the decision makers to determine appropriate product specifications in the product planning stage. Traditionally, in the QFD, the product specifications are determined by a rather subjective evaluation, which is based on the knowledge and experience of the decision makers. In this paper, the traditional QFD methodology is firstly reviewed. An improved Hybrid Quality Function Deployment (HQFD) [MSOfficel]is then presented to tackle the shortcomings of traditional QFD methodologies in determining the engineering characteristics. A structured questionnaire to collect and analyze the customer requirements, a methodology to establish a QFD record base and effective case retrieval, and a model to more objectively determine the target values of engineering characteristics are also described.
Bone Drilling System for Quantifying Hand Feeling in Orthopedic Surgery
( C. -y. Wu ),( J. -y. Su ),( C. -s. Hsu ),( Y. -h. Chen ),( K. -f. Chang ),( C. -c. Huang ),( H. -m. Wu ),( Y. -c. Tsai ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
In this work, a bone drilling system was designed to quantify “hand feeling”, which can benefit surgeons to be more acquainted with bone hardness. A bi-axial force/torque sensor is mounted on the bone drilling system in order to measure the thrust force and the torque caused by drilling in bones. The system is assembled with a motorized stage, which is directly integrated with a surgical handpiece by an adjustable holder, to drill into various bones (porcine mandible, porcine femur, porcine rib) at different feed speeds and spindle speeds. The results reveal that the feed speed is positively corresponded with force and torque. However, the effect of spindle speed on force and torque is negligible. In addition, drilling bones without spraying water can cause the drilling temperature to increase to 73.3°C. According to the data from the experiments, the exact force and torque during bone drilling can be predicted with the given parameters. Thus, surgeons are capable of preventing the use of excessive force during bone drilling.