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Ting Zhang,Xuze Qin,Yuxin Cao,Jianxin Zhang,Jun-Xing Zhao 한국식품과학회 2020 Food Science and Biotechnology Vol.29 No.11
The objective of this study is to investigate theeffects of sea buckthorn oil (SBO) on proliferation, adipogenicdifferentiation and insulin sensitivity of 3T3-L1cells. Results showed that SBO increased cell proliferationability, accompanied by up-regulated proliferating cellnuclear antigen content (p\0.05) and p38 activity(p\0.05). SBO also promoted adipogenesis and enhancedadipogenic transcriptional factors expression. Mitochondrialbiogenesis related gene expressions were elevated inSBO treated cells (p\0.05). Of note, SBO also increasedglucose uptake and glucose transporter 4 abundance(p\0.05). Cells treated with SBO exhibited greaterphosphorylated insulin receptor substrate 1 (p\0.05),phosphorylated-Akt (p\0.05) and phosphorylated AMPactivatedprotein kinase (p\0.01) contents. When takentogether, these results suggest that SBO promotes 3T3-L1cells proliferation, adipogenesis and insulin sensitivity.