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H. Han(한호현),Y. Park(박예진),Y. Choi(최유미),U. Yong(용의중),B. Kang(강병민),W. Shin(신우정),S. Min(민소연),H. J. Kim(김현중),J. Jang(장진아) Korean Society for Precision Engineering 2021 한국정밀공학회 학술발표대회 논문집 Vol.2021 No.11월
Intestinal disease is a global health problem affecting millions of people. To investigate therapeutic compounds and unveil the mechanisms of the diseases, numerous in vitro intestine models have been developed as alternatives to animal surrogates. Intestinal organoids have shown that they can emulate major human physiology, but it is difficult to control their growth and maturation. On the other hand, microphysiological systems (MPSs) have been enabled to recapitulate intestinal tissues in vitro and its ecosystem with commensal microbiomes, their geometrical complexity is limited to 2D or 2.5D architectures. For this reason, 3D bioprinting has gained growing interest since it can be used to mimic 3D complex physiology such as cell-cell or cell-matrix interaction. Here, we bioprinted a tubular intestine model using a colon-derived decellularized extracellular matrix (Colon dECM). We observed that Colon dECM promotes spontaneous maturation of intestinal epithelial cells, especially its enteroendocrine functions. Furthermore, the 3D bioprinted tubular model with a hollow lumen showed cellular maturation and self-organization demonstrating distinctive tissue morphogenesis. We envisage this advanced in vitro intestine model as a platform to study intestinal morphogenesis, disease, and treatments.